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    Process for producing small particles of biologically active molecules
    1.
    发明授权
    Process for producing small particles of biologically active molecules 失效
    用于生产生物活性分子的小颗粒的方法

    公开(公告)号：US06569458B1

    公开(公告)日：2003-05-27

    申请号：US08006682

    申请日：1993-01-21

    申请人： Wayne R. Gombotz ,  Michael S. Healy ,  Larry R. Brown ,  Henry E. Auer

    发明人： Wayne R. Gombotz ,  Michael S. Healy ,  Larry R. Brown ,  Henry E. Auer

    IPC分类号： A61K916

    CPC分类号： A61K9/1694 ,  A61K9/1688

    摘要： Small diameter particles of biologically active molecules are produced by atomizing solutions of the molecules through a nozzle into very cold liquified gases, which immediately freeze the atomized droplets. The resulting frozen particles having diameters of approximately 10 to 90 micrometers are lyophilized to produce porous particles, suspended in a non-solvent for the molecules, and exposed to ultrasonic energy or homogenization to produce particles having diameters of 0.1 to 10 micrometers with greater than 70 to 95% of the initial biological activity of the molecules in solution.

    摘要翻译： 生物活性分子的小直径颗粒通过将分子的溶液通过喷嘴雾化成非常冷的液化气体而产生，其立即冷冻雾化的液滴。 将所得直径约为10至90微米的冷冻颗粒冻干以产生悬浮于分子的非溶剂中的多孔颗粒，并暴露于超声波能量或均化，以产生直径为0.1至10微米的颗粒，大于70 至溶液中分子的初始生物活性的95％。

    Very low temperature casting of controlled release microspheres
    2.
    发明授权
    Very low temperature casting of controlled release microspheres 失效
    控释微球的极低温铸造

    公开(公告)号：US5019400A

    公开(公告)日：1991-05-28

    申请号：US346143

    申请日：1989-05-01

    申请人： Wayne R. Gombotz ,  Michael S. Healy ,  Larry R. Brown

    发明人： Wayne R. Gombotz ,  Michael S. Healy ,  Larry R. Brown

    IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/58 ,  A61K47/32 ,  A61K47/34 ,  B01J2/06 ,  F26B3/12 ,  F26B5/00 ,  F26B5/06 ,  F26B7/00

    CPC分类号： F26B7/00 ,  A61K9/1694 ,  F26B3/12 ,  F26B5/00 ,  Y10T428/2989

    摘要： A process for preparing microspheres using very cold temperatures to freeze polymer-biologically active agent mixtures into polymeric microspheres with very high retention of biological activity and material. Polymer is dissolved in a solvent together with an active agent that can be either dissolved in the solvent or dispersed in the solvent in the form of microparticles. The polymer/active agent mixture is atomized into a vessel containing a liquid non-solvent, alone or frozen and overlayed with a liquified gas, at a temperature below the freezing point of the polymer/active agent solution. The cold liquified gas or liquid immediately freezes the polymer droplets. As the droplets and non-solvent for the polymer is warmed, the solvent in the droplets thaws and is extracted into the non-solvent, resulting in hardened microspheres.

    摘要翻译： 使用非常低的温度制备微球以将聚合物 - 生物活性剂混合物冷冻成具有非常高的保留生物活性和材料的聚合物微球体的方法。 将聚合物与可以溶解在溶剂中或以微粒形式分散在溶剂中的活性剂一起溶解在溶剂中。 在低于聚合物/活性剂溶液的凝固点的温度下，将聚合物/活性剂混合物雾化成含有液体非溶剂的容器，单独或冷冻并用液化气覆盖。 冷液化气体或液体立即冻结聚合物液滴。 当聚合物的液滴和非溶剂被加热时，液滴中的溶剂解冻并被萃取到非溶剂中，导致硬化的微球体。

    Method and apparatus for cover assembly for thermal cycling of samples
    5.
    发明授权
    Method and apparatus for cover assembly for thermal cycling of samples 有权
    用于样品热循环的盖组件的方法和装置

    公开(公告)号：US07081600B2

    公开(公告)日：2006-07-25

    申请号：US11103059

    申请日：2005-04-11

    申请人： Larry R. Brown ,  William D. Brumley ,  Kenneth J. Zajac

    发明人： Larry R. Brown ,  William D. Brumley ,  Kenneth J. Zajac

    IPC分类号： B01L7/00 ,  H05B3/20 ,  H05B3/34

    CPC分类号： B01L3/50851 ,  B01L3/50853 ,  B01L7/52 ,  B01L7/54 ,  B01L2300/046 ,  B01L2300/0829 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1844

    摘要： A flexible heating cover assembly for an apparatus for heating samples of biological material with substantial temperature uniformity includes a housing having a plurality of engageable enclosure components; a resistive heater having a plurality of heater element areas; a heater backing plate providing stability to the resistive heater; a force distribution system that distributes a force over the heater backing plate; and a support plate providing stiffness for the force distribution system, wherein the arrangement of the resistive heater, the heater backing plate, the force distribution system and the support plate provide substantial temperature uniformity among a plurality of sample tubes for receiving samples of biological material. The flexible heating cover assembly improves the uniformity, efficiency, quality, reliability and controllability of the thermal response during thermal cycling of the biological material.

    摘要翻译： 一种用于加热具有显着温度均匀性的生物材料样品的装置的柔性加热盖组件包括具有多个可接合外壳部件的壳体; 电阻加热器，具有多个加热元件区域; 加热器背板，为电阻加热器提供稳定性; 力分配系统，其在加热器背板上分布力; 以及为力分配系统提供刚度的支撑板，其中电阻加热器，加热器背板，力分配系统和支撑板的布置在用于接收生物材料样品的多个样品管之间提供显着的温度均匀性。 柔性加热盖组件改善了生物材料热循环期间的热响应的均匀性，效率，质量，可靠性和可控性。