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公开(公告)号：US08515537B2
公开(公告)日：2013-08-20
申请号：US12797823
申请日：2010-06-10
IPC分类号： A61N1/00
CPC分类号： A61N1/36557
摘要： A medical device system and associated method control the delivery of a therapy to a patient. The system includes an activity sensor and detects a change in activity level of the patient. The system further include an optical sensor to sense signal corresponding to tissue light attenuation. The system computes a tissue oxygenation measurement in response to detecting a change in activity level. A parameter controlling delivery of the therapy is adjusted in response to detecting the decreased tissue oxygenation.
摘要翻译： 医疗装置系统和相关联的方法控制对患者的治疗的递送。 该系统包括活动传感器并检测患者的活动水平的变化。 该系统还包括用于感测对应于组织光衰减的信号的光学传感器。 响应于检测到活动水平的变化，系统计算组织氧合测量。 响应于检测到组织氧合减少而调整治疗递送的参数。
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22.发明申请COEFFICENT DETERMINATION FOR BLOOD OXYGEN SATURATION AND TOTAL HEMOGLOBIN CONCENTRATION INDICES 有权血氧饱和度和总HEMOGLOBIN浓度指标的系数确定公开(公告)号：US20120130208A1
公开(公告)日：2012-05-24
申请号：US12948884
申请日：2010-11-18
IPC分类号： A61B5/1459
CPC分类号： A61B5/1459 , A61B5/0075 , A61B5/14535 , A61B5/14542 , A61B5/14551 , A61B5/1495 , A61B5/4836
摘要： A first concentration of a chromophore corresponding to a measurement volume of an optical sensor is determined. A second concentration of the chromophore is obtained in the vicinity of the measurement volume corresponding to a change in at least one of a total concentration of the chromophore and a relative concentration of a first form of the chromophore to the total concentration of the chromophore in the measurement volume. Light remittance measurements including a first light wavelength and a second light wavelength are obtained corresponding to the first chromophore concentration and the second chromophore concentration. A coefficient for computing an index of a change in the chromophore concentration is computed using the difference between the first and second chromophore concentrations and the first and second light remittance measurements.
摘要翻译： 确定对应于光学传感器的测量体积的发色团的第一浓度。 在测量体积附近获得发色团的第二浓度，其对应于发色团的总浓度和发色团的第一形式的相对浓度与发色团的总浓度中的至少一个的变化相关 测量体积。 对应于第一发色团浓度和第二发色团浓度获得包括第一光波长和第二光波长的光汇率测量。 使用第一和第二生色团浓度与第一和第二光汇率测量之间的差来计算计算发色团浓度变化指数的系数。
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23.发明申请Device and Method for Monitoring of Absolute Oxygen Saturation and Tissue Hemoglobin Concentration 有权用于监测绝对氧饱和度和组织血红蛋白浓度的装置和方法公开(公告)号：US20100317938A1
公开(公告)日：2010-12-16
申请号：US12797744
申请日：2010-06-10
申请人： Jonathan L. Kuhn , Can Cinbis , James K. Carney
发明人： Jonathan L. Kuhn , Can Cinbis , James K. Carney
IPC分类号： A61B5/1455
CPC分类号： A61B5/14552 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/7239 , A61N1/36557
摘要： A method and medical device for detecting signals that detects emitted light scattered by a volume of tissue delivered along a first pathway at a plurality of wavelengths to generate corresponding first detected light intensity output signals, detects emitted light scattered by the volume of tissue delivered along a second pathway different from the first pathway at a plurality of wavelengths to generate corresponding second detected light intensity output signals, determines whether a difference between the emitted light detected along the first pathway and the emitted light detected along the second pathway is greater than a predetermined threshold, and alters sensing by the device in response to the determining whether a difference is greater than the predetermined threshold.
摘要翻译： 一种用于检测信号的方法和医疗装置，其检测由沿着第一路径以多个波长传送的组织体积散射的发射光，以产生相应的第一检测到的光强度输出信号，以检测由沿着 在多个波长处与第一路径不同的第二路径以产生相应的第二检测光强度输出信号，确定沿着第一路径检测的发射光与沿着第二路径检测的发射光之间的差是否大于预定阈值 并且改变响应于确定差异是否大于预定阈值的设备的感测。
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24.发明申请Device and Method for Monitoring of Absolute Oxygen Saturation and Total Hemoglobin Concentration 有权用于监测绝对氧饱和度和总血红蛋白浓度的装置和方法公开(公告)号：US20100317937A1
公开(公告)日：2010-12-16
申请号：US12797736
申请日：2010-06-10
IPC分类号： A61B5/1455
CPC分类号： A61B5/14552 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/7239 , A61N1/36557
摘要： A medical device for monitoring of oxygen saturation includes an optical sensor adapted for positioning adjacent to a tissue volume. The optical sensor has a light emitting portion capable of emitting light at a plurality of wavelengths and a light detecting portion capable of generating an electrical output signal corresponding to light incident on the detecting portion. A control module coupled to the optical sensor controls the light emitted by the light emitting portion. A monitoring module receives the output signal from the light detecting portion and computes a volume-independent measure of oxygen saturation in the volume of tissue using the output signal.
摘要翻译： 用于监测氧饱和度的医疗装置包括适于邻近组织体积定位的光学传感器。 光学传感器具有能够发射多个波长的光的发光部和能够产生与入射到检测部上的光对应的电输出信号的光检测部。 耦合到光学传感器的控制模块控制由发光部分发射的光。 监测模块接收来自光检测部分的输出信号，并使用输出信号计算组织体积中的氧饱和度的体积无关测量。
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25.发明授权Device and method for monitoring of absolute oxygen saturation and tissue hemoglobin concentration 有权用于监测绝对氧饱和度和组织血红蛋白浓度的装置和方法公开(公告)号：US08666466B2
公开(公告)日：2014-03-04
申请号：US12797770
申请日：2010-06-10
申请人： Jonathan L. Kuhn , Can Cinbis , James K. Carney
发明人： Jonathan L. Kuhn , Can Cinbis , James K. Carney
IPC分类号： A61B5/00
CPC分类号： A61B5/14552 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/7239 , A61N1/36557
摘要： A method and medical device for detecting signals that detects emitted light scattered by a volume of tissue delivered along a first pathway and a second pathway different from the first pathway, detects emitted light scattered by a volume of tissue delivered along a third pathway and a fourth pathway different from the third pathway, determines a first uniformity corresponding to the emitted light detected along the first pathway and the second pathway, determines a second uniformity corresponding to the emitted light detected along third pathway and the fourth pathway, determines a total uniformity in response to the determined first uniformity and the determined second uniformity, and alters sensing by the device in response to the determined total uniformity.
摘要翻译： 一种用于检测信号的方法和医疗装置，其检测由沿着第一路径传送的组织体积散射的发射光和不同于第一路径的第二路径的信号，检测由沿着第三路径传送的组织体积散射的发射光， 确定与沿着第一路径和第二路径检测到的发射光相对应的第一均匀度，确定对应于沿着第三路径和第四路径检测的发射光的第二均匀度，确定响应中的总均匀性 到所确定的第一均匀性和确定的第二均匀性，并且改变由所述装置响应于所确定的总均匀性的感测。
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26.发明授权公开(公告)号：US08489168B2
公开(公告)日：2013-07-16
申请号：US12948884
申请日：2010-11-18
IPC分类号： A61B5/1455
CPC分类号： A61B5/1459 , A61B5/0075 , A61B5/14535 , A61B5/14542 , A61B5/14551 , A61B5/1495 , A61B5/4836
摘要： A first concentration of a chromophore corresponding to a measurement volume of an optical sensor is determined. A second concentration of the chromophore is obtained in the vicinity of the measurement volume corresponding to a change in at least one of a total concentration of the chromophore and a relative concentration of a first form of the chromophore to the total concentration of the chromophore in the measurement volume. Light remittance measurements including a first light wavelength and a second light wavelength are obtained corresponding to the first chromophore concentration and the second chromophore concentration. A coefficient for computing an index of a change in the chromophore concentration is computed using the difference between the first and second chromophore concentrations and the first and second light remittance measurements.
摘要翻译： 确定对应于光学传感器的测量体积的发色团的第一浓度。 在测量体积附近获得发色团的第二浓度，其对应于发色团的总浓度和发色团的第一形式的相对浓度与发色团的总浓度中的至少一个的变化相关 测量体积。 对应于第一发色团浓度和第二发色团浓度获得包括第一光波长和第二光波长的光汇率测量。 使用第一和第二生色团浓度与第一和第二光汇率测量之间的差来计算计算发色团浓度变化指数的系数。
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27.发明授权Device and method for monitoring of absolute oxygen saturation and total hemoglobin concentration 有权用于监测绝对氧饱和度和总血红蛋白浓度的装置和方法公开(公告)号：US08463345B2
公开(公告)日：2013-06-11
申请号：US12797736
申请日：2010-06-10
IPC分类号： A61B5/0215
CPC分类号： A61B5/14552 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/7239 , A61N1/36557
摘要： A medical device for monitoring of oxygen saturation includes an optical sensor adapted for positioning adjacent to a tissue volume. The optical sensor has a light emitting portion capable of emitting light at a plurality of wavelengths and a light detecting portion capable of generating an electrical output signal corresponding to light incident on the detecting portion. A control module coupled to the optical sensor controls the light emitted by the light emitting portion. A monitoring module receives the output signal from the light detecting portion and computes a volume-independent measure of oxygen saturation in the volume of tissue using the output signal.
摘要翻译： 用于监测氧饱和度的医疗装置包括适于邻近组织体积定位的光学传感器。 光学传感器具有能够发射多个波长的光的发光部和能够产生与入射到检测部上的光对应的电输出信号的光检测部。 耦合到光学传感器的控制模块控制由发光部分发射的光。 监测模块接收来自光检测部分的输出信号，并使用输出信号计算组织体积中的氧饱和度的体积无关测量。
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公开(公告)号：US20090270953A1
公开(公告)日：2009-10-29
申请号：US12107921
申请日：2008-04-23
申请人： Robert M. Ecker , Jonathan L. Kuhn , James D. Reinke , Can Cinbis , Timothy J. Davis , Paul F. Gerrish , Jonathan P. Roberts
发明人： Robert M. Ecker , Jonathan L. Kuhn , James D. Reinke , Can Cinbis , Timothy J. Davis , Paul F. Gerrish , Jonathan P. Roberts
CPC分类号： A61B5/0086 , A61B2562/028 , A61N1/3621 , A61N1/36557 , A61N1/375 , A61N1/3956
摘要： A reflectance-type optical sensor includes one or more photodiodes formed in a semiconductor substrate. A well having sidewalls and a bottom is formed in the top surface of the substrate, and a reflective layer is formed on the sidewalls and bottom. A light-emitting diode (LED) is mounted in the well, so that light emitted laterally and rearwardly from the LED strikes the sidewalls or bottom and is redirected in a direction generally perpendicular to the top surface of the substrate. The optical sensor can be fabricated using microelectromechanical systems (MEMS) fabrication techniques.
摘要翻译： 反射型光学传感器包括在半导体衬底中形成的一个或多个光电二极管。 在衬底的顶表面中形成具有侧壁和底部的阱，并且在侧壁和底部上形成反射层。 发光二极管（LED）安装在井中，使得从LED侧向和向后发射的光撞击侧壁或底部，并且在大体上垂直于衬底的顶表面的方向上重定向。 光学传感器可以使用微机电系统（MEMS）制造技术来制造。
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公开(公告)号：US09636059B2
公开(公告)日：2017-05-02
申请号：US13612967
申请日：2012-09-13
申请人： Can Cinbis , James K. Carney
发明人： Can Cinbis , James K. Carney
IPC分类号： G01N33/46 , G01N31/00 , C12M1/00 , A61B5/1459 , A61B5/00 , A61B5/024 , A61B5/046 , A61B5/0464 , A61B5/145 , A61N1/39
CPC分类号： A61B5/1459 , A61B5/0059 , A61B5/024 , A61B5/046 , A61B5/0464 , A61B5/14542 , A61B5/7214 , A61N1/3925
摘要： A medical device for sensing cardiac events that includes a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, updates, for each of the plurality of wavelengths, a first normalization coefficient and a second normalization coefficient in response to the detected emitted light, and adjusts the determined plurality of light measurements in response to the first normalization coefficient and the second normalization coefficient.
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公开(公告)号：US07684872B2
公开(公告)日：2010-03-23
申请号：US11380315
申请日：2006-04-26
申请人： James K. Carney , Michael A. Schugt , Qingshan Ye , Can Cinbis
发明人： James K. Carney , Michael A. Schugt , Qingshan Ye , Can Cinbis
IPC分类号： A61N1/08
CPC分类号： A61B5/0422 , A61B5/0215 , A61B5/02158 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B2562/028 , A61N1/056 , A61N1/36514
摘要： A medical device for implantation within a patient comprising a lead body including a conductor within the lead body and a transducer supported by the lead body. The conductor is electrically coupled to the transducer by a conductive fluid, paste or gel. The conductive fluid, paste or gel may be contained within a well in the lead body. The transducer may be a MEMS chip and/or an integrated circuit and may perform any of a variety of functions such as sensing physiological data.
摘要翻译： 一种用于植入患者体内的医疗装置，包括：引线体，其包括引线体内的导体;以及由引线体支撑的换能器。 导体通过导电流体，糊剂或凝胶电耦合到换能器。 导电流体，糊状物或凝胶可以包含在引线体内的阱中。 换能器可以是MEMS芯片和/或集成电路，并且可以执行诸如感测生理数据的各种功能中的任何一种。
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