公开(公告)号：US08718957B2

公开(公告)日：2014-05-06

申请号：US12988146

申请日：2009-04-16

申请人： Martin Furmanski ,  Anders Roslund ,  Bo Olde ,  Kristian Solem

发明人： Martin Furmanski ,  Anders Roslund ,  Bo Olde ,  Kristian Solem

IPC分类号： G01F17/00

CPC分类号： G01M3/2815 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M5/16859 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2230/06

摘要： A device is provided for monitoring the integrity of a flow circuit in fluid communication with a receptacle. The flow circuit includes a pumping device for transferring fluid through the flow circuit. The device operates according to a monitoring method in which a pressure signal is received from a pressure sensor, the pressure signal being indicative of fluid pressure in the receptacle or the flow circuit. The pressure signal is then processed for detection of a beating signal. The beating signal manifests itself as an amplitude modulation of the pressure signal and is formed by interference between pressure waves generated by a pulse generator associated with the receptacle and pressure waves generated by the pumping device. The integrity of the flow circuit is determined based at least partly on the presence or absence of the beating signal. The device and the flow circuit may be part of an apparatus for extracorporeal blood treatment, and the method may be implemented as a computer program product.

摘要翻译： 提供了一种用于监测与容器流体连通的流动回路的完整性的装置。 流动回路包括用于通过流动回路传送流体的泵送装置。 该装置根据其中从压力传感器接收压力信号的监测方法进行操作，压力信号表示容器或流路中的流体压力。 然后处理压力信号以检测跳动信号。 跳动信号表现为压力信号的幅度调制，并且由与由插座相关联的脉冲发生器产生的压力波和由泵送装置产生的压力波之间的干扰形成。 至少部分地基于跳动信号的存在或不存在确定流动电路的完整性。 装置和流路可以是用于体外血液处理的装置的一部分，并且该方法可以被实现为计算机程序产品。

公开(公告)号：US08715216B2

公开(公告)日：2014-05-06

申请号：US13000856

申请日：2009-06-26

申请人： Bo Olde ,  Kristian Solem

发明人： Bo Olde ,  Kristian Solem

IPC分类号： A61M37/00

CPC分类号： G01M3/2846 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  G01L27/002 ,  G01M3/2815 ,  G01N33/49

摘要： A monitoring device is arranged to receive a time-dependent measurement signal from a pressure sensor in a fluid containing system, which is associated with a first pulse generator and a second pulse generator. The pressure sensor is arranged in the fluid containing system to detect a first pulse originating from the first pulse generator and a second pulse originating from the second pulse generator. The monitoring device is configured to process the measurement signal to remove the first pulse. In this process, the monitoring device receives the measurement signal, obtains a first pulse profile which is a predicted temporal signal profile of the first pulse, and filters the measurement signal in the time-domain, using the first pulse profile, to essentially eliminate the first pulse while retaining the second pulse. The fluid containing system may include an extracorporeal blood flow circuit and a blood circuit of a human patient.

摘要翻译： 监视装置被布置成从与第一脉冲发生器和第二脉冲发生器相关联的流体容纳系统中的压力传感器接收与时间相关的测量信号。 压力传感器布置在流体容纳系统中以检测源自第一脉冲发生器的第一脉冲和源自第二脉冲发生器的第二脉冲。 监视装置被配置为处理测量信号以去除第一脉冲。 在该过程中，监视装置接收测量信号，获得作为第一脉冲的预测时间信号分布的第一脉冲分布，并使用第一脉冲分布对时域中的测量信号进行滤波，基本上消除 第一个脉冲同时保留第二个脉冲。 流体容纳系统可以包括体外血液回路和人类患者的血液回路。

公开(公告)号：US20130204542A1

公开(公告)日：2013-08-08

申请号：US13519245

申请日：2010-12-22

申请人： Bo Olde ,  Kristian Solem

发明人： Bo Olde ,  Kristian Solem

IPC分类号： G01N19/08

CPC分类号： G01N19/08 ,  A61B5/024 ,  A61B2562/0247 ,  A61B2562/226 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M5/16859 ,  A61M2205/13 ,  A61M2205/15 ,  A61M2205/3331 ,  A61M2230/04 ,  A61M2230/06

摘要： A device is configured to monitor the integrity of a connection system between first and second fluid containing systems comprising first and second pulse generators. A pressure sensor is arranged in the first fluid containing system to detect first pulses originating from the first pulse generator and second pulses originating from the second pulse generator. The device operates a monitoring method, by generating (42) a time-dependent pressure signal based on measurement data obtained from the pressure sensor such that the pressure signal contains a sequence of apparent pulses. The apparent pulses represent a superposition of the second pulses on the first pulses when the connection system (C) is intact. The device processes (44) the pressure signal to calculate a parameter value based on a pulse feature of at least one of the apparent pulses in the pressure signal. The parameter value represents a disturbance caused by the superposition of the second pulses on the first pulses, and may be given as a measure of statistical dispersion, pulse-to-pulse symmetry, or first pulse similarity. The device determines (45) the integrity of the connection system based at least partly on the parameter value. The first fluid containing system may be an extracorporeal blood circuit, and the second fluid containing system may be a human or animal subject.

摘要翻译： 设备被配置为监视包括第一和第二脉冲发生器的第一和第二流体容纳系统之间的连接系统的完整性。 压力传感器布置在第一流体容纳系统中以检测源自第一脉冲发生器的第一脉冲和源自第二脉冲发生器的第二脉冲。 该装置通过基于从压力传感器获得的测量数据产生（42）依赖于时间的压力信号来操作监视方法，使得压力信号包含表观脉冲序列。 当连接系统（C）完好时，表观脉冲表示第一脉冲上的第二脉冲的叠加。 装置处理（44）压力信号，以基于压力信号中的表观脉冲中的至少一个的脉冲特征来计算参数值。 参数值表示由第二脉冲叠加在第一脉冲上引起的干扰，并且可以作为统计色散，脉冲对脉冲对称或第一脉冲相似度的量度给出。 该设备至少部分地基于参数值确定（45）连接系统的完整性。 第一流体容纳系统可以是体外血液回路，并且第二流体容纳系统可以是人或动物受试者。

公开(公告)号：US20110112595A1

公开(公告)日：2011-05-12

申请号：US13000856

申请日：2009-06-26

申请人： Kristian Solem ,  Bo Olde

发明人： Kristian Solem ,  Bo Olde

IPC分类号： A61N1/365 ,  G06F19/00

CPC分类号： G01M3/2846 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  G01L27/002 ,  G01M3/2815 ,  G01N33/49

摘要： A monitoring device is arranged to receive a time-dependent measurement signal from a pressure sensor in a fluid containing system, which is associated with a first pulse generator and a second pulse generator. The pressure sensor is arranged in the fluid containing system to detect a first pulse originating from the first pulse generator and a second pulse originating from the second pulse generator. The monitoring device is configured to process the measurement signal to remove the first pulse. In this process, the monitoring device receives the measurement signal, obtains a first pulse profile which is a predicted temporal signal profile of the first pulse, and filters the measurement signal in the time-domain, using the first pulse profile, to essentially eliminate the first pulse while retaining the second pulse. The fluid containing system may include an extracorporeal blood flow circuit and a blood circuit of a human patient.

摘要翻译： 监视装置被布置成从与第一脉冲发生器和第二脉冲发生器相关联的流体容纳系统中的压力传感器接收与时间相关的测量信号。 压力传感器布置在流体容纳系统中以检测源自第一脉冲发生器的第一脉冲和源自第二脉冲发生器的第二脉冲。 监视装置被配置为处理测量信号以去除第一脉冲。 在该过程中，监视装置接收测量信号，获得作为第一脉冲的预测时间信号分布的第一脉冲分布，并且使用第一脉冲分布对时域中的测量信号进行滤波，以基本上消除 第一个脉冲同时保留第二个脉冲。 流体容纳系统可以包括体外血液回路和人类患者的血液回路。

公开(公告)号：US20100094158A1

公开(公告)日：2010-04-15

申请号：US12441921

申请日：2007-09-06

申请人： Kristian Solem ,  Bo Olde

发明人： Kristian Solem ,  Bo Olde

IPC分类号： A61B5/053

CPC分类号： A61M1/14 ,  A61B5/021 ,  A61B5/0535 ,  A61B5/0537 ,  A61M1/16 ,  A61M1/34 ,  A61M1/341 ,  A61M2205/50 ,  A61M2230/65

摘要： The invention relates to estimation of a patient's propensity to suffer from symptomatic hypotension during extracorporeal blood treatment. An electromagnetic test signal, which is applied over a thoracic region of the patient via at least one transmitter electrode. A result signal produced in response to the test signal is received via at least one receiver electrode on the patient. A test parameter is derived based on the result signal. The test parameter expresses a fluid status of the thoracic region of the patient, and it is determined whether the test parameter fulfills an alarm criterion. If the test parameter fulfills an alarm criteria, an alarm signal is generated. This signal indicates that the patient is hypotension prone, and that appropriate measures should be taken.

摘要翻译： 本发明涉及在体外血液治疗期间估计患者患有症状性低血压的倾向。 电磁测试信号，其通过至少一个发射器电极施加在患者的胸部区域上。 响应于测试信号产生的结果信号经由患者上的至少一个接收器电极被接收。 基于结果信号导出测试参数。 测试参数表示患者胸部区域的流体状态，确定测试参数是否满足报警标准。 如果测试参数符合报警标准，则会产生报警信号。 该信号表示患者是低血压倾向，应采取适当的措施。

公开(公告)号：US20090272678A1

公开(公告)日：2009-11-05

申请号：US12308052

申请日：2007-06-04

申请人： Leif Sornmo ,  Kristian Solem ,  Bo Olde

发明人： Leif Sornmo ,  Kristian Solem ,  Bo Olde

IPC分类号： B01D61/30 ,  A61B5/02 ,  A61B5/1455 ,  A61B5/053

CPC分类号： A61B5/14551 ,  A61B5/021 ,  A61B5/02116 ,  A61M1/3639 ,  A61M2205/18 ,  A61M2205/50 ,  A61M2230/30

摘要： The invention relates to prediction of a rapid symptomatic drop in a subject's blood pressure, e.g. during a medical treatment or when operating an aircraft. To this aim, a pulse shape parameter (Pps) with respect to a peripheral body part (105) of the subject (P) is registered by means of a pulse oximetry instrument (110) adapted to detect light response variations in blood vessels. An initial pulse magnitude measure is calculated based on a pulse shape parameter (Pps) received at a first instance. During a measurement period subsequent to the first instance, a respective pulse magnitude measure is calculated based on each of a number of received pulse shape parameters (Pps). It is further investigated, for each pulse magnitude measure in the measurement period, whether or not the measure fulfils a decision criterion relative to the initial pulse magnitude measure. An alarm triggering signal (α) is generated if the decision criterion is found to be fulfilled.

摘要翻译： 本发明涉及预测受试者血压中快速有症状的下降，例如， 在治疗期间或在操作飞行器时。 为此目的，通过适于检测血管中的光反应变化的脉搏血氧仪（110）来记录相对于被检体（P）的外周身体部分（105）的脉搏形状参数（Pps）。 基于在一次接收的脉冲形状参数（Pps）来计算初始脉冲幅度测量。 在第一次之后的测量周期期间，基于接收的脉冲形状参数（Pps）的数量来计算相应的脉冲幅度测量。 对于测量周期中的每个脉冲幅度测量，进一步研究测量是否满足相对于初始脉冲幅度测量的判定标准。 如果发现判定标准被满足，则产生报警触发信号（α）。

公开(公告)号：US11123010B2

公开(公告)日：2021-09-21

申请号：US13519067

申请日：2010-12-22

申请人： Bo Olde ,  Kristian Solem

发明人： Bo Olde ,  Kristian Solem

IPC分类号： A61B5/00 ,  A61B5/021 ,  A61B5/024 ,  A61M1/36 ,  A61B5/0205 ,  A61M1/30 ,  A61B5/053

摘要： A monitoring arrangement 100 is configured to predict a rapid symptomatic drop in a subject's blood pressure, e.g. during a medical treatment or when operating aircraft. To this aim, a pulse shape parameter (pps) with respect to a peripheral body part (105) of the subject (P) is repeatedly registered by means of a pulse oximetry instrument (110) adapted to detect light response variations in blood vessels. A respective pulse magnitude measure is calculated based on each of a number of received pulse shape parameters (pps), and a statistical dispersion measure is calculated based on the thus-calculated pulse magnitude measure. It is investigated whether or not the statistical dispersion measure fulfils a decision criterion relative to a reference measure. An output signal (α) is generated if the decision criterion is found to be fulfilled.

公开(公告)号：US10980431B2

公开(公告)日：2021-04-20

申请号：US13519559

申请日：2010-12-22

申请人： Bo Olde ,  Kristian Solem

发明人： Bo Olde ,  Kristian Solem

IPC分类号： A61B5/0215 ,  A61M1/36

摘要： A monitoring device is included in a medical system to implement a method for prediction of a rapid symptomatic drop in a subject's blood pressure, e.g. during a medical treatment such as dialysis. To this aim, a pulse shape parameter (pPS) with respect to a pulse generator of the subject is registered by means of a pressure sensor arranged in an extracorporeal blood flow circuit coupled to a cardiovascular system of the subject (P). The pressure sensor is configured to detect pressure variations in blood vessels of the subject (P). It is investigated, during measurement period, whether or not one or more of the pulse shape parameters fulfil a decision criterion. An output signal (a) is generated if the decision criterion is found to be fulfilled, to indicate a predicted rapid symptomatic blood pressure decrease in the subject (P). The decision criterion may operate on pulse magnitude measures calculated for the received pulse shape parameters (pPS), or statistical dispersion measures calculated based on the thus-calculated pulse magnitude measures.

公开(公告)号：US09612182B2

公开(公告)日：2017-04-04

申请号：US13519248

申请日：2010-12-22

申请人： Bo Olde ,  Kristian Solem

发明人： Bo Olde ,  Kristian Solem

IPC分类号： A61M1/36 ,  G01N11/02 ,  A61M5/168

CPC分类号： G01N11/02 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3661 ,  A61M5/16859 ,  A61M2205/13 ,  A61M2205/15 ,  A61M2205/3331 ,  A61M2230/04

摘要： A device and method for detecting fault conditions in a fluid connection system between a first fluid containing system including a first pulse generator (e.g., an extracorporeal blood circuit) and a second fluid containing system including a second pulse generator (e.g., a human or animal vascular system). A pressure sensor detects first pulses from the first pulse generator and second pulses from the second pulse generator. A time-dependent monitoring signal based on data obtained from said pressure sensor is generated and processed to calculate a parameter value indicative of the shape of at least part of a first pulse in the monitoring signal. The parameter value is evaluated to detect the fault condition. The fault condition may involve disconnection of an access device; reversed connection of access devices; occlusion of the fluid path through an access device; or infiltration in tissue surrounding an access point in the vascular system.

公开(公告)号：US20130172803A1

公开(公告)日：2013-07-04

申请号：US13519148

申请日：2010-12-22

申请人： Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby ,  Anders Wieslander

发明人： Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby ,  Anders Wieslander

IPC分类号： A61M1/30

CPC分类号： A61M1/3656 ,  A61B5/02125 ,  A61B5/0215 ,  A61B5/02405 ,  A61B5/4836 ,  A61M1/30 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3653 ,  A61M1/3659 ,  A61M2205/3331 ,  A61M2205/6018

摘要： A control system (23) is arranged to control the operation of an apparatus (200) for extracorporeal blood treatment. The apparatus (200) comprises an extracorporeal blood circuit (20) and a connection system (C) for connecting the blood circuit (20) to the vascular system of a patient. The blood circuit (20) comprises a blood processing device (6), and at least one pumping device (3). The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The blood treatment mode involves operating the blood circuit (20) to pump blood from the vascular system via the connection system (C) through the blood processing device (6) and back to the vascular system via the connection system (C). The control system (23) is operable to obtain measurement data from at least one energy transfer sensor (40) arranged to sense a transfer of energy between the patient and the connection system (C) or between the patient and the blood circuit (20). The control system (23) is configured to, in the pre-treatment mode, process the measurement data for identification of a characteristic change indicating a connection of the blood circuit (20) to the vascular system of the patient, and, upon such identification, take dedicated action. The action may involve activating at least part of a patient protection system and/or enabling entry into the blood treatment mode. The control system may be included in an apparatus (200) for blood treatment, such as a dialysis machine.

摘要翻译： 控制系统（23）被布置成控制用于体外血液处理的装置（200）的操作。 装置（200）包括用于将血液回路（20）连接到患者血管系统的体外血液回路（20）和连接系统（C）。 血液回路（20）包括血液处理装置（6）和至少一个泵送装置（3）。 控制系统可操作以在预处理模式和血液处理模式之间切换。 血液处理模式包括操作血液回路（20），以经由连接系统（C）从血管系统通过血液处理装置（6）泵送血液，并通过连接系统（C）返回血管系统。 控制系统（23）可操作以从至少一个能量传递传感器（40）获得测量数据，所述能量传递传感器（40）布置成感测患者和连接系统（C）之间或患者与血液回路（20）之间的能量传递， 。 控制系统（23）被配置为在预处理模式下处理用于识别指示血液回路（20）与患者的血管系统的连接的特征变化的测量数据，并且在这种识别 ，采取专门的行动。 该动作可以涉及激活患者保护系统的至少一部分和/或使得能够进入血液处理模式。 控制系统可以包括在用于血液处理的装置（200）中，例如透析机。