公开(公告)号：US20110039848A1

公开(公告)日：2011-02-17

申请号：US12989530

申请日：2009-04-23

申请人： Hitoshi Fujita ,  Junya Ikeda ,  Satoki Imai

发明人： Hitoshi Fujita ,  Junya Ikeda ,  Satoki Imai

IPC分类号： A61K31/5377 ,  C07D413/14 ,  C07D417/04 ,  A61K31/501 ,  A61P29/00 ,  A61P37/08 ,  A61P11/00 ,  A61P11/06

CPC分类号： C07D417/04 ,  C07D417/14

摘要： Provided are: a five-membered ring compound represented by formula (1) or a pharmaceutically acceptable salt thereof; and a medicine containing the compound or salt. The compound or salt inhibits the infiltration of leukocytes such as eosinophils and lymphocytes, is effective as a therapeutic agent for various kinds of inflammation, and is so safe that the compound or salt can be taken for long. In formula (1), R1 is (substituted) phenyl or pyridyl; R2 is (substituted) pyrazinediyl, pyrimidinediyl, or pyridazinediyl; R3 to R5 each is alkyl (provided that —N(R4)R5 may be morpholino); and Y2 is alkylene.

摘要翻译： 提供：由式（1）表示的五元环化合物或其药学上可接受的盐; 和含有该化合物或盐的药物。 化合物或盐抑制白细胞如嗜酸性粒细胞和淋巴细胞的浸润，作为各种炎症的治疗剂是有效的，并且使得化合物或盐可以长时间服用是安全的。 在式（1）中，R 1是（取代的）苯基或吡啶基; R2是（取代的）吡嗪二基，嘧啶二基或哒嗪二基; R 3至R 5各自为烷基（条件是-N（R 4）R 5可以是吗啉代）; 而Y2是亚烷基。

公开(公告)号：US07754728B2

公开(公告)日：2010-07-13

申请号：US10528343

申请日：2003-09-26

申请人： Yoshiaki Isobe ,  Haruo Takaku ,  Haruhisa Ogita ,  Masanori Tobe ,  Ayumu Kurimoto ,  Tetsuhiro Ogino ,  Hitoshi Fujita

发明人： Yoshiaki Isobe ,  Haruo Takaku ,  Haruhisa Ogita ,  Masanori Tobe ,  Ayumu Kurimoto ,  Tetsuhiro Ogino ,  Hitoshi Fujita

IPC分类号： C07D473/18 ,  C07D473/16 ,  A61K31/522 ,  A61P11/06 ,  A61P37/08

CPC分类号： A61K31/5377 ,  A61K31/522 ,  A61K31/55

摘要： A drug for topically administration which is effective as an antiallergic agent. The drug for topically administration contains as an active ingredient an adenine compound represented by the general formula (1): [wherein ring A represents a 6 to 10 membered, mono or bicyclic, aromatic hydrocarbon or a 5 to 10 membered, mono or bicyclic, aromatic heterocycle containing one to three heteroatoms selected among 0 to 2 nitrogen atoms, 0 or 1 oxygen atom, and 0 or 1 sulfur atom; n is an integer of 0 to 2; m is an integer of 0 to 2; R represents halogeno, (un)substituted alkyl, etc.; X1 represents oxygen, sulfur, NR1 (R1 represents hydrogen or alkyl), or a single bond; Y1 represents a single bond, alkylene, etc.; Y2 represents a single bond, alkylene, etc.; Z represents alkylene; and at least one of Q1 and Q2 represents —COOR10 (wherein R10 represents (un)substituted alkyl, etc.), etc.] or a pharmaceutically acceptable salt of the compound.

摘要翻译： 用作局部给药的药物，其作为抗过敏剂有效。 用于局部给药的药物含有作为活性成分的由通式（1）表示的腺嘌呤化合物：[其中环A表示6至10元，单或双环，芳族烃或5至10元，单或双环， 含有1至3个选自0至2个氮原子，0或1个氧原子和0或1个硫原子的杂原子的芳族杂环; n为0〜2的整数， m为0〜2的整数; R代表卤代，（取代）烷基等; X1代表氧，硫，NR1（R1代表氢或烷基）或单键; Y1表示单键，亚烷基等; Y2表示单键，亚烷基等; Z表示亚烷基; 并且Q1和Q2中的至少一个表示-COOR 10（其中R 10表示（un）取代的烷基等）等）或该化合物的药学上可接受的盐。

公开(公告)号：US07400556B2

公开(公告)日：2008-07-15

申请号：US10541725

申请日：2003-12-12

申请人： Takashi Osa ,  Tomomi Murakami ,  Hitoshi Fujita

发明人： Takashi Osa ,  Tomomi Murakami ,  Hitoshi Fujita

IPC分类号： G04C10/00

CPC分类号： G04C10/02

摘要： An electronic timepiece with a solar cell includes a timepiece movement, a timepiece case for housing the timepiece movement, a casing ring for housing and holding the timepiece movement in the timepiece case, a solar cell and a dial. The solar cell is disposed almost vertically to a solar cell positioning portion provided in the casing ring, and the solar cell has a slender strip shape formed on a flexible substrate. Consequently, the solar cell is not disposed in the timepiece movement, and it is only necessary to change the casing ring as an external component even when a panel cover diameter is changed. Further, a solar cell can be coiled to match the size of the casing ring when it is incorporated in the casing ring, so that a common solar cell can be used despite a change in the panel cover diameter of the timepiece.

摘要翻译： 具有太阳能电池的电子钟表包括钟表运动，用于容纳钟表运动的钟表壳体，用于容纳和保持钟表壳体中的钟表运动的壳环，太阳能电池和表盘。 太阳能电池几乎垂直于设置在壳环中的太阳能电池定位部分，太阳能电池具有形成在柔性基板上的细长条形状。 因此，太阳能电池不设置在钟表运动中，即使当面板盖直径改变时，仅需要改变作为外部部件的外壳。 此外，太阳能电池可以被卷绕以匹配壳体环的尺寸，当壳体环被结合到壳体环中时，使得尽管钟表的面板盖直径发生变化，但是可以使用公共的太阳能电池。

公开(公告)号：US06809270B2

公开(公告)日：2004-10-26

申请号：US10095988

申请日：2002-03-13

申请人： Hitoshi Fujita

发明人： Hitoshi Fujita

IPC分类号： B60R2200

CPC分类号： G01G23/3707

摘要： A weighing apparatus by which a past record of measured weight values can be known later is provided. Weight measured by a weight sensor is inputted to a MPU via an I/O (input-output) unit. The MPU stores the inputted weight data in a memory together with the date and time which a timepiece circuit indicates, either when the MPU determines that the weight is being measured (for example, when the weight equals or exceeds a predetermined value) or when a command to record the weight data is given by an external unit such as a personal computer (PC) via an I/O unit. The stored weight data and date-time data are read from the memory by the MPU when a readout command is given by the external unit, and are outputted to the external unit via the I/O unit.

摘要翻译： 提供了一种称重装置，通过该称重装置可以知道以后测量的重量值的过去记录。 通过重量传感器测量的重量通过I / O（输入 - 输出）单元输入到MPU。 或者当MPU确定正在测量重量时（例如，当重量等于或超过预定值）时，MPU将输入的重量数据与时钟电路指示的日期和时间一起存储在存储器中，或者当 记录重量数据的命令由诸如个人计算机（PC）的外部单元通过I / O单元给出。 存储的重量数据和日期时间数据由外部单元给出读出命令时由MPU从存储器中读出，并通过I / O单元输出到外部单元。

公开(公告)号：US06604597B2

公开(公告)日：2003-08-12

申请号：US10177144

申请日：2002-06-24

申请人： Hiroaki Fujii ,  Koji Tanaka ,  Hitoshi Fujita ,  Koichi Furukawa

发明人： Hiroaki Fujii ,  Koji Tanaka ,  Hitoshi Fujita ,  Koichi Furukawa

IPC分类号： B60R2244

CPC分类号： B60R22/44 ,  B60R2022/444 ,  B60R2022/4473

摘要： A seat belt retractor includes a base frame, a spool journalled to the base frame, a webbing wound around the spool, and a motor for rotating the spool. A speed-reduction mechanism is interposed between the motor and the spool. The speed-reduction mechanism includes at least one transmission train with a predetermined gear ratio, a common transmission element connected to the transmission train, and a resistant torque device connected to the transmission train. The common transmission element transmits rotation of the motor to the spool when the torque of the rotation is smaller than the preset value. Winding of the webbing is made based on the wearing condition of the webbing and the running condition of the vehicle.

摘要翻译： 一种座椅安全带卷收器，包括基座框架，安装在基座框架上的卷轴，缠绕在卷轴上的织带以及用于旋转卷轴的马达。 减速机构夹在电机和阀芯之间。 减速机构包括至少一个具有预定齿轮比的传动系，连接到传动系的公共传动元件和连接到传动系的阻力转矩装置。 当旋转的转矩小于预设值时，公共传动元件将电机的旋转传递到线轴。 基于织带的磨损状况和车辆的行驶状态进行织带的卷绕。

公开(公告)号：US20120178743A1

公开(公告)日：2012-07-12

申请号：US13402850

申请日：2012-02-22

申请人： Yoshiaki ISOBE ,  Haruo Takaku ,  Haruhisa Ogita ,  Masanori Tobe ,  Ayumu Kurimoto ,  Tetsuhiro Ogino ,  Hitoshi Fujita

发明人： Yoshiaki ISOBE ,  Haruo Takaku ,  Haruhisa Ogita ,  Masanori Tobe ,  Ayumu Kurimoto ,  Tetsuhiro Ogino ,  Hitoshi Fujita

IPC分类号： A61K31/52 ,  A61K31/5377 ,  A61P37/08 ,  A61P37/00 ,  A61P31/12 ,  A61P17/00 ,  C07D473/18 ,  A61K31/55

CPC分类号： A61K31/5377 ,  A61K31/522 ,  A61K31/55

摘要： An antiallergic agent for topical administration containing an adenine compound of general formula (1): [wherein ring A represents a 6 to 10 membered, mono or bicyclic, aromatic hydrocarbon or a 5 to 10 membered, mono or bicyclic, aromatic heterocycle containing one to three heteroatoms selected among 0 to 2 nitrogen atoms, 0 or 1 oxygen atom, and 0 or 1 sulfur atom; n is an integer of 0 to 2; m is an integer of 0 to 2; R represents halogeno, (un)substituted alkyl, etc.; X1 represents oxygen, sulfur, NR1 (R1 represents hydrogen or alkyl), or a single bond; Y1 represents a single bond, alkylene, etc.; Y2 represents a single bond, alkylene, etc.; Z represents alkylene; and at least one of Q1 and Q2 represents —COOR10 (wherein R10 represents (un)substituted alkyl, etc.), etc.] or a pharmaceutically acceptable salt of the compound.

摘要翻译： 一种用于局部给药的抗过敏剂，其含有通式（1）的腺嘌呤化合物：[其中环A表示6至10元，单或双环，芳烃或5至10元单或双环芳族杂环， 选自0至2个氮原子，0或1个氧原子和0或1个硫原子的3个杂原子; n为0〜2的整数， m为0〜2的整数; R代表卤代，（取代）烷基等; X1代表氧，硫，NR1（R1代表氢或烷基）或单键; Y1表示单键，亚烷基等; Y2表示单键，亚烷基等; Z表示亚烷基; 并且Q1和Q2中的至少一个表示-COOR 10（其中R 10表示（un）取代的烷基等）等）或该化合物的药学上可接受的盐。

公开(公告)号：US20110263550A1

公开(公告)日：2011-10-27

申请号：US13084503

申请日：2011-04-11

申请人： Toshinari Sugasawa ,  Takashi Nakajima ,  Hitoshi Fujita ,  Toshio Kanai

发明人： Toshinari Sugasawa ,  Takashi Nakajima ,  Hitoshi Fujita ,  Toshio Kanai

IPC分类号： A61K31/56 ,  A61P11/00 ,  A61K31/5377

CPC分类号： A61K31/56 ,  A61K9/10 ,  A61K31/5377 ,  C07D277/42

摘要： Disclosed is a method for the prevention and/or treatment of a chronic obstructive pulmonary disease by administrating a 5-membered cyclic compound represented by the formula below: or a pharmaceutically acceptable salt of the compound or a prodrug of the compound or salt: wherein X represents an oxygen or sulfur atom; R1 represents a hydrogen atom, a substituted or unsubstituted alkyl or the like; R2 represents a hydrogen atom, a substituted or unsubstituted alkyl or the like; Y1 represents single bond, a substituted or unsubstituted alkylene or the like; the wavy line means an (E) or (Z) coordination; R3 represents a hydrogen atom, a substituted or unsubstituted aryl or the like; Y2 represents a substituted or unsubstituted alkylene or an alkenylene; R4 represents a hydrogen atom, a substituted or unsubstituted alkanoyl or the like; and R5 represents a hydrogen atom or a substituted or unsubstituted alkyl.

摘要翻译： 本发明公开了一种预防和/或治疗慢性阻塞性肺疾病的方法，该方法是通过给予由下式表示的5元环状化合物：或化合物的药学上可接受的盐或其化合物或盐的前体药物：其中X 表示氧或硫原子; R1表示氢原子，取代或未取代的烷基等; R 2表示氢原子，取代或未取代的烷基等; Y1表示单键，取代或未取代的亚烷基等; 波浪线表示（E）或（Z）配位; R3表示氢原子，取代或未取代的芳基等; Y2表示取代或未取代的亚烷基或亚烯基; R4表示氢原子，取代或未取代的烷酰基等; 并且R 5表示氢原子或取代或未取代的烷基。

公开(公告)号：US20080276656A1

公开(公告)日：2008-11-13

申请号：US11996889

申请日：2006-07-18

申请人： Susumu Kitamura ,  Hitoshi Fujita ,  Hiroichi Shibasaki ,  Masanori Komori ,  Nobutaka Matsunishi ,  Toshinari Miyoshi ,  Masashi Matsumoto ,  Takahisa Ikegami

发明人： Susumu Kitamura ,  Hitoshi Fujita ,  Hiroichi Shibasaki ,  Masanori Komori ,  Nobutaka Matsunishi ,  Toshinari Miyoshi ,  Masashi Matsumoto ,  Takahisa Ikegami

IPC分类号： D06F25/00 ,  D06F39/10 ,  D06F58/02 ,  D06F58/22

CPC分类号： D06F25/00 ,  D06F58/22

摘要： A drum type washing and drying machine has a water tank (4), a rotary drum rotatably provided in the water tank (5), a dehumidifying heat exchanger for dehumidifying air introduced from inside of the rotary drum (5), a heater unit for heating the air dehumidified by the dehumidifying heat exchanger, and a blower (131) for introducing the air in the rotary drum (5) into the dehumidifying heat exchanger and delivering into the rotary drum (5) the air heated by the heater unit. A filter (160) is placed in a suction-side channel between the rotary drum (5) and the blower and on an upstream side of air flow produced by the blower (131) in a drying process. The filter (160) is placed so as to be soaked in water supplied into the water tank in a washing process or in a rinsing process.

摘要翻译： 滚筒式洗涤干燥机具有水箱（4），可旋转地设置在水箱（5）中的旋转滚筒，用于对从旋转滚筒（5）内部引入的空气进行除湿的除湿热交换器，用于 加热由除湿热交换器除湿的空气，以及用于将旋转滚筒（5）中的空气引入到除湿热交换器中并将由加热器单元加热的空气输送到旋转滚筒（5）的鼓风机（131）。 在干燥过程中，将过滤器（160）放置在旋转滚筒（5）和鼓风机之间以及由鼓风机（131）产生的空气流的上游侧的吸入侧通道中。 将过滤器（160）放置成在洗涤过程或漂洗过程中浸入供应到水箱中的水中。

公开(公告)号：US20070274576A1

公开(公告)日：2007-11-29

申请号：US11802959

申请日：2007-05-29

申请人： Ryoko Morita ,  Kenichi Isoyama ,  Koichi Iwamori ,  Hirofumi Yamaguchi ,  Mayumi Takimoto ,  Hitoshi Fujita

发明人： Ryoko Morita ,  Kenichi Isoyama ,  Koichi Iwamori ,  Hirofumi Yamaguchi ,  Mayumi Takimoto ,  Hitoshi Fujita

IPC分类号： G06K9/00

CPC分类号： B60R25/1004 ,  B60R25/24 ,  B60R2325/205

摘要： A vehicle is provided with an identification information memory in which identification information of the vehicle is memorized, and a transmitter for transmitting the identification information. A portable terminal is provided with a receiver for receiving the identification information transmitted from the transmitter, a registration information memory in which identification information of a ridable vehicle is memorized as registration information in advance, and a controller for executing authentication between the identification information and the registration information and executing a warning processing when a result of authentication shows inconsistency.

摘要翻译： 车辆设置有识别信息存储器，其中记录了车辆的识别信息，以及发送器，用于发送识别信息。 便携式终端设置有用于接收从发送机发送的识别信息的接收机，其中可预约地存储可移动车辆的识别信息作为登记信息的登记信息存储器，以及用于执行识别信息和 注册信息，并且当认证结果显示不一致时执行警告处理。

公开(公告)号：US06951866B2

公开(公告)日：2005-10-04

申请号：US10222922

申请日：2002-08-19

申请人： Hitoshi Fujita ,  Fujio Antoku ,  Norio Fujiwara ,  Kiyotaka Iwai ,  Hiroshi Tanaka ,  Hajime Kawakami

发明人： Hitoshi Fujita ,  Fujio Antoku ,  Norio Fujiwara ,  Kiyotaka Iwai ,  Hiroshi Tanaka ,  Hajime Kawakami

IPC分类号： C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D491/044 ,  C07D491/052 ,  C07D239/49 ,  A61K31/505 ,  C07D239/48

CPC分类号： C07D405/04 ,  C07D405/12 ,  C07D405/14

摘要： 1. A pyrimidine derivative of the formula (1) or a salt thereof; has an inhibitory activity of production of Th2 type cytokines such as IL-4, IL-5, etc., and is useful as an therapeutic agent for allergic diseases, autoimmune diseases such as systemic lupus erythemathosus, etc., and acquired immunodeficiecy syndrome (AIDS) and so on.

摘要翻译： 1.式（1）的嘧啶衍生物或其盐; 具有产生Th2型细胞因子如IL-4，IL-5等的抑制活性，可用作过敏性疾病，系统性红斑狼疮等自身免疫性疾病等治疗剂，以及获得性免疫缺陷综合征 艾滋病）等。