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51 条记录 (耗时 0.054 秒)

    Cytokine receptor zcytor19
    22.
    发明授权
    Cytokine receptor zcytor19 有权
    细胞因子受体zcytor19

    公开(公告)号：US07601809B2

    公开(公告)日：2009-10-13

    申请号：US11539072

    申请日：2006-10-05

    申请人： Scott R. Presnell ,  Wenfeng Xu ,  Julia E. Novak ,  Theodore E. Whitmore ,  Francis J. Grant

    发明人： Scott R. Presnell ,  Wenfeng Xu ,  Julia E. Novak ,  Theodore E. Whitmore ,  Francis J. Grant

    IPC分类号： C07K14/715 ,  C07K14/54

    CPC分类号： C07K14/47 ,  C07K14/715 ,  C07K2319/00 ,  Y10T436/143333

    摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor19, are located on chromosome 1p36.11, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor19，一种新型的II类细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor19的多核苷酸位于染色体1p36.11上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。

    ZCYTOR19 POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES AND METHODS OF USE
    24.
    发明申请
    ZCYTOR19 POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES AND METHODS OF USE 审中-公开
    ZCYTOR19多核苷酸，多肽，抗体和使用方法

    公开(公告)号：US20120064571A1

    公开(公告)日：2012-03-15

    申请号：US13267430

    申请日：2011-10-06

    申请人： Scott R. Presnell ,  Francis J. Grant ,  Emily C. Costerison ,  Theodore E. Whitmore

    发明人： Scott R. Presnell ,  Francis J. Grant ,  Emily C. Costerison ,  Theodore E. Whitmore

    IPC分类号： C12P21/02 ,  C12N15/63 ,  C12N5/10 ,  C07H21/00

    CPC分类号： C07K14/47 ,  C07K14/715 ,  C07K2319/00 ,  Y10T436/143333

    摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor19, are located on chromosome 1p36.11, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor19，一种新型的II类细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor19的多核苷酸位于染色体1p36.11上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。

    Recombinant production of glucagon receptors
    30.
    发明授权
    Recombinant production of glucagon receptors 失效
    胰高血糖素受体的重组产生

    公开(公告)号：US5776725A

    公开(公告)日：1998-07-07

    申请号：US86631

    申请日：1993-07-01

    申请人： Wayne R. Kindsvogel ,  Laura J. Jelinek ,  Paul O. Sheppard ,  Francis J. Grant ,  Joseph L. Kuijper ,  Donald C. Foster ,  Si Lok ,  Patrick J. O'Hara

    发明人： Wayne R. Kindsvogel ,  Laura J. Jelinek ,  Paul O. Sheppard ,  Francis J. Grant ,  Joseph L. Kuijper ,  Donald C. Foster ,  Si Lok ,  Patrick J. O'Hara

    IPC分类号： C07K14/72 ,  C07K16/28 ,  C12N5/10 ,  C12N15/06 ,  C12N15/12 ,  C12N15/62 ,  C12Q1/66 ,  C12Q1/68 ,  G01N33/74

    CPC分类号： C07K14/72 ,  C12Q1/66 ,  G01N33/74 ,  C07K2319/00 ,  C07K2319/02 ,  G01N2333/605 ,  G01N2333/72

    摘要： The present invention provides isolated DNA molecules comprising a DNA segment encoding a glucagon receptor. Also provided are DNA constructs comprising a first DNA segment encoding a glucagon receptor operably linked to additional DNA segments required for the expression of the first DNA segment, as well as host cells containing such DNA constructs. The present invention also provides a method for detecting the presence of glucagon antagonists, comprising the steps of (a) exposing a compound in the presence of a glucagon against to a recombinant glucagon receptor coupled to a response pathway under conditions and for time sufficient to allow binding of the compound to the receptor and an associated response through the pathway, and (b) detecting a reduction in the stimulation of the response pathway resulting from the binding of the compound to the glucagon receptor, relative to the stimulation of the response pathway by the glucagon agonist alone and therefrom determining the presence of a glucagon antagonist.

    摘要翻译： 本发明提供了分离的DNA分子，其包含编码胰高血糖素受体的DNA区段。 还提供了DNA构建体，其包含编码与第一DNA区段表达所需的另外的DNA区段可操作地连接的胰高血糖素受体的第一DNA区段，以及含有这种DNA构建体的宿主细胞。 本发明还提供了一种用于检测胰高血糖素拮抗剂的存在的方法，其包括以下步骤：（a）在条件和时间足以允许的情况下，在与胰岛素反应途径偶联的重组胰高血糖素受体上暴露化合物 化合物与受体的结合和通过途径的相关应答，以及（b）相对于刺激响应途径，检测由化合物与胰高血糖素受体的结合引起的反应途径的刺激减少 胰高血糖素激动剂单独和由此决定胰高血糖素拮抗剂的存在。