公开(公告)号：US08414684B2

公开(公告)日：2013-04-09

申请号：US12791732

申请日：2010-06-01

申请人： Yan Liu ,  Christopher A. Pohl ,  Michael McAdams ,  Hamish Small ,  Zhongqing Lu ,  Milton Liu ,  Khosro Moshfegh

发明人： Yan Liu ,  Christopher A. Pohl ,  Michael McAdams ,  Hamish Small ,  Zhongqing Lu ,  Milton Liu ,  Khosro Moshfegh

IPC分类号： B01D53/22 ,  B01D19/00

CPC分类号： B01D19/0073 ,  B01D19/0031 ,  B01D19/0036 ,  G01N30/32 ,  G01N30/96 ,  G01N2030/146

摘要： A degas assembly including a low pressure fluid channel for carrying a wash fluid at a first pressure, a pressurized channel for carrying eluent including a gas at a second pressure higher than the first pressure, and a degas separator defining a fluid barrier between the low pressure fluid channel and pressurized fluid channel, the separator configured to retain liquid in the pressurized fluid channel and allow gas to flow through the separator to the low pressure fluid channel. The pressurized fluid channel may extend along an outer periphery of the low pressure fluid channel. The eluent may be received from an eluent generator at a pressure of at least about 3300 psi, and in various embodiments up to about 5000 psi. A liquid chromatography system and method are also disclosed.

摘要翻译： 一种脱气组件，包括用于在第一压力下承载洗涤流体的低压流体通道，用于承载包含在高于第一压力的第二压力的气体的洗脱液的加压通道，以及限定低压下的流体阻挡层的脱气分离器 流体通道和加压流体通道，分离器构造成将液体保持在加压流体通道中并允许气体通过分离器流动到低压流体通道。 加压流体通道可以沿着低压流体通道的外周延伸。 洗脱液可以在至少约3300psi的压力下从洗脱液发生器接收，并且在各种实施方案中可高达约5000psi。 还公开了液相色谱系统和方法。

公开(公告)号：US20110290726A1

公开(公告)日：2011-12-01

申请号：US12791732

申请日：2010-06-01

申请人： Yan Liu ,  Christopher A. Pohl ,  Michael McAdams ,  Hamish Small ,  Zhongqing Lu ,  Milton Liu ,  Khosro Moshfegh

发明人： Yan Liu ,  Christopher A. Pohl ,  Michael McAdams ,  Hamish Small ,  Zhongqing Lu ,  Milton Liu ,  Khosro Moshfegh

IPC分类号： B01D19/00

CPC分类号： B01D19/0073 ,  B01D19/0031 ,  B01D19/0036 ,  G01N30/32 ,  G01N30/96 ,  G01N2030/146

摘要： A degas assembly including a low pressure fluid channel for carrying a wash fluid at a first pressure, a pressurized channel for carrying eluent including a gas at a second pressure higher than the first pressure, and a degas separator defining a fluid barrier between the low pressure fluid channel and pressurized fluid channel, the separator configured to retain liquid in the pressurized fluid channel and allow gas to flow through the separator to the low pressure fluid channel. The pressurized fluid channel may extend along an outer periphery of the low pressure fluid channel. The eluent may be received from an eluent generator at a pressure of at least about 3300 psi, and in various embodiments up to about 5000 psi. A liquid chromatography system and method are also disclosed.

摘要翻译： 一种脱气组件，包括用于在第一压力下承载洗涤流体的低压流体通道，用于承载包含在高于第一压力的第二压力的气体的洗脱液的加压通道，以及限定低压下的流体阻挡层的脱气分离器 流体通道和加压流体通道，分离器构造成将液体保持在加压流体通道中并允许气体通过分离器流动到低压流体通道。 加压流体通道可以沿着低压流体通道的外周延伸。 洗脱液可以在至少约3300psi的压力下从洗脱液发生器接收，并且在各种实施方案中可高达约5000psi。 还公开了液相色谱系统和方法。

公开(公告)号：US08628652B2

公开(公告)日：2014-01-14

申请号：US13364078

申请日：2012-02-01

申请人： Hamish Small ,  Yan Liu ,  Christopher A. Pohl

发明人： Hamish Small ,  Yan Liu ,  Christopher A. Pohl

IPC分类号： B01D61/44

CPC分类号： G01N30/96 ,  B01D61/427 ,  F04B17/00 ,  G01N30/32 ,  G01N30/34 ,  G01N30/6095

摘要： A continuous electrochemical pump comprising a water generator compartment, an anode compartment on one side of said generator compartment, a cation exchange barrier, separating the generator compartment from the anode compartment, it first electrode in electrical communication with the anode compartment, a cathode compartment adjacent the generator chamber, an anion exchange barrier, separating the generation compartment from the cathode compartment, and a second electrode in electrical communication with the cathode compartment. Use of the pump as a sample concentrator. A feedback loop for the pump. A reservoir, with or without an intermediate piston, on the output side of the pump.

摘要翻译： 一种连续电化学泵，包括水发生器室，在所述发生器室的一侧上的阳极室，阳离子交换屏障，将发电机室与阳极隔室分离，第一电极与阳极室电连通，阴极室相邻 所述发生器室，阴离子交换屏障，将所述发电室与所述阴极室分开，以及与所述阴极室电连通的第二电极。 使用泵作为样品浓缩器。 泵的反馈回路。 在泵的输出侧具有或不具有中间活塞的储存器。

公开(公告)号：US20060269452A1

公开(公告)日：2006-11-30

申请号：US11502294

申请日：2006-08-09

申请人： Yan Liu ,  Hamish Small ,  Nabojsa Avdalovic

发明人： Yan Liu ,  Hamish Small ,  Nabojsa Avdalovic

IPC分类号： B01L9/00

CPC分类号： G01N30/96 ,  C25B1/16 ,  C25B1/22 ,  G01N30/02 ,  G01N30/34 ,  G01N2030/965 ,  Y10T436/25 ,  B01D15/36 ,  B01D15/426

摘要： Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generation chamber separated from the cation source reservoir by a barrier (e.g. a charged membrane) substantially preventing liquid flow while providing a cation transport bridge, applying an electric potential between an anode cation source reservoir and a cathode in the base generation chamber to electrolytically generate hydroxide ions therein and to cause cations in the cation source reservoir to electromigrate and to be transported across the barrier toward the cathode to combine with the transported cations to form cation hydroxide, and removing the cation hydroxide in an aqueous liquid stream as an effluent from the first base generation chamber. Suitable cation sources include a salt solution, a cation hydroxide solution or cation exchange resin.

公开(公告)号：US5773615A

公开(公告)日：1998-06-30

申请号：US600856

申请日：1996-02-13

申请人： Hamish Small ,  John M. Riviello ,  Steven B. Rabin

发明人： Hamish Small ,  John M. Riviello ,  Steven B. Rabin

IPC分类号： G01N30/02 ,  G01N30/60 ,  G01N30/96

CPC分类号： G01N30/96 ,  G01N2030/965 ,  Y10T436/25125

摘要： Method and apparatus for ion chromatography including passage of sample through a chromatographic separation column, through a suppressor column containing a resin with exchangeable ions, and then through a detector. The suppressor column is equipped with an electrical potential supplying device to electrolyze water and regenerate the suppressor column.

摘要翻译： 用于离子色谱法的方法和装置，包括样品通过色谱分离柱，通过含有可交换离子的树脂的抑制柱，然后通过检测器。 抑制柱配备有电解水并且再生抑制柱的电位供给装置。

公开(公告)号：US5597734A

公开(公告)日：1997-01-28

申请号：US503999

申请日：1995-07-19

申请人： Hamish Small ,  John Riviello ,  Christopher A. Pohl

发明人： Hamish Small ,  John Riviello ,  Christopher A. Pohl

IPC分类号： A61B17/60 ,  A61B17/64 ,  G01N30/02 ,  G01N30/60 ,  G01N30/96

CPC分类号： G01N30/96 ,  G01N2030/965

摘要： An ion chromatography method for analysis of a plurality of analyte ions in a sequence of samples in which ion chromatography is performed on a sample, which is passed to a non-precipitating suppressor ion exchange resin and analyzed, the suppressor being regenerated in one step prior to processing of a subsequent sample.

摘要翻译： 一种用于分析样品序列中的多个分析物离子的离子色谱法，其中对样品进行离子色谱，所述样品被传递到非沉淀抑制离子交换树脂，并分析了在一个步骤中再生的抑制剂 以处理随后的样品。

公开(公告)号：US4732686A

公开(公告)日：1988-03-22

申请号：US811144

申请日：1985-12-19

申请人： Hamish Small ,  Mark E. Soderquist ,  James W. Pischke

发明人： Hamish Small ,  Mark E. Soderquist ,  James W. Pischke

IPC分类号： G01N30/96 ,  B01D15/08

CPC分类号： G01N30/96

摘要： Apparatus and method for the chromatographic separation and analysis of ionic species. This process is carried out utilizing, in an ion separator column, the combination of a low capacity, high performance resin as the stationary phase, and a weakly ionized electrolyte as the eluant or developing reagent, to effect resolution of ionic species in solution. For anion separation, a weak base resin of low capacity and high efficiency is used as the stationary phase, and a solution of a weak base or water as the mobile phase. For cation separation, a weak acid resin of low capacity and high efficiency is used as the stationary phase and a solution of a weak acid as the mobile phase. Because the eluant employed has a very low background conductivity, it will register only insignificantly on the readout from the conductivity cell. Thus, the method of the invention obviates the need for the eluant suppressor or "stripper" device used in conventional ion chromatography. The invention thereby enables continuous, uninterrupted measurements and eliminates the reservoirs, pumps, complex valving and electronics associated with such suppressor columns.

摘要翻译： 离子物质色谱分离和分析的仪器和方法。 该方法在离子分离塔中利用作为固定相的低容量高性能树脂和作为洗脱剂或显色剂的弱离子化电解质的组合来实现溶液中离子物质的分离。 对于阴离子分离，使用低容量和高效率的弱碱性树脂作为固定相，将弱碱或水作为流动相的溶液。 对于阳离子分离，使用低容量和高效率的弱酸性树脂作为固定相和弱酸作为流动相的溶液。 因为所使用的洗脱液具有非常低的背景电导率，所以它将仅在电导率电池的读数上不重要地注册。 因此，本发明的方法消除了在常规离子色谱法中使用的洗脱液抑制剂或“汽提器”装置的需要。 因此，本发明能够进行连续的，不间断的测量并且消除与这种抑制器柱相关联的储存器，泵，复杂阀门和电子装置。

公开(公告)号：US4628743A

公开(公告)日：1986-12-16

申请号：US738125

申请日：1985-06-14

申请人： Theodore E. Miller, Jr. ,  Hamish Small

发明人： Theodore E. Miller, Jr. ,  Hamish Small

IPC分类号： G01F1/704 ,  G01F11/00 ,  G01F11/28 ,  G01F13/00 ,  G01F1/68 ,  G01F1/70 ,  G01P5/18

CPC分类号： G01F11/00 ,  G01F1/7044 ,  G01F11/28 ,  G01F13/00

摘要： Apparatus for accurately metering liquid flow based on the injection of a brief heat pulse into the flowing stream, e.g., via a miniature thermistor, and detection of an electronic time derivative of temperature downstream with, e.g., a second microprobe thermistor. This detection triggers a subsequent heat pulse and the cycle repeats, with pulse total corresponding to elapsed liquid throughput, and pulse frequency to flow rate.

摘要翻译： 基于将短暂的热脉冲注入到流动流中，例如通过微型热敏电阻，以及利用例如第二微孔热敏电阻检测下游温度的电子时间导数的装置。 该检测触发随后的加热脉冲，循环重复，脉冲总数对应于经过的液体通过量，脉冲频率与流速。

公开(公告)号：US5914025A

公开(公告)日：1999-06-22

申请号：US781537

申请日：1997-01-09

申请人： Hamish Small

发明人： Hamish Small

IPC分类号： G01N30/02 ,  B01J39/26 ,  B01J41/20 ,  G01N30/34 ,  G01N30/46 ,  G01N30/60 ,  G01N30/96 ,  B01D61/48

CPC分类号： G01N30/96 ,  B01J39/26 ,  B01J41/20 ,  G01N30/34 ,  G01N2030/965 ,  G01N30/461

摘要： A method and apparatus for generating an acid or base eluent in an aqueous stream solely from an ion exchange bed for liquid chromatography of anions or cations and for simultaneously suppressing conductivity of the eluent in the ion exchange bed after chromatographic separation. For a system in which a base is generated for the analysis of anions by ion chromatography, the method uses a bed of cation exchange material with first and second bed sections arranged in series. For anion analysis, the method includes:(a) flowing an aqueous feed stream through the first bed section while applying an electrical potential to form an aqueous eluent stream comprising a cation hydroxide base,(b) flowing a liquid sample stream containing anions to be detected and the eluent through a chromatographic separator portion of said first bed section, to separate said anions to be detected,(c) flowing said aqueous separated anion stream through said second bed section substantially free of anion exchange material and including exchangeable hydronium ions, while applying an electrical potential to convert said base to weakly ionized form, and displacing some of said exchangeable hydronium ions with cations from said base, cations electromigrating from said second bed section to said first bed section in the opposite direction to said aqueous feed stream to replenish exchangeable cations displaced from said first bed in step (a), and(d) flowing said suppressor effluent stream past a detector in which the separated anions in said suppressor effluent are detected.

摘要翻译： 一种仅在离子交换床中进行阴离子或阳离子液相色谱的含水流中产生酸或碱洗脱液的方法和装置，并同时抑制色谱分离后离子交换床中的洗脱液的电导率。 对于通过离子色谱分析阴离子产生碱的系统，该方法使用具有串联排列的第一和第二床部分的阳离子交换材料床。 对于阴离子分析，所述方法包括：（a）在施加电势的同时使含水进料流流过第一床部分以形成包含阳离子氢氧化物碱的含水洗脱液流，（b）使含有阴离子的液体样品流流动为 检测和洗脱液通过所述第一床部分的色谱分离部分分离，以分离待检测的阴离子，（c）使所述含水分离的阴离子物流通过所述第二床部分基本上不含阴离子交换材料并且包括可交换的水合氢离子，同时 施加电位以将所述碱转化为弱电离形式，以及使来自所述碱的阳离子将一些所述可交换的水合氢离子置换，所述阳离子以与所述含水进料流相反的方向从所述第二床部分电解至所述第一床部分，以补充 在步骤（a）中从所述第一床排出的可交换阳离子，和（d）使所述抑制剂流出物st 通过其中检测到所述抑制流出物中分离的阴离子的检测器。

公开(公告)号：US4414842A

公开(公告)日：1983-11-15

申请号：US364705

申请日：1982-04-02

申请人： Hamish Small ,  Theodore E. Miller, Jr.

发明人： Hamish Small ,  Theodore E. Miller, Jr.

IPC分类号： G01N30/02 ,  G01N30/96 ,  G01N21/00

CPC分类号： G01N30/96 ,  G01N30/02

摘要： An improved technique for the measurement of ions in solution where the ions of interest are chromatographically displaced from an ion exchange column by an eluting ion which is or is made light-absorbing, and where the eluted sample ions, which are transparent (at the monitored wavelength), are detected and quantified from the decrements they cause in effluent absorbance as revealed by photometric monitoring.

摘要翻译： 用于测量溶液中离子的改进技术，其中感兴趣的离子通过被吸收或被吸收的洗脱离子从离子交换柱色谱位移，并且其中被洗涤的样品离子是透明的 波长），由其通过光度监测显示的流出物吸光度引起的减量进行检测和量化。