公开(公告)号：US08354114B2

公开(公告)日：2013-01-15

申请号：US12090435

申请日：2006-10-17

Applicant: Bin Lu ,  Hong Jin

Inventor： Bin Lu ,  Hong Jin

IPC: A61K39/145 ,  A61K39/285

CPC classification number: C12N7/00 ,  A61K35/76 ,  A61K38/00 ,  A61K39/12 ,  A61K39/145 ,  A61K39/295 ,  A61K2039/5254 ,  C07K14/005 ,  C12N15/86 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16151 ,  C12N2760/16222 ,  C12N2760/16234 ,  C12N2760/16243 ,  C12N2760/16251

Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics.

Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。

公开(公告)号：US20120263744A1

公开(公告)日：2012-10-18

申请号：US13449087

申请日：2012-04-17

Applicant: Xing Cheng ,  Hyun Jung Park ,  Hong Jin

Inventor： Xing Cheng ,  Hyun Jung Park ,  Hong Jin

IPC: A61K39/155 ,  A61P31/14

CPC classification number: C07K14/005 ,  A61K2039/525 ,  A61K2039/5254 ,  C07K16/1027 ,  C12N2760/18522

Abstract: The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e.g., attenuated recombinant RSV), nucleic acids, and polypeptides, e.g., comprising mutations in the attachment protein G, are also provided, as are immunogenic compositions comprising such isolated or recombinant RSV, nucleic acids, and polypeptides. Related methods are also described.

Abstract translation: 提供了人呼吸道合胞病毒亚组B株9320基因组的完整多核苷酸序列。 还提供了由该多核苷酸序列编码的蛋白质。 还提供了分离或重组的RSV（例如减毒的重组RSV），核酸和多肽，例如包含附着蛋白G中的突变，包含这种分离的或重组的RSV，核酸和多肽的免疫原性组合物也是如此。 还描述了相关方法。

公开(公告)号：US08114415B2

公开(公告)日：2012-02-14

申请号：US12254131

申请日：2008-10-20

Applicant: Erich Hoffmann ,  Hong Jin ,  Bin Lu ,  Gregory Duke ,  George Kemble ,  Zhongying Chen

Inventor： Erich Hoffmann ,  Hong Jin ,  Bin Lu ,  Gregory Duke ,  George Kemble ,  Zhongying Chen

IPC: A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  C12P21/04

CPC classification number: C12N15/86 ,  A61K2039/5254 ,  C07K14/005 ,  C12N7/00 ,  C12N15/85 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16162 ,  C12N2760/16222 ,  C12N2760/16234 ,  C12N2760/16243 ,  C12N2760/16262 ,  C12N2840/20

Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.

Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。

公开(公告)号：US08088393B2

公开(公告)日：2012-01-03

申请号：US12822781

申请日：2010-06-24

Applicant: Hong Jin

Inventor： Hong Jin

IPC: A61K39/145 ,  A61P31/16 ,  C12N7/01 ,  C12N7/02

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/542 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16171

Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.

Abstract translation: 提供了包含流感血凝素和神经氨酸酶变体的多肽，多核苷酸，方法，组合物和疫苗。

公开(公告)号：US08012736B2

公开(公告)日：2011-09-06

申请号：US10423828

申请日：2003-04-25

Applicant: Erich Hoffman ,  Hong Jin ,  Bin Lu ,  Greg Duke ,  George Kemble

Inventor： Erich Hoffman ,  Hong Jin ,  Bin Lu ,  Greg Duke ,  George Kemble

IPC: C12N7/02

CPC classification number: A61K39/145 ,  A61K2039/5254 ,  C07K14/005 ,  C12N7/00 ,  C12N15/85 ,  C12N15/86 ,  C12N15/87 ,  C12N2760/16122 ,  C12N2760/16143 ,  C12N2760/16162 ,  C12N2760/16222 ,  C12N2760/16243 ,  C12N2760/16262

Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.

Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。

公开(公告)号：US20100190232A1

公开(公告)日：2010-07-29

申请号：US12537288

申请日：2009-08-07

Applicant: Hong Jin ,  Robert Brazas ,  Bin Lu

Inventor： Hong Jin ,  Robert Brazas ,  Bin Lu

IPC: C12N7/01

CPC classification number: C12N7/045 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/543 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18543 ,  C12N2760/18561 ,  C12N2800/40 ,  G01N33/56983 ,  G01N2469/20 ,  G01N2500/00

Abstract: The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.

Abstract translation: 本发明提供具有减毒表型并且包含病毒P，M2-1和/或M2-2蛋白中的一个或多个突变的重组呼吸道合胞病毒，以及包含这样的病毒的活减毒疫苗和编码这种病毒的核酸 病毒 描述了重组RSV P，M2-1和M2-2蛋白。 还提供了产生减毒重组RSV的方法，以及定量利用副粘病毒科重组病毒的中和抗体的方法。

公开(公告)号：US07572904B2

公开(公告)日：2009-08-11

申请号：US10811508

申请日：2004-03-26

Applicant: Xing Cheng ,  Hyun Jung Park ,  Hong Jin

Inventor： Xing Cheng ,  Hyun Jung Park ,  Hong Jin

IPC: C07H21/00 ,  A61K39/155

CPC classification number: C07K14/005 ,  A61K2039/525 ,  A61K2039/5254 ,  C07K16/1027 ,  C12N2760/18522

Abstract: The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e.g., attenuated recombinant RSV), nucleic acids, and polypeptides, e.g., comprising mutations in the attachment protein G, are also provided, as are immunogenic compositions comprising such isolated or recombinant RSV, nucleic acids, and polypeptides. Related methods are also described.

Abstract translation: 提供了人呼吸道合胞病毒亚组B株9320基因组的完整多核苷酸序列。 还提供了由该多核苷酸序列编码的蛋白质。 还提供了分离的或重组的RSV（例如，减毒的重组RSV），核酸和多肽，例如包含附着蛋白G中的突变，以及包含这种分离或重组的RSV，核酸和多肽的免疫原性组合物。 还描述了相关方法。

公开(公告)号：US20050084947A1

公开(公告)日：2005-04-21

申请号：US10975060

申请日：2004-10-25

Applicant: Hong Jin ,  Roderick Tang ,  Shengqiang Li ,  Martin Bryant

Inventor： Hong Jin ,  Roderick Tang ,  Shengqiang Li ,  Martin Bryant

IPC: A61K39/00 ,  A61K39/155 ,  A61P31/14 ,  C07K14/11 ,  C07K14/135 ,  C12N7/01 ,  C12N7/04 ,  C12N15/86

CPC classification number: C12N7/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/51 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/543 ,  C07K14/005 ,  C12N15/86 ,  C12N2760/16022 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18543 ,  C12N2760/18561 ,  C12N2840/20

Abstract: The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.

Abstract translation: 本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。 根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。 此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。

公开(公告)号：US20150221998A1

公开(公告)日：2015-08-06

申请号：US14395380

申请日：2012-04-20

Applicant: Hong Jin ,  George H. Brilmyer ,  Michael T. Nispel ,  Dongxue Ren ,  Dajun BAI

Inventor： Hong Jin ,  George H. Brilmyer ,  Michael T. Nispel ,  Dongxue Ren ,  Dajun BAI

IPC: H01M10/6551 ,  H01M2/10

CPC classification number: H01M10/6551 ,  H01M2/0292 ,  H01M2/1022 ,  H01M2/1077 ,  H01M2/206 ,  H01M10/613 ,  H01M10/6553 ,  Y10T29/49108

Abstract: The present invention provides an energy storage system, particularly a battery system, that is capable of preventing self from overheating, comprising at least one energy storage unit each having two terminal posts extending outwards from the interior thereof; when there are at least two energy storage units, electrical connection therebetween is achieved by electrical connection elements that bridge the terminal posts of different energy storage units; at least one of the terminal posts and/or the electrical connection elements is in thermal connection with a heat transfer surface enlarging structure made of solid heat conductive materials. The present invention further relates to a method for preventing overheat of an energy storage system.

Abstract translation: 本发明提供一种能够防止自身过热的能量存储系统，特别是电池系统，包括至少一个能量存储单元，每个能量存储单元具有从其内部向外延伸的两个端子柱; 当存在至少两个能量存储单元时，它们之间的电连接通过桥接不同能量存储单元的端子柱的电连接元件实现; 端子柱和/或电连接元件中的至少一个与由固体导热材料制成的传热表面扩大结构热连接。 本发明还涉及一种用于防止储能系统过热的方法。

公开(公告)号：US20150194713A1

公开(公告)日：2015-07-09

申请号：US14395378

申请日：2012-04-20

Applicant: Hong Jin ,  George H. Brilmyer ,  Michael T. Nispel ,  Dongxue Ren

Inventor： Hong Jin ,  George H. Brilmyer ,  Michael T. Nispel ,  Dongxue Ren

IPC: H01M10/6551 ,  H01M10/06

CPC classification number: H01M10/6551 ,  H01M2/0292 ,  H01M2/1022 ,  H01M2/1077 ,  H01M2/206 ,  H01M10/06 ,  H01M10/613 ,  H01M10/6553

Abstract: The present invention discloses an overheat prevention energy storage system preventing self from overheating, comprising a heat dissipating external surface, wherein at least a portion of the external surface is coated with at least one layer of heat dissipation coating of high emissivity. The present invention further discloses a method for preventing overheat of the energy storage system and a method for forming at least one layer of heat dissipation coating of high emissivity onto at least part of an external surface of the energy storage system or assemblies thereof.

Abstract translation: 本发明公开了一种防止自身过热的过热预防能量储存系统，其包括散热外表面，其中外表面的至少一部分涂覆有至少一层高发射率的散热涂层。 本发明进一步公开了一种用于防止能量储存系统过热的方法以及用于在能量存储系统或其组件的至少部分外表面上形成至少一层高发射率的散热涂层的方法。