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    Process for the preparation of Chlorambucil derivatives
    22.
    发明授权
    Process for the preparation of Chlorambucil derivatives 失效
    苯丁酸酐衍生物的制备方法

    公开(公告)号：US4261910A

    公开(公告)日：1981-04-14

    申请号：US62789

    申请日：1979-08-01

    申请人： Kiro Asano ,  Humio Tamura ,  Hiromitsu Tanaka ,  Satoru Enomoto

    发明人： Kiro Asano ,  Humio Tamura ,  Hiromitsu Tanaka ,  Satoru Enomoto

    IPC分类号： C07J1/00 ,  C07J41/00 ,  A61K31/56

    CPC分类号： C07J1/0074 ,  C07J41/0088

    摘要： The Chlorambucil derivatives are novel compounds having the formula (I). ##STR1## wherein R represents a hydrogen atom or an acyl group such as ##STR2## and n is 1 or 2. The Chlorambucil derivatives can be produced by binding Chlorambucil to hydroxyl group at 17-position of estradiol or its derivative in the presence of a binding agent selected from the group consisting of compounds having the formulaX(CH.sub.2).sub.n COOHX(CH.sub.2).sub.n COXHOOC(CH.sub.2).sub.n COOH andXOC(CH.sub.2).sub.n COXwherein n is 1 or 2 and X represents a halogen atom.

    摘要翻译： 苯丁酸氮芥衍生物是具有式（I）的新化合物。 （I）其中R表示氢原子或酰基，例如“IMAGE”，n为1或2.苯扎巴酸衍生物可以通过将苯丁酸氮芥在17位雌二醇或其衍生物上的羟基结合而制备 选自具有式X（CH 2）n COOH X（CH 2）n COX HOOC（CH 2）n COOH和XOC（CH 2）n COX的化合物的结合剂的存在，其中n为1或2，X表示卤素原子。

    Mouse spermatogenesis genes related to human male sterility
    28.
    发明授权
    Mouse spermatogenesis genes related to human male sterility 有权
    与人类雄性不育相关的小鼠精子发生基因

    公开(公告)号：US07842783B2

    公开(公告)日：2010-11-30

    申请号：US10504582

    申请日：2003-02-14

    申请人： Yoshitake Nishimune ,  Hiromitsu Tanaka ,  Masami Nozaki

    发明人： Yoshitake Nishimune ,  Hiromitsu Tanaka ,  Masami Nozaki

    IPC分类号： C07K17/00

    CPC分类号： C12Q1/6883 ,  C07K14/47 ,  C12N15/52 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： The present invention provides a polynucleotide or a complementary sequence thereof, which polynucleotide is complementary to mRNA transcribed from a human male infertility-associated gene Scot-t, and has one or more mutations selected from the following group: “t” at 870th position is replaced by “g”; and “t” at 1667th position is replaced by “c”, in the DNA sequence of SEQ ID NO:168; various molecular biological materials relating thereto; various molecular biological materials relating to male infertility-associated gene mutations; and various test methods and diagnostic methods using the same.

    摘要翻译： 本发明提供了多核苷酸或其互补序列，该多核苷酸与从人类男性不育相关基因Scot-t转录的mRNA互补，并具有一个或多个选自以下组的突变：第870位的“t”为 换成“g”; 在第1667位的“t”被SEQ ID NO：168的DNA序列中的“c”代替; 与此有关的各种分子生物学材料; 与男性不育相关基因突变相关的各种分子生物学材料; 和各种测试方法和使用其的诊断方法。

    Liquid crystal display panel and method of making the same
    30.
    发明申请
    Liquid crystal display panel and method of making the same 审中-公开
    液晶显示面板及其制作方法

    公开(公告)号：US20080068547A1

    公开(公告)日：2008-03-20

    申请号：US11896380

    申请日：2007-08-31

    申请人： Hiromitsu Tanaka

    发明人： Hiromitsu Tanaka

    IPC分类号： G02F1/1337 ,  H01L21/02

    CPC分类号： G02F1/133707 ,  G02F1/13378

    摘要： Recesses and protrusions are formed on the surface of an orientation film that is formed on a substrate of the liquid crystal display panel comprising a glass substrate 1 and a TFT 2. An ion beam is radiated on the entire surface of the uneven orientation film to reach the saturating condition, thereby increasing the effective orientation surface area. If there are large bumps on the surface of the orientation film 3 that is radiated by an ion beam from an ion beam source to cause shadow portions, the ion beam is radiated on the shadow portions from the opposite direction. In order to form recesses and protrusions on the orientation film, it is preferable to have an orientation plate mesh structure having rough mesh depth and pitch and a particular solvent composition that easily causes recesses and protrusions on the surface chosen as the orientation material.

    摘要翻译： 在形成在包括玻璃基板1和TFT2的液晶显示面板的基板上的取向膜的表面上形成凹部和突起。离子束辐射在不均匀取向膜的整个表面上以到达 饱和状态，从而增加有效的取向表面积。 如果通过离子束从离子束源辐射的取向膜3的表面上存在大的凸起，以产生阴影部分，则离子束从相反方向辐射在阴影部分上。 为了在取向膜上形成凹部和突起，优选具有粗网眼深度和间距粗糙度的定向板网状结构以及在作为取向材料选择的表面上容易引起凹凸的特定溶剂组成。