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43 条记录 (耗时 0.033 秒)

    Gas laser
    21.
    发明授权
    Gas laser 失效
    气体激光

    公开(公告)号：US4649546A

    公开(公告)日：1987-03-10

    申请号：US577272

    申请日：1984-02-06

    申请人： Rudolf Schmid

    发明人： Rudolf Schmid

    IPC分类号： H01S3/032 ,  H01S3/034 ,  H01S3/02

    CPC分类号： H01S3/034 ,  H01S3/0323

    摘要： A gas laser, includes:a tube having two ends to be filled with gas; anda plate-shaped window hermetically sealing at least one of the ends of the tube;the window including a carrier plate and a layer coating the inside of the carrier plate;the tube being formed of a first material with a first thermal coefficient of expansion (H.sub.1) at least in vicinity of the one end thereof having the window;the layer being formed of a second material with a second thermal coefficient of expansion (H.sub.2);the carrier plate being formed of a third material with a third thermal coefficient of expansion (H.sub.3);the first and second materials being unadapted to each other; andthe third material being thermally matched to the first material.

    摘要翻译： 气体激光器包括：具有两端填充有气体的管; 和一个板状窗口密封所述管的至少一个端部; 窗口包括载体板和涂覆载体板内部的层; 所述管由具有第一热膨胀系数（H1）的第一材料形成，所述第一材料至少在其一端附近具有窗口; 该层由具有第二热膨胀系数（H2）的第二材料形成; 载体板由具有第三热膨胀系数（H3）的第三材料形成; 第一和第二材料相互不相配; 并且所述第三材料与所述第一材料热匹配。

    Process for the manufacture of optically active compounds
    22.
    发明授权
    Process for the manufacture of optically active compounds 失效
    光学活性化合物的制造方法

    公开(公告)号：US4578462A

    公开(公告)日：1986-03-25

    申请号：US525529

    申请日：1983-08-22

    申请人： Hans-Jurgen Hansen ,  Rudolf Schmid ,  Max Schmid

    发明人： Hans-Jurgen Hansen ,  Rudolf Schmid ,  Max Schmid

    IPC分类号： C07C17/093 ,  C07D295/084 ,  C07F9/50 ,  C07F15/00 ,  C07C93/10 ,  C07D295/08

    CPC分类号： C07D295/084 ,  C07C17/093 ,  C07F15/0006 ,  C07F15/0066 ,  C07F15/008 ,  C07F9/5027

    摘要： The manufacture of optically active bifunctional compounds of the general formula ##STR1## wherein R represents protected hydroxymethyl, protected formyl or alkoxycarbonyl and R.sup.1 represents a group of the formula ##STR2## or --CH.sub.2 --CH.dbd.NR.sup.2 in which R.sup.2 and R.sup.3 represent lower alkyl or cycloalkyl or R.sup.2 and R.sup.3 together with the nitrogen atom represent a heterocyclic ring,by isomerizing compounds of the general formula ##STR3## wherein R, R.sup.2 and R.sup.3 have the above significance and R.sup.3 can additionally signify hydrogen,is described.The compounds of formula I are potential intermediates in the manufacture of, inter alia, natural vitamin E and natural vitamin K.sub.1.

    摘要翻译： 制备通式为“IMAGE”I的光学活性双官能化合物，其中R表示被保护的羟甲基，受保护的甲酰基或烷氧基羰基，R 1表示下式的基团：其中R 2和R 3表示较低的式“IMAGE”或-CH 2 -CH = NR 2 烷基或环烷基或R 2和R 3与氮原子一起表示杂环，通过异构化通式为II，其中R，R 2和R 3具有上述含义并且R 3可以另外表示氢的化合物。 式I化合物是天然维生素E和天然维生素K1的制造中的潜在中间体。

    Manufacture of tocopheryl acetate
    26.
    发明授权
    Manufacture of tocopheryl acetate 有权
    醋酸生育酚的制造

    公开(公告)号：US07169943B2

    公开(公告)日：2007-01-30

    申请号：US10535604

    申请日：2003-09-29

    申请人： Werner Bonrath ,  Claus Dittel ,  Thomas Netscher ,  Thomas Pabst ,  Rudolf Schmid

    发明人： Werner Bonrath ,  Claus Dittel ,  Thomas Netscher ,  Thomas Pabst ,  Rudolf Schmid

    IPC分类号： C07D311/72

    CPC分类号： C07D311/72 ,  C07C67/293 ,  C07C69/017 ,  C07C69/16

    摘要： A process for the manufacture of 3-phytyl-2,5,6-trimethylhydroquinone-1-acetate, and optionally therefrom tocopheryl acetate, comprises either C-alkylating 2,3,6-trimethylhydroquinone-1-acetate with isophytol or phytol in the presence of a sulphur(VI) containing catalyst of the formula R1SO2OH, wherein R1 signifies hydroxy, halogen, lower alkyl, halogenated lower alkyl or aryl, in an aprotic organic solvent, or O-alkylating 2,3,6-trimethylhydroquinone-1-acetate with a phytyl halide in a polar aprotic organic solvent in the presence of a base, and subjecting the so-obtained 4-O-phytyl-2,3,6-trimethylhydroquinone-1-acetate to a rearrangement reaction, and in each case optionally submitting the so-obtained 3-phytyl-2,5,6-trimethylhydroquinone-1-acetate to a ring closure reaction to produce tocopheryl acetate. The invention also includes the novel compound 3-phytyl-2,5,6-trimethylhydroquinone-1-acetate and certain stereoisomers thereof, and also the further novel compound 4-hydroxy-2,3,6-trimethyl-5-[3-(4,8,12-trimethyltridecyl)-but-3enyl]phenyl acetate which itself is one of several isomers of 3-phytyl-2,5,6-trimethylhydroquinone-1-acetate formed by isomerization under the influence of heating, e.g. during its distillation as part of the isolation and purification procedure following its manufacture as indicated above. (All-rac)-α-tocopherol, which may be derived from its acetate, is known to be the most active industrially important member of the vitamin E group.

    摘要翻译： 制备3-植酰基-2,5,6-三甲基氢醌-1-乙酸酯和任选地由其生产生物聚乙酸乙酯的方法包括将2,3,6-三甲基氢醌-1-乙酸酯与间苯二酚或植醇的C-烷基化 含有式R 1 SO 2 OH的含硫（VI）催化剂的存在，其中R 1表示羟基，卤素，低级烷基， 卤代低级烷基或芳基，在非质子有机溶剂中，或在极性非质子有机溶剂中，在碱的存在下，用苄基卤与烷基卤反应，并将如此得到的 4-O-植酰基-2,3,6-三甲基氢醌-1-乙酸酯进行重排反应，并且在每种情况下任选地将如此获得的3-植酰基-2,5,6-三甲基氢醌-1-乙酸酯加入到环中 封闭反应生成醋酸生育酚。 本发明还包括新型化合物3-植酰基-2,5,6-三甲基氢醌-1-乙酸酯及其某些立体异构体，以及另外的新化合物4-羟基-2,3,6-三甲基-5- [3- （4,8,12-三甲基十三烷基） - 丁烯基]苯基乙酸酯，其本身是在加热的影响下通过异构化形成的3-植酰基-2,5,6-三甲基氢醌-1-乙酸酯的几种异构体之一，例如 在其蒸馏期间作为如上所述的其制造之后的分离和纯化方法的一部分。 （全 - 外消旋）-α-生育酚可以衍生自其乙酸酯已知是维生素E组中最活跃的工业上重要的成员。

    Manufacture of tocopheryl acetate
    28.
    发明申请
    Manufacture of tocopheryl acetate 有权
    醋酸生育酚的制造

    公开(公告)号：US20060094886A1

    公开(公告)日：2006-05-04

    申请号：US10535604

    申请日：2003-09-29

    申请人： Werner Bonrath ,  Claus Dittel ,  Thomas Netscher ,  Thomas Pabst ,  Rudolf Schmid

    发明人： Werner Bonrath ,  Claus Dittel ,  Thomas Netscher ,  Thomas Pabst ,  Rudolf Schmid

    IPC分类号： C07D311/04 ,  C07C67/02

    CPC分类号： C07D311/72 ,  C07C67/293 ,  C07C69/017 ,  C07C69/16

    摘要： A process for the manufacture of 3-phytyl-2,5,6-trimethylhydroquinone-1-acetate, and optionally therefrom tocopheryl acetate, comprises either C-alkylating 2,3,6-trimethylhydroquinone-1-acetate with isophytol or phytol in the presence of a sulphur(VI) containing catalyst of the formula R1SO2OH, wherein R1 signifies hydroxy, halogen, lower alkyl, halogenated lower alkyl or aryl, in an aprotic organic solvent, or O-alkylating 2,3,6-trimethylhydroquinone-1-acetate with a phytyl halide in a polar aprotic organic solvent in the presence of a base, and subjecting the so-obtained 4-O-phytyl-2,3,6-trimethylhydroquinone-1-acetate to a rearrangement reaction, and in each case optionally submitting the so-obtained 3-phytyl-2,5,6-trimethylhydroquinone-1-acetate to a ring closure reaction to produce tocopheryl acetate. The invention also includes the novel compound 3-phytyl-2,5,6-trimethylhydroquinone-1-acetate and certain stereoisomers thereof, and also the further novel compound 4-hydroxy-2,3,6-trimethyl-5-[3-(4,8,12-trimethyltridecyl)-but-3enyl]phenyl acetate which itself is one of several isomers of 3-phytyl-2,5,6-trimethylhydroquinone-1-acetate formed by isomerization under the influence of heating, e.g. during its distillation as part of the isolation and purification procedure following its manufacture as indicated above. (All-rac)-α-tocopherol, which may be derived from its acetate, is known to be the most active industrially important member of the vitamin E group.

    摘要翻译： 制备3-植酰基-2,5,6-三甲基氢醌-1-乙酸酯和任选地由其生产生物聚乙酸乙酯的方法包括将2,3,6-三甲基氢醌-1-乙酸酯与间苯二酚或植醇的C-烷基化 含有式R 1 SO 2 OH的含硫（VI）催化剂的存在，其中R 1表示羟基，卤素，低级烷基， 卤代低级烷基或芳基，在非质子有机溶剂中，或在极性非质子有机溶剂中，在碱的存在下，用苄基卤与烷基卤反应，并将如此得到的 4-O-植酰基-2,3,6-三甲基氢醌-1-乙酸酯进行重排反应，并且在每种情况下任选地将如此获得的3-植酰基-2,5,6-三甲基氢醌-1-乙酸酯加入到环中 封闭反应生成醋酸生育酚。 本发明还包括新型化合物3-植酰基-2,5,6-三甲基氢醌-1-乙酸酯及其某些立体异构体，以及另外的新化合物4-羟基-2,3,6-三甲基-5- [3- （4,8,12-三甲基十三烷基） - 丁烯基]苯基乙酸酯，其本身是在加热的影响下通过异构化形成的3-植酰基-2,5,6-三甲基氢醌-1-乙酸酯的几种异构体之一，例如 在其蒸馏期间作为如上所述的其制造之后的分离和纯化方法的一部分。 （全 - 外消旋）-α-生育酚可以衍生自其乙酸酯已知是维生素E组中最活跃的工业上重要的成员。

    Phosphine ligands
    29.
    发明授权
    Phosphine ligands 失效
    膦配体

    公开(公告)号：US06984744B2

    公开(公告)日：2006-01-10

    申请号：US10721038

    申请日：2003-11-21

    申请人： Piotr Osinski ,  Kazimierz Michal Pietrusiewicz ,  Rudolf Schmid

    发明人： Piotr Osinski ,  Kazimierz Michal Pietrusiewicz ,  Rudolf Schmid

    IPC分类号： C07F15/00 ,  C07F9/02 ,  C23C37/00 ,  C07C5/03

    CPC分类号： C07B53/00 ,  C07F9/65683 ,  C07F9/65685 ,  C07F15/0073

    摘要： The invention is concerned with new phosphine ligands of formula I wherein R1 and R2 are independently of each other unsubstituted alkyl, aryl, cycloalkyl or heteroaryl, or alkyl, aryl, cycloalkyl or heteroaryl each of which independently is substituted by alkyl, alkoxy, halogen, hydroxy, amino, mono- or dialkylamino, aryl, —SO2—R7, —SO3−, —CO—NR8R8′, carboxy, alkoxycarbonyl, trialkylsilyl, diarylalkylsilyl, dialkylarylsilyl or triarylsilyl; R3 is alkyl, cycloalkyl, aryl or heteroaryl; R4′ and R4 are independently of each other hydrogen, alkyl or optionally substituted aryl; or R4′ and R4 together with the C-atom they are attached, form a 3-8-membered carbocyclic ring; dotted line is optionally a double bond; R5 and R6 are independently of each other hydrogen, alkyl or aryl, R7 is alkyl or aryl; and R8 and R8′ are independently of each other hydrogen, alkyl or aryl; the substituents attached by the bold bonds are in cis relation to each other; metal complexes with such ligands in asymmetric reactions.

    摘要翻译： 本发明涉及式I的新的膦配体，其中R 1和R 2彼此独立地为未取代的烷基，芳基，环烷基或杂芳基，或烷基，芳基， 环烷基或杂芳基，其各自独立地被烷基，烷氧基，卤素，羟基，氨基，一或二烷基氨基，芳基，-SO 2 -R 7，-SO 3 -CO-NR 8 R 8，羧基，烷氧基羰基，三烷基甲硅烷基，二芳基烷基甲硅烷基，二烷基芳基甲硅烷基或二芳基烷基甲硅烷基 三芳基甲硅烷基 R 3是烷基，环烷基，芳基或杂芳基; R 4'和R 4彼此独立地为氢，烷基或任选取代的芳基; 或R 4'和R 4与它们所连接的C原子一起形成3-8元碳环; 虚线可选地是双键; R 5和R 6彼此独立地为氢，烷基或芳基，R 7为烷基或芳基; R 8和R 8'彼此独立地为氢，烷基或芳基; 通过粗体键连接的取代基彼此成顺式关系; 与不对称反应中的这种配体的金属络合物。