公开(公告)号：US06503737B1

公开(公告)日：2003-01-07

申请号：US09410551

申请日：1999-10-01

Applicant: Christopher Reeves ,  Daniel Chu ,  Chaitan Khosla ,  Daniel Santi ,  Kai Wu

Inventor： Christopher Reeves ,  Daniel Chu ,  Chaitan Khosla ,  Daniel Santi ,  Kai Wu

IPC: C12P1962

CPC classification number: C07D498/18 ,  C07K2319/00 ,  C12N9/1029 ,  C12N9/1205 ,  C12N15/52 ,  C12P17/188 ,  C12P19/32

Abstract: Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.

Abstract translation: 包含编码FK-520聚酮化合物合成酶和FK-520修饰酶的重组载体的宿主细胞可用于产生FK-520聚酮化合物。 包含一个或多个FK-520聚酮化合物结构域，模块，开放阅读框及其变体的重组DNA构建体可用于生产重组聚酮化合物合酶和各种不同的聚酮化合物，作为药物和兽用产品的应用。

公开(公告)号：US20130252930A1

公开(公告)日：2013-09-26

申请号：US13881411

申请日：2011-12-16

Applicant: Daniel Chu ,  Bing Wang ,  Tao Ye

Inventor： Daniel Chu ,  Bing Wang ,  Tao Ye

IPC: C07J73/00 ,  C07J43/00 ,  C07J61/00 ,  C07J63/00

CPC classification number: C07J73/008 ,  C07D401/08 ,  C07D403/08 ,  C07D405/08 ,  C07D413/08 ,  C07D471/04 ,  C07J1/0011 ,  C07J13/005 ,  C07J21/005 ,  C07J31/006 ,  C07J43/003 ,  C07J61/00 ,  C07J63/002 ,  C07J73/003 ,  C07J73/005

Abstract: Provided herein are inhibitors of CYP11B, CYP17, and/or CYP21 enzymes of Formula (Z), (IX), (X), (XI), (XII), (XIII), (XIV), (XV), (XVI), or (XVII). Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions. Formula (Z)

Abstract translation: 本文提供式（Z），（IX），（X），（XI），（XII），（XIII），（XIV），（XV），（XVI）的CYP11B，CYP17和/ ）或（XVII）。 本文还描述了包含本文所述的至少一种化合物和本文所述的化合物或药物组合物用于治疗雄激素依赖性疾病，病症和病症的药物组合物。 式（Z）

公开(公告)号：US08420650B2

公开(公告)日：2013-04-16

申请号：US13077785

申请日：2011-03-31

Applicant: Bing Wang ,  Daniel Chu

Inventor： Bing Wang ,  Daniel Chu

IPC: A61K31/50 ,  A01N43/58 ,  C07D237/36

CPC classification number: A61K31/5025 ,  A61K31/282 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/5377 ,  A61K33/24 ,  A61N5/10 ,  A61N2005/1098 ,  C07D471/06

Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

公开(公告)号：US20120129763A1

公开(公告)日：2012-05-24

申请号：US13358374

申请日：2012-01-25

Applicant: Daniel Chu ,  Tao Ye

Inventor： Daniel Chu ,  Tao Ye

IPC: A61K38/14 ,  A61P31/04 ,  C07K9/00

CPC classification number: C07K9/008

Abstract: Semi-synthetic glycopeptides having antibacterial activity are described, in particular, the semi-synthetic glycopeptides described herein are made by chemical modification of a glycopeptide (Compound A, Compound B, Compound H or Compound C) or monosaccharide made by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in acidic medium to give the amino acid-4 monosaccharide; conversion of the monosaccharide to the amino-sugar derivative; acylation of the amino substituent on the amino acid-4 amino-substituted sugar moiety on these scaffolds with certain acyl groups; and conversion of the acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides. Key reaction is the treatment of properly protected intermediate compound with isocyanate or carrying a Hofmann degradation of the primary amide of the 3rd amino acid asparagines with phenyl-bis-trifluoroacetate to give the primary amine. Also provided are methods for the synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

Abstract translation: 具体描述了具有抗菌活性的半合成糖肽，特别是本文所述的半合成糖肽通过化学修饰糖肽（化合物A，化合物B，化合物H或化合物C）或通过水解二糖部分 在酸性介质中母体糖肽的氨基酸-4得到氨基酸-4单糖; 单糖转化为氨基糖衍生物; 在这些支架上的氨基酸4氨基取代的糖部分上的氨基取代基被某些酰基酰化; 并将这些支架的大环上的酸部分转化为某些取代的酰胺。 关键反应是用异氰酸酯处理适当保护的中间体化合物或者用苯基二 - 三氟乙酸盐对第三氨基酸天门冬酰胺的伯酰胺进行霍夫曼降解，得到伯胺。 还提供了合成化合物的方法，含有该化合物的药物组合物，以及该化合物用于治疗和/或预防疾病，特别是细菌感染的方法。

公开(公告)号：US20110015119A1

公开(公告)日：2011-01-20

申请号：US12552221

申请日：2009-09-01

Applicant: Daniel Chu ,  Tao Ye ,  Bing Wang

Inventor： Daniel Chu ,  Tao Ye ,  Bing Wang

IPC: A61K38/12 ,  C07K7/50 ,  A61P31/04

CPC classification number: C07K9/008 ,  A61K38/00 ,  A61K45/06

Abstract: Semi-synthetic glycopeptides having antibacterial activity are described, in particular, the semi-synthetic glycopeptides described herein are made by chemical modification of a glycopeptide (Compound A, Compound B, Compound H or Compound C) or monosaccharide made by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in acidic medium to give the amino acid-4 monosaccharide; conversion of the monosaccharide to the amino-sugar derivative; acylation of the amino substituent on the amino acid-4 amino-substituted sugar moiety on these scaffolds with certain acyl groups; and conversion of the acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides. Key reaction is the treatment of properly protected intermediate compound with isocyanate. Also provided are methods for the synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

Abstract translation: 具体描述了具有抗菌活性的半合成糖肽，特别是本文所述的半合成糖肽通过化学修饰糖肽（化合物A，化合物B，化合物H或化合物C）或通过水解二糖部分 在酸性介质中母体糖肽的氨基酸-4得到氨基酸-4单糖; 单糖转化为氨基糖衍生物; 在这些支架上的氨基酸4氨基取代的糖部分上的氨基取代基被某些酰基酰化; 并将这些支架的大环上的酸部分转化为某些取代的酰胺。 关键反应是用异氰酸酯处理适当保护的中间体化合物。 还提供了合成化合物的方法，含有该化合物的药物组合物，以及该化合物用于治疗和/或预防疾病，特别是细菌感染的方法。

公开(公告)号：US20100105700A1

公开(公告)日：2010-04-29

申请号：US12603377

申请日：2009-10-21

Applicant: Daniel Chu ,  Peter L. Myers ,  Bing Wang

Inventor： Daniel Chu ,  Peter L. Myers ,  Bing Wang

IPC: A61K31/473 ,  C07D221/18 ,  C07D311/06 ,  C07D401/02 ,  A61K31/497 ,  A61K31/506 ,  A61K31/352 ,  A61P35/00

CPC classification number: A61K31/352 ,  A61K31/473 ,  A61K31/497 ,  A61K31/506 ,  C07J73/003 ,  C07J73/005 ,  C07J75/005

Abstract: Provided herein are inhibitors of CYP17 enzyme. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions.

Abstract translation: 本文提供了CYP17酶的抑制剂。 本文还描述了包含本文所述的至少一种化合物和本文所述的化合物或药物组合物用于治疗雄激素依赖性疾病，病症和病症的药物组合物。

公开(公告)号：US07570466B2

公开(公告)日：2009-08-04

申请号：US11069175

申请日：2005-03-01

Applicant: Daniel Chu

Inventor： Daniel Chu

IPC: H02H9/00

CPC classification number: G11C16/30 ,  H03K17/102 ,  Y10T307/74

Abstract: A negative switch may enable switching of two different negative voltages. The switch may include a negative cascode bias generator which biases the gate of a cascade protection device. When the negative switch is passing a large negative voltage, the bias generator generates a lowered voltage to provide a cascade voltage for snapback protection of a passing transistor. When a relatively low negative voltage is to be switched, the bias generator may produce a positive voltage greater than the threshold voltage of the cascode protection device so that both high and low negative voltages may be switched by the same circuit without exposing the passing device to a voltage in excess of its snapback limit.

Abstract translation: 负开关可以实现两个不同负电压的切换。 开关可以包括偏置级联保护装置的栅极的负共源共栅偏压发生器。 当负开关通过大的负电压时，偏置发生器产生降低的电压，以提供级联电压以用于通过晶体管的快速保护。 当要切换相对较低的负电压时，偏置发生器可以产生大于共源共栅保护装置的阈值电压的正电压，使得高电压和低负电压都可以由同一电路切换，而不会使经过的装置暴露于 超过其回跳限制的电压。

公开(公告)号：US07456183B2

公开(公告)日：2008-11-25

申请号：US10474331

申请日：2002-04-08

Applicant: Daniel Chu ,  Rustum Boyce ,  David Duhl ,  Bryan Chang

Inventor： Daniel Chu ,  Rustum Boyce ,  David Duhl ,  Bryan Chang

IPC: A61K31/47 ,  A61K31/425 ,  A61K31/415 ,  A61K31/40 ,  A61P7/00 ,  C07D209/02 ,  C07D209/44 ,  C07D209/46 ,  C07D209/48 ,  C07D217/22 ,  C07D235/24 ,  C07D235/28 ,  C07D277/62 ,  C07D403/02

CPC classification number: C07D209/46 ,  C07D209/48 ,  C07D217/24 ,  C07D235/08 ,  C07D235/10

Abstract: Compounds having the general structure I are provided. X and Y are independently selected from the group consisting of CH2, N, NR9, C═O, C═S, S═O, SO2, S, O, (CR6R7)n, C(═O)—(CR6R7)n, and C(═S)—(CR6R7)n, where n is 1, 2, or 3. W is selected from the group consisting of (formula I) and L is selected from the group consisting of N, O, S═O, SO2, C(O), NC(O), NC(S), OC(O), OC(S), C(NR10), C(NOR10), and a covalent bond. Z1, Z2, and Z3 are independently selected from the group consisting of substituted carbon and nitrogen. Compounds of formula I are agonists of the melanocortin-4 receptor (“MC-4r2) and therefore may have useful properties for controlling diseases related to MC-4r action in humans, such as obesity and type II diabetes.

Abstract translation: 提供具有一般结构I的化合物。 X和Y独立地选自CH 2，N，NR 9，CO，CS，SO，SO 2，S ，（O） - （CR 6），（O） - （CR 6） C（-S） - （CR 6 R 7）N ，和C（-S） - （CR 6） 其中n为1,2或3.W选自（式I），L选自N，O，SO，SO 2， C（O），NC（O），NC（S），OC（O），OC（S），C（NR 10） ，和共价键。 Z 1，Z 2，Z 3和Z 3独立地选自取代的碳和氮。 式I化合物是黑皮质素-4受体（“MC-4r2”）的激动剂，因此可能具有控制人类MC-4r作用相关疾病如肥胖和II型糖尿病的有用性质。

公开(公告)号：US07368422B2

公开(公告)日：2008-05-06

申请号：US11361311

申请日：2006-02-24

Applicant: Yaohui Lei ,  Yu Bai ,  Daniel Chu ,  Zhi-Jie Ni ,  John Jian-Xin Wang

Inventor： Yaohui Lei ,  Yu Bai ,  Daniel Chu ,  Zhi-Jie Ni ,  John Jian-Xin Wang

IPC: A61K38/02 ,  A61K38/12 ,  A61K31/70 ,  C07K7/64 ,  C07K9/00 ,  C07K5/12

CPC classification number: C07K9/008

Abstract: Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

Abstract translation: 具有抗菌活性的半合成糖肽基于重排的万古霉素或去甲基 - 万古霉素支架的修饰，特别是在该支架上的具有某些酰基的氨基取代的糖部分上的氨基取代基的烷基化或酰化; 和/或将该支架的大环上的酸部分转化为某些取代的酰胺。 还提供了合成化合物的方法，含有化合物的药物组合物，以及用于治疗和/或预防疾病，特别是细菌感染的化合物的使用方法。

公开(公告)号：US20070272878A1

公开(公告)日：2007-11-29

申请号：US11694105

申请日：2007-03-30

Applicant: Daniel Chu ,  Paul Patt

Inventor： Daniel Chu ,  Paul Patt

IPC: A61N5/00

CPC classification number: G01N21/253 ,  B01L7/52 ,  G01N2201/101

Abstract: Translational motion of a scanning head relative to a planar target, or vice versa, is achieved by a belt and pulley system with a counterweight that is also driven by a belt and pulley system at the same speed but in the opposite direction as the scanning head. The components and belt and pulley system are oriented such that all moving components remain on one side of the target and remain so during their entire range of movement.

Abstract translation: 扫描头相对于平面目标的平移运动，反之亦然，通过皮带和皮带轮系统来实现，该带和滑轮系统具有配重，该配重也由皮带和滑轮系统以与扫描头相同的速度但与之相反的方向驱动 。 部件和皮带轮系统被定向成使得所有移动部件保持在目标的一侧并且在其整个移动范围内保持。