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31 条记录 (耗时 0.036 秒)

    Very low temperature casting of controlled release microspheres
    23.
    发明授权
    Very low temperature casting of controlled release microspheres 失效
    控释微球的极低温铸造

    公开(公告)号：US5019400A

    公开(公告)日：1991-05-28

    申请号：US346143

    申请日：1989-05-01

    申请人： Wayne R. Gombotz ,  Michael S. Healy ,  Larry R. Brown

    发明人： Wayne R. Gombotz ,  Michael S. Healy ,  Larry R. Brown

    IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/58 ,  A61K47/32 ,  A61K47/34 ,  B01J2/06 ,  F26B3/12 ,  F26B5/00 ,  F26B5/06 ,  F26B7/00

    CPC分类号： F26B7/00 ,  A61K9/1694 ,  F26B3/12 ,  F26B5/00 ,  Y10T428/2989

    摘要： A process for preparing microspheres using very cold temperatures to freeze polymer-biologically active agent mixtures into polymeric microspheres with very high retention of biological activity and material. Polymer is dissolved in a solvent together with an active agent that can be either dissolved in the solvent or dispersed in the solvent in the form of microparticles. The polymer/active agent mixture is atomized into a vessel containing a liquid non-solvent, alone or frozen and overlayed with a liquified gas, at a temperature below the freezing point of the polymer/active agent solution. The cold liquified gas or liquid immediately freezes the polymer droplets. As the droplets and non-solvent for the polymer is warmed, the solvent in the droplets thaws and is extracted into the non-solvent, resulting in hardened microspheres.

    摘要翻译： 使用非常低的温度制备微球以将聚合物 - 生物活性剂混合物冷冻成具有非常高的保留生物活性和材料的聚合物微球体的方法。 将聚合物与可以溶解在溶剂中或以微粒形式分散在溶剂中的活性剂一起溶解在溶剂中。 在低于聚合物/活性剂溶液的凝固点的温度下，将聚合物/活性剂混合物雾化成含有液体非溶剂的容器，单独或冷冻并用液化气覆盖。 冷液化气体或液体立即冻结聚合物液滴。 当聚合物的液滴和非溶剂被加热时，液滴中的溶剂解冻并被萃取到非溶剂中，导致硬化的微球体。

    Business method to treat and/or prevent a gastric acid disorder with a proton pump inhibitor (PPI) and a cholinergic agonist to induce rapid onset of PPI action with or without food
    25.
    发明申请
    Business method to treat and/or prevent a gastric acid disorder with a proton pump inhibitor (PPI) and a cholinergic agonist to induce rapid onset of PPI action with or without food 审中-公开

    公开(公告)号：US20080214619A1

    公开(公告)日：2008-09-04

    申请号：US11830787

    申请日：2007-07-30

    申请人： M. Michael Wolfe ,  Larry R. Brown ,  Peter J. Manso

    发明人： M. Michael Wolfe ,  Larry R. Brown ,  Peter J. Manso

    IPC分类号： A61K31/435 ,  A61K31/27 ,  A61K31/4178 ,  A61P43/00

    CPC分类号： G06Q10/00 ,  G06Q50/22

    摘要： Pharmaceutical proton pump inhibitor (PPI) medications and methods are disclosed for preventing and/or treating gastrointestinal disorders characterized by abnormalities in gastric acid secretion at anytime of the day or night without the need for food effect or to be taken with food. The medications comprise a PPI and a cholinergic agonist for inducing rapid onset of PPI action, for increasing the duration of PPI efficacy and for optimizing clinical PPI effectiveness that may be administered at any time of the day or night without food or on an empty stomach, and possibly on an as-needed or on demand basis. In carrying out the methods, a PPI and cholinergic agonist may be administered together as a single unitary dose in the form of a liquid or solid, or administered together, but separately as either liquids or solids or a combination thereof. Preferably, an oral solid dosage form of the present invention allows for release of a proton pump inhibitor at a pH of about 5 or higher, e.g., pH about 5.5, 6, 6.5 or 7, followed by release of a cholinergic agonist within between about 10 minutes and about 60 minutes, preferably within about 15 minutes and about 30 minutes, after release of the proton pump inhibitor from the dosage form, so that it can be administered at any time of the day or night independent of food or food effect. It is believed that the methods and compositions of the present invention will increase the duration of PPI efficacy by between at least about 5 fold and about 10 fold or even about 20 fold, as compared to the duration of PPI efficacy derived from current PPI dosage forms administered alone and without food or a food effect. Kits comprising a PPI, a cholinergic agonist and optionally an antacid are disclosed, such as kits containing each drug in conventional and commercially available dry or liquid dosage forms for simultaneous or concomitant administration or in dry dosage forms to provide for the easy preparation of a liquid composition from the dry dosage forms. These new medications and methods will simplify the traditional continuous PPI regimen and improve patient compliance.

    Flexible heating cover assembly for thermal cycling of samples of biological material
    26.
    发明授权
    Flexible heating cover assembly for thermal cycling of samples of biological material 有权
    用于生物材料样品热循环的柔性加热盖组件

    公开(公告)号：US06730883B2

    公开(公告)日：2004-05-04

    申请号：US10262994

    申请日：2002-10-02

    申请人： Larry R. Brown ,  William D. Brumley ,  Kenneth J. Zajac

    发明人： Larry R. Brown ,  William D. Brumley ,  Kenneth J. Zajac

    IPC分类号： C12M100

    CPC分类号： B01L3/50851 ,  B01L3/50853 ,  B01L7/52 ,  B01L7/54 ,  B01L2300/046 ,  B01L2300/0829 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1844

    摘要： A flexible heating cover assembly for an apparatus for heating samples of biological material with substantial temperature uniformity includes a housing having a plurality of engageable enclosure components; a resistive heater having a plurality of heater element areas; a heater backing plate providing stability to the resistive heater; a force distribution system that distributes a force over the heater backing plate; and a support plate providing stiffness for the force distribution system, wherein the arrangement of the resistive heater, the heater backing plate, the force distribution system and the support plate provide substantial temperature uniformity among a plurality of sample tubes for receiving samples of biological material. The flexible heating cover assembly improves the uniformity, efficiency, quality, reliability and controllability of the thermal response during thermal cycling of the biological material.

    摘要翻译： 一种用于加热具有显着温度均匀性的生物材料样品的装置的柔性加热盖组件包括具有多个可接合外壳部件的壳体; 电阻加热器，具有多个加热元件区域; 加热器背板，为电阻加热器提供稳定性; 力分配系统，其在加热器背板上分布力; 以及为力分配系统提供刚度的支撑板，其中电阻加热器，加热器背板，力分配系统和支撑板的布置在用于接收生物材料样品的多个样品管之间提供显着的温度均匀性。 柔性加热盖组件改善了生物材料热循环期间的热响应的均匀性，效率，质量，可靠性和可控性。

    Process for producing small particles of biologically active molecules
    27.
    发明授权
    Process for producing small particles of biologically active molecules 失效
    用于生产生物活性分子的小颗粒的方法

    公开(公告)号：US06569458B1

    公开(公告)日：2003-05-27

    申请号：US08006682

    申请日：1993-01-21

    申请人： Wayne R. Gombotz ,  Michael S. Healy ,  Larry R. Brown ,  Henry E. Auer

    发明人： Wayne R. Gombotz ,  Michael S. Healy ,  Larry R. Brown ,  Henry E. Auer

    IPC分类号： A61K916

    CPC分类号： A61K9/1694 ,  A61K9/1688

    摘要： Small diameter particles of biologically active molecules are produced by atomizing solutions of the molecules through a nozzle into very cold liquified gases, which immediately freeze the atomized droplets. The resulting frozen particles having diameters of approximately 10 to 90 micrometers are lyophilized to produce porous particles, suspended in a non-solvent for the molecules, and exposed to ultrasonic energy or homogenization to produce particles having diameters of 0.1 to 10 micrometers with greater than 70 to 95% of the initial biological activity of the molecules in solution.

    摘要翻译： 生物活性分子的小直径颗粒通过将分子的溶液通过喷嘴雾化成非常冷的液化气体而产生，其立即冷冻雾化的液滴。 将所得直径约为10至90微米的冷冻颗粒冻干以产生悬浮于分子的非溶剂中的多孔颗粒，并暴露于超声波能量或均化，以产生直径为0.1至10微米的颗粒，大于70 至溶液中分子的初始生物活性的95％。

    Non-invasive transdermal detection of analytes
    28.
    发明授权
    Non-invasive transdermal detection of analytes 失效
    非侵入性透皮检测分析物

    公开(公告)号：US06492180B2

    公开(公告)日：2002-12-10

    申请号：US09339147

    申请日：1999-06-24

    申请人： Larry R. Brown ,  Elazer Edelman ,  David Tseng

    发明人： Larry R. Brown ,  Elazer Edelman ,  David Tseng

    IPC分类号： G01N3320

    CPC分类号： G01N33/84 ,  A61B2010/0009 ,  G01N33/52 ,  G01N33/94

    摘要： A method and apparatus for non-invasive extraction and/or detection of chemicals such as heavy metals, drugs such as cocaine and analytes such as blood glucose has been developed. A patch or hydrogel containing a reagent such as N-methyl pyrrole, or a similar compound, is used to extract the chemical or analyte to be measured through the skin or hair. This method is most useful for detecting analytes which are generally present in relatively constant blood concentrations. The method is particularly useful for the detection of heavy metals such as lead, lithium, copper, iron, and has been demonstrated to be useful with drugs such as cocaine and acetominaphen, and metabolic analytes like blood glucose. In the preferred embodiment, the method involves the use of the water miscible solvent N-methyl pyrrolidone (NMP) in an aqueous solution which is incorporated into an adsorbent pad or hydrogel. This adsorbent pad is placed on the skin for a defined time period, removed and then analyzed for the substance of interest. An analytical method can also be incorporated as part of the adsorbent pad in order to conduct both the extraction of the chemical of interest and the assay in situ. Examples demonstrating the very broad range of materials which can be extracted. Comparative examples demonstrate that the same results cannot be obtained using other reagents such as dimethylsulfoxide (DMSO).

    摘要翻译： 已经开发了用于非侵入性提取和/或检测诸如重金属，药物如可卡因和分析物如血糖的方法和装置。 使用含有诸如N-甲基吡咯或类似化合物的试剂的贴剂或水凝胶通过皮肤或毛发提取要测量的化学物质或分析物。 该方法对于通常以相对恒定的血液浓度存在的分析物最有用。 该方法对于重金属如铅，锂，铜，铁等的检测特别有用，并已被证明可用于可卡因和醋胺苯甲酸等药物和代谢分析物如血糖。 在优选的实施方案中，该方法包括在掺入吸附垫或水凝胶的水溶液中使用水混溶性N-甲基吡咯烷酮（NMP）。 将该吸附垫放置在皮肤上一段规定的时间内，然后移除，然后分析感兴趣的物质。 也可以将分析方法作为吸附垫的一部分，以便进行目的化学物质的提取和原位检测。 证明可以提取的材料范围非常广泛的例子。 比较例证明，使用其它试剂如二甲基亚砜（DMSO）不能得到相同的结果。

    Sustained release animal repellents
    30.
    发明授权
    Sustained release animal repellents 失效
    持续释放动物驱避剂

    公开(公告)号：US06395290B2

    公开(公告)日：2002-05-28

    申请号：US09130677

    申请日：1998-08-06

    申请人： Larry R. Brown

    发明人： Larry R. Brown

    IPC分类号： A01N2510

    CPC分类号： A01N35/02 ,  A01N25/18 ,  A01N63/02 ,  Y10S514/92 ,  A01N25/10 ,  A01N2300/00

    摘要： Compositions and methods for repelling an animal from an area or object are described. The compositions include an animal repellent dissolved or dispersed in a polymer where the repellent is released from the polymer over a period of time in an amount effective to repel an animal from the area. Capture of the repellent in the polymeric matrix allows for concentration of the repellent in an easily movable or removable device. Moreover, the repellent is not diluted by contact with water. The composition is provided in a usable form as a film, a sheet, a shaped article, pellets, or microparticles. The method for repelling an animal from an area or object includes preparing a device incorporating the above compositions and placing the device in an area or near or on an object desired to be protected. The devices can be manufactured by solvent evaporation, solvent removal, coextrusion, spray drying, and hot melt encapsulation. In a preferred embodiment the polymer is ethylene vinyl acetate copolymer and the repellent is methyl nonyl ketone or animal predator urine.

    摘要翻译： 描述了从区域或物体排斥动物的组合物和方法。 组合物包括溶解或分散在聚合物中的动物驱避剂，其中驱避剂在一段时间内从聚合物中释放，其量有效地从该区域排斥动物。 在聚合物基质中捕获驱避剂允许将驱避剂浓缩在易于移动或可移除的装置中。 此外，驱避剂不会与水接触而稀释。 该组合物以可用的形式提供为膜，片，成形制品，丸粒或微粒。 用于从区域或对象排斥动物的方法包括制备包含上述组合物的装置并将该装置放置在期望保护的物体的一个区域中或附近或之上。 这些装置可以通过溶剂蒸发，溶剂去除，共挤出，喷雾干燥和热熔胶封来制造。 在优选的实施方案中，聚合物是乙烯乙酸乙烯酯共聚物，驱避剂是甲基壬基酮或动物捕食者尿。