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公开(公告)号：US20070163366A1
公开(公告)日：2007-07-19
申请号：US11484068
申请日：2006-07-11
申请人： Sung-young Jeong , Hun-joo Lee
发明人： Sung-young Jeong , Hun-joo Lee
IPC分类号： G01N1/00
摘要： Provided are a device and a method for pre-treating and injecting a liquid specimen. The device includes a first syringe comprising: a first tube having an open top and a first hole in the bottom; and protrusions formed in a lower and outer wall of the first tube; a second syringe comprising: a second tube having an open top and a second hole in the bottom and having an inner diameter greater than an outer diameter of the first tube; a second piston capable of moving along an inner wall of the second tube and having a third hole; and a communication channel providing a fluid communication between the first hole of the first tube and the third hole of the second piston and fixing the second piston to the first tube; and a joint portion being attachable to and detachable from a top of the second tube and having an opening having a shape which corresponds to a transverse cross-section of the first tube and grooves having a shape which corresponds to the shape of the protrusions such that the first tube can pass through the joint portion when the protrusions are matched with the grooves.
摘要翻译： 提供了用于预处理和注射液体样本的装置和方法。 该装置包括第一注射器，其包括：第一管，其具有开口顶部和底部中的第一孔; 以及形成在所述第一管的下壁和外壁中的突起; 第二注射器，包括：第二管，其在底部具有开口顶部和第二孔，并且具有大于第一管的外径的内径; 第二活塞，其能够沿着所述第二管的内壁移动并具有第三孔; 以及连通通道，其在所述第一管的所述第一孔和所述第二活塞的所述第三孔之间提供流体连通并将所述第二活塞固定到所述第一管; 以及接合部，其可连接到所述第二管的顶部并且可从所述第二管的顶部拆卸，并具有具有对应于所述第一管的横截面的形状的开口和具有对应于所述突起的形状的形状的开口，使得 当突起与槽匹配时，第一管可以穿过接合部。
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22.发明申请HNF-1alpha gene including novel single-nucleotide polymorphism, protein encoded by the HNF-1alpha gene, and polynucleotide, microarray, kit, and method for diagnosis of MODY3 失效HNF-1α基因包括新型单核苷酸多态性，HNF-1alpha基因编码的蛋白质，多核苷酸，微阵列，试剂盒和MODY3诊断方法公开(公告)号：US20050181406A1
公开(公告)日：2005-08-18
申请号：US11049806
申请日：2005-02-03
申请人： Sung-young Jeong , Jin-soon Hwang
发明人： Sung-young Jeong , Jin-soon Hwang
CPC分类号： C07H21/04 , C07K14/4702 , C12Q1/6883 , C12Q2600/156
摘要： Provided are a HNF-1 α gene including a novel single-nucleotide polymorphism and a protein encoded by the HNF-1 α gene, a polynucleotide associated with MODY3 diabetes based on the HNF-1 α gene, a microarray and a diagnostic kit including the polynucleotide, and a method for diagnosis of MODY3 diabetes.
摘要翻译： 提供了包括新型单核苷酸多态性和由HNF-1α基因编码的蛋白质的HNF-1α基因，与基于HNF-1α基因的MODY3糖尿病相关的多核苷酸，微阵列和包括 多核苷酸，以及MODY3糖尿病诊断方法。
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23.发明授权Microfluidic device and method for concentration and lysis of cells or viruses 有权用于细胞或病毒浓缩和溶解的微流控装置和方法公开(公告)号：US08252569B2
公开(公告)日：2012-08-28
申请号：US13034857
申请日：2011-02-25
申请人： Yoon-kyoung Cho , Jeong-gun Lee , Sung-young Jeong
发明人： Yoon-kyoung Cho , Jeong-gun Lee , Sung-young Jeong
CPC分类号： B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L2200/10 , B01L2300/1861 , B01L2400/0421 , B01L2400/0424 , B01L2400/043 , B01L2400/0439 , C12M47/02 , C12M47/04 , C12M47/06 , Y10T436/25 , Y10T436/2575
摘要： A microfluidic device for the concentration and lysis of cells or viruses and a method of concentrating and lysing cells or viruses using the microfluidic device include: magnetic beads, a reaction chamber in which the magnetic beads are accommodated and a laser source. The reaction chamber includes a plurality of electrodes which cross each other and are separated by a dielectric to generate an electric field and a vibrating part agitating the magnetic beads in the chamber. The laser source radiates a laser onto the magnetic beads in the reaction chamber.
摘要翻译： 用于细胞或病毒的浓缩和裂解的微流体装置以及使用微流体装置浓缩和裂解细胞或病毒的方法包括：磁珠，容纳磁珠的反应室和激光源。 反应室包括彼此交叉并被电介质隔开以产生电场的多个电极以及搅拌室中的磁珠的振动部分。 激光源将激光辐射到反应室中的磁珠上。
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24.发明授权Microfluidic device and method for concentration and lysis of cells or viruses 有权用于细胞或病毒浓缩和溶解的微流控装置和方法公开(公告)号：US07959862B2
公开(公告)日：2011-06-14
申请号：US11610938
申请日：2006-12-14
申请人： Yoon-kyoung Cho , Jeong-gun Lee , Sung-young Jeong
发明人： Yoon-kyoung Cho , Jeong-gun Lee , Sung-young Jeong
IPC分类号： G01N15/06
CPC分类号： B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L2200/10 , B01L2300/1861 , B01L2400/0421 , B01L2400/0424 , B01L2400/043 , B01L2400/0439 , C12M47/02 , C12M47/04 , C12M47/06 , Y10T436/25 , Y10T436/2575
摘要： A microfluidic device for the concentration and lysis of cells or viruses and a method of concentrating and lysing cells or viruses using the microfluidic device include: magnetic beads, a reaction chamber in which the magnetic beads are accommodated and a laser source. The reaction chamber includes a plurality of electrodes which cross each other and are separated by a dielectric to generate an electric field and a vibrating part agitating the magnetic beads in the chamber. The laser source radiates a laser onto the magnetic beads in the reaction chamber.
摘要翻译： 用于细胞或病毒的浓缩和裂解的微流体装置以及使用微流体装置浓缩和裂解细胞或病毒的方法包括：磁珠，容纳磁珠的反应室和激光源。 反应室包括彼此交叉并被电介质隔开以产生电场的多个电极以及搅拌室中的磁珠的振动部分。 激光源将激光辐射到反应室中的磁珠上。
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公开(公告)号：US07838036B2
公开(公告)日：2010-11-23
申请号：US12716695
申请日：2010-03-03
申请人： Chang-eun Yoo , Sung-young Jeong , Young-rok Kim
发明人： Chang-eun Yoo , Sung-young Jeong , Young-rok Kim
CPC分类号： B01J20/28009 , B01D15/1807 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/327 , C08F20/02 , C08F26/06 , C12N1/066 , C12N13/00
摘要： Provided is a method of isolating nucleic acid from cells using a single surface, wherein a compound represented by Formula 1 is bound to the surface. Also provided are an apparatus for isolation of nucleic acids, and a bead for isolating nucleic acids.
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公开(公告)号：US20060246473A1
公开(公告)日：2006-11-02
申请号：US11317601
申请日：2005-12-23
申请人： Ji-young Oh , Nam Huh , Sang-hyun Peak , Sung-young Jeong
发明人： Ji-young Oh , Nam Huh , Sang-hyun Peak , Sung-young Jeong
CPC分类号： C12Q1/689
摘要： Provided are a primer set for amplifying a target sequence specific to Bordetella pertussis, Chlamydophila pneumoniae, Haemophilus influenzae, Klebsiella pneumoniae, Legionella pneumophila, Moraxella catarrhalis, Mycoplasma pneumoniae, Pseudomonas aeruginosa, Stapylococcus aureus, and Streptococcus pneumoniae, the primer set including at least one oligonucleotide of 10 to 100 nucleotides in length, selected from the group consisting of oligonucleotides each of which comprises a fragment of at least 10 contiguous nucleotides present in a sequence as set forth in SEQ ID NO: 1 and at least one oligonucleotides of 10 to 100 nucleotides in length, selected from the group consisting of oligonucleotides each of which comprises a fragment of at least 10 contiguous nucleotides present in a sequence as set forth in SEQ ID NO: 2; and probes specific to a specific species of the 10 bacterial species.
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公开(公告)号：US08546544B2
公开(公告)日：2013-10-01
申请号：US12807191
申请日：2010-08-30
CPC分类号： G01N33/57407 , C07K16/2863 , C07K2317/33 , G01N33/57492
摘要： Antibodies specifically binding to c-Met protein, hybridoma cell lines, and compositions comprising the antibodies are disclosed herein. Methods of making and using the antibodies and compositions are also disclosed.
摘要翻译： 本文公开了与c-Met蛋白，杂交瘤细胞系以及包含抗体的组合特异性结合的抗体。 还公开了制备和使用抗体和组合物的方法。
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公开(公告)号：US08481689B2
公开(公告)日：2013-07-09
申请号：US12807191
申请日：2010-08-30
摘要： Antibodies specifically binding to c-Met protein, hybridoma cell lines, and compositions comprising the antibodies are disclosed herein. Methods of making and using the antibodies and compositions are also disclosed.
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29.发明授权Method and apparatus for isolating and purifying nucleic acid using a single surface 有权使用单个表面分离和纯化核酸的方法和设备公开(公告)号：US07718371B2
公开(公告)日：2010-05-18
申请号：US11693259
申请日：2007-03-29
申请人： Chang eun Yoo , Sung-young Jeong , Young-rok Kim
发明人： Chang eun Yoo , Sung-young Jeong , Young-rok Kim
CPC分类号： B01J20/28009 , B01D15/1807 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/327 , C08F20/02 , C08F26/06 , C12N1/066 , C12N13/00
摘要： Provided is a method of isolating nucleic acid from cells using a single surface, wherein a compound represented by Formula 1 is bound to the surface. Also provided are an apparatus for isolation of nucleic acids, and a bead for isolating nucleic acids.
摘要翻译： 提供了使用单个表面从细胞中分离核酸的方法，其中由式1表示的化合物结合到表面。 还提供了用于分离核酸的装置和用于分离核酸的珠粒。
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30.发明申请Multiplex PCR primer set for amplifying human MODY genes 1,4,5,6 and 7 审中-公开用于扩增人MODY基因1,4,5,6和7的多重PCR引物组公开(公告)号：US20050003418A1
公开(公告)日：2005-01-06
申请号：US10871302
申请日：2004-06-19
申请人： Mi-kyung Kim , Hyo-jeong Han , Soo-jung Kim , Sung-young Jeong , Kui-hyun Kim , Jung-nam Lee , Yoon-jung Choi
发明人： Mi-kyung Kim , Hyo-jeong Han , Soo-jung Kim , Sung-young Jeong , Kui-hyun Kim , Jung-nam Lee , Yoon-jung Choi
CPC分类号： C12Q1/6883 , C07H21/04 , C12Q2600/156 , C12Q2600/16
摘要： A primer pool including at least two sets of primers for amplifying at least two target sequences of human MODY gene 1, 4, 5, 6, or 7, the at least two sets of primers being selected from the group consisting of sets of primers, each set including an oligonucleotide having one of SEQ ID NOS. 1 through 32, 41 and 42 and its variant oligonucleotide.
摘要翻译： 一种引物库，其包含至少两组用于扩增人MODY基因1,4,5,6或7的至少两个靶序列的引物，所述至少两组引物选自引物组， 每组包含具有SEQ ID NOS之一的寡核苷酸。 1至32,41和42及其变体寡核苷酸。
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