公开(公告)号：US20130210081A1

公开(公告)日：2013-08-15

申请号：US13880224

申请日：2011-11-29

Applicant: Hiroshi Koeda

Inventor： Hiroshi Koeda

IPC: B01L7/00

CPC classification number: B01L7/5255 ,  B01L3/5082 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/0673 ,  B01L2300/18 ,  B01L2400/0457

Abstract: A thermal cycler (1) includes a holder (11) that holds a biotip (100) filled with a reaction mixture and liquid having a smaller specific gravity than the reaction mixture and being immiscible with the reaction mixture, the biotip (100) including a channel (110) in which the reaction mixture moves, a heating unit (12) that heats a first portion (111) of the channel when the biotip (100) is in the holder (11), and a driving unit (20) that disposes the holder (11) and the heating unit (12) by making a switch between a first disposition and a second disposition, the first disposition being such that the first portion (111) is in a lowest part of the channel (110) with respect to a gravitational force direction when the biotip (100) is in the holder (11), the second disposition being such that a second portion (112) that is a different portion from the first portion (111) relative to a moving direction of the reaction mixture is in the lowest part of the channel (110) with respect to the gravitational force direction when the biotip (100) is in the holder (11).

Abstract translation: 热循环器（1）包括保持器（11），其保持填充有反应混合物的生物体（100）和比反应混合物小的比例的液体，并且与反应混合物不混溶，所述生物体（100）包括 通道（110），当所述生物体（100）在所述保持器（11）中时，加热所述通道的第一部分（111）的加热单元（12）和驱动单元（20），所述驱动单元 通过在第一配置和第二配置之间进行开关来设置保持器（11）和加热单元（12），第一配置使得第一部分（111）在通道（110）的最下部分具有 当所述生物体（100）在所述保持器（11）中时，相对于重力方向，所述第二配置使得与所述第一部分（111）相对于所述第一部分（111）的移动方向的不同部分的第二部分 反应混合物相对于g在通道（110）的最低部分中 当所述生物体（100）在所述保持器（11）中时，所述湍流力方向。

公开(公告)号：US20070048191A1

公开(公告)日：2007-03-01

申请号：US11497736

申请日：2006-08-02

Applicant: Hiroshi Koeda

Inventor： Hiroshi Koeda

IPC: B01L3/02

CPC classification number: B01L3/0268 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L2200/0673 ,  B01L2200/143 ,  B01L2300/0645 ,  B01L2400/0439 ,  Y10T436/113332 ,  Y10T436/115831 ,  Y10T436/2575

Abstract: Provided is a method of manufacturing a biochip using a droplet discharging device including a droplet discharging head having a cavity and a nozzle hole provided in communication with the cavity, and a liquid housing unit connected to the cavity via a passage, having the steps of filling a retention liquid which separates without getting mixed with the sample liquid into the liquid housing unit, the passage, and the cavity; injecting the sample liquid into the liquid housing unit; moving the sample liquid from the liquid housing unit to the cavity by discharging the retention liquid from the nozzle hole; stopping the discharge of the retention liquid at the moving step upon detecting with a sensor that the sample liquid reached a position adjacent to the nozzle hole; and delivering the sample liquid as droplets onto the object by discharging the sample liquid from the nozzle hole.

Abstract translation: 提供一种使用液滴排出装置制造生物芯片的方法，所述液滴排出装置包括具有空腔的喷液头和与空腔连通的喷嘴孔，以及通过通道连接到空腔的液体容纳单元，具有填充 分离而不与样品液体混合进入液体容纳单元，通道和空腔中的保留液体; 将样品液体注入到液体容纳单元中; 通过从喷嘴孔排出保留液体将样品液体从液体容纳单元移动到空腔; 当用传感器检测到样品液体到达与喷嘴孔相邻的位置时，在移动步骤停止保留液体的排出; 并通过从喷嘴孔排出样品液体将样品液体作为液滴输送到物体上。

公开(公告)号：US06989513B2

公开(公告)日：2006-01-24

申请号：US10465842

申请日：2003-06-20

Applicant: Katsuji Arakawa ,  Masahiro Fujii ,  Hiroshi Koeda

Inventor： Katsuji Arakawa ,  Masahiro Fujii ,  Hiroshi Koeda

IPC: H05B3/10

CPC classification number: H05B3/148

Abstract: A stable and durable heat-generating element and substrate, a method of efficient and highly precise manufacture of same, and equipment utilizing same are obtained. Employing as material a silicon substrate into at least a portion of which boron or another impurity is diffused to impart conductivity, a heater portion, in which are provided one or a plurality of slits the corner portions of which are removed or are rounded, is fabricated integrally on the silicon substrate by etching processes. Simultaneously with this, a depression portion provided below to control the heating state of the heater portion is formed integrally.

Abstract translation: 获得稳定且耐用的发热元件和基板，其高效且高精度制造的方法以及利用其的设备。 将作为材料的硅衬底作为其至少一部分硼或另一杂质扩散以赋予导电性的材料，加热器部分设置有一个或多个切口，其角部被去除或被倒圆形， 通过蚀刻工艺一体地在硅衬底上。 与此同时，下面设置的用于控制加热器部分的加热状态的凹部形成为一体。

公开(公告)号：US20050139920A1

公开(公告)日：2005-06-30

申请号：US10988418

申请日：2004-11-12

Applicant: Hiroshi Koeda

Inventor： Hiroshi Koeda

IPC: H01L51/50 ,  G09F9/30 ,  H01L21/00 ,  H01L21/02 ,  H01L21/50 ,  H01L21/52 ,  H01L21/77 ,  H01L23/48 ,  H01L27/01 ,  H01L27/12 ,  H01L27/32 ,  H01L29/78 ,  H01L29/786 ,  H05B33/10 ,  H05B33/14

CPC classification number: H01L27/1266 ,  H01L27/1214 ,  H01L27/3253 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A semiconductor device is provided. The semiconductor device includes an element; a mounting board; and a single film made of a conductive material directly coupling the element with the mounting board.

Abstract translation: 提供半导体器件。 半导体器件包括元件; 安装板; 以及由导电材料制成的单个膜直接将该元件与安装板连接。

公开(公告)号：US06271955B1

公开(公告)日：2001-08-07

申请号：US09585880

申请日：2000-05-31

Applicant: Mitsuro Atobe ,  Hiroshi Koeda ,  Shinichi Yotsuya

Inventor： Mitsuro Atobe ,  Hiroshi Koeda ,  Shinichi Yotsuya

IPC: G02B2600

CPC classification number: G02B26/0841

Abstract: A spatial light modulator is constructed from a conductive silicon mirror substrate and a glass electrode substrate including sodium, anode-bonded together. The silicon mirror substrate has micromirrors arranged in a matrix, torsion bars coupling these micromirrors in the x-direction, and a frame coupled to both ends of the torsion bars. A glass electrode substrate has a central depression, a rim around the periphery thereof, pillars projecting from within the depression, and electrodes and wiring driving micromirrors formed within the depression in an inclining manner. Both ends of the torsion bars are bonded to the rim of the frame portion, and intermediate portions of the torsion bars are bonded to the pillars. Both ends of the torsion bars are cut away from the frame portion during dicing.

Abstract translation: 空间光调制器由导电硅镜基板和包括阳极粘合在一起的钠的玻璃电极基板构成。 硅镜基板具有以矩阵形式布置的微镜，在x方向上连接这些微镜的扭杆以及耦合到扭杆的两端的框架。 玻璃电极基板具有中央凹部，围绕其周边的边缘，从凹部内突出的支柱，以及以倾斜方式形成在凹部内的微电子驱动微镜的电极和布线。 扭杆的两端粘接到框架部分的边缘，并且扭杆的中间部分结合到支柱上。 在切割期间，扭杆的两端被切割离开框架部分。

公开(公告)号：US5999306A

公开(公告)日：1999-12-07

申请号：US756463

申请日：1996-11-26

Applicant: Mitsuro Atobe ,  Hiroshi Koeda ,  Shinichi Yotsuya

Inventor： Mitsuro Atobe ,  Hiroshi Koeda ,  Shinichi Yotsuya

IPC: G02B26/00 ,  G02B26/08 ,  G03B21/00 ,  G03B21/26 ,  H01L21/84

CPC classification number: G02B26/0841

Abstract: A spatial light modulator is constructed from a conductive silicon mirror substrate and a glass electrode substrate including sodium, anode-bonded together. The silicon mirror substrate has micromirrors arranged in a matrix, torsion bars coupling these micromirrors in the x-direction, and a frame coupled to both ends of the torsion bars. A glass electrode substrate has a central depression, a rim around the periphery thereof, pillars projecting from within the depression, and electrodes and wiring driving micromirrors formed within the depression in an inclining manner. Both ends of the torsion bars are bonded to the rim of the frame portion, and intermediate portions of the torsion bars are bonded to the pillars. Both ends of the torsion bars are cut away from the frame portion during dicing.

公开(公告)号：US5912684A

公开(公告)日：1999-06-15

申请号：US795413

申请日：1997-02-03

Applicant: Masahiro Fujii ,  Keiichi Mukaiyama ,  Hiroyuki Maruyama ,  Tadaaki Hagata ,  Mitsuro Atobe ,  Shinichi Kamisuki ,  Shinichi Yotsuya ,  Hiroshi Koeda ,  Yoshihiro Ohno ,  Hitoshi Tanbo

Inventor： Masahiro Fujii ,  Keiichi Mukaiyama ,  Hiroyuki Maruyama ,  Tadaaki Hagata ,  Mitsuro Atobe ,  Shinichi Kamisuki ,  Shinichi Yotsuya ,  Hiroshi Koeda ,  Yoshihiro Ohno ,  Hitoshi Tanbo

IPC: B41J2/14 ,  B41J2/16 ,  C04B37/04 ,  B41J2/04 ,  B41J2/045

CPC classification number: B41J2/14314 ,  B41J2/16 ,  B41J2/1623 ,  B41J2/1629 ,  B41J2/1631 ,  B41J2/1632 ,  B41J2/1645 ,  B41J2/1646 ,  B41J2002/14338 ,  B41J2202/11

Abstract: An inkjet head comprising a nozzle, an ink passage in communication with the nozzle, a diaphragm provided at one part of the ink passage, and an electrode provided in opposition to the diaphragm whereby an electrical pulse is applied between the diaphragm and electrode to deform the diaphragm by means of electrostatic force, thereby ejecting ink droplets from the nozzle. The actuator contains at least a vibration chamber formed by the diaphragm and electrode, and is sealed or made airtight with the volume V so that the ratio between the actuator volume V and the volume .DELTA.V eliminated by a distortion of the diaphragm during ink-jet head drive is within the range 2.ltoreq.V/.DELTA.V.ltoreq.8.

Abstract translation: 一种喷墨头，包括喷嘴，与喷嘴连通的墨通道，设置在墨通道的一部分处的隔膜以及与隔膜相对设置的电极，由此在隔膜和电极之间施加电脉冲以使 通过静电力隔膜，从喷嘴喷出墨滴。 致动器至少包括由隔膜和电极形成的振动室，并且与体积V密封或制成气密，使得在喷墨期间通过隔膜的变形消除了致动器体积V和体积DELTA V之间的比率 磁头驱动器在2

公开(公告)号：US09144800B2

公开(公告)日：2015-09-29

申请号：US13880224

申请日：2011-11-29

Applicant: Hiroshi Koeda

Inventor： Hiroshi Koeda

IPC: C12P19/34 ,  B01L7/00 ,  B01L3/00

CPC classification number: B01L7/5255 ,  B01L3/5082 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/0673 ,  B01L2300/18 ,  B01L2400/0457

Abstract: A thermal cycler (1) includes a holder (11) that holds a biotip (100) filled with a reaction mixture and liquid having a smaller specific gravity than the reaction mixture and being immiscible with the reaction mixture, the biotip (100) including a channel (110) in which the reaction mixture moves, a heating unit (12) that heats a first portion (111) of the channel when the biotip (100) is in the holder (11), and a driving unit (20) that disposes the holder (11) and the heating unit (12) by making a switch between a first disposition and a second disposition, the first disposition being such that the first portion (111) is in a lowest part of the channel (110) with respect to a gravitational force direction when the biotip (100) is in the holder (11), the second disposition being such that a second portion (112) that is a different portion from the first portion (111) relative to a moving direction of the reaction mixture is in the lowest part of the channel (110) with respect to the gravitational force direction when the biotip (100) is in the holder (11).

Abstract translation: 热循环器（1）包括保持器（11），其保持填充有反应混合物的生物体（100）和比反应混合物小的比例的液体，并且与反应混合物不混溶，所述生物体（100）包括 通道（110），当所述生物体（100）在所述保持器（11）中时，加热所述通道的第一部分（111）的加热单元（12）和驱动单元（20），所述驱动单元 通过在第一配置和第二配置之间进行开关来设置保持器（11）和加热单元（12），第一配置使得第一部分（111）在通道（110）的最下部分具有 当所述生物体（100）在所述保持器（11）中时，相对于重力方向，所述第二配置使得与所述第一部分（111）相对于所述第一部分（111）的移动方向的不同部分的第二部分 反应混合物相对于g在通道（110）的最低部分中 当所述生物体（100）在所述保持器（11）中时，所述湍流力方向。

公开(公告)号：US08679424B2

公开(公告)日：2014-03-25

申请号：US13324102

申请日：2011-12-13

Applicant: Hiroshi Koeda

Inventor： Hiroshi Koeda

IPC: F15D1/00

CPC classification number: B01L7/52 ,  B01L3/5021 ,  B01L3/50851 ,  B01L7/525 ,  B01L7/5255 ,  B01L2200/0673 ,  B01L2200/0689 ,  B01L2300/0803 ,  B01L2300/0832 ,  B01L2300/185 ,  B01L2400/0409 ,  B01L2400/0469 ,  Y10T137/71 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: A biotip according to an embodiment of the invention moves a reaction mixture along a longitudinal direction under the force of gravity. The biotip includes a chamber formed of a transparent material and filled with a liquid having a smaller specific gravity than the reaction mixture and immiscible with the reaction mixture, and a seal that seals the chamber. The liquid has a volume resistivity of greater than 0 Ω·cm and 5×1013 Ω·cm or less.

Abstract translation: 根据本发明的实施方式的生物体在重力的作用下沿着纵向方向移动反应混合物。 生物体包括由透明材料形成并充满比反应混合物更小的液体并且与反应混合物不混溶的液体的腔室，以及密封腔室的密封件。 液体的体积电阻率大于0，OHgr·cm和5×1013·OHgr··cm以下。

公开(公告)号：US07718006B2

公开(公告)日：2010-05-18

申请号：US11417319

申请日：2006-05-03

Applicant: Hiroshi Koeda ,  Shinichi Yotsuya

Inventor： Hiroshi Koeda ,  Shinichi Yotsuya

IPC: C23C16/00

CPC classification number: C23C14/042 ,  H01L51/0011 ,  H01L51/56

Abstract: A mask includes a base plate having aperture parts, and chips having aperture patterns and positioned in the aperture parts of the base plate. The mask is arranged on a bottom surface of a bed plate with a substrate on which a film is to be formed sandwiched therebetween. Magnets are arranged on the bed plate, and plugs which are attracted to the magnets are arranged in the base plate.

Abstract translation: 掩模包括具有开口部分的基板和具有孔图案并且位于基板的孔部中的芯片。 掩模布置在床板的底表面上，其上将要形成有薄膜的基板。 磁铁布置在床板上，并且被吸引到磁体的塞子被布置在基板中。