Benzimidazolone Compounds Having 5-HT4 Receptor Agonistic Activity
    24.
    发明申请
    Benzimidazolone Compounds Having 5-HT4 Receptor Agonistic Activity 审中-公开
    具有5-HT4受体激动活性的苯并咪唑酮化合物

    公开(公告)号:US20100273794A1

    公开(公告)日:2010-10-28

    申请号:US12831713

    申请日:2010-07-07

    摘要: This invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds for the manufacture of medicament for gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes and apnea syndrome.These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.

    摘要翻译: 本发明提供式(I)化合物或其药学上可接受的盐,以及含有这些化合物的组合物以及这些化合物在制备胃食管反流疾病,胃肠道疾病,胃动力障碍,非溃疡的药物中的用途 消化不良,功能性消化不良,肠易激综合征(IBS),便秘,消化不良,食管炎,胃食管疾病,恶心,中枢神经系统疾病,阿尔茨海默病,认知障碍,呕吐,偏头痛,神经系统疾病,疼痛,心血管疾病,心力衰竭,心脏 心律失常,糖尿病和呼吸暂停综合征。 这些化合物具有5-HT 4受体激动活性,因此可用于治疗哺乳动物特别是人类的胃食管反流病,非溃疡性消化不良,功能性消化不良,肠易激综合征等。

    METAL COMPLEX, LIGHT-EMITTING DEVICE AND DISPLAY
    25.
    发明申请
    METAL COMPLEX, LIGHT-EMITTING DEVICE AND DISPLAY 审中-公开
    金属复合材料,发光装置和显示器

    公开(公告)号:US20090198069A1

    公开(公告)日:2009-08-06

    申请号:US11909686

    申请日:2006-03-24

    IPC分类号: C07F15/00

    摘要: An object of the present invention is to provide a novel metal complex. A metal complex having a composition of [(PtII)2(MI)4(L)8], where MI is H+, AgI, AuI or CuI, and L is a compound represented by the following chemical formula. A metal complex having a composition of [(PtII)2(MI)4(X)2(L)6], where MI is AgI, AuI or CuI, X is Cl−, Br− or I−, and L is a compound represented by the following chemical formula. In the formula, R1, R2 and R3 are independently a hydrogen atom, a chlorine atom, a bromine atom, an iodine atom, a hydroxyl group, a phenyl group, a trifluoromethylphenyl group, a pentafluorophenyl group, a naphthyl group, a methyl group, an ethyl group, an i-propyl group, a t-butyl group, a trifluoromethyl group, a hydroxymethyl group or a hydroxyethyl group. At least one of R1, R2 and R3 in the formula is not a hydrogen atom.

    摘要翻译: 本发明的目的是提供一种新的金属络合物。 具有[(PtII)2(MI)4(L)8]的组成的金属络合物,其中MI是H +,AgI,AuI或CuI,L是由以下化学式表示的化合物。 具有[(PtII)2(MI)4(X)2(L)6]的组成的金属络合物,其中MI为AgI,AuI或CuI,X为Cl-,Br-或I-,L为 化合物由下列化学式表示。 在该式中,R 1,R 2和R 3独立地为氢原子,氯原子,溴原子,碘原子,羟基,苯基,三氟甲苯基,五氟苯基,萘基,甲基 乙基,异丙基,叔丁基,三氟甲基,羟甲基或羟乙基。 式中的R 1,R 2和R 3中的至少一个不是氢原子。

    Impact test apparatus
    26.
    发明申请
    Impact test apparatus 失效
    冲击试验装置

    公开(公告)号:US20080178655A1

    公开(公告)日:2008-07-31

    申请号:US12009412

    申请日:2008-01-21

    IPC分类号: G01M7/00

    CPC分类号: G01M7/08

    摘要: An apparatus for performing an impact test of an object of test by use of a hammer is disclosed. The apparatus includes a pendulum arm swingable in an up-down direction in response to rotation of a rotary cam. The rotary cam is driven to rotate by a rotational drive unit, so that the hammer provided on a distal end portion of the pendulum arm successively applies impacts to the object of test.

    摘要翻译: 公开了一种用于通过使用锤进行测试对象的冲击试验的装置。 该装置包括响应于旋转凸轮的旋转而在上下方向上摆动的摆臂。 旋转凸轮通过旋转驱动单元被驱动旋转,使得设置在摆臂的远端部分上的锤连续地对测试对象施加冲击。

    Production process for high purity tricyclo-[5.2.1.02,6]decane-2-carboxylic acid ester
    27.
    发明授权
    Production process for high purity tricyclo-[5.2.1.02,6]decane-2-carboxylic acid ester 有权
    高纯度三环[5.2.1.02,6]癸烷-2-羧酸酯的制备方法

    公开(公告)号:US07253300B2

    公开(公告)日:2007-08-07

    申请号:US10942880

    申请日:2004-09-17

    IPC分类号: C07C67/36 C07C69/74

    摘要: In a process for producing tricyclo[5.2.1.02,6]decane-2-carboxylic acid ester by reacting tricyclo[5.2.1.02,6]deca-3-ene with carbon monoxide and alcohol in the presence of HF, carried out separately are (a) a step in which tricyclo[5.2.1.02,6]deca-3-ene is reacted with carbon monoxide to produce acyl fluoride and (b) a step in which acyl fluoride obtained in the step described above is reacted with alcohol to produce an ester. Also, the reaction conditions at the step (a) described above are selected or a step for carrying out isomerization reaction of tricyclo[5.2.1.02,6]decane-2-carboxylic fluoride obtained at the step (a) is interposed between the step (a) and the step (b). Further, the crude product of tricyclo[5.2.1.02,6]decane-2-carboxylic acid ester thus obtained is subjected to contact treatment with specific glycol in the presence of an acid catalyst and then distilled.

    摘要翻译: 在三环[5.2.1.0 2,6]癸烷-3-羧酸酯的三辛酸[5.2.1.0 2,6]癸烷-2-羧酸酯的制备方法中, 在一种HF存在下与一氧化碳和乙醇一起使用,分别进行(a)将三环[5.2.1.0 2,6]癸-3-烯与一氧化碳反应的步骤 产生酰氟和(b)使上述步骤中得到的酰基氟与醇反应生成酯的步骤。 此外,选择上述步骤(a)中的反应条件或在步骤(a)中获得的三环[5.2.1.0 2,6]癸烷-2-羧酸氟化物进行异构化反应的步骤 (a)介于步骤(a)和步骤(b)之间。 此外,将由此获得的三环[5.2.1.0 2,6]癸烷-2-羧酸酯的粗产物在酸催化剂存在下用特定的二醇进行接触处理,然后蒸馏。

    Vehicle impact testing device
    28.
    发明授权
    Vehicle impact testing device 失效
    车辆碰撞试验装置

    公开(公告)号:US06997036B2

    公开(公告)日:2006-02-14

    申请号:US10482933

    申请日:2002-06-25

    IPC分类号: G01M7/00

    CPC分类号: G01M17/0078

    摘要: A vehicle impact testing device is provided with a towing device for running a test car along a running road surface to collide with a barrier. The towing device is movably suspended from a pair of guide rails received in a recess formed below the running road surface. The towing device is disposed between the guide rails, thereby making effective use of the space between the guide rails. Further, the towing device is disposed at a position below the running road surface, so that it does not interfere with the running of the test car.

    摘要翻译: 车辆碰撞试验装置具有用于沿着行驶路面行驶试验车辆以与障碍物碰撞的牵引装置。 牵引装置可移动地悬挂在容纳在形成在行驶路面下方的凹部中的一对导轨上。 牵引装置设置在导轨之间,从而有效地利用导轨之间的空间。 此外,牵引装置设置在行驶路面下方的位置,使其不干扰试车的行驶。

    Skew adjusing circuit and semiconductor integrated circuit
    29.
    发明申请
    Skew adjusing circuit and semiconductor integrated circuit 失效
    歪斜电路和半导体集成电路

    公开(公告)号:US20050251712A1

    公开(公告)日:2005-11-10

    申请号:US11181918

    申请日:2005-07-15

    申请人: Takashi Kojima

    发明人: Takashi Kojima

    CPC分类号: H03K19/00323

    摘要: An output signal of a flip flop at an output stage is supplied to delay gates connected in series thereto. A selector selects the output signal of the flip flop at the output stage or an output signal of one of the delay gates and supplies the selected signal to an external device. A signal to be selected by the selector depends on the value of data stored in a selector value setting register. When a skew adjustment is performed, the output signal of the flip flop at the output stage is held in a write data holding register. The signal supplied to the external device is held in a read data buffer through an input/output register of the external device. Until the value of the signal stored in the write data holding register matches the value of the signal held in the read data buffer, the value of the data stored in the selector value setting register is varied.

    摘要翻译: 在输出级的触发器的输出信号被提供给与其串联连接的延迟门。 选择器在输出级选择触发器的输出信号或者延迟门之一的输出信号,并将所选择的信号提供给外部设备。 由选择器选择的信号取决于存储在选择器值设置寄存器中的数据的值。 当进行偏斜调整时,输出级的触发器的输出信号保持在写入数据保持寄存器中。 提供给外部设备的信号通过外部设备的输入/输出寄存器保存在读取数据缓冲器中。 直到存储在写入数据保持寄存器中的信号的值与保持在读取数据缓冲器中的信号的值相匹配,存储在选择器值设置寄存器中的数据的值是变化的。

    Skew adjusting circuit and semiconductor integrated circuit
    30.
    发明授权
    Skew adjusting circuit and semiconductor integrated circuit 失效
    倾斜调整电路和半导体集成电路

    公开(公告)号:US06944801B2

    公开(公告)日:2005-09-13

    申请号:US10013497

    申请日:2001-12-13

    申请人: Takashi Kojima

    发明人: Takashi Kojima

    CPC分类号: H03K19/00323

    摘要: An output signal of a flip flop at an output stage is supplied to delay gates connected in series thereto. A selector selects the output signal of the flip flop at the output stage or an output signal of one of the delay gates and supplies the selected signal to an external device. A signal to be selected by the selector depends on the value of data stored in a selector value setting register. When a skew adjustment is performed, the output signal of the flip flop at the output stage is held in a write data holding register. The signal supplied to the external device is held in a read data buffer through an input/output register of the external device. Until the value of the signal stored in the write data holding register matches the value of the signal held in the read data buffer, the value of the data stored in the selector value setting register is varied.

    摘要翻译: 在输出级的触发器的输出信号被提供给与其串联连接的延迟门。 选择器在输出级选择触发器的输出信号或者延迟门之一的输出信号,并将所选择的信号提供给外部设备。 由选择器选择的信号取决于存储在选择器值设置寄存器中的数据的值。 当进行偏斜调整时,输出级的触发器的输出信号保持在写入数据保持寄存器中。 提供给外部设备的信号通过外部设备的输入/输出寄存器保存在读取数据缓冲器中。 直到存储在写入数据保持寄存器中的信号的值与保持在读取数据缓冲器中的信号的值相匹配,存储在选择器值设置寄存器中的数据的值是变化的。