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公开(公告)号：US10968423B2
公开(公告)日：2021-04-06
申请号：US15905463
申请日：2018-02-26
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes
IPC: C12M1/42 , C12M1/00 , C12M1/36 , C12M3/00 , C12N13/00 , A61B5/15 , G01N35/02 , G01N33/487 , A61K35/00 , G01N33/49
Abstract: Disclosed herein are multi-cuvette cartridges, flow cells, and electrical pulse systems for treatment of large volumes of biological samples with pulsed electric fields. The multi-cuvette cartridges systems may include mechanical motors for automatic positioning and alignment between the cuvettes and the electrodes of the electrical pulse systems. The flow cell systems may include fluidic systems, such as pumps, nozzles and valves, which may operate in coordination with the electrical systems for efficient exposition of biological samples. Embodiments having flow cell systems that allow “on-demand” production of activated sample are also disclosed.
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公开(公告)号：US10692684B2
公开(公告)日：2020-06-23
申请号：US15377539
申请日：2016-12-13
Applicant: General Electric Company
Inventor： Antonio Caiafa , Philippe Ernest , Dominique Poincloux
Abstract: A circuit assembly includes plural voltage control modules configured to be operably coupled in series to a connection and configured to control voltage delivered to an X-ray electrode. Each voltage module includes an on/off circuit portion, a balancing circuit portion, and a tuning circuit portion. The on/off circuit portion is configured to provide a voltage for activating or deactivating the X-ray electrode. The balancing circuit portion is coupled in parallel to the on/off circuit portion, and includes a capacitor and a resistor coupled in parallel. The tuning circuit portion is coupled in parallel to the balancing circuit portion and the on/off circuit portion, and is configured to adjust a voltage provided to the X-ray electrode.
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公开(公告)号：US10439393B2
公开(公告)日：2019-10-08
申请号：US15339266
申请日：2016-10-31
Applicant: General Electric Company
Inventor： Antonio Caiafa , Ahmed Elasser , Dong Dong
IPC: H02J3/00
Abstract: A switching system includes a switching assembly and a transformer. The switching assembly includes multiple sets of switch cells conductively coupled to different power conductors that extend between a power source and a load and conduct different phases of current. Each set of switch cells controls conduction of a different phase of current to the load. The transformer has a primary winding and multiple secondary windings that are conductively coupled to the sets of switch cells. Responsive to receiving an activation control signal from the transformer via the secondary windings, the sets of switch cells are configured to activate to conduct the multiple phases of current from the power source to the load along the power conductors.
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公开(公告)号：US10421956B2
公开(公告)日：2019-09-24
申请号：US15955377
申请日：2018-04-17
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Allen Lawrence Garner , Andrew Soliz Torres
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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公开(公告)号：US10369200B2
公开(公告)日：2019-08-06
申请号：US15252032
申请日：2016-08-30
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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Patent Agency Ranking
公开(公告)号：US10329551B2
公开(公告)日：2019-06-25
申请号：US15651900
申请日：2017-07-17
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Allen Lawrence Garner , Andrew Soliz Torres
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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公开(公告)号：US20180191262A1
公开(公告)日：2018-07-05
申请号：US15399287
申请日：2017-01-05
Applicant: General Electric Company
Inventor： Antonio Caiafa
CPC classification number: H02M7/003 , F02C7/16 , F17C2221/012 , F17C2221/033 , F17C2223/0161 , F17C2223/033 , F17C2225/0123 , F17C2227/0302 , F17C2227/0393 , F17C2265/066 , F17C2270/0168 , H02K7/1807 , Y02T10/32
Abstract: A cryogenic fuel power system includes an engine. The cryogenic fuel power system includes a cryogenic fuel supply that supplies cryogenic fuel to be used as fuel by the engine. The cryogenic fuel power system includes a cryogenic bus configured to provide the cryogenic fuel from the cryogenic fuel supply to the engine. The cryogenic fuel power system includes power electronics circuitry that converts power from the engine into a form to be applied to one or more loads. The power electronics circuitry is positioned in thermal communication with the cryogenic bus to transfer heat from the power electronics circuitry to the cryogenic fuel.
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公开(公告)号：US09856722B2
公开(公告)日：2018-01-02
申请号：US14808713
申请日：2015-07-24
Applicant: General Electric Company
Inventor： Dong Dong , Antonio Caiafa , Mohammed Agamy , Ahmed Elasser
IPC: E21B43/12 , H03K17/10 , H03K17/691 , H02M1/08 , E21B41/00 , H05G1/58 , H03K17/687
CPC classification number: E21B43/128 , E21B41/0085 , H02M1/08 , H03K17/102 , H03K17/6874 , H03K17/691 , H05G1/58 , Y10T307/406 , Y10T307/76
Abstract: Power systems and methods are disclosed herein. The systems and methods use a switching system coupled with a power source and subterranean pumps for pumping a resource from beneath a surface of earth. A first capacitor is between a first switching device and a first transformer, and stores electric energy received from the first transformer to activate the first switching device. A bias capacitor is between the first capacitor and the first switching device, and receives a bias voltage via a second transformer. The bias capacitor applies the bias voltage to the first switching device to prevent the first switching device from activating unless a combination of the voltage received by the first switching device via the first transformer and the bias voltage is at least as large as the activation voltage of the first switching device.
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公开(公告)号：US20170314009A1
公开(公告)日：2017-11-02
申请号：US15651900
申请日：2017-07-17
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Allen Lawrence Garner , Andrew Soliz Torres
CPC classification number: C12N13/00 , A61B5/150755 , C12M35/02 , G01N33/49 , H03K3/53
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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公开(公告)号：US20170022766A1
公开(公告)日：2017-01-26
申请号：US14808783
申请日：2015-07-24
Applicant: General Electric Company
Inventor： Dong Dong , Antonio Caiafa , Mohammed Agamy , Ahmed Elasser , Philip Michael Cioffi
CPC classification number: H02J4/00 , E21B43/128
Abstract: A switch assembly includes one or more solid state semiconductor switches configured to be disposed within a downhole pipe assembly. The one or more switches are configured to operate in a closed state to conduct electric current supplied by a power source disposed above a surface to pumps disposed beneath the surface to cause the pumps to extract a resource from beneath the surface via the pipe assembly. The one or more switches also are configured to operate in an open state to stop conducting the electric current from the power source to the pumps.
Abstract translation: 开关组件包括被配置为设置在井下管组件内的一个或多个固态半导体开关。 一个或多个开关被配置为在闭合状态下操作以传导由设置在表面上方的电源供应的电流，以泵送设置在表面下方的泵，以使得泵经由管组件从表面下方提取资源。 一个或多个开关还被配置为在打开状态下操作以停止将电流从电源传导到泵。
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