公开(公告)号：US08309428B2

公开(公告)日：2012-11-13

申请号：US11612656

申请日：2006-12-19

Applicant: David F. Lemmerhirt ,  Collin A. Rich

Inventor： David F. Lemmerhirt ,  Collin A. Rich

IPC: H01L21/30

CPC classification number: B06B1/0292 ,  A61B8/00 ,  A61B8/4472

Abstract: The first integrated circuit/transducer device 36 of the handheld probe includes CMOS circuits 110 and cMUT elements 112. The cMUT elements 112 function to generate an ultrasonic beam, detect an ultrasonic echo, and output electrical signals, while the CMOS circuits 110 function to perform analog or digital operations on the electrical signals generated through operation of the cMUT elements 112. The manufacturing method for the first integrated circuit/transducer device 36 of the preferred embodiment includes the steps of depositing the lower electrode S102; depositing a sacrificial layer S104; depositing a dielectric layer S106; depositing the upper electrode S108; depositing a protective layer on the upper electrode S110; and removing the sacrificial layer S112. In the preferred embodiment, the manufacturing method also includes the step of depositing a sealant layer to seal a cavity between the lower electrode and the upper electrode S114.

Abstract translation: 手持式探头的第一集成电路/传感器装置36包括CMOS电路110和cMUT元件112.CMUT元件112用于产生超声波束，检测超声回波并输出电信号，同时CMOS电路110用于执行 对通过cMUT元件112的操作产生的电信号进行模拟或数字操作。优选实施例的第一集成电路/换能器装置36的制造方法包括以下步骤：沉积下电极S102; 沉积牺牲层S104; 沉积介电层S106; 沉积上电极S108; 在上电极S110上沉积保护层; 并去除牺牲层S112。 在优选实施例中，制造方法还包括沉积密封剂层以密封下电极和上电极S114之间的腔的步骤。

公开(公告)号：US08303894B2

公开(公告)日：2012-11-06

申请号：US12857290

申请日：2010-08-16

Applicant: Collin A. Rich

Inventor： Collin A. Rich

IPC: G01N21/00 ,  G01N1/00 ,  C12M1/36 ,  C12Q3/00 ,  B08B7/00 ,  G01N35/08

CPC classification number: G01N1/14 ,  G01N15/06 ,  G01N15/1404 ,  G01N2015/1413 ,  G05D7/0682 ,  Y10T137/0402 ,  Y10T137/85978 ,  Y10T137/85986 ,  Y10T436/115831 ,  Y10T436/117497

Abstract: The fluidic system including a sheath pump that pumps sheath fluid from a sheath container into an interrogation zone, a waste pump that pumps waste fluid from the interrogation zone to a waste container, in which the flow rate of the sheath fluid is different from the flow rate of the waste fluid thereby drawing a sample fluid from a sample container into the interrogation zone, a detection system that provides a data set of input signals from the sample fluid, an analysis engine that recognizes aggregate particle events in the data set, and a controller that automatically adjusts the flow rate of the sample fluid into the interrogation zone based on the recognition of aggregate particle events, by controlling at least one of the flow rates of the sheath fluid and the waste fluid.

Abstract translation: 流体系统包括将皮套流体从护套容器泵送到询问区域的护套泵，将废液从询问区泵送到废物容器的废水泵，其中护套流体的流速不同于流动 从而将样品流体从样品容器抽入询问区，提供来自样品流体的输入信号的数据集的检测系统，识别数据集中的聚集粒子事件的分析引擎和 控制器，通过控制鞘液和废液的流速中的至少一个，基于聚集颗粒事件的识别，自动调节进入询问区的样品流体的流量。

公开(公告)号：US08229684B2

公开(公告)日：2012-07-24

申请号：US12770341

申请日：2010-04-29

Applicant: Clement James Goebel ,  Collin A. Rich

Inventor： Clement James Goebel ,  Collin A. Rich

IPC: G06F17/40 ,  G06F17/00

CPC classification number: G01N15/1459 ,  G01N2015/0092 ,  G01N2015/1477

Abstract: The detection system of the first preferred embodiment includes a detector, having a wide dynamic range, that receives photonic inputs from an interrogation zone and produces an analog signal; and an analog-to-digital converter (ADC), having a high bit resolution, that is coupled to the detector and converts an analog signal to a digital signal. The digital signal includes an initial data set of the full dynamic range of the input signals from the flow cytometer sample. The method of extracting and analyzing data from a flow cytometer system of the first preferred embodiment preferably includes the steps of: collecting a full dynamic range of input signals from a flow cytometer sample; recognizing and annotating aggregate particle events; and storing an initial data set and an annotated data set of the full dynamic range of the input signals from the flow cytometer sample.

Abstract translation: 第一优选实施例的检测系统包括具有宽动态范围的检测器，其接收来自询问区的光子输入并产生模拟信号; 以及具有高比特分辨率的模数转换器（ADC），其耦合到检测器并将模拟信号转换为数字信号。 数字信号包括来自流式细胞仪样本的输入信号的完整动态范围的初始数据集。 从第一优选实施例的流式细胞仪系统提取和分析数据的方法优选地包括以下步骤：从流式细胞仪样品收集输入信号的完整动态范围; 识别和注释聚集粒子事件; 并存储来自流式细胞仪样本的输入信号的完整动态范围的初始数据集和注释数据集。

公开(公告)号：US07857005B2

公开(公告)日：2010-12-28

申请号：US12425830

申请日：2009-04-17

Applicant: Collin A. Rich ,  Nathaniel C. Bair

Inventor： Collin A. Rich ,  Nathaniel C. Bair

IPC: F16L55/04

CPC classification number: F16L55/04 ,  F04B43/12 ,  F15B1/021 ,  F15B1/10 ,  F15B21/008 ,  F15B2201/205 ,  F15B2201/215 ,  F15B2201/3151 ,  G01N15/1404 ,  G01N15/1459 ,  Y10T137/3118

Abstract: A pulsation attenuator for a fluidic system with a fluidic pump. The pulsation attenuator includes a fluidic channel, a first fluidic device adapted to attenuate pulsations, and a second fluidic device adapted to attenuate pulsations. Preferably, the first fluidic device includes a first fluidic resistor and a first fluidic capacitor, and the second fluidic device includes a second fluidic resistor and a second fluidic capacitor. Preferably, the first fluidic resistor and second fluidic resistor are resistive channels. Preferably, the first fluidic capacitor and second fluidic capacitor include a membrane that expands and accumulates fluid and then contracts and reintroduces the accumulated fluid into the fluidic channel.

Abstract translation: 一种具有流体泵的流体系统的脉动衰减器。 脉动衰减器包括流体通道，适于衰减脉动的第一流体装置，以及适于衰减脉动的第二流体装置。 优选地，第一流体装置包括第一流体电阻器和第一流体电容器，并且第二流体装置包括第二流体电阻器和第二流体电容器。 优选地，第一流体电阻器和第二流体电阻器是电阻通道。 优选地，第一流体电容器和第二流体电容器包括膨胀和积聚流体然后收缩并将积聚的流体再引入流体通道的膜。

公开(公告)号：US20090201501A1

公开(公告)日：2009-08-13

申请号：US12197192

申请日：2008-08-22

Applicant: Nathaniel C. Bair ,  Collin A. Rich ,  Richard L. Fisher

Inventor： Nathaniel C. Bair ,  Collin A. Rich ,  Richard L. Fisher

IPC: G01N21/53

CPC classification number: G01N21/53 ,  G01N15/1434 ,  G01N2021/6497 ,  Y10T436/115831

Abstract: The preferred embodiments of the invention is an optical system for a flow cytometer including a flow channel with an interrogation zone, and an illumination source that impinges the flow channel in the interrogation zone from a particular direction. The optical system preferably includes a lens system and a detection system. The lens system preferably includes multiple lens surfaces arranged around the flow channel and adapted to collect and collimate light from the interrogation zone. The detection system preferably includes multiple detectors adapted to detect light from the lens system. Each detector preferably includes a local filter that independently filters for specific wavelengths. Thus, the user may easily swap the filters in any order to achieve the same detection parameters.

Abstract translation: 本发明的优选实施例是用于流式细胞仪的光学系统，其包括具有询问区的流动通道，以及照射源，其将特定方向上的询问区中的流动通道入射。 光学系统优选地包括透镜系统和检测系统。 透镜系统优选地包括围绕流动通道设置的多个透镜表面，并且适于收集和准直来自询问区域的光。 检测系统优选地包括适于检测来自透镜系统的光的多个检测器。 每个检测器优选地包括独立地滤波特定波长的局部滤波器。 因此，用户可以以任何顺序容易地交换滤波器以实现相同的检测参数。

公开(公告)号：US06926670B2

公开(公告)日：2005-08-09

申请号：US10054330

申请日：2002-01-22

Applicant: Collin A. Rich ,  Yafan Zhang ,  Nader Najafi ,  Matthew Z. Straayer ,  Sonbol Massoud-Ansari

Inventor： Collin A. Rich ,  Yafan Zhang ,  Nader Najafi ,  Matthew Z. Straayer ,  Sonbol Massoud-Ansari

IPC: A61B5/00 ,  A61B5/0215 ,  A61B5/027 ,  A61B8/14

CPC classification number: A61B5/6852 ,  A61B5/0031 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/027 ,  A61B5/0295 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/4839 ,  A61B5/6862 ,  A61B5/6876 ,  A61B5/6882 ,  A61B2562/028

Abstract: The present invention relates to an implantable microfabricated sensor device and system for measuring a physiologic parameter of interest within a patient. The implantable device is micro electromechanical system (MEMS) device and includes a substrate having an integrated inductor and at least one sensor formed thereon. A plurality of conductive paths electrically connect the integrated inductor with the sensor. Cooperatively, the integrated inductor, sensor and conductive paths defining an LC tank resonator.

Abstract translation: 本发明涉及一种用于测量患者内感兴趣的生理参数的可植入微制造传感器装置和系统。 可植入装置是微机电系统（MEMS）装置，并且包括具有集成电感器的基板和形成在其上的至少一个传感器。 多个导电路径将集成电感器与传感器电连接。 合成的集成电感器，传感器和导电路径限定了LC槽谐振器。

公开(公告)号：US08399278B2

公开(公告)日：2013-03-19

申请号：US12974349

申请日：2010-12-21

Applicant: David F. Lemmerhirt ,  Collin A. Rich

Inventor： David F. Lemmerhirt ,  Collin A. Rich

IPC: H01L21/00

CPC classification number: B06B1/0292 ,  A61B8/00 ,  A61B8/4472

Abstract: The integrated circuit/transducer device of the preferred embodiment includes a substrate, a complementary-metal-oxide-semiconductor (CMOS) circuit that is fabricated on the substrate, and a capacitive micromachined ultrasonic transducer (cMUT) element that is also fabricated on the substrate. The CMOS circuit and cMUT element are fabricated during the same foundry process and are connected. The cMUT includes a lower electrode, an upper electrode, a membrane structure that support the upper electrode, and a cavity between the upper electrode and lower electrode.

Abstract translation: 优选实施例的集成电路/换能器装置包括衬底，制造在衬底上的互补金属氧化物半导体（CMOS）电路，以及还制造在衬底上的电容微加工超声换能器（cMUT）元件 。 CMOS电路和cMUT元件在相同的铸造过程中制造并连接。 cMUT包括下电极，上电极，支撑上电极的膜结构，以及上电极和下电极之间的空腔。

公开(公告)号：US08229707B2

公开(公告)日：2012-07-24

申请号：US13175926

申请日：2011-07-04

Applicant: David Olson ,  Collin A. Rich ,  Clement James Goebel, III

Inventor： David Olson ,  Collin A. Rich ,  Clement James Goebel, III

IPC: G06F17/40 ,  G06F17/00

CPC classification number: G01N15/1429 ,  G01N35/00712 ,  G01N35/0092

Abstract: A method of extracting and analyzing a data set from a flow cytometer system of the preferred embodiment comprises the steps of (1) running a sample and saving all collected raw data, (2) viewing raw (or “unmodified”) data, (3) modifying the raw data (e.g., scaling and/or culling the raw data), (4) reviewing and saving the modified data, and (5) exporting the saved data. Once the sample has been run and all collected data have been saved, the user can repeat the steps of modifying the raw data, saving the modified data, and exporting the saved data as many times as necessary and/or desirable.

Abstract translation: 从优选实施例的流式细胞仪系统提取和分析数据集的方法包括以下步骤：（1）运行样本并保存所有收集的原始数据，（2）查看原始（或“未修改”）数据，（3 ）修改原始数据（例如，缩放和/或剔除原始数据），（4）查看和保存修改的数据，以及（5）导出保存的数据。 一旦样品运行并且所有收集的数据都被保存，用户可以重复修改原始数据，保存修改的数据，以及根据需要和/或期望导出保存的数据的步骤。

公开(公告)号：US08187888B2

公开(公告)日：2012-05-29

申请号：US13178776

申请日：2011-07-08

Applicant: Collin A. Rich

Inventor： Collin A. Rich

IPC: G01N35/08 ,  G01N33/48

CPC classification number: G01N15/1404 ,  G01N2015/1413 ,  G05D7/0682 ,  Y10T436/25375

Abstract: The fluidic system of the preferred embodiment includes a sheath pump to pump sheath fluid from a sheath container into an interrogation zone and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone. The fluidic system also includes a controller to adjust the flow rate of the sample fluid from the sample container into the interrogation zone. The fluidic system is preferably incorporated into a flow cytometer with a flow cell that includes the interrogation zone.

Abstract translation: 优选实施例的流体系统包括护套泵，以将护套流体从护套容器泵送到询问区域，以及废物泵将废液从询问区泵送到废物容器中。 护套泵和/或废水泵将样品流体从样品容器中抽入询问区。 流体系统还包括控制器，用于调节样品流体从样品容器进入询问区域的流速。 流体系统优选地结合到具有包括询问区的流动池的流式细胞仪中。

公开(公告)号：US07996188B2

公开(公告)日：2011-08-09

申请号：US11466391

申请日：2006-08-22

Applicant: David Olson ,  Collin A. Rich ,  Clement James Goebel, III

Inventor： David Olson ,  Collin A. Rich ,  Clement James Goebel, III

IPC: G01N15/00 ,  G06F17/40

CPC classification number: G01N15/1429 ,  G01N35/00712 ,  G01N35/0092

Abstract: A method of extracting and analyzing a data set from a flow cytometer system of the preferred embodiment comprises the steps of (1) running a sample and saving all collected raw data, (2) viewing raw (or “unmodified”) data, (3) modifying the raw data (e.g., scaling and/or culling the raw data), (4) reviewing and saving the modified data, and (5) exporting the saved data. Once the sample has been run and all collected data have been saved, the user can repeat the steps of modifying the raw data, saving the modified data, and exporting the saved data as many times as necessary and/or desirable.

Abstract translation: 从优选实施例的流式细胞仪系统提取和分析数据集的方法包括以下步骤：（1）运行样本并保存所有收集的原始数据，（2）查看原始（或“未修改”）数据，（3 ）修改原始数据（例如，缩放和/或剔除原始数据），（4）查看和保存修改的数据，以及（5）导出保存的数据。 一旦样品运行并且所有收集的数据都被保存，用户可以重复修改原始数据，保存修改的数据，以及根据需要和/或期望导出保存的数据的步骤。