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公开(公告)号：US20150168392A1
公开(公告)日：2015-06-18
申请号：US14570675
申请日：2014-12-15
Applicant: IMEC VZW , Katholieke Universiteit Leuven, KU LEUVEN R&D
Inventor： Pol Van Dorpe , Sarp Kerman , Peter Peumans , Willem Van Roy
IPC: G01N33/543 , G01N21/64
CPC classification number: G01N33/54373 , G01N15/1436 , G01N15/1456 , G01N21/6428 , G01N21/6454 , G01N21/648 , G01N21/7743 , G01N2015/1006 , G01N2021/6482 , G01N2021/7786
Abstract: An integrated fluorescence detector for detecting fluorescent particles is described. An example integrated fluorescence detector comprises a substrate, the substrate comprising an integrated detection element for detecting fluorescence radiation from fluorescent particles upon excitation of the particles with incident excitation radiation. The integrated fluorescence detector also comprises a sensing layer adapted for accommodating fluorescent particles to be sensed. The integrated fluorescence detector further comprises a photonics crystal layer arranged in between the sensing layer and the substrate, the photonics crystal layer comprising an absorption material designed such that the photonics crystal layer is configured for diffracting incident excitation radiation into a lateral direction in which the photonics crystal layer extends for incident excitation radiation having a wavelength within at least 10 nm of the predetermined excitation wavelength.
Abstract translation: 描述了用于检测荧光颗粒的集成荧光检测器。 示例性的集成荧光检测器包括衬底，该衬底包括用于在用入射激发辐射激发颗粒时检测来自荧光颗粒的荧光辐射的集成检测元件。 集成荧光检测器还包括适于容纳要感测的荧光颗粒的感测层。 集成荧光检测器还包括布置在感测层和衬底之间的光子晶体层，光子晶体层包括设计成使得光子晶体层被配置为将入射激发辐射衍射到横向方向的吸收材料，其中光子 晶体层对于具有在预定激发波长的至少10nm内的波长的入射激发辐射延伸。
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22.发明申请公开(公告)号：US20250114793A1
公开(公告)日：2025-04-10
申请号：US18909640
申请日：2024-10-08
Applicant: IMEC VZW
Inventor： Christopher Adams , Peter Peumans , Andy Lambrechts , Murali Jayapala , Tim Stakenborg
IPC: B01L3/00 , G01N15/1429
Abstract: A system for label-free identification and/or classification and/or selection of at least one cell is provided. The system comprises a microfluidic environment configured to be traversable by the at least one cell, an imaging sensor configured to gather imaging information with respect to at least a part of the microfluidic environment, and a processing unit connected to the imaging sensor. In this context, the microfluidic environment comprises at least one sub-environment configured to interact with the at least one cell. Furthermore, the processing unit is configured to detect at least one sub-environment interaction event based on persistence of the at least one cell imaged by the imaging sensor in the temporal domain. In addition to this, the processing unit is configured to identify and/or classify and/or select the at least one cell based on the at least one sub-environment interaction event.
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公开(公告)号：US12145123B2
公开(公告)日：2024-11-19
申请号：US17416465
申请日：2019-12-16
Applicant: IMEC VZW , Katholieke Universiteit Leuven
Inventor： Peter Peumans , Ahmed Taher , Nicolas Vergauwe , Benjamin Jones
Abstract: The present invention provides a micro-reactor (1) adapted to host chemical reactions having at least one microfluidic layer, said micro-reactor (1) comprising a fluid inlet (2) and a fluid outlet (3); a plurality of micro-reaction chambers (10) arranged in rows (7) and columns (6), each micro-reaction chamber comprising a chamber inlet (10a) and a chamber outlet (10b); a plurality of supply channels (4) for supplying fluid to from said fluid inlet (2) to said micro-reaction chambers (10) and further arranged for draining said micro-reaction chambers (10) to said fluid outlet (3), said supply channels (10) extending in a first direction (D1) along the columns (6) of micro-reaction chambers (10) and arranged such that there is one supply channel (4) between adjacent columns (6). The micro-reaction chambers (10) in the columns (6) are arranged such that the chamber inlets (10a) of a column are in fluid contact with the same supply channel (4) and the chamber outlets (10b) are in fluid contact with the supply channel (4) adjacent to the supply channel (4) arranged in fluidic contact with the chamber inlets (10a). Further, the plurality of supply channels (4) comprises a first end supply channel (4a) arranged for supplying fluid to a first end column (6a) of the micro-reaction chambers (10) and a second end supply channel (4b) arranged for draining fluid from the second, opposite, end column (6b) of said micro-reaction chambers (10); and wherein the micro-reactor (1) further comprises at least one reagent inlet (8) in fluid contact with the first end supply channel 4a and a reagent outlet (9) in fluid contact with the second end supply channel such that reagents introduced to the at least one reagent inlet (8) fill the plurality of micro-reaction chambers (10) in a second direction (D2) along the rows (7) of micro-reaction chambers (10) to the reagent outlet (9).
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公开(公告)号：US11471887B2
公开(公告)日：2022-10-18
申请号：US16693750
申请日：2019-11-25
Applicant: IMEC VZW
Inventor： Peter Peumans , Benjamin Jones , Nicolas Vergauwe
IPC: B01L3/00
Abstract: A microfluidic device comprising a plurality of microreactors is provided. Each microreactor includes at least a first inlet and a second inlet for supplying a first fluid and a second fluid, respectively, to said microreactor and at least one waste channel for draining fluid from said microreactor. The device further comprises a shared first microfluidic supply system for supplying a first fluid to the first inlets of the plurality of microreactors, a shared second microfluidic supply system for supplying a second fluid to the second inlets of the plurality of microreactors. At least one of said inlets to each microreactor comprises at least one valve-less fluidic resistance element having a fluidic resistance that is substantially larger than the fluidic resistance of the corresponding shared microfluidic supply system. A chemical reaction sequencer apparatus including the microfluidic device and a method for supplying reagents to a plurality of microreactors are also provided.
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公开(公告)号：US11241687B2
公开(公告)日：2022-02-08
申请号：US15529396
申请日：2015-11-26
Applicant: IMEC VZW
Inventor： Peter Peumans , Liesbet Lagae , Paolo Fiorini
Abstract: The present disclosure relates to devices and methods for analyzing a fluid sample. An example device comprises a fluidic substrate comprising a micro-fluidic component embedded therein, for propagating a fluid sample; a needle or inlet for providing the fluid sample which is fluidically connected to the micro-fluidic component; a lid attached to the fluidic substrate thereby at least partly covering the fluidic substrate and at least partly closing the micro-fluidic component; wherein the fluidic substrate is a glass fluidic substrate and wherein the lid is a microchip. The present disclosure also relates to a method for fabricating a fluid analysis device. The method comprises providing a fluidic substrate; providing a lid; attaching the lid to the fluidic substrate to close the fluidic substrate at least partly.
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Patent Agency Ranking
公开(公告)号：US11096608B2
公开(公告)日：2021-08-24
申请号：US15100067
申请日：2014-12-03
Applicant: IMEC VZW
Inventor： Pol Van Dorpe , Peter Peumans
Abstract: The present disclosure relates to devices and methods for non-invasive measuring of analytes. At least one embodiment relates to a wearable system for non-invasive measuring of a concentration of an analyte in skin tissue. The wearable system includes an integrated circuit that includes a first optical unit. The first optical unit includes a Raman spectrometer. The first optical unit also includes an OCT spectrometer and an interferometer optically coupled to the OCT spectrometer or an infrared (IR) spectrometer. The first optical unit additionally includes a light coupler. The wearable system further includes a first light source for performing Raman spectroscopy. The wearable system additionally includes a second light source for performing OCT spectroscopy or IR spectroscopy. Still further, the wearable system includes read-out electronics to determine an optical model of the skin tissue based on the spectroscopic data and to determine the concentration of the analyte.
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公开(公告)号：US10928305B2
公开(公告)日：2021-02-23
申请号：US15736399
申请日：2016-06-30
Applicant: IMEC VZW
Inventor： Peter Peumans , Liesbet Lagae , Willem Van Roy , Tim Stakenborg , Pol Van Dorpe
Abstract: A sensor device for quantifying luminescent targets comprises a light source, a detector, a modulator, and a processor. The light source is adapted for exciting the luminescent target. The detector is adapted for detecting the luminescence of the luminescent target resulting in a measured signal which comprises a desired signal originating from the luminescent target and a background signal. The modulator is adapted for modulating a physical parameter resulting in a modulation of the desired signal which is different from the modulation of the background signal. The processor is configured to correlate the modulation of the physical parameter with the modulation of the desired signal and/or the modulation of the background signal.
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公开(公告)号：US20180188156A1
公开(公告)日：2018-07-05
申请号：US15736399
申请日：2016-06-30
Applicant: IMEC VZW
Inventor： Peter Peumans , Liesbet Lagae , Willem Van Roy , Tim Stakenborg , Pol Van Dorpe
CPC classification number: G01N21/1717 , G01N21/645 , G01N21/648 , G01N2021/1731
Abstract: A sensor device for quantifying luminescent targets comprises a light source, a detector, a modulator, and a processor. The light source is adapted for exciting the luminescent target. The detector is adapted for detecting the luminescence of the luminescent target resulting in a measured signal which comprises a desired signal originating from the luminescent target and a background signal. The modulator is adapted for modulating a physical parameter resulting in a modulation of the desired signal which is different from the modulation of the background signal. The processor is configured to correlate the modulation of the physical parameter with the modulation of the desired signal and/or the modulation of the background signal.
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公开(公告)号：US20170326546A1
公开(公告)日：2017-11-16
申请号：US15529396
申请日：2015-11-26
Applicant: IMEC VZW
Inventor： Peter Peumans , Liesbet Lagae , Paolo Fiorini
CPC classification number: B01L3/502707 , A61K9/0014 , B01L3/5027 , B01L3/50273 , B01L3/50857 , B01L3/565 , B01L9/527 , B01L2200/10 , B01L2300/0645
Abstract: The present disclosure relates to devices and methods for analyzing a fluid sample. An example device comprises a fluidic substrate comprising a micro-fluidic component embedded therein, for propagating a fluid sample; a needle or inlet for providing the fluid sample which is fluidically connected to the micro-fluidic component; a lid attached to the fluidic substrate thereby at least partly covering the fluidic substrate and at least partly closing the micro-fluidic component; wherein the fluidic substrate is a glass fluidic substrate and wherein the lid is a microchip. The present disclosure also relates to a method for fabricating a fluid analysis device. The method comprises providing a fluidic substrate; providing a lid; attaching the lid to the fluidic substrate to close the fluidic substrate at least partly.
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公开(公告)号：US09709442B2
公开(公告)日：2017-07-18
申请号：US15297720
申请日：2016-10-19
Applicant: SAMSUNG ELECTRONICS CO., LTD. , IMEC VZW
Inventor： Woochang Lee , Peter Peumans
IPC: G01N21/25 , G01J3/28 , G01J3/42 , G01J3/02 , A61B5/1455
CPC classification number: G01J3/2823 , A61B5/1455 , G01J3/0205 , G01J3/021 , G01J3/0218 , G01J3/18 , G01J3/2803 , G01J3/36 , G01J3/42 , G02B6/12007
Abstract: A spectral detector includes a plurality of spectral detection units, each of the spectral detection units including an optical signal processor configured to deliver an optical signal incident to the spectral detection unit to an outside of the spectral detection unit, and a resonator configured to modulate a spectrum of an optical signal incident to the optical signal processor by interacting with the optical signal processor, at least some of the resonators of the plurality of spectral detection units having different lengths from each other, and a number of optical signal processors included in each respective spectral detection unit varying according to a length of the resonator included in the respective spectral detection unit.
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