公开(公告)号：US5820548A

公开(公告)日：1998-10-13

申请号：US784845

申请日：1997-01-15

申请人： Ulrich Sieben ,  Michael Kraus ,  Bernhard Wolf

发明人： Ulrich Sieben ,  Michael Kraus ,  Bernhard Wolf

IPC分类号： A61M31/00 ,  A61N1/30 ,  A61N1/40 ,  A61N2/00 ,  A61M5/00

CPC分类号： A61N1/30 ,  A61N1/40 ,  A61N2/002

摘要： An apparatus 1 serves for treating tumors in particular. This apparatus has, for example, a sensor-actuator head 3 with at least one sensor 10 for determining the acidification of the immediate surroundings of the tumor cells. An active ingredient dispensing device for exerting chemical influence and/or electrodes for exerting physical influence through electrical and/or electromagnetic fields on the tumorous tissue area to be treated are provided on the sensor-actuator head. The sensor(s) 10 as well as the active ingredient dispensing facility and/or the treatment electrodes are connected with a control facility for controlling chemical and/or physical treatment of the tumorous tissue area as a function of measured values.

摘要翻译： 装置1特别用于治疗肿瘤。 该装置具有例如具有至少一个传感器10的传感器 - 致动器头3，用于确定肿瘤细胞的周围环境的酸化。 用于施加化学影响的活性成分分配装置和/或用于通过电疗和/或电磁场对待治疗的肿瘤组织区域施加物理影响的活性成分分配装置设置在传感器致动头上。 传感器10以及活性成分分配设备和/或治疗电极与控制设备连接，用于根据测量值控制肿瘤组织区域的化学和/或物理治疗。

公开(公告)号：US5059979A

公开(公告)日：1991-10-22

申请号：US538954

申请日：1990-06-15

申请人： Ljubomir Micic ,  Daniel Mlynek ,  Ulrich Sieben ,  Klaus Heberle

发明人： Ljubomir Micic ,  Daniel Mlynek ,  Ulrich Sieben ,  Klaus Heberle

IPC分类号： H03J5/02 ,  H03L7/189

CPC分类号： H03L7/189

摘要： A digital control circuit with a device for generating a high-resolution tuning voltage is suitable for use in receivers for RF signals, particularly in consumer equipment. The tuning voltage can be electronically switched from one value to another at a high speed. The transient time required with conventional control loops is nearly eliminated since the low-pass filter or the digital integrator is preset to its steady-state integration value. To generate the tuning voltage, dynamic digital-to-analog convertors are provided which, despite their high resolution, require only a smoothing filter with a short response time and a short time constant.

摘要翻译： 具有用于产生高分辨率调谐电压的装置的数字控制电路适用于RF信号的接收机，特别是在消费设备中。 调谐电压可以从一个值以高速电子切换到另一个值。 传统控制回路所需的瞬态时间几乎消除，因为低通滤波器或数字积分器被预设为其稳态积分值。 为了产生调谐电压，提供了动态数模转换器，尽管它们的高分辨率，仅需要具有短的响应时间和短时间常数的平滑滤波器。

公开(公告)号：US4858008A

公开(公告)日：1989-08-15

申请号：US249141

申请日：1988-09-26

申请人： Ulrich Sieben ,  Heinrich Schemmann

发明人： Ulrich Sieben ,  Heinrich Schemmann

IPC分类号： H04N5/06 ,  H04N5/10

CPC分类号： H04N5/10 ,  H04N5/06

摘要： A circuit is arranged to derive the internal vertical synchronizing signals and field identification signals for a digital television signal. The circuit operates from the internal horizontal synchronizing signals and the separated external synchronizing signals and employs a sign inverter, an accumulator, an absolute value device, a comparator, a counter and AND gates, as well as an OR gate. These components, as coupled, produce the above-noted signals by digital generation and requires no subcircuits that are independent of the horizontal oscillator which horizontal oscillator is arranged in a phase lock loop.

摘要翻译： 电路被布置成导出用于数字电视信号的内部垂直同步信号和场识别信号。 该电路由内部水平同步信号和分离的外部同步信号进行工作，并使用符号反相器，累加器，绝对值器件，比较器，计数器和与门，以及OR门。 耦合的这些部件通过数字生成产生上述信号，并且不需要独立于水平振荡器的子电路，水平振荡器被布置在锁相环中。

公开(公告)号：US07501276B2

公开(公告)日：2009-03-10

申请号：US10202419

申请日：2002-07-23

申请人： Werner Baumann ,  Ralf Ehret ,  Mirko Lehmann ,  Günter Igel ,  Hans-Jürgen Gahle ,  Ulrich Sieben ,  Ingo Freund ,  Martin Brischwein

发明人： Werner Baumann ,  Ralf Ehret ,  Mirko Lehmann ,  Günter Igel ,  Hans-Jürgen Gahle ,  Ulrich Sieben ,  Ingo Freund ,  Martin Brischwein

IPC分类号： C12M1/42 ,  C12N15/87

CPC分类号： C12N15/89 ,  C12M35/02 ,  C12M35/04 ,  C12M35/08 ,  C12N13/00

摘要： A process is provided for the intracellular manipulation of a biological cell (3) which is positioned adhering to a support area (5) in a culture medium (2). Inside the support area (5) for the cell (3) an opening into the membrane of the cell (3) is created spaced from its support edge. The edge of the cell membrane surrounding the opening, adhering to the support area (5), thus seals off the cell fluid situated in the interior of the cell (3) from the culture medium (2) and insulates the cell fluid against the culture medium (2). The interior of the cell (3) is manipulated through the opening. An apparatus for implementing the process is also provided, including an object carrier (4) with a support area (5) for adhering the cell and a poration tool (6) for creating the opening in the cell membrane. The poration tool (6) may be any of various chemical, mechanical and/or electrical devices.

摘要翻译： 提供了一种用于细胞内操作生物细胞（3）的方法，所述生物细胞（3）定位为粘附在培养基（2）中的支持区域（5）。 在电池（3）的支撑区域（5）的内部，与电池（3）的隔膜形成的开口与其支撑边缘间隔开。 围绕开口的细胞膜的边缘附着在支撑区域（5）上，从而将位于细胞（3）内部的细胞液体与培养基（2）密封在一起，并使细胞液体抵抗培养物 中等（2）。 电池（3）的内部通过开口被操纵。 还提供了一种用于实现该方法的装置，包括具有用于粘附细胞的支撑区域（5）的物体载体（4）和用于在细胞膜中形成开口的引锭工具（6）。 引锭工具（6）可以是各种化学，机械和/或电气装置中的任何一种。

公开(公告)号：US20060233662A1

公开(公告)日：2006-10-19

申请号：US10569329

申请日：2004-08-19

申请人： Mirko Lehmann ,  Ulrich Sieben

发明人： Mirko Lehmann ,  Ulrich Sieben

IPC分类号： G01N31/22

CPC分类号： B01L3/502707 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00545 ,  B01J2219/00549 ,  B01J2219/00576 ,  B01J2219/00578 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L2300/0636 ,  B01L2300/0654 ,  C40B40/06 ,  C40B40/10 ,  G01N21/78 ,  G01N33/54366

摘要： In a carrier medium having at least two defined regions, biological and/or chemical substances are applied to the regions of the carrier medium for analyzing an analyte. The carrier medium is also provided with a stored code that indicates which biological and/or chemical substance is located in which defined region. The application of multiple biological and/or chemical substances to one carrier medium enables multiple analyses to be performed simultaneously on the analyte. This approach reduces the required quantities of the biological and/or chemical substances needed to perform the desired analyses of the analyte. The carrier medium itself does not reveal which biological and/or chemical substance is located in which region; this information may instead be provided by the code.

摘要翻译： 在具有至少两个限定区域的载体介质中，将生物和/或化学物质施加到载体介质的区域以分析分析物。 载体介质还具有指示哪个生物和/或化学物质位于哪个限定区域的存储代码。 将多种生物和/或化学物质应用于一种载体介质使得能够在分析物上同时进行多次分析。 该方法减少了对分析物进行所需分析所需的生物和/或化学物质所需的量。 载体介质本身不显露哪个生物和/或化学物质位于哪个区域; 该信息可以由代码提供。

公开(公告)号：US06916673B2

公开(公告)日：2005-07-12

申请号：US10169008

申请日：2000-12-19

申请人： Ulrich Sieben ,  Günter Igel

发明人： Ulrich Sieben ,  Günter Igel

IPC分类号： H01L31/12 ,  H01L31/173 ,  H01L21/00

CPC分类号： H01L31/173

摘要： The invention relates to a method for producing an optical transmitting and receiving device (1, 1a) comprising a light emitting transmission element (3, 3a) and a receiving element (4, 4a) which converts this light into an electrical magnitude. The transmission and receiving elements are inserted into a silicon substrate. The optical transmitting and receiving device (1) is preferably inserted in a monolithic manner into a common substrate, comprising a sequence of superimposed layers for the light emitting transmission element (3) and the light receiving element (4). An electrically insulating intermediate layer (9, 9a) is incorporated between the transmission and receiving element.

摘要翻译： 本发明涉及一种用于制造光发射和接收装置（1,1a）的方法，该光发射和接收装置（1,1a）包括发光透射元件（3,3a）和接收元件（4,4a），其将该光转换成电量 。 将传输和接收元件插入到硅衬底中。 光发送和接收装置（1）优选地以单片方式插入公共衬底中，包括用于发光透射元件（3）和光接收元件（4）的叠加层序列。 电绝缘中间层（9,9a）结合在传输和接收元件之间。

公开(公告)号：US20050135964A1

公开(公告)日：2005-06-23

申请号：US10743263

申请日：2003-12-22

申请人： Ulrich Sieben

发明人： Ulrich Sieben

IPC分类号： B01L3/00 ,  C40B70/00 ,  G01N31/22 ,  G01N33/50 ,  G01N33/543 ,  G06F19/20 ,  G06K7/10 ,  G06K19/06

CPC分类号： G01N33/543 ,  B01J2219/00542 ,  B01J2219/00547 ,  B01J2219/00554 ,  B01J2219/00659 ,  B01L3/545 ,  B01L2300/021 ,  B01L2300/0819 ,  C40B70/00 ,  G06K19/06037 ,  G16B25/00

摘要： The invention relates to a carrier medium (10, 20, 30, 30′) for analyzing an analyte, to which biological and/or chemical substances (A through I) are applied in at least two defined regions (11, 21, 31, 31′), with a code (12, 32, 3′) showing which biological and/or chemical substance (A through I) is located in which of the defined regions (11, 21, 31, 31′). The invention also relates to a method for manufacturing carrier media with the following steps: a. producing a set of identical carrier media (30) having a first arrangement of the defined regions (31) and/or a first arrangement of the biological and/or chemical substances (A through I) within the defined regions (31), b. assigning a different code (32) to each of these carrier media (30), c. storing the arrangement of the defined regions (31) and/or the arrangement of the biological and/or chemical substances (A through I) within the defined regions (31) of the carrier media (30) along with the associated code (32), d. selecting a second arrangement of the defined regions (31), and/or of the biological and/or chemical substances (A through I) in the defined regions (31), that is different from the first arrangement, e. implementing steps a through c for the second arrangement, f. implementing steps a through c for subsequent arrangements different from the arrangements already used.

摘要翻译： 本发明涉及一种用于分析分析物的载体介质（10,20,30,30'），其中生物和/或化学物质（A至I）被施加到至少两个限定的区域（11,21,31， 31'），其中代码（12,32,3'）表示哪个生物和/或化学物质（A至I）位于哪个限定区域（11,21,31,31'）中。 本发明还涉及以下步骤制造载体介质的方法：a。 b）制定一组相同的载体介质（30），其具有限定区域（31）的第一布置和/或生物和/或化学物质（A至I）的第​​一布置。 向每个这些载体介质（30）分配不同的代码（32），c。 在载体介质（30）的限定区域（31）内存储限定区域（31）的布置和/或生物和/或化学物质（A至I）的布置以及相关代码（32） ，d。 在限定区域（31）中选择与第一布置不同的限定区域（31）和/或生物和/或化学物质（A至I）的第​​二布置， 执行第二安排的步骤a至c，f。 执行步骤a至c以用于与已经使用的布置不同的后续布置。

公开(公告)号：US06765394B1

公开(公告)日：2004-07-20

申请号：US09868538

申请日：2001-11-26

申请人： Günter Igel ,  Ulrich Sieben ,  Jürgen Giehl

发明人： Günter Igel ,  Ulrich Sieben ,  Jürgen Giehl

IPC分类号： G01R2726

CPC分类号： G01R33/038

摘要： The invention relates to a capacitive magnetic field sensor. This sensor has a first electrode (2) and a second electrode (3), which are spaced apart from one another and which form a measurement capacitance. The first electrode (2) is situated on a first substrate body (4), and the second electrode (3) on a second substrate body (5). The second substrate body (5) is designed as a deformable membrane in the vicinity of the second electrode (3). A magnetic body (6) is situated in the vicinity of the second electrode (3) and the membrane, and is rigidly connected to the membrane and to the second electrode (3). As a result of this rigid connection, the influence of an external magnetic field on the magnetic body causes not only the magnetic body (6) to change its position but also causes the membrane and the second electrode (3) to change their position, since they are rigidly connected to said magnetic body. Because the second electrode (3) changes its position, its distance from the first electrode (2) changes, and thus the measurement capacitance, which acts as a measure of the externally applied magnetic field. This capacitive magnetic field sensor is distinguished by very small exterior dimensions, great mechanical stability, and low temperature dependence.

摘要翻译： 本发明涉及电容式磁场传感器。 该传感器具有彼此间隔开并形成测量电容的第一电极（2）和第二电极（3）。 第一电极（2）位于第一基板主体（4）上，第二电极（3）位于第二基板主体（5）上。 第二基板体（5）被设计为在第二电极（3）附近的可变形膜。 磁体（6）位于第二电极（3）和膜附近，并且刚性地连接到膜和第二电极（3）。 作为这种刚性连接的结果，外部磁场对磁体的影响不仅使磁体（6）改变其位置，而且还使膜和第二电极（3）改变其位置，因为 它们刚性地连接到所述磁体。 因为第二电极（3）改变其位置，所以其与第一电极（2）的距离改变，因此测量电容用作外部施加的磁场的量度。 该电容式磁场传感器的外形尺寸非常小，机械稳定性好，温度依赖性低。

公开(公告)号：US06638743B2

公开(公告)日：2003-10-28

申请号：US10119354

申请日：2002-04-09

申请人： Werner Baumann ,  Ralf Ehret ,  Mirko Lehmann ,  Günter Igel ,  Hans-Jörg Gahle ,  Bernhard Wolf ,  Ulrich Sieben ,  Ingo Freund ,  Martin Brischwein

发明人： Werner Baumann ,  Ralf Ehret ,  Mirko Lehmann ,  Günter Igel ,  Hans-Jörg Gahle ,  Bernhard Wolf ,  Ulrich Sieben ,  Ingo Freund ,  Martin Brischwein

IPC分类号： C12N1300

CPC分类号： C12N15/89 ,  C12M35/02 ,  C12M35/04 ,  C12M35/08 ,  C12N13/00

摘要： A method is provided for measuring a state variable of a biological cell (3) located in a nutrient medium (2) and supported on and adhering to a support area (5). Within the support area (5) for the cell (3) and at a distance from the support area edge, an opening is made in the membrane of the cell (3). The edge of the cell membrane that surrounds the opening and adheres to the support area (5) seals off the liquid found inside the cell (3) from the nutrient medium (2). Through the opening the state variable (2) is measured. An apparatus for performing the method is also provided.

公开(公告)号：US06475760B1

公开(公告)日：2002-11-05

申请号：US09321051

申请日：1999-05-27

申请人： Werner Baumann ,  Ralf Ehret ,  Mirko Lehmann ,  Günter Igel ,  Hans-Jürgen Gahle ,  Bernhard Wolf ,  Ulrich Sieben ,  Ingo Freund ,  Martin Brischwein

发明人： Werner Baumann ,  Ralf Ehret ,  Mirko Lehmann ,  Günter Igel ,  Hans-Jürgen Gahle ,  Bernhard Wolf ,  Ulrich Sieben ,  Ingo Freund ,  Martin Brischwein

IPC分类号： C12N1300

CPC分类号： C12N15/89 ,  C12M35/02 ,  C12M35/04 ,  C12M35/08 ,  C12N13/00

摘要： A process is provided for the intracellular manipulation of a biological cell (3) which is positioned adhering to a support area (5) in a culture medium (2). Inside the support area (5) for the cell (3) an opening into the membrane of the cell (3) is created spaced from its support edge. The edge of the cell membrane surrounding the opening, adhering to the support area (5), thus seals off the cell fluid situated in the interior of the cell (3) from the culture medium (2) and insulates the cell fluid against the culture medium (2). The interior of the cell (3) is manipulated through the opening. An apparatus for implementing the process is also provided, including an object carrier (4) with a support area (5) for adhering the cell and a poration tool (6) for creating the opening in the cell membrane. The poration tool (6) may be any of various chemical, mechanical and/or electrical devices.

摘要翻译： 提供了一种用于细胞内操作生物细胞（3）的方法，所述生物细胞（3）定位为粘附在培养基（2）中的支持区域（5）。 在电池（3）的支撑区域（5）的内部，与电池（3）的隔膜形成的开口与其支撑边缘间隔开。 围绕开口的细胞膜的边缘附着在支撑区域（5）上，从而将位于细胞（3）内部的细胞液体与培养基（2）密封并使细胞液体抵抗培养物 中等（2）。 电池（3）的内部通过开口被操纵。 还提供了一种用于实现该方法的装置，包括具有用于粘附细胞的支撑区域（5）的物体载体（4）和用于在细胞膜中形成开口的引锭工具（6）。 引锭工具（6）可以是各种化学，机械和/或电气装置中的任何一种。