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    CURABLE THERAPEUTIC IMPLANT COMPOSITION
    21.
    发明申请
    CURABLE THERAPEUTIC IMPLANT COMPOSITION 审中-公开
    可固化治疗植入物组合物

    公开(公告)号：US20080248086A1

    公开(公告)日：2008-10-09

    申请号：US12062689

    申请日：2008-04-04

    申请人： Soheil Asgari

    发明人： Soheil Asgari

    IPC分类号： A61F2/04

    CPC分类号： A61L27/446 ,  A61L27/58

    摘要： The exemplary embodiments of the present invention relates to a curable therapeutic implant composition for use in the filling of a cavity in a living organism, comprising particles of a metallic material, and a curable matrix-forming, non-particulate material, wherein at least one of the metallic material or the matrix-forming material is at least partially degradable in-vivo. Furthermore, the exemplary embodiments of the present invention relate to methods of filling a cavity in a living organism with the use of the curable implant composition.

    摘要翻译： 本发明的示例性实施方案涉及用于填充活生物体中的空腔的可固化治疗性植入物组合物，其包含金属材料颗粒和可固化基质形成非颗粒材料，其中至少一种 的金属材料或基质形成材料在体内至少部分可降解。 此外，本发明的示例性实施例涉及使用可固化植入物组合物填充生物体中的空腔的方法。

    HIGH SURFACE CULTIVATION SYSTEM WITH SURFACE INCREASING SUBSTRATE
    22.
    发明申请
    HIGH SURFACE CULTIVATION SYSTEM WITH SURFACE INCREASING SUBSTRATE 审中-公开
    表面增强基体的高表面培养体系

    公开(公告)号：US20080206735A1

    公开(公告)日：2008-08-28

    申请号：US12039709

    申请日：2008-02-28

    申请人： Soheil Asgari

    发明人： Soheil Asgari

    IPC分类号： C12N5/02 ,  C12M3/00 ,  C12M1/24

    CPC分类号： C12M23/08 ,  C12M27/12 ,  C12M27/20 ,  C12M27/22

    摘要： An exemplary embodiment of a culture vessel suitable is provided for a cultivation of cells and/or tissues. The exemplary vessel comprising at least one reversibly closable aperture in the vessel wall, and at least one surface-increasing substrate within the vessel, with the substrate being made of a single mold. According to another exemplary embodiment, a system can be provided comprising at least two vessels being interconnected via at least one aperture in their vessel wall, and a cultivation process using such a vessel or system, in which at least one type of cells, tissue, tissue-like cell cultures, organs, organ-like cell cultures, or multicellular organisms may be cultivated in the presence of at least one fluid or solid medium, e.g., provided for growing and/or cultivating the culture.

    摘要翻译： 提供了适合培养细胞和/或组织的培养容器的示例性实施方案。 示例性容器在容器壁中包括至少一个可逆封闭的孔，以及容器内的至少一个增加表面的衬底，衬底由单个模具制成。 根据另一示例性实施例，可以提供一种系统，其包括至少两个血管，其通过其血管壁中的至少一个孔相互连接，以及使用这种血管或系统的培养过程，其中至少一种类型的细胞， 组织样细胞培养物，器官，器官样细胞培养物或多细胞生物体可以在至少一种流体或固体培养基的存在下培养，例如用于培养和/或培养培养物。

    RESERVOIR IMPLANTS AND STENTS
    23.
    发明申请
    RESERVOIR IMPLANTS AND STENTS 审中-公开
    储存植入物和茎

    公开(公告)号：US20080195196A1

    公开(公告)日：2008-08-14

    申请号：US12030680

    申请日：2008-02-13

    申请人： Soheil Asgari

    发明人： Soheil Asgari

    IPC分类号： A61F2/06

    CPC分类号： A61F2/88 ,  A61F2/856 ,  A61F2/91 ,  A61F2002/065 ,  A61F2250/0023 ,  A61F2250/0039 ,  A61F2250/0068

    摘要： Exemplary embodiments of the present invention related to medical implants, such as e.g. stents are provided. For example, the implant can comprise at least one hollow space or lumen within the structural material or structure of the device, other than a pore or pore system, which may be used as a reservoir for a specific amount of active ingredient to be released after implantation into the body.

    摘要翻译： 与医疗植入物相关的本发明的示例性实施方案，例如 提供支架。 例如，植入物可以包括除了孔或孔系统之外的装置的结构材料或结构内的至少一个中空空间或内腔，其可以用作特定量的待释放的活性成分的储存器 植入身体。

    Composition comprising an agent providing a signal, an implant material and a drug
    24.
    发明申请
    Composition comprising an agent providing a signal, an implant material and a drug 审中-公开
    包含提供信号的药剂，植入材料和药物的组合物

    公开(公告)号：US20060177379A1

    公开(公告)日：2006-08-10

    申请号：US11322694

    申请日：2005-12-30

    申请人： Soheil Asgari

    发明人： Soheil Asgari

    IPC分类号： A61K49/10 ,  A61K49/04 ,  A61F2/06

    CPC分类号： A61K49/18 ,  A61K47/6957 ,  A61K49/04 ,  A61L31/022 ,  A61L31/18

    摘要： The present invention relates to compositions or combinations of materials for non-degradable and degradable implantable medical devices with regard to the setup of their signal generating properties and control of their therapeutic effectiveness, as well as to a method for the control of degradation of degradable or partially degradable medical devices composed like this, based on their signal generation, and to a method for supervision of their therapeutic effectiveness and/or the release of therapeutically active ingredients from such devices.

    摘要翻译： 本发明涉及用于不可降解和可降解的可植入医疗装置的材料的组合物或组合，其关于其信号产生性质的设置及其治疗有效性的控制，以及控制降解或降解的可降解或 基于其信号产生的这样构成的可部分降解的医疗装置以及用于监测其治疗有效性和/或从这些装置释放治疗活性成分的方法。

    BIODEGRADABLE THERAPEUTIC IMPLANT FOR BONE OR CARTILAGE REPAIR
    26.
    发明申请
    BIODEGRADABLE THERAPEUTIC IMPLANT FOR BONE OR CARTILAGE REPAIR 审中-公开
    生物可降解的治疗植入物用于骨或修复

    公开(公告)号：US20080249638A1

    公开(公告)日：2008-10-09

    申请号：US12098722

    申请日：2008-04-07

    申请人： Soheil Asgari

    发明人： Soheil Asgari

    IPC分类号： A61F2/02 ,  A61F2/28

    CPC分类号： A61L27/58 ,  A61F2/28 ,  A61F2/30756 ,  A61F2002/30052 ,  A61F2002/30062 ,  A61F2002/30677 ,  A61F2002/3092 ,  A61F2210/0004 ,  A61F2250/0043 ,  A61F2250/0067 ,  A61F2310/00011 ,  A61F2310/00179 ,  A61L27/446 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/604

    摘要： The exemplary embodiments of the present invention relate to an at least partially biodegradable implant suitable for implantation into a subject for repairing a bone or cartilage defect, comprising a matrix forming an open-celled structure having a plurality of interconnected spaces, whereas the channels of the matrix are substantially completely filled with metallic material particles, and wherein at least one of the metallic material or the matrix material is at least partially degradable in-vivo. Furthermore, the present invention relates to a method for repairing a bone or cartilage defect in a living organism, comprising implanting an implant according to the exemplary embodiments of the present invention into the defective bone or cartilage, or replacing the defective bone or cartilage at least partially.

    摘要翻译： 本发明的示例性实施方案涉及适于植入受试者以修复骨或软骨缺损的至少部分可生物降解的植入物，其包括形成具有多个互连空间的开孔结构的基质， 基质基本上完全被金属材料颗粒填充，并且其中至少一种金属材料或基质材料在体内是至少部分可降解的。 此外，本发明涉及一种用于修复活体中的骨或软骨缺损的方法，包括将根据本发明的示例性实施方案的植入物植入有缺陷的骨或软骨中，或至少将所述有缺陷的骨或软骨替代 部分地。

    HIGH SURFACE CULTIVATION SYSTEM
    27.
    发明申请
    HIGH SURFACE CULTIVATION SYSTEM 审中-公开
    高表面培养系统

    公开(公告)号：US20080213742A1

    公开(公告)日：2008-09-04

    申请号：US12039235

    申请日：2008-02-28

    申请人： Soheil Asgari ,  Dejan Ilic ,  Harald Danhamer

    发明人： Soheil Asgari ,  Dejan Ilic ,  Harald Danhamer

    IPC分类号： C12N5/02 ,  C12M3/00 ,  C12M1/24

    CPC分类号： C12M27/22 ,  B01F9/0016 ,  B01F9/0021 ,  B01F9/06 ,  C12M23/08 ,  C12M27/12 ,  C12M27/20

    摘要： An exemplary embodiment of a reversibly closable vessel suitable for the cultivation of cells and/or tissues can be provided. The exemplary vessel can comprise at least one reversibly closable aperture in the vessel wall, a convection arrangement inside the vessel which can comprise at least one blade. The arrangement can be configured to generate and/or modulate a convection in a fluid within the vessel when the vessel and/or the blade is agitated The convection arrangement and/or the blade can be at least particularly made from a porous material.

    摘要翻译： 可以提供适于培养细胞和/或组织的可逆封闭容器的示例性实施方案。 示例性容器可以包括容器壁中的至少一个可逆闭合的孔，该容器内的对流装置可包括至少一个叶片。 该装置可以被配置为当容器和/或叶片被搅动时，在容器内的流体中产生和/或调制对流。对流装置和/或叶片可以至少特别地由多孔材料制成。

    PARTIALLY BIOABSORBABLE IMPLANT
    29.
    发明申请
    PARTIALLY BIOABSORBABLE IMPLANT 审中-公开
    部分可生物植入

    公开(公告)号：US20080177378A1

    公开(公告)日：2008-07-24

    申请号：US12016835

    申请日：2008-01-18

    申请人： Soheil Asgari

    发明人： Soheil Asgari

    IPC分类号： A61F2/82 ,  A61F2/02

    CPC分类号： A61L27/427 ,  A61L27/54 ,  A61L27/58 ,  A61L31/124 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00

    摘要： An exemplary embodiment of the present invention provides an at least partially biodegradable medical implant having a plurality of in-vivo biodegradable organic polymer particles embedded in a matrix of a plurality of compressed metal-based particles. Methods for the manufacture thereof are also provided. The implant may preferably be further functionalized by inclusion of active ingredients such as therapeutically active agents or markers.

    摘要翻译： 本发明的示例性实施方案提供了至少部分可生物降解的医用植入物，其具有嵌入多个压缩金属基颗粒的基质中的多个体内可生物降解的有机聚合物颗粒。 还提供了制造方法。 植入物可以优选通过包含活性成分例如治疗活性剂或标记进一步官能化。

    THERMOSET PARTICLES AND METHODS FOR PRODUCTION THEREOF
    30.
    发明申请
    THERMOSET PARTICLES AND METHODS FOR PRODUCTION THEREOF 审中-公开
    热敏颗粒及其生产方法

    公开(公告)号：US20070088114A1

    公开(公告)日：2007-04-19

    申请号：US11550623

    申请日：2006-10-18

    申请人： Soheil Asgari

    发明人： Soheil Asgari

    IPC分类号： C08K3/22

    CPC分类号： A61L27/26 ,  A61K9/1664 ,  A61K9/1694 ,  A61L27/50 ,  B01J21/18 ,  B01J23/38 ,  B01J31/06 ,  B01J35/08 ,  C08J3/24 ,  C08K3/22 ,  D01D5/0007

    摘要： Thermoset-based particles and processes for the manufacture thereof can be provided, where the particles may have a spherical or fibrous shape. A reaction mixture can be provided that includes a thermosetting resin, a crosslinker, a surface active agent, and a solvent. The reaction mixture can be an emulsion, a suspension or a dispersion which may optionally be sprayed or electrospun. Crosslinking of the resin can be performed by addition of an initiator or by exposing the reaction mixture to heat and/or radiation to form polymerized particles. The particles may be dried, sintered, pyrolyzed or carbonized, and/or impregnated with an active agent.

    摘要翻译： 可以提供基于热固性的颗粒及其制造方法，其中颗粒可以具有球形或纤维形状。 可以提供包含热固性树脂，交联剂，表面活性剂和溶剂的反应混合物。 反应混合物可以是可以任选地喷雾或静电纺丝的乳液，悬浮液或分散体。 可以通过加入引发剂或通过将反应混合物暴露于加热和/或辐射以形成聚合的颗粒来进行树脂的交联。 颗粒可以被干燥，烧结，热解或碳化，和/或用活性剂浸渍。