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29 条记录 (耗时 0.052 秒)

    Dicarboxylic Acid Foamable Vehicle and Pharmaceutical Compositions Thereof
    25.
    发明申请
    Dicarboxylic Acid Foamable Vehicle and Pharmaceutical Compositions Thereof 审中-公开

    公开(公告)号：US20190076356A1

    公开(公告)日：2019-03-14

    申请号：US16189767

    申请日：2018-11-13

    申请人： Foamix Pharmaceuticals Ltd.

    发明人： Dov Tamarkin ,  Doron Friedman ,  Tal Berman ,  Enbal Ziv ,  David Schuz

    IPC分类号： A61K9/12 ,  A61K8/362 ,  A61K8/37 ,  A61K8/49 ,  A61K8/86 ,  A61K8/04 ,  A61Q19/00 ,  A01N25/16 ,  A61K9/00

    摘要： The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.

    Foamable Compositions and Kits Comprising One or More of a Channel Agent, a Cholinergic Agent, A nitric Oxide Donor and Related Agents and Their Uses
    29.
    发明申请
    Foamable Compositions and Kits Comprising One or More of a Channel Agent, a Cholinergic Agent, A nitric Oxide Donor and Related Agents and Their Uses 审中-公开
    包含一种或多种通道剂，胆碱能药物，一氧化氮受体和相关剂及其用途的可发泡组合物和试剂盒

    公开(公告)号：US20150025060A1

    公开(公告)日：2015-01-22

    申请号：US14448670

    申请日：2014-07-31

    申请人： Foamix Pharmaceuticals Ltd.

    发明人： Dov Tamarkin ,  Meir Eini ,  Doron Friedman ,  Tal Berman ,  Alex Besonov

    IPC分类号： A61K31/554 ,  A61K31/505 ,  A61K47/10 ,  A61K31/4422

    CPC分类号： A61K31/554 ,  A01N25/16 ,  A61K9/1075 ,  A61K9/12 ,  A61K31/4422 ,  A61K31/505 ,  A61K47/10

    摘要： The present invention relates to a foamable therapeutic composition comprising: (a) a therapeutically effective concentration of at least one active agent selected from the group consisting of a channel agent, a cholinergic agent, and a nitric oxide donor; and (b) a foamable carrier comprising: i. about 50% to about 98% of a solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, and mixtures thereof; ii. 0% to about 48% of a secondary solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, a co-solvent, a penetration enhancer and mixtures thereof; iii. a surface-active agent; iv. about 0% to about 5% by weight of at least one polymeric agent; and v. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the composition is housed in a container and is substantially flowable, and which upon release expands to form a breakable foam; and wherein the foamable carrier is selected to generate a foam of good to excellent quality. The invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering such a composition to an afflicted target site.

    摘要翻译： 本发明涉及可发泡治疗组合物，其包含：（a）治疗有效浓度的至少一种选自通道剂，胆碱能药和一氧化氮供体的活性剂; 和（b）可发泡载体，包括：i。 约50％至约98％的选自水的溶剂; 亲水性溶剂; 疏水溶剂; 有效溶剂; 极性溶剂，硅氧烷，软化剂及其混合物; ii。 0％至约48％的选自水的第二溶剂; 亲水性溶剂; 疏水溶剂; 有效溶剂; 极性溶剂，硅氧烷，软化剂，​​助溶剂，渗透增强剂及其混合物; iii。 表面活性剂; iv。 约0重量％至约5重量％的至少一种聚合物; 和v。浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂; 其中所述组合物容纳在容器中并且基本上是可流动的，并且其在释放时膨胀以形成可破坏的泡沫; 并且其中所述可发泡载体被选择以产生良好至优异质量的泡沫。 本发明进一步提供治疗，减轻或预防哺乳动物受试者病症的方法，包括将所述组合物施用于受影响的靶位点。