公开(公告)号：US20170362244A1

公开(公告)日：2017-12-21

申请号：US15639970

申请日：2017-06-30

Applicant: Gilead Sciences, Inc.

Inventor： Kerim Babaoglu ,  Constantine G. Boojamra ,  Eugene J. Eisenberg ,  Hon Chung Hui ,  Richard L. Mackman ,  Jay P. Parrish ,  Michael Sangi ,  Oliver L. Saunders ,  Dustin Siegel ,  David Sperandio ,  Hai Yang

IPC: C07D487/04 ,  C07D519/00 ,  C07D513/04 ,  C07D495/04 ,  A61K45/06 ,  A61K31/675 ,  A61K31/551 ,  A61K31/55 ,  A61K31/5377 ,  C07F9/6561 ,  A61K31/519

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/551 ,  A61K31/675 ,  A61K45/06 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00 ,  C07F9/65616

Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

公开(公告)号：US09108953B2

公开(公告)日：2015-08-18

申请号：US14549848

申请日：2014-11-21

Applicant: Gilead Sciences, Inc.

Inventor： Kerim Babaoglu ,  Britton K. Corkey ,  Robert H. Jiang ,  David Sperandio ,  Hai Yang

IPC: C07D413/04 ,  C07D413/14 ,  C07D451/04

CPC classification number: C07D413/04 ,  C07D413/14 ,  C07D451/04

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula I wherein R1, R2, R3, R4, R7, W, X, and Z are as described herein.

Abstract translation: 本申请涉及可用作含溴结构域的蛋白质（包括含溴结构域蛋白质的蛋白质4（BRD4））的抑制剂或其它方式调节其含有活性的蛋白质的化学化合物，以及含有这些化合物的组合物和制剂，以及 使用和制造这些化合物。 化合物包括其中R 1，R 2，R 3，R 4，R 7，W，X和Z如本文所述的式I化合物。

公开(公告)号：US20150166546A1

公开(公告)日：2015-06-18

申请号：US14566340

申请日：2014-12-10

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. Boojamra ,  Hon Chung Hui ,  Petr Jansa ,  Richard L. Mackman ,  Jay P. Parrish ,  Michael Sangi ,  Dustin Siegel ,  David Sperandio ,  Hai Yang

IPC: C07D487/04

CPC classification number: A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/675 ,  A61K45/06 ,  C07D487/04 ,  C07D487/08 ,  C07D519/00 ,  C07F9/6561

Abstract: The invention provides compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections. The compounds and compositions are useful for treating Pneumovirinae virus infection including Human respiratory syncytial virus infections.

Abstract translation: 本发明提供了用于治疗病毒感染的化合物及其药学上可接受的盐和酯及其组合物。 化合物和组合物可用于治疗肺炎链球菌病毒感染，包括人呼吸道合胞病毒感染。

公开(公告)号：US20140296246A1

公开(公告)日：2014-10-02

申请号：US14227736

申请日：2014-03-27

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Gregory Chin ,  Britton Kenneth Corkey ,  Jinfa Du ,  Kristyna Elbel ,  Robert H. Jiang ,  Tetsuya Kobayashi ,  Ruben Martinez ,  Samuel E. Metobo ,  Michael R. Mish ,  Sophie Shevick ,  David Sperandio ,  Hai Yang ,  Jeff Zablocki

IPC: C07D413/14 ,  C07D413/04

CPC classification number: C07D413/14 ,  C07D413/04 ,  C07D417/14

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, and X are described herein.

Abstract translation: 本申请涉及可用作含溴结构域的蛋白质（包括含溴结构域蛋白质的蛋白质4（BRD4））的抑制剂或其它方式调节其含有活性的蛋白质的化学化合物，以及含有这些化合物的组合物和制剂，以及 使用和制造这些化合物。 化合物包括其中R1a，R1b，R2a，R2b，R3和X在本文中描述的式（I）的化合物。

公开(公告)号：US20130273037A1

公开(公告)日：2013-10-17

申请号：US13865069

申请日：2013-04-17

Applicant: GILEAD SCIENCES, INC.

Inventor： Dustin Siegel ,  David Sperandio ,  Hai Yang ,  Michael Sangi ,  Jay P. Parrish ,  Hon Chung Hui

IPC: C07D487/04 ,  C07D471/04 ,  A61K45/06 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61K31/4545 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5377 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00

Abstract: Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

公开(公告)号：US20240043427A1

公开(公告)日：2024-02-08

申请号：US17997594

申请日：2021-04-29

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Hon C. Hui ,  Richard L. Mackman ,  Michael R. Mish ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Dustin S. Siegel ,  Doris T. Tang ,  Hai Yang

IPC: C07D487/04 ,  C07D519/00 ,  A61K45/06 ,  C07K16/28

CPC classification number: C07D487/04 ,  C07D519/00 ,  C07K16/2827 ,  C07K16/2818 ,  A61K45/06

Abstract: The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.

公开(公告)号：US20180282316A1

公开(公告)日：2018-10-04

申请号：US16001832

申请日：2018-06-06

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Gregory Chin ,  Britton Kenneth Corkey ,  Jinfa Du ,  Kristyna M. Elbel ,  Robert H. Jiang ,  Tetsuya Kobayashi ,  Rick Andrew Lee ,  Ruben Martinez ,  Samuel E. Metobo ,  Michael R. Mish ,  Manuel Munoz ,  Sophia L. Shevick ,  David Sperandio ,  Hai Yang ,  Jeff Zablocki

IPC: C07D413/04 ,  C07D453/02 ,  C07D417/14 ,  C07D471/04 ,  C07D413/14

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.

公开(公告)号：US09957275B2

公开(公告)日：2018-05-01

申请号：US15639970

申请日：2017-06-30

Applicant: Gilead Sciences, Inc.

Inventor： Kerim Babaoglu ,  Constantine G. Boojamra ,  Eugene J. Eisenberg ,  Hon Chung Hui ,  Richard L. Mackman ,  Jay P. Parrish ,  Michael Sangi ,  Oliver L. Saunders ,  Dustin Siegel ,  David Sperandio ,  Hai Yang

IPC: C07D487/04 ,  C07D487/08 ,  C07D495/04 ,  C07D513/04 ,  A61K31/519 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/551 ,  A61K31/675 ,  C07F9/6561 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/551 ,  A61K31/675 ,  A61K45/06 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00 ,  C07F9/65616

Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

公开(公告)号：US20170342079A1

公开(公告)日：2017-11-30

申请号：US15618974

申请日：2017-06-09

Applicant: Gilead Sciences, Inc.

Inventor： Hon Chung Hui ,  Jay P. Parrish ,  Michael Sangi ,  Dustin Siegel ,  David Sperandio ,  Hai Yang

IPC: C07D487/04 ,  C07D471/04 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/53 ,  A61K31/519 ,  A61K31/5025 ,  C07D519/00 ,  A61K31/4545

CPC classification number: C07D487/04 ,  A61K31/4545 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5377 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00

Abstract: Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

公开(公告)号：US20170029427A1

公开(公告)日：2017-02-02

申请号：US15191974

申请日：2016-06-24

Applicant: Gilead Sciences, Inc.

Inventor： Dustin Siegel ,  David Sperandio ,  Hai Yang ,  Michael Sangi ,  Jay P. Parrish ,  Hon Chung Hui

IPC: C07D487/04 ,  A61K45/06 ,  A61K31/5025

CPC classification number: C07D487/04 ,  A61K31/4545 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5377 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00

Abstract: Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

Abstract translation: 提供了用于治疗病毒感染的化合物及其药学上可接受的盐和酯及其组合物。 化合物和组合物可用于治疗肺炎链球菌病毒感染。 提供的化合物，组合物和方法特别可用于治疗人呼吸道合胞病毒感染。