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    Continuous methods for treating liquids and manufacturing certain constituents (e.g., nanoparticles) in liquds, apparatuses and nanoparticles and nanoparticle/liquid solution(s) resulting therefrom
    21.
    发明申请
    Continuous methods for treating liquids and manufacturing certain constituents (e.g., nanoparticles) in liquds, apparatuses and nanoparticles and nanoparticle/liquid solution(s) resulting therefrom 有权

    公开(公告)号：US20210052638A1

    公开(公告)日：2021-02-25

    申请号：US16501474

    申请日：2019-10-09

    申请人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

    发明人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

    IPC分类号： A61K33/30 ,  B01J19/08 ,  A61K9/51 ,  A61K33/38

    摘要： This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. The continuous process causes at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, zeta potential and properties present in a liquid.

    Continuous methods for treating liquids and manufacturing certain constituents (e.g., nanoparticles) in liquids, apparatuses and nanoparticles and nanoparticle/liquid solution(s) resulting therefrom
    22.
    发明授权
    Continuous methods for treating liquids and manufacturing certain constituents (e.g., nanoparticles) in liquids, apparatuses and nanoparticles and nanoparticle/liquid solution(s) resulting therefrom 有权

    公开(公告)号：US10441608B2

    公开(公告)日：2019-10-15

    申请号：US15199009

    申请日：2016-06-30

    申请人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

    发明人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

    IPC分类号： A61K33/30 ,  B01J19/08 ,  A61K9/51 ,  A61K33/38

    摘要： This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. The continuous process causes at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, zeta potential and properties present in a liquid.

    Continuous methods for treating liquids and manufacturing certain constituents (e.g., nanoparticles) in liquids, apparatuses and nanoparticles and nanoparticle/liquid solution(s) resulting therefrom
    24.
    发明授权
    Continuous methods for treating liquids and manufacturing certain constituents (e.g., nanoparticles) in liquids, apparatuses and nanoparticles and nanoparticle/liquid solution(s) resulting therefrom 有权
    用于处理液体并在液体，装置和纳米颗粒中制造某些组分（例如纳米颗粒）和由此产生的纳米颗粒/液体溶液的连续方法

    公开(公告)号：US09387452B2

    公开(公告)日：2016-07-12

    申请号：US14010721

    申请日：2013-08-27

    申请人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

    发明人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

    IPC分类号： B01J19/08

    CPC分类号： A61K33/30 ,  A61K9/5192 ,  A61K33/38 ,  B01J19/088 ,  B01J2219/0809 ,  B01J2219/0813 ,  B01J2219/0816 ,  B01J2219/082 ,  B01J2219/0822 ,  B01J2219/083 ,  B01J2219/0841 ,  B01J2219/0869 ,  B01J2219/0877 ,  B01J2219/0896

    摘要： This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. The continuous process causes at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, zeta potential and properties present in a liquid.

    摘要翻译： 本发明一般涉及用于连续制造纳米颗粒，微粒和纳米颗粒/液体溶液的新颖方法和新型装置。 纳米颗粒（和/或微米尺寸的颗粒）包含各种可能的组合物，尺寸和形状。 引起颗粒（例如，纳米颗粒）存在（例如，通过例如优选利用至少一种的方式在液体（例如水）中存在（例如，产生和/或将液体倾向于其存在（例如，调节）） 可调节的等离子体（例如，由至少一个AC和/或DC电源产生），其等离子体与液体的至少一部分表面连通。 至少一个后续和/或基本上同时可调节的电化学处理技术也是优选的。 多重可调等离子体和/或可调电化学处理技术是优选的。 连续过程使至少一种液体流入，通过和流出至少一个槽构件，这种液体在所述槽构件中被处理，调节和/或实现。 结果包括在液体中形成的成分，包括具有新颖尺寸，形状，组成，ζ电位和存在于液体中的性质的微米级颗粒和/或纳米颗粒（例如金属基纳米颗粒）。

    Continuous Methods for Treating Liquids and Manufacturing Certain Constituents (e.g., Nanoparticles) in Liquids, Apparatuses and Nanoparticles and Nanoparticle/Liquid Solution(s) Resulting Therefrom
    26.
    发明申请
    Continuous Methods for Treating Liquids and Manufacturing Certain Constituents (e.g., Nanoparticles) in Liquids, Apparatuses and Nanoparticles and Nanoparticle/Liquid Solution(s) Resulting Therefrom 有权
    用于处理液体和在液体，装置和纳米颗粒中制造某些成分（例如纳米颗粒）的连续方法和由此产生的纳米颗粒/液体溶液

    公开(公告)号：US20150064278A1

    公开(公告)日：2015-03-05

    申请号：US14010721

    申请日：2013-08-27

    申请人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

    发明人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

    IPC分类号： B01J19/08 ,  A61K33/30 ,  A61K9/51 ,  A61K33/38

    CPC分类号： A61K33/30 ,  A61K9/5192 ,  A61K33/38 ,  B01J19/088 ,  B01J2219/0809 ,  B01J2219/0813 ,  B01J2219/0816 ,  B01J2219/082 ,  B01J2219/0822 ,  B01J2219/083 ,  B01J2219/0841 ,  B01J2219/0869 ,  B01J2219/0877 ,  B01J2219/0896

    摘要： This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. The continuous process causes at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, zeta potential and properties present in a liquid.

    摘要翻译： 本发明一般涉及用于连续制造纳米颗粒，微粒和纳米颗粒/液体溶液的新颖方法和新型装置。 纳米颗粒（和/或微米尺寸的颗粒）包含各种可能的组合物，尺寸和形状。 引起颗粒（例如，纳米颗粒）存在（例如，通过例如优选利用至少一种的方式在液体（例如水）中存在（例如，产生和/或将液体倾向于其存在（例如，调节）） 可调节的等离子体（例如，由至少一个AC和/或DC电源产生），其等离子体与液体的至少一部分表面连通。 至少一个后续和/或基本上同时可调节的电化学处理技术也是优选的。 多重可调等离子体和/或可调电化学处理技术是优选的。 连续过程使至少一种液体流入，通过和流出至少一个槽构件，这种液体在所述槽构件中被处理，调节和/或实现。 结果包括在液体中形成的成分，包括具有新颖尺寸，形状，组成，ζ电位和存在于液体中的性质的微米级颗粒和/或纳米颗粒（例如金属基纳米颗粒）。

    Macrocomposite bodies and production methods
    27.
    发明授权
    Macrocomposite bodies and production methods 失效
    宏观复合体和生产方法

    公开(公告)号：US5501263A

    公开(公告)日：1996-03-26

    申请号：US976989

    申请日：1993-01-08

    申请人： Ratnesh K. Dwivedi ,  Kurt J. Becker ,  Danny R. White ,  Steven D. Keck ,  Mark G. Mortenson

    发明人： Ratnesh K. Dwivedi ,  Kurt J. Becker ,  Danny R. White ,  Steven D. Keck ,  Mark G. Mortenson

    IPC分类号： C04B35/622 ,  C04B35/65 ,  C22C1/10 ,  C22C47/00 ,  C22C47/08 ,  C22C47/12 ,  B22D19/14

    CPC分类号： C22C1/1036 ,  C04B35/652 ,  B22F2003/1014 ,  C22C2001/1063

    摘要： The present invention relates to a novel process for making a macrocomposite body. Specifically, a metal matrix composite body is first formed and thereafter, a ceramic body or a ceramic matrix composite body is caused to form from at least one surface of the already formed metal matrix composite body. The ceramic or ceramic composite body can be formed by, for example, changing from spontaneous infiltration conditions which permit a molten matrix metal to infiltrate a filler material or preform to conditions which favor the growth of a ceramic oxidation reaction product from the matrix metal (e.g., the matrix metal serves the dual role of a matrix metal and a parent metal for growth of oxidation reaction product). The growth of oxidation reaction product can occur from one or more surfaces of a metal matrix composite body and can be controlled to result in any desired shape. Moreover, the oxidation reaction product can be caused to grow directly into an atmosphere to form a ceramic body or can be caused to grow into an adjacently located filler material to form a ceramic matrix composite body. The oxidation reaction product can be formed substantially immediately after the metal matrix composite body is formed or may be formed at any point later in time.

    摘要翻译： 本发明涉及一种制造大复合体的新方法。 具体地说，首先形成金属基体复合体，然后从已经形成的金属基体复合体的至少一个表面形成陶瓷体或陶瓷基复合体。 陶瓷或陶瓷复合体可以通过例如从自发渗透条件形成，这允许熔融基质金属渗透填料或预成型体以有利于从基体金属生长陶瓷氧化反应产物的条件（例如， ，基质金属起着基质金属和母体金属作为氧化反应产物生长的双重作用）。 氧化反应产物的生长可以从金属基质复合体的一个或多个表面发生，并且可以被控制以产生任何所需的形状。 此外，可以使氧化反应产物直接生长到大气中以形成陶瓷体，或者可以使其生长成相邻的填料，形成陶瓷基复合体。 氧化反应产物可以在形成金属基质复合体之后基本上立即形成，或者可以在任何时间点形成。

    Gold-platinum based bi-metallic nanocrystal suspensions, electrochemical manufacturing processes therefor and uses for the same
    29.
    发明授权
    Gold-platinum based bi-metallic nanocrystal suspensions, electrochemical manufacturing processes therefor and uses for the same 有权
    金 - 铂金属双金属纳米晶体悬浮液，其电化学制造工艺及其用途

    公开(公告)号：US09387225B2

    公开(公告)日：2016-07-12

    申请号：US14008931

    申请日：2012-03-30

    申请人： Adam R. Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliakov ,  Mark G. Mortenson

    发明人： Adam R. Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliakov ,  Mark G. Mortenson

    IPC分类号： A61K33/24 ,  A61K9/14 ,  C22C1/04 ,  C22C5/02 ,  C22C5/04 ,  C22C30/00 ,  A61K9/10

    CPC分类号： A61K33/24 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1611 ,  B82Y5/00 ,  C22C1/0466 ,  C22C5/02 ,  C22C5/04 ,  C22C30/00

    摘要： The present invention relates to novel gold-platinum based bi-metallic nanocrystal suspensions that have nanocrystal surfaces that are substantially free from organic or other impurities or films associated with typical chemical reductants/stabilizers and/or raw materials used in nanoparticle formation processes. Specifically, the surfaces are “clean” relative to the surfaces of metal-based nanoparticles made using chemical reduction (and other) processes that require organic (or other) reductants and/or surfactants to grow (and/or suspend) metal nanoparticles from metal ions in a solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension. The invention further includes pharmaceutical compositions thereof and the use of the bi-metallic nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which metal-based therapy is already known, including, for example, for cancerous diseases or conditions.

    摘要翻译： 本发明涉及具有纳米晶体表面的新型金 - 铂基双金属纳米晶体悬浮液，其基本上不含与用于纳米颗粒形成过程中的典型化学还原剂/稳定剂和/或原料相关的有机或其它杂质或膜。 具体地说，相对于使用需要有机（或其它）还原剂和/或表面活性剂从金属生长（和/或悬浮）金属纳米粒子的化学还原（和其它）方法制备的金属基纳米颗粒的表面，表面“干净” 离子在溶液中。 本发明包括用于制备双金属纳米晶体悬浮液的新型电化学制造装置和技术。 这些技术不需要使用或存在氯离子/原子和/或氯化物或氯基材料用于制造过程/最终悬浮液。 本发明还包括其药物组合物，以及双金属纳米晶体或其悬浮液或胶体在治疗或预防金属基治疗已知的疾病或病症中的应用，包括例如癌性疾病或病症 。

    Continuous Methods for Treating Liquids and Manufacturing Certain Constituents (e.g., Nanoparticles) in Liquids, Apparatuses and Nanoparticles and Nanoparticle /Liquid Solution(s) Therefrom
    30.
    发明申请
    Continuous Methods for Treating Liquids and Manufacturing Certain Constituents (e.g., Nanoparticles) in Liquids, Apparatuses and Nanoparticles and Nanoparticle /Liquid Solution(s) Therefrom 有权
    用于处理液体和在液体，装置和纳米颗粒中制备某些成分（例如纳米颗粒）和纳米颗粒/液体溶液的连续方法

    公开(公告)号：US20100187091A1

    公开(公告)日：2010-07-29

    申请号：US12686815

    申请日：2010-01-13

    申请人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

    发明人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

    IPC分类号： B22F9/16 ,  H05H1/24 ,  B01J19/08

    CPC分类号： H05H1/48 ,  B01J19/088 ,  B01J2219/0004 ,  B01J2219/0809 ,  B01J2219/0813 ,  B01J2219/082 ,  B01J2219/083 ,  B01J2219/0841 ,  B01J2219/0869 ,  B01J2219/0871 ,  B01J2219/0877 ,  B22F9/20 ,  B22F2999/00 ,  B82Y30/00 ,  B82Y40/00 ,  B22F2202/06 ,  B22F2202/13

    摘要： This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. The continuous process causes at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, zeta potential and properties present in a liquid.

    摘要翻译： 本发明一般涉及用于连续制造纳米颗粒，微粒和纳米颗粒/液体溶液的新颖方法和新型装置。 纳米颗粒（和/或微米尺寸的颗粒）包含各种可能的组合物，尺寸和形状。 引起颗粒（例如，纳米颗粒）存在（例如，通过例如优选利用至少一种的方式在液体（例如水）中存在（例如，产生和/或将液体倾向于其存在（例如，调节）） 可调节的等离子体（例如，由至少一个AC和/或DC电源产生），其等离子体与液体的至少一部分表面连通。 至少一个后续和/或基本上同时可调节的电化学处理技术也是优选的。 多重可调等离子体和/或可调电化学处理技术是优选的。 连续过程使至少一种液体流入，通过和流出至少一个槽构件，这种液体在所述槽构件中被处理，调节和/或实现。 结果包括在液体中形成的成分，包括具有新颖尺寸，形状，组成，ζ电位和存在于液体中的性质的微米级颗粒和/或纳米颗粒（例如金属基纳米颗粒）。