专利检索 ap:("James E. Audia" OR "Paul A. Hyslop" OR "Jeffrey S. Nissen" OR "Richard C. Thompson" OR "Jay S. Tung" OR "Laura I. Tanner") AND inv:"Jeffrey S. Nissen" 第 3 页

21.

发明授权
Compounds having effects on serotonin-related systems 失效

公开(公告)号：US5789402A

公开(公告)日：1998-08-04

申请号：US471121

申请日：1995-06-06

申请人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong

发明人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong

IPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D513/04 , A61K31/55 , C07D401/00 , C07D405/00 , C07D409/00

CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04

摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.

22.

发明授权
8-substituted tetrahydro-beta-carbolines 失效
标题翻译： 8-取代的四氢-β-咔啉

公开(公告)号：US5631265A

公开(公告)日：1997-05-20

申请号：US380564

申请日：1995-02-06

申请人： James E. Audia , James J. Droste , Jeffrey S. Nissen

发明人： James E. Audia , James J. Droste , Jeffrey S. Nissen

IPC分类号： A61K31/435 , A61P1/00 , A61P25/00 , A61P43/00 , C07D471/04 , A61K31/395

CPC分类号： C07D471/04

摘要： The present invention provides novel tetrahydro-beta-carboline compounds and intermediates having useful central nervous system activity. The invention provides formulations and methods for using the tetrahydro-beta-carboline and related intermediate compounds. Finally, the invention provides an article of manufacture.

摘要翻译： 本发明提供了具有有用的中枢神经系统活性的新颖的四氢-β-咔啉化合物和中间体。本发明提供了使用四氢-β-咔啉及相关中间体化合物的配方和方法。最后，本发明提供了一种制造品。

23.

发明授权
5-HT.sub.1F agonists for the treatment of migraine 失效
标题翻译： 5-HT1F激动剂用于治疗偏头痛

公开(公告)号：US5521196A

公开(公告)日：1996-05-28

申请号：US318329

申请日：1994-10-05

申请人： James E. Audia , Jeffrey S. Nissen

发明人： James E. Audia , Jeffrey S. Nissen

IPC分类号： A61K31/4427 , A61K31/445 , A61P25/04 , A61P25/06 , C07D401/14 , C07D401/04

CPC分类号： C07D401/14

摘要： This invention provides novel 5-HT.sub.1F agonists which are useful for the treatment of migraine and associated disorders.

摘要翻译： 本发明提供了可用于治疗偏头痛和相关疾病的新型5-HT1F激动剂。

24.

发明授权
Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds 失效
标题翻译：杂环化合物，包含其的药物组合物，以及通过使用这些化合物抑制β-淀粉样蛋白肽释放和/或其合成的方法

公开(公告)号：US06849650B2

公开(公告)日：2005-02-01

申请号：US10246558

申请日：2002-09-19

申请人： Eugene D. Thorsett , Warren J. Porter , Jeffrey S. Nissen , Lee H. Latimer , James E. Audia , James Droste

发明人： Eugene D. Thorsett , Warren J. Porter , Jeffrey S. Nissen , Lee H. Latimer , James E. Audia , James Droste

IPC分类号： A61K31/4245 , A61K31/41 , C07D271/06

CPC分类号： A61K31/4245

摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。

25.

发明授权
N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds 失效

公开(公告)号：US06333351B1

公开(公告)日：2001-12-25

申请号：US09303655

申请日：1999-05-03

申请人： Jing Wu , Eugene D. Thorsett , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Varghese John , Lawrence Y. Fang , James E. Audia

发明人： Jing Wu , Eugene D. Thorsett , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Varghese John , Lawrence Y. Fang , James E. Audia

IPC分类号： C07C22906

CPC分类号： A61K31/198 , A61K31/223 , A61K31/277

摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

26.

发明授权
Compounds having effects on serotonin-related systems 失效
标题翻译：对5-羟色胺相关系统有影响的化合物

公开(公告)号：US06172073B2

公开(公告)日：2001-01-09

申请号：US09049837

申请日：1998-03-27

申请人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong

发明人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong

IPC分类号： A61K31445

CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04

摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.

摘要翻译： 一系列异烷基链烷胺是用于治疗与5-羟色胺和5-羟色胺1A受体再摄取相关或受其影响的病症的有效药物。该化合物特别可用于缓解尼古丁和烟草戒断症状，以及用于治疗抑郁症和使用5-羟色胺再摄取抑制剂的其它病症。

27.

发明授权
N-(aryl/heteroaryl) amino acid derivatives pharmaceutical compositions comprising same and methods for inhibiting .beta.-amyloid peptide release and/or its synthesis by use of such compounds 失效
标题翻译：包含其的N-（芳基/杂芳基）氨基酸衍生物药物组合物和通过使用这些化合物抑制β-淀粉样蛋白肽释放和/或其合成的方法

公开(公告)号：US06096782A

公开(公告)日：2000-08-01

申请号：US976191

申请日：1997-11-21

申请人： James E. Audia , Beverly K. Folmer , Varghese John , Lee H. Latimer , Jeffrey S. Nissen , Warren J. Porter , Eugene D. Thorsett , Jing Wu

发明人： James E. Audia , Beverly K. Folmer , Varghese John , Lee H. Latimer , Jeffrey S. Nissen , Warren J. Porter , Eugene D. Thorsett , Jing Wu

IPC分类号： A61K31/00 , A61K31/198 , A61K31/223 , C07C237/08 , C07C237/10 , C07C237/12 , C07C271/22 , C07D209/20 , C07D215/38 , C07D233/54 , C07D233/61 , C07D277/62 , C07D277/82 , A01N37/20 , A01N43/50 , C07C229/24

CPC分类号： C07D215/38 , A61K31/00 , A61K31/198 , A61K31/223 , C07C237/08 , C07C237/10 , C07C237/12 , C07C271/22 , C07D209/20 , C07D233/64 , C07D277/62 , C07D277/82

摘要： Disclosed are compounds which inhibit .beta.-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits .beta.-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默氏病的效用。还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及预防和治疗这些药物组合物的阿尔茨海默氏病的方法。

28.

发明授权
5HT.sub.1F agonists for the treatment of migraine 失效
标题翻译： 5HT1F激动剂用于治疗偏头痛

公开(公告)号：US5721252A

公开(公告)日：1998-02-24

申请号：US642069

申请日：1996-05-03

申请人： James E. Audia , Jeffrey S. Nissen

发明人： James E. Audia , Jeffrey S. Nissen

IPC分类号： A61K31/4427 , A61K31/445 , A61P25/04 , A61P25/06 , C07D401/14 , A61K31/44

CPC分类号： C07D401/14

摘要： This invention provides novel 5-HT.sub.1F agonists which are useful for the treatment of migraine and associated disorders.

摘要翻译： 本发明提供了可用于治疗偏头痛和相关疾病的新型5-HT1F激动剂。