公开(公告)号：US20230020787A1

公开(公告)日：2023-01-19

申请号：US17363084

申请日：2021-06-30

Applicant: International Business Machines Corporation

Inventor： Binquan Luan ,  Rodrigo Neumann Barros Ferreira ,  BREANNDAN O'CONCHUIR ,  Anshul Gupta ,  Fausto Martelli ,  Mathias B Steiner ,  Tonia Elengikal

IPC: C01B32/50 ,  B01D57/02

Abstract: A system may include a chamber with a main sub-chamber and a first porous membrane separating a first sub-chamber from the main sub-chamber. The system may include a fluid in the chamber and an input directing inflow into main sub-chamber proximate an entry end of the chamber. The system may include a first output permitting outflow from the first sub-chamber proximate an exit end of the chamber wherein a molecule entering at the entry end must traverse a length of the chamber to exit at the exit end.

公开(公告)号：US20170234833A1

公开(公告)日：2017-08-17

申请号：US15583501

申请日：2017-05-01

Applicant: International Business Machines Corporation

Inventor： Binquan Luan ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

IPC: G01N27/447 ,  C12Q1/68 ,  G01N33/487

CPC classification number: G01N27/44791 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N27/403 ,  G01N33/48721

Abstract: Techniques for increasing the capture zone in nano and microchannel-based polymer testing structures using concentric arrangements of nanostructures, such as nanopillars are provided. In one aspect, a testing structure for testing polymers is provided that includes a first fluid reservoir and a second fluid reservoir formed in an electrically insulating substrate; at least one channel formed in the insulating substrate that interconnects the first fluid reservoir and the second fluid reservoir; and an arrangement of nanostructures within either the first fluid reservoir or the second fluid reservoir wherein the nanostructures are arranged so as to form multiple concentric circles inside either the first fluid reservoir or the second fluid reservoir with each of the concentric circles being centered at an entry point of the channel. A method of analyzing a polymer using the testing structure is also provided.

公开(公告)号：US09518294B2

公开(公告)日：2016-12-13

申请号：US14615924

申请日：2015-02-06

Applicant: International Business Machines Corporation

Inventor： Binquan Luan ,  Ruhong Zhou

IPC: C12Q1/68 ,  G01N27/447 ,  G01N27/453 ,  B82Y30/00 ,  B82Y5/00

CPC classification number: C12Q1/6869 ,  B82Y5/00 ,  B82Y30/00 ,  G01N27/447 ,  G01N27/44791 ,  G01N27/453 ,  Y10S977/742 ,  Y10S977/781 ,  Y10S977/924

Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.

公开(公告)号：US20150276664A1

公开(公告)日：2015-10-01

申请号：US14225694

申请日：2014-03-26

Applicant: International Business Machines Corporation

Inventor： Binquan Luan ,  Sung-wook Nam

IPC: G01N27/414 ,  C12Q1/68 ,  G01N27/447

CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  G01N27/44791

Abstract: A technique includes providing a nanodevice. A gate electrode structure has nanochannels with a first end connected to a first common trench and a second end connected to a second common trench. A gate electrode extends laterally as a continuous line on the gate electrode structure and is formed in each of the nanochannels. The gate electrode forms a separate nano-ring electrode around a partial circumference inside each of the nanochannels. The gate electrode is parallel to the first and second common trenches and is perpendicular to the nanochannels.

公开(公告)号：US09146211B1

公开(公告)日：2015-09-29

申请号：US14225694

申请日：2014-03-26

Applicant: International Business Machines Corporation

Inventor： Binquan Luan ,  Sung-wook Nam

IPC: C12Q1/68 ,  G01N27/414 ,  G01N27/447

CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  G01N27/44791

Abstract: A technique includes providing a nanodevice. A gate electrode structure has nanochannels with a first end connected to a first common trench and a second end connected to a second common trench. A gate electrode extends laterally as a continuous line on the gate electrode structure and is formed in each of the nanochannels. The gate electrode forms a separate nano-ring electrode around a partial circumference inside each of the nanochannels. The gate electrode is parallel to the first and second common trenches and is perpendicular to the nanochannels.

Abstract translation: 一种技术包括提供一种纳米设备。 栅极电极结构具有纳米通道，其第一端连接到第一公共沟槽，第二端连接到第二公共沟槽。 栅极电极在栅电极结构上作为连续线横向延伸并形成在每个纳米通道中。 栅电极在每个纳米通道内围绕部分圆周形成单独的纳米环电极。 栅电极平行于第一和第二公共沟槽并且垂直于纳米通道。

公开(公告)号：US20150160159A1

公开(公告)日：2015-06-11

申请号：US14624868

申请日：2015-02-18

Applicant: International Business Machines Corporation

Inventor： Ali Afzali-Ardakani ,  Stefan Harrer ,  Binquan Luan ,  Hongbo Peng ,  Stephen M. Rossnagel ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  Philip S. Waggoner

IPC: G01N27/447

CPC classification number: G01N33/48721 ,  B82Y15/00 ,  C12Q1/6869 ,  G01N27/44743 ,  G01N27/44791 ,  Y10S977/924 ,  C12Q2563/157

Abstract: A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.

Abstract translation: 纳米器件包括填充有导电流体的储存器和分离储存器的膜。 通过具有由绝缘层分隔的电极层的膜形成纳米孔。 某一电极层具有第一类型的有机涂层，并且一对电极层具有第二类型。 第一类型的有机涂层形成运动控制瞬态键合到用于运动控制的纳米孔中的一个分子，而第二种类型形成与分子的基底的不同键合位点的第一和第二瞬态键。 当对一对电极层施加电压时，由纳米孔中的基底产生隧穿电流，并且隧穿电流通过形成为待测量的第一和第二瞬态键作为用于区分基极的电流签名行进。 运动控制瞬态键比第一和第二瞬态键强。

公开(公告)号：US20150153305A1

公开(公告)日：2015-06-04

申请号：US14615910

申请日：2015-02-06

Applicant: International Business Machines Corporation

Inventor： Binquan Luan ,  Ruhong Zhou

IPC: G01N27/447 ,  C12Q1/68

CPC classification number: C12Q1/6869 ,  B82Y5/00 ,  B82Y30/00 ,  G01N27/447 ,  G01N27/44791 ,  G01N27/453 ,  Y10S977/742 ,  Y10S977/781 ,  Y10S977/924

Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.

Abstract translation: 提供用于棘轮双链分子的机制。 双链分子通过第一电压脉冲被驱动到膜的Y通道中。 Y型通道包括杆和支杆，并且分支在连接处连接到杆。 基于第一电压脉冲的Y通道的连接处的双链分子比破坏双链分子的碱基对所需的力弱。 通过在第二电压脉冲下将双链分子驱动到Y通道的结中，将双链分子分成第一单链和第二单链。

公开(公告)号：US20140318968A1

公开(公告)日：2014-10-30

申请号：US13873815

申请日：2013-04-30

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Binquan Luan ,  Ruhong Zhou

IPC: G01N27/447

CPC classification number: G01N27/44791 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y35/00 ,  G01N27/4473 ,  G01N27/44743 ,  G01N33/48721 ,  Y10S977/742 ,  Y10S977/845 ,  Y10S977/88

Abstract: A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged carbon nanotube to pass but to block a molecule attached to the carbon nanotube. The opening is filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged carbon nanotubes through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged carbon nanotubes passing into the opening, and to bias the electric field generator to determine a critical voltage related to a force of separation between the carbon nanotube and the molecule.

Abstract translation: 用于检测分子特征的纳米传感器包括具有开口的膜，该开口被配置为允许带电的碳纳米管通过，但是阻挡附着在碳纳米管上的分子。 开口充满电解液。 电场发生器被配置为相对于开口产生电场，以驱动带电的碳纳米管通过开口。 传感器电路耦合到电场发生器以感测由于带电的碳纳米管进入开口而导致的电流变化，并且偏置电场发生器以确定与碳纳米管和分子之间的分离力相关的临界电压。

公开(公告)号：US20250104815A1

公开(公告)日：2025-03-27

申请号：US18372896

申请日：2023-09-26

Applicant: International Business Machines Corporation

Inventor： Binquan Luan

IPC: G16C20/10

Abstract: A semi-empirical water model based upon an xTB model modified with an energy function (xTB-M) is capable of temperature-dependent predictions of chemical reactions in water. The unmodified xTB model does not provide accurate predictions of chemical reactions in water because the model is incapable of correctly reproducing the caging effect that occurs during chemical reactions in aqueous solutions; thus, chemical reactions simulated with the unmodified model have water density values that are higher than the experimental water density values. The energy function of the xTB-M model corrects the water densities in the unmodified model by accurately calculating the hydrophobic forces between oxygen-pairs in a water simulation thus producing a semi-empirical water model with accurate water density values. By outfitting the water simulation with an NPT or NVT ensemble, the xTB-M model is able to accurately predict the behavior and stability of chemical reactions in water at different temperatures.

公开(公告)号：US11980841B2

公开(公告)日：2024-05-14

申请号：US17661999

申请日：2022-05-04

Applicant: International Business Machines Corporation

Inventor： Binquan Luan ,  Rodrigo Neumann Barros Ferreira ,  Breanndan O'Conchuir ,  Fausto Martelli ,  Ronaldo Giro ,  Mathias B. Steiner ,  Bruce Gordon Elmegreen ,  Tonia Elengikal ,  Anshul Gupta

IPC: B01D53/04 ,  B01D53/047

CPC classification number: B01D53/0446 ,  B01D53/047 ,  B01D2256/10 ,  B01D2257/504 ,  B01D2259/402

Abstract: A gas capture system is configured to purify gas streams. The gas capture system includes a first capture system including a plurality of first chambers interconnected by a first path. Each first chamber includes a first adsorbent. The gas capture system further includes a second capture system including a plurality of second chambers interconnected by a second path. Each second chamber includes a second adsorbent. The gas capture system further includes a third path connecting each first chamber to the second path such that a first output of the first capture system is input into the second capture system. The gas capture system further includes a fourth path connecting each second chamber to the first path such that a second output of the second capture system is input into the first capture system.