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公开(公告)号：US06287803B1
公开(公告)日：2001-09-11
申请号：US08965130
申请日：1997-11-06
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Robert H. Reid , Martin Rosenberg , Phillip Zarfos
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Robert H. Reid , Martin Rosenberg , Phillip Zarfos
IPC分类号： C12N1531
CPC分类号： G01N33/68 , A61K38/00 , A61K39/00 , C07K14/3156 , C07K2319/00 , G01N2333/315
摘要： The invention provides era polypeptides and DNA (RNA) encoding era polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing era polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码时代多肽的时代多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用时代多肽筛选抗菌化合物的方法。
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公开(公告)号：US06248863B1
公开(公告)日：2001-06-19
申请号：US09343986
申请日：1999-06-29
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： C07K500
CPC分类号： C07K14/31 , A61K39/00 , C07K16/1275 , C12N9/78 , C12Y305/04025
摘要： The invention provides phoH homolog polypeptides and DNA (RNA) encoding phoH homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phoH homolog polypeptides to screen for anitbacterial compounds.
摘要翻译： 本发明提供phoH同系物多肽和编码phoH同源多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用phoH同系物多肽来筛选脱细菌化合物的方法。
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公开(公告)号：US6025175A
公开(公告)日：2000-02-15
申请号：US110910
申请日：1998-07-06
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Martin Karl Russel Burnham
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Martin Karl Russel Burnham
IPC分类号： A61K38/00 , A61K39/00 , C07K14/315 , C12N1/21 , C12N9/12 , C12N9/78 , C12N15/54 , C07K16/00 , C12N15/00 , C12Q1/68
CPC分类号： C12N9/1205 , C07K14/3156 , C12N9/78 , C12Y207/01002 , A61K38/00 , A61K39/00
摘要： The invention provides Glucose Kinase polypeptides and DNA (RNA) encoding Glucose Kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Glucose Kinase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了葡萄糖激酶多肽和编码葡萄糖激酶多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。 还提供了利用葡萄糖激酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US6020159A
公开(公告)日：2000-02-01
申请号：US910501
申请日：1997-08-04
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Martin Rosenberg , Julie M Pratt , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Martin Rosenberg , Julie M Pratt , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： C12N15/09 , A61K38/00 , A61K38/43 , A61K39/00 , A61K39/085 , A61K39/395 , A61P31/04 , C07K14/31 , C07K16/12 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/04 , C12N9/12 , C12N9/88 , C12N15/00 , C12N15/60 , C12R1/445 , C12P21/06 , C07H17/00
CPC分类号： C12N9/1205 , C07K14/31 , C12N9/00 , C12N9/0006 , C12N9/88 , A61K38/00 , A61K39/00
摘要： The invention provides 3-DEHYDROQUINATE SYNTHASE polypeptides and DNA (RNA) encoding 3-DEHYDROQUINATE SYNTHASE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing 3-DEHYDROQUINATE SYNTHASE polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了3-脱水氨基酸合成酶多肽和编码3-脱水氨基酸合成酶多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还提供了利用3-脱氢氨基酸合成酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US5885805A
公开(公告)日：1999-03-23
申请号：US915107
申请日：1997-08-20
申请人： Michael Arthur Lonetto , Patrick Vernon Warren , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward
发明人： Michael Arthur Lonetto , Patrick Vernon Warren , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward
IPC分类号： G01N33/50 , A61K31/70 , A61K38/00 , A61K38/04 , A61K38/44 , A61K38/55 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/04 , A61P43/00 , C07K14/31 , C07K16/12 , C12N1/00 , C12N1/21 , C12N9/00 , C12N9/04 , C12N9/12 , C12N9/14 , C12N9/88 , C12N15/00 , C12N15/09 , C12N15/31 , C12N15/53 , C12N15/54 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/19 , C12R1/44 , C12R1/445 , G01N33/15 , G01N33/53 , G01N33/569 , G01N33/573 , C12P21/04 , C12N15/63
CPC分类号： C12N9/0006 , C07K14/31 , C12N9/00 , C12N9/1205 , C12N9/88 , A61K38/00 , A61K39/00 , C07K2319/00 , Y10S435/883
摘要： The invention provides gbpA polypeptides and DNA (RNA) encoding gbpA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gbpA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了gbpA多肽和编码gbpA多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用gbpA多肽筛选抗菌化合物的方法。
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公开(公告)号：US5882643A
公开(公告)日：1999-03-16
申请号：US964494
申请日：1997-11-05
IPC分类号： G01N33/50 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/46 , A61K38/48 , A61K39/00 , A61K39/09 , A61K39/395 , A61K48/00 , A61P9/00 , A61P11/00 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/10 , A61P43/00 , C07K14/315 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/52 , C12N15/00 , C12N15/09 , C12N15/57 , C12P21/08 , C12Q1/00 , C12Q1/02 , C12Q1/68 , C12R1/19 , C12R1/46 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/573 , C12N9/50
CPC分类号： C12N9/52 , A61K38/00 , A61K39/00 , A61K48/00 , Y10S435/885
摘要： lep polypeptides and DNA (RNA) encoding such lep and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such lep for the treatment of infection, particularly bacterial infections. Antagonists against such lep and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of lep nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding leader peptidase and for detecting the polypeptide in a host.
摘要翻译： 公开了编码这种lep的lep多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种lep治疗感染，特别是细菌感染的方法。 还公开了抗这种lep的拮抗剂及其用作治疗感染，特别是细菌感染的治疗剂。 还公开了用于检测与宿主中的lep核酸序列和多肽的存在相关的疾病的诊断测定。 还公开了用于检测编码前导肽酶的多核苷酸并用于检测宿主中的多肽的诊断测定法。
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公开(公告)号：US06586578B1
公开(公告)日：2003-07-01
申请号：US08911844
申请日：1997-08-15
IPC分类号： C07H2102
摘要： The invention provides Defl polypeptides and DNA (RNA) encoding Defl polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Defl polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了Def1多肽和编码Def1多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还提供了利用Def1多肽筛选抗菌化合物的方法。
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公开(公告)号：US06335433B1
公开(公告)日：2002-01-01
申请号：US08965902
申请日：1997-11-07
申请人： Sanjoy Biswas , Martin Karl Russel Burnham , Michael Arthur Lonetto , Patrick Vernon Warren , Richard Lloyd Warren
发明人： Sanjoy Biswas , Martin Karl Russel Burnham , Michael Arthur Lonetto , Patrick Vernon Warren , Richard Lloyd Warren
IPC分类号： C07H2102
CPC分类号： C12N9/0093 , A61K38/00 , A61K39/00 , C12N9/1096 , C12N9/78
摘要： The invention provides nrdD polypeptides and DNA (RNA) encoding nrdD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nrdD polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了nrdD多肽和编码nrdD多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用nrdD多肽筛选抗菌化合物的方法。
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公开(公告)号：US06320036B1
公开(公告)日：2001-11-20
申请号：US09310867
申请日：1999-05-13
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： C07H2104
CPC分类号： C12N9/0006 , A61K38/00 , A61K39/00 , C07K14/31 , C07K2319/00 , C12N9/00 , C12N9/1205 , C12N9/88 , Y10S435/883
摘要： The invention provides gbpA polypeptides and DNA (RNA) encoding gbpA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gbpA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了gbpA多肽和编码gbpA多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用gbpA多肽筛选抗菌化合物的方法。
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公开(公告)号：US06307022B1
公开(公告)日：2001-10-23
申请号：US09342458
申请日：1999-06-29
IPC分类号： C07K100
摘要： The invention provides def polypeptides and DNA (RNA) encoding def polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing def polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了定义多肽和编码定义多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用def多肽筛选抗菌化合物的方法。
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