公开(公告)号：US07402595B2

公开(公告)日：2008-07-22

申请号：US10504132

申请日：2003-02-12

Applicant: Fumio Itoh ,  Hiroyuki Kimura ,  Hideki Igata ,  Tomohiro Kawamoto ,  Mitsuru Sasaki ,  Shuji Kitamura

Inventor： Fumio Itoh ,  Hiroyuki Kimura ,  Hideki Igata ,  Tomohiro Kawamoto ,  Mitsuru Sasaki ,  Shuji Kitamura

IPC: C07D217/02 ,  A61K31/47

CPC classification number: A61K31/4725 ,  A61K31/472 ,  A61K31/5377 ,  C07D217/24 ,  C07D217/26

Abstract: A JNK inhibitor containing a compound having an isoquinolinone skeleton or a salt thereof, such as a compound represented by the formula wherein ring A and ring B are each an optionally substituted benzene ring, X is —O—, —N═, —NR3— or —CHR3—, R2 is an acyl group, an optionally esterified or thioesterified carboxyl group, an optionally substituted carbamoyl group or an optionally substituted amino group and the like, a broken line shows a single bond or a double bond, and R1 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like, and the like.

Abstract translation: 含有异喹啉骨架或其盐的化合物的JNK抑制剂，例如下式表示的化合物，其中环A和环B各自为任选取代的苯环，X为-O-，-N-，-NR- SO 3 - 或-CHR 3 - ，R 2是酰基，任选酯化或硫酯化羧基，任选取代的氨基甲酰基或 任选取代的氨基等，虚线表示单键或双键，R 1是氢原子，任选取代的烃基，任选取代的杂环基等， 等等。

公开(公告)号：US07368578B2

公开(公告)日：2008-05-06

申请号：US10527426

申请日：2003-09-09

Applicant: Yu Momose ,  Nobuyuki Takakura ,  Tsuyoshi Maekawa ,  Hiroyuki Odaka ,  Hiroyuki Kimura

Inventor： Yu Momose ,  Nobuyuki Takakura ,  Tsuyoshi Maekawa ,  Hiroyuki Odaka ,  Hiroyuki Kimura

IPC: C07D263/02 ,  C07D263/00 ,  C07D263/30 ,  C07D261/00 ,  C07D261/04 ,  C07D261/06 ,  A01N43/76 ,  A01N43/80

CPC classification number: C07D263/32 ,  C07F9/6558 ,  C07F9/65583

Abstract: The present invention provides a compound represented by the formula: wherein R1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom, a sulfur atom and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH2)n-Z1- or -Z1-(CH2)n— (n is an integer of 0 to 8, Z1 is a bond, an oxygen atom, a sulfur atom and the like); ring B is a nitrogen-containing heterocycle optionally further having 1 to 3 substituents; W is a bond or a divalent hydrocarbon group having 1 to 20 carbon atoms; R2 is a hydrogen atom, a cyano group, —PO(OR9)(OR10) (R9 and R10 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, and R9 and R10 are optionally bonded to form an optionally substituted ring) and the like, or a salt thereof, which has a superior adipose tissue weight decreasing action, a hypoglycemic action and a hypolipidemic action, and which is useful as an agent for the prophylaxis or treatment of obesity, diabetes mellitus, hyperlipidemia, impaired glucose tolerance, hypertension and the like.

Abstract translation: 本发明提供由下式表示的化合物：其中R 1是任选取代的5元杂环基; X，Y和V相同或不同，各自为键，氧原子，硫原子等; Q为碳原子数为1〜20的二价烃基; 环A是任选进一步具有1至3个取代基的芳环; Z是 - （CH 2）n - - - - - - - - 1 - （CH 2） （n为0〜8的整数，Z 1为键，氧原子，硫原子等）; n为0〜8的整数。 环B是任选进一步具有1至3个取代基的含氮杂环; W是碳原子数为1〜20的键或二价烃基; R 2是氢原子，氰基，-PO（OR 9）（OR 10）（R 10） SUP＆gt;和R 10相同或不同，各自为氢原子或任选取代的烃基，R 9和R 10为 任选地键合以形成任选取代的环）等，或其盐，其具有优异的脂肪组织重量减少作用，降血糖作用和降血脂作用，并且其可用作预防或治疗 肥胖症，糖尿病，高脂血症，葡萄糖耐量降低，高血压等。

公开(公告)号：US20080007350A1

公开(公告)日：2008-01-10

申请号：US11775230

申请日：2007-07-10

Applicant: Hiroyuki Kimura

Inventor： Hiroyuki Kimura

IPC: H03L7/00

CPC classification number: H03K4/50

Abstract: An oscillator circuit having a relatively simple circuit structure while enabling full swing with low power consumption includes an oscillation core block, a voltage restriction block, and a differential output block. Drain terminals of first and second transistors are each connected to the voltage restriction block. The voltage restriction block restricts the amplitude of an oscillation signal to a reference voltage. Source terminals of third and fourth transistors are connected to drain terminals of fifth and sixth transistors, and source terminals of seventh and eighth transistors are connected to drain terminals of ninth and tenth transistors. This supplies the differential output block with current generated by the amplitude restriction. The differential output block converts the current into drive voltage to ground voltage to perform full swing.

Abstract translation: 具有相对简单的电路结构同时能够实现全功能低功耗的振荡器电路包括振荡磁芯块，电压限制块和差分输出块。 第一和第二晶体管的漏极端子都连接到电压限制块。 电压限制块将振荡信号的幅度限制为参考电压。 第三和第四晶体管的源极端子连接到第五和第六晶体管的漏极端子，第七和第八晶体管的源极端子连接到第九和第十晶体管的漏极端子。 由差分输出块提供由幅度限制产生的电流。 差分输出块将电流转换为驱动电压至地电压，以进行全速摆幅。

公开(公告)号：US20070176668A1

公开(公告)日：2007-08-02

申请号：US11670398

申请日：2007-02-01

Applicant: Hiroyuki Kimura

Inventor： Hiroyuki Kimura

IPC: H03L5/00

CPC classification number: H03K19/018521

Abstract: A level shifter circuit, which includes a Schmitt trigger function, shifts voltage of a high level signal into a low voltage and shifts a signal at an intermediate value of an input voltage. The level shifter circuit includes an input terminal connected to low and high voltage circuits. The low voltage circuit outputs a low drive voltage or ground voltage. The high voltage circuit outputs a high drive voltage or a high reference voltage, which is supplied to an RS latch circuit via a potential adjustment circuit at a level equal to an output potential at the low voltage circuit. The RS latch circuit uses the output of the potential adjustment circuit when the input voltage shifts to a high level and uses the output of the low voltage circuit when the input voltage shifts to a low level.

Abstract translation: 包括施密特触发功能的电平移位器电路将高电平信号的电压转换成低电压，并以输入电压的中间值移位信号。 电平移位器电路包括连接到低压和高压电路的输入端子。 低压电路输出低驱动电压或接地电压。 高电压电路输出高的驱动电压或高的参考电压，其通过电位调节电路以等于低电压电路的输出电位的电平提供给RS锁存电路。 当输入电压变为高电平时，RS锁存电路使用电位调整电路的输出，当输入电压变为低电平时，使用低电压电路的输出。

公开(公告)号：US20070121039A1

公开(公告)日：2007-05-31

申请号：US11555880

申请日：2006-11-02

Applicant: Keiji Tago ,  Hiroshi Tabatake ,  Hiroyuki Kimura ,  Tetsuya Iizuka

Inventor： Keiji Tago ,  Hiroshi Tabatake ,  Hiroyuki Kimura ,  Tetsuya Iizuka

IPC: G02F1/1335

CPC classification number: G02F1/133555 ,  G02F1/133371 ,  G02F1/133514 ,  G02F2001/133388 ,  G02F2201/52

Abstract: In order to make a boundary inconspicuous, which is located between an image area which displays an image by translucent pixels and a dummy area which always displays a white color by reflection pixels, a size ratio of transparent areas in color filters of the reflection pixels with respect to reflection areas therein is made larger than a size ratio of transparent areas in color filters of the translucent pixels with respect to reflection areas therein. In such a way, brightness of the display is balanced by adjusting quantities of transmission light through the transparent areas of the reflection pixels with respect to quantities of reflection light generated unexpectedly on transmission areas of the translucent pixels. Then, degrees of whiteness in the translucent pixels and the reflection pixels are approximated to each other.

Abstract translation: 为了使位于通过半透明像素显示图像的图像区域和总是通过反射像素显示白色的虚拟区域之间的边界不显眼，反射像素的滤色器中的透明区域的尺寸比例与 相对于其中的反射区域的尺寸比其中的反射区域大于半透明像素的滤色器中的透明区域的尺寸比。 以这种方式，通过相对于在半透明像素的透射区域上意外产生的反射光的量来调整穿过反射像素的透明区域的透射光的量来平衡显示器的亮度。 然后，半透明像素和反射像素的白度相互相近。

公开(公告)号：US20070091039A1

公开(公告)日：2007-04-26

申请号：US11544563

申请日：2006-10-10

Applicant: Masahiro Tada ,  Yoshiaki Nakazaki ,  Akihiko Saitoh ,  Hiroyuki Kimura ,  Shinichi Hirota

Inventor： Masahiro Tada ,  Yoshiaki Nakazaki ,  Akihiko Saitoh ,  Hiroyuki Kimura ,  Shinichi Hirota

IPC: G09G3/36

CPC classification number: G09G3/3696 ,  G09G2300/0809 ,  G09G2320/0223

Abstract: In order to prevent a gradation shift due to variations in the thickness of a film used to form an auxiliary capacitance, a detection capacitance having a layer structure similar to that of the auxiliary capacitance placed for each pixel is provided on an array substrate. Furthermore, the capacitance value of the detection capacitance as a representative of the plurality of auxiliary capacitances is detected, and the potential amplitude ΔVcs of a power supply line connected to the auxiliary capacitance is adjusted based on this detected value.

Abstract translation: 为了防止由于用于形成辅助电容的膜的厚度的变化引起的灰度偏移，在阵列基板上设置具有与为每个像素放置的辅助电容类似的层结构的检测电容。 此外，检测作为多个辅助电容的代表的检测电容的电容值，并且基于该检测值来调整连接到辅助电容的电源线的电位振幅ΔVcs。

公开(公告)号：US07199124B2

公开(公告)日：2007-04-03

申请号：US10470751

申请日：2002-02-01

Applicant: Shigenori Ohkawa ,  Kenichi Naruo ,  Seiji Miwatashi ,  Hiroyuki Kimura ,  Tomohiro Kawamoto

Inventor： Shigenori Ohkawa ,  Kenichi Naruo ,  Seiji Miwatashi ,  Hiroyuki Kimura ,  Tomohiro Kawamoto

IPC: C07D403/04 ,  A61K31/506 ,  C07D401/04 ,  C07D401/14 ,  A61K31/4439

CPC classification number: C07D417/04 ,  C07D403/14 ,  C07D417/14

Abstract: The present invention relates to a c-Jun N-terminal kinase inhibitor containing an azole compound (I) substituted by a nitrogen-containing aromatic group having substituent(s)(except a compound represented by the formula: ) or a salt thereof or a prodrug thereof.

Abstract translation: 本发明涉及含有被具有取代基的含氮芳香族基团取代的唑类化合物（I）的c-Jun N-末端激酶抑制剂（除了下式所示的化合物：

公开(公告)号：US07164610B2

公开(公告)日：2007-01-16

申请号：US10323771

申请日：2002-12-20

Applicant: Hiroyuki Kimura ,  Kunio Tani ,  Tetsu Tashiro ,  Makoto Yamamoto ,  Toshihiro Sezaki

Inventor： Hiroyuki Kimura ,  Kunio Tani ,  Tetsu Tashiro ,  Makoto Yamamoto ,  Toshihiro Sezaki

IPC: G06F9/312

CPC classification number: G11C16/16 ,  G11C16/08 ,  G11C16/10 ,  G11C16/26 ,  G11C16/344 ,  G11C2216/22

Abstract: A microcomputer with a built-in non-volatile semiconductor memory, which can automatically perform a work of temporarily interrupting automatic writing or automatic erase and accepting an interruption process when an interruption occurs during the automatic writing or automatic erase by using an interrupt request signal for a microcomputer as an external input for controlling automatic writing or automatic erase of a flash memory.

Abstract translation: 具有内置非易失性半导体存储器的微型计算机，其可以在自动写入或自动擦除期间通过使用中断请求信号自动执行临时中断自动写入或自动擦除和接受中断处理的工作 作为用于控制闪存的自动写入或自动擦除的外部输入的微计算机。

公开(公告)号：US20060079536A1

公开(公告)日：2006-04-13

申请号：US10525158

申请日：2003-08-21

Applicant: Tsuneo Yasuma ,  Akira Mori ,  Masahiro Kawase ,  Hiroyuki Kimura ,  Masato Yoshida ,  Albert Gyorkos ,  Scott Pratt ,  Christopher Corrette

Inventor： Tsuneo Yasuma ,  Akira Mori ,  Masahiro Kawase ,  Hiroyuki Kimura ,  Masato Yoshida ,  Albert Gyorkos ,  Scott Pratt ,  Christopher Corrette

IPC: A61K31/519 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7-membered ring; ring B is an optionally substituted 5- to 7-membered heterocyclic ring; X1 is CR1, CR1R2, N or NR13; X2 is N or NR3; Y is C, CR4 or N, Z is CR5, CR5R6, N or NR7; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and is a single bond or a double bond; R1, R2, R3, R4, R5, R6, R7 and R13 are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7-membered ring; Q is C, CR5 or N; R8, R9, R10, R11 and R12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided. Also specify X1, R3, R1, Y and X3 in formula (II) and (III) as before.

Abstract translation: 提供了包含式（I）化合物的钙受体调节剂：其中环A是任选取代的5-至7-元环; 环B是任选取代的5-至7-元杂环; X 1是CR 1，CR 1，R 2，N或NR 13， ; X 2是N或NR 3; Y是C，CR 4或N，Z是CR 5，CR 5，R 6，N或NR 7 ; Ar是任选取代的环状基团; R为H，任选取代的烃基等; “img id =”custom-character-00001“he =”1.78mm“wi =”2.12mm“file =”US20060079536A1-20060413-P00001.TIF“alt =”custom character“img-content =”character“img- format =“tif”/>是单键或双键; R 1，R 2，R 3，R 4，R 5， R 6，R 7和R 13独立地是H，任选取代的烃基; 或其盐或其前药。 式（II）和（III）的化合物：其中环A是任选取代的5-至7-元环; Q是C，CR 5或N; R 9，R 9，R 10，R 11和R 12都是 还可以提供H，任选取代的烃基等，或其盐。 还可以在式（II）中指定X 1，R 3，R 3，R 3，Y和X 3，和（ III）。

公开(公告)号：US20060029251A1

公开(公告)日：2006-02-09

申请号：US11198953

申请日：2005-08-08

Applicant: Etsuko Maeda ,  Yoichi Takaragi ,  Hiroyuki Kimura

Inventor： Etsuko Maeda ,  Yoichi Takaragi ,  Hiroyuki Kimura

IPC: G06K9/00

CPC classification number: G06T1/0028 ,  G06Q20/042

Abstract: The present invention provides an image processing system, which can reduce calculation time by alleviating a calculation load in assessing the occurrence of tampering of an image. For example, the image processing system of the present invention first identifies a type of a form of an image to be assessed in assessing the occurrence of tampering. Next, a characteristic amount of a certain region (flexible region) corresponding to the identified type of a form is extracted as a characteristic amount of the image to be assessed. Then, the extracted characteristic amount of image to be assessed and the characteristic amount extracted from a certain region in an original image are compared and the compared result is notified as the assessment result. A flexible region, to which a user writes, is preferably specified as said certain region.

Abstract translation: 本发明提供一种图像处理系统，其可以通过减轻计算负荷来评估图像的篡改的发生而减少计算时间。 例如，本发明的图像处理系统首先在评估篡改的发生时识别要评估的图像的形式的类型。 接下来，提取与所识别的形式的类型相对应的特定区域（柔性区域）的特征量作为要评估的图像的特征量。 然后，比较提取的要评估的特征量的图像和从原始图像中的特定区域提取的特征量，并将比较结果作为评估结果通知。 用户写入的柔性区域优选地被指定为所述特定区域。