公开(公告)号：US07172867B2

公开(公告)日：2007-02-06

申请号：US10611310

申请日：2003-07-01

申请人： Ryoichi Hashida ,  Shinji Kagaya ,  Yuji Sugita ,  Hirohisa Saito

发明人： Ryoichi Hashida ,  Shinji Kagaya ,  Yuji Sugita ,  Hirohisa Saito

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C07K14/70567 ,  A01K2217/075 ,  A61K31/5575 ,  A61K38/00 ,  G01N2500/10

摘要： Differential expression of genes whose expression is different in the activated eosinophils of atopic dermatitis patients was measured by comparative analysis using a gene chip. As a result, the TR3 and TINUR genes, whose expression is significantly elevated in activated eosinophils, were successfully identified. The present inventors discovered that these genes can be used to test for allergic disease and to screen candidate compounds for therapeutic agents for allergic disease.

摘要翻译： 通过使用基因芯片的比较分析来测定特应性皮炎患者的活化嗜酸性粒细胞中表达不同的基因的差异表达。 结果，TR3和TINUR基因在活化嗜酸性粒细胞中的表达显着升高。 本发明人发现，这些基因可用于测试过敏性疾病并筛选用于过敏性疾病的治疗剂的候选化合物。

公开(公告)号：US20050110032A1

公开(公告)日：2005-05-26

申请号：US10904622

申请日：2004-11-19

申请人： Hirohisa Saito ,  Yoshiyuki Hirose ,  Youichi Nagai ,  Hiroyuki Kitabayashi ,  Ayako Ikeda

发明人： Hirohisa Saito ,  Yoshiyuki Hirose ,  Youichi Nagai ,  Hiroyuki Kitabayashi ,  Ayako Ikeda

IPC分类号： F21V8/00 ,  G02F1/1335 ,  H01L33/06 ,  H01L33/32 ,  H01L33/46 ,  H01L33/50 ,  H01L33/00

CPC分类号： H01L33/505 ,  G02B6/0046 ,  H01L33/46 ,  H01L2224/48091 ,  H01L2924/00014

摘要： A light-emitting diode (1) is furnished with a semiconductor laminate (6), optically reflective layers (17) and (19), an optically reflective film (25), and a phosphorescent plate (27). The laminate (6) is formed by an n-type cladding layer (9), an active layer (11), a p-type cladding layer (13), and a p-type contact layer (15), laminated in order onto a substrate (7). The optically reflective layers (17) and (19) are provided respectively on the p-type contact layer (15) and on the back side (7b) of the substrate (7). The optically reflective film (25) is provided on three side surfaces of the laminate (6). The phosphorescent plate (27) is mounted on a side face, among the side faces of the laminate (6), on which there is no optically reflective film (25). Blue light (L1) output from the active layer (11) is reflected at each of the optically reflective layers, and is gathered on the side face on which the phosphorescent plate (27) is provided. A portion of the blue light (L1) turns into yellow light (2) in the phosphorescent plate (27), and white light derived from the blue light (L1) and yellow light (L2) is emitted.

摘要翻译： 发光二极管（1）配备有半导体层叠体（6），光反射层（17）和（19），光反射膜（25）和磷光板（27）。 层叠体（6）由n型包覆层（9），有源层（11），p型覆盖层（13）和p型接触层（15）依次层叠而形成 衬底（7）。 光反射层（17）和（19）分别设置在基板（7）的p型接触层（15）和背面（7b）上。 光反射膜（25）设置在层叠体（6）的三个侧面上。 磷光板（27）安装在层叠体（6）的没有光反射膜（25）的侧面中的侧面上。 从有源层（11）输出的蓝光（L 1）在每个光反射层被反射，聚集在设置有磷光板（27）的侧面上。 蓝色光（L 1）的一部分在磷光板（27）中变成黄色光（2），发出蓝色光（L 1）和黄色光（L 2）衍生的白色光。

公开(公告)号：US06641861B2

公开(公告)日：2003-11-04

申请号：US09962578

申请日：2001-09-24

申请人： Hirohisa Saito ,  Yoshiyuki Yamamoto ,  Kiichi Meguro ,  Takahiro Imai

发明人： Hirohisa Saito ,  Yoshiyuki Yamamoto ,  Kiichi Meguro ,  Takahiro Imai

IPC分类号： B05D512

CPC分类号： H01L23/3736 ,  H01L21/4871 ,  H01L23/142 ,  H01L23/3732 ,  H01L23/49562 ,  H01L2924/0002 ,  H01L2924/1423 ,  Y10T428/24942 ,  Y10T428/24975 ,  Y10T428/249961 ,  Y10T428/249967 ,  Y10T428/249988 ,  Y10T428/24999 ,  Y10T428/26 ,  Y10T428/30 ,  Y10T428/31678 ,  H01L2924/00

摘要： A method of fabricating a heatsink including a substrate of a sintered compact containing Cu and W, and a thin diamond film layer formed on the surface of the substrate with good adherence, involves immersing the substrate in acid to reduce the Cu content of a surface region thereof and to roughen exposed W at that surface region, and then forming the thin diamond film layer on that surface region by vapor synthesis. Alternatively, a thin diamond film layer is formed on a surface of a porous body substrate, and then a hole in the porous body substrate is filled with Cu.

摘要翻译： 一种制造包括含有Cu和W的烧结体的衬底的散热体的方法以及形成在衬底表面上的良好粘附性的薄金刚石膜层包括将衬底浸入酸中以降低表面区域的Cu含量 并在该表面区域粗化暴露的W，然后通过气相合成在该表面区域上形成薄金刚石膜层。 或者，在多孔体基板的表面上形成薄金刚石膜层，然后用Cu填充多孔体基板的孔。

公开(公告)号：US06618539B2

公开(公告)日：2003-09-09

申请号：US09961191

申请日：2001-09-24

申请人： Yoshiyuki Hirose ,  Tadashi Tomikawa ,  Hirohisa Saito

发明人： Yoshiyuki Hirose ,  Tadashi Tomikawa ,  Hirohisa Saito

IPC分类号： G02B600

CPC分类号： H01L21/67103 ,  G02B6/30 ,  H01L23/345 ,  H01L2924/0002 ,  H01L2924/00

摘要： To provide a heater module which can improve the temperature uniformity in an optical waveguide while keeping the power consumption and the thickness of the optical waveguide module. A heater module 20 in accordance with the present invention is a heater module 20 for heating an optical waveguide device 12 so as to regulate its temperature; and comprises a heat-generating circuit 22 adapted to generate heat when energized, and a heat-transmitting section 21 disposed on the upper face of the heat-generating circuit 22 and formed with a recessed groove portion for mounting the optical waveguide device 12. When the optical waveguide device 12 is mounted on the bottom face of the heat-transmitting section 21 formed with the recessed groove section, the optical waveguide device 12 can be heated not only from its bottom face, but also from its side faces by edge parts constituting the recessed groove portion, whereby the temperature uniformity can be enhanced.

公开(公告)号：US06361857B1

公开(公告)日：2002-03-26

申请号：US09232011

申请日：1999-01-14

申请人： Hirohisa Saito ,  Yoshiyuki Yamamoto ,  Kiichi Meguro ,  Takahiro Imai

发明人： Hirohisa Saito ,  Yoshiyuki Yamamoto ,  Kiichi Meguro ,  Takahiro Imai

IPC分类号： B32B900

CPC分类号： H01L23/3736 ,  H01L21/4871 ,  H01L23/142 ,  H01L23/3732 ,  H01L23/49562 ,  H01L2924/0002 ,  H01L2924/1423 ,  Y10T428/24942 ,  Y10T428/24975 ,  Y10T428/249961 ,  Y10T428/249967 ,  Y10T428/249988 ,  Y10T428/24999 ,  Y10T428/26 ,  Y10T428/30 ,  Y10T428/31678 ,  H01L2924/00

摘要： A thin diamond film layer is formed on a substrate with good adherence. A heatsink includes a substrate of a sintered compact including Cu and W, and a thin diamond film layer formed on the surface of the substrate. The Cu content in the substrate is at least 5% by weight. In an X-ray diffraction chart obtained by irradiating the thin diamond film layer with an X-ray, the diffraction peak intensity of the (110) plane of W is at least 100 times the diffraction peak intensity of the (200) plane of Cu.

摘要翻译： 在具有良好粘附性的基材上形成薄金刚石膜层。 散热器包括包含Cu和W的烧结体的基板，以及形成在基板的表面上的薄金刚石膜层。 基材中的Cu含量为至少5重量％。 在通过用X射线照射薄金刚石膜层而获得的X射线衍射图中，W的（110）面的衍射峰强度为Cu的（200）面的衍射峰强度的至少100倍 。

公开(公告)号：US06267637B1

公开(公告)日：2001-07-31

申请号：US09437092

申请日：1999-11-09

申请人： Hirohisa Saito ,  Takashi Tsuno ,  Hiromu Shiomi ,  Yoshiaki Kumazawa ,  Takahiro Imai

发明人： Hirohisa Saito ,  Takashi Tsuno ,  Hiromu Shiomi ,  Yoshiaki Kumazawa ,  Takahiro Imai

IPC分类号： H01J924

CPC分类号： H01J1/3042 ,  H01J2201/30457

摘要： An electron-emitting element comprises a diamond substrate, and a diamond protrusion grown on a surface of the diamond substrate so as to have a pointed portion in a form capable of emitting an electron. Since the diamond protrusion formed by growth has a sharply pointed tip portion, it can fully emit electrons. Preferably, the surface of the diamond substrate is a {100} face, and the diamond protrusion is surrounded by {111} faces.

摘要翻译： 电子发射元件包括金刚石衬底和在金刚石衬底的表面上生长的金刚石突起，以便具有能够发射电子的形式的尖端部分。 由于通过生长形成的金刚石突起具有尖锐的尖端部分，所以它可以完全发射电子。 优选地，金刚石基底的表面是{100}面，并且金刚石突起被{111}面包围。