公开(公告)号：US08865726B2

公开(公告)日：2014-10-21

申请号：US13393767

申请日：2010-09-03

Applicant: Steven W. Andrews ,  Kevin Ronald Condroski ,  Lisa A. De Meese ,  Jay Bradford Fell ,  John P. Fischer ,  John A. Josey ,  Kevin Koch ,  Yvan Le Huerou ,  Gregory F. Miknis ,  Martha E. Rodriguez ,  George T. Topalov ,  Eli M. Wallace ,  Rui Xu

Inventor： Steven W. Andrews ,  Kevin Ronald Condroski ,  Lisa A. De Meese ,  Jay Bradford Fell ,  John P. Fischer ,  John A. Josey ,  Kevin Koch ,  Yvan Le Huerou ,  Gregory F. Miknis ,  Martha E. Rodriguez ,  George T. Topalov ,  Eli M. Wallace ,  Rui Xu

IPC: C07D487/04 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D487/04

Abstract: Compounds of Formula I: and salts thereof in which R1, R2, R2a, R3, n, X and ring B have the meanings given in the specification, are inhibitors of mTOR and are useful in the treatment of diseases which are sensitive to inhibition of mTOR, such as cancers.

Abstract translation: 式I化合物及其盐，其中R 1，R 2，R 2a，R 3，n，X和环B具有本说明书中给出的含义，是mTOR的抑制剂，可用于治疗对抑制作用敏感的疾病 mTOR，如癌症。

公开(公告)号：US08853216B2

公开(公告)日：2014-10-07

申请号：US12811983

申请日：2009-01-09

Applicant: Josef Bencsik ,  James F. Blake ,  Nicholas C. Kallan ,  Ian S. Mitchell ,  Keith L. Spencer ,  Dengming Xiao ,  Rui Xu ,  Christine Chabot ,  Steven Do ,  Jun Liang ,  Brian Safina ,  Birong Zhang ,  James Graham

Inventor： Josef Bencsik ,  James F. Blake ,  Nicholas C. Kallan ,  Ian S. Mitchell ,  Keith L. Spencer ,  Dengming Xiao ,  Rui Xu ,  Christine Chabot ,  Steven Do ,  Jun Liang ,  Brian Safina ,  Birong Zhang ,  James Graham

IPC: C07D239/70 ,  A61K31/517 ,  A61P35/00 ,  A61P29/00 ,  A61P25/00 ,  A61P9/00 ,  A61P15/02 ,  A61P17/00

CPC classification number: C07D239/70

Abstract: The present invention provides a compound and pharmaceutically acceptable salts thereof, comprising the Formula I. Also provided are methods of using the compound of this invention as an AKT protein kinase inhibitor and for the treatment of hyperproliferative diseases such as cancer.

Abstract translation: 本发明提供了包含式I的化合物及其药学上可接受的盐。还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。

公开(公告)号：US20140005213A1

公开(公告)日：2014-01-02

申请号：US14001657

申请日：2012-02-24

Applicant: James F. Blake ,  Robert Kirk Delisle ,  Lisa A. De Meese ,  James M. Graham ,  Yvan Le Huerou ,  Michael Lyon ,  John E. Robinson ,  Eli M. Wallace ,  Bin Wang ,  Rui Xu

Inventor： James F. Blake ,  Robert Kirk Delisle ,  Lisa A. De Meese ,  James M. Graham ,  Yvan Le Huerou ,  Michael Lyon ,  John E. Robinson ,  Eli M. Wallace ,  Bin Wang ,  Rui Xu

IPC: C07D471/04 ,  C07D491/048 ,  C07D487/10 ,  C07D487/04

CPC classification number: C07D471/04 ,  C07D401/06 ,  C07D487/04 ,  C07D487/10 ,  C07D491/048 ,  C07D519/00

Abstract: Compounds of Formula I: in which R1, R2, R3, R4 and R10 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.

Abstract translation: R 1，R 2，R 3，R 4和R 10具有本说明书中给出的含义的式I化合物是可用于治疗由PIM-1和/或PIM-2和/或PIM-2介导的疾病的受体酪氨酸抑制剂， 3激酶。

公开(公告)号：US20130045390A1

公开(公告)日：2013-02-21

申请号：US13377537

申请日：2011-10-09

Applicant: Rui Xu ,  Weiwei Zhang ,  Hongqing Huang ,  Junjie Huang ,  Quan Liu ,  Jungmao Tsai ,  Hui Fang Duan

Inventor： Rui Xu ,  Weiwei Zhang ,  Hongqing Huang ,  Junjie Huang ,  Quan Liu ,  Jungmao Tsai ,  Hui Fang Duan

IPC: B32B9/04 ,  C09D129/04 ,  C08K5/5415 ,  B82Y30/00

CPC classification number: C08J5/18 ,  B05D3/007 ,  B05D5/06 ,  B82Y30/00 ,  C01P2004/64 ,  C08J2329/04 ,  C08K9/06 ,  C09C1/3081 ,  C09D129/04 ,  G02B1/08 ,  G02B1/14 ,  G02B5/305 ,  Y10T428/31663

Abstract: The present invention provides a base film of modified polyvinyl alcohol as well as a method for preparing the base film of modified polyvinyl alcohol and a polarizer made from the base film. The method includes steps of: (1) executing surface graft modification of nano-silicon dioxides with fluorinated silane to obtain modified nano-silicon dioxide powders; (2) adding the modified nano-silicon dioxide powders obtained from the step (1) to an aqueous solution of polyvinyl alcohol polymers, in order to prepare a composite solution of polyvinyl alcohol polymers; and (3) pouring the composite solution of polyvinyl alcohol polymers prepared from the step (2) onto a surface of a casting substrate to obtain a base film of modified polyvinyl alcohol (PVA). The present invention enhances the heat and humidity resistances and the stability of the PVA base film, and improves its mechanical performance and sticking-resistance.

Abstract translation: 本发明提供改性聚乙烯醇的基膜以及改性聚乙烯醇的基膜的制备方法和由该基膜制成的偏光片。 该方法包括以下步骤：（1）用氟化硅烷进行纳米二氧化硅的表面接枝改性，得到改性纳米二氧化硅粉末; （2）将由步骤（1）获得的改性纳米二氧化硅粉末加入到聚乙烯醇聚合物的水溶液中，以制备聚乙烯醇聚合物的复合溶液; 和（3）将由步骤（2）制备的聚乙烯醇聚合物的复合溶液倒入流延基材的表面，得到改性聚乙烯醇（PVA）的基膜。 本发明提高了耐热耐湿性和PVA基膜的稳定性，提高了其机械性能和耐粘附性。

公开(公告)号：US20120221573A1

公开(公告)日：2012-08-30

申请号：US13385042

申请日：2012-01-30

Applicant: Donald Coolidge Wunsch, II ,  Rui Xu ,  Sejun Kim

Inventor： Donald Coolidge Wunsch, II ,  Rui Xu ,  Sejun Kim

IPC: G06F17/30

CPC classification number: G06F17/30539 ,  G06F19/24

Abstract: Methods and systems for improved unsupervised learning are described. The unsupervised learning can consist of biclustering a data set, e.g., by biclustering subsets of the entire data set. In an example, the biclustering does not include feeding know and proven results into the biclustering methodology or system. A hierarchical approach can be used that feeds proven clusters back into the biclustering methodology or system as the input. Data that does not cluster may be discarded. Thus, a very large unknown data set can be acted on to learn about the data. The system is also amenable to parallelization.

Abstract translation: 描述了改进的无监督学习的方法和系统。 无监督学习可以包括例如通过对整个数据集进行二聚簇的二聚簇数据集的二聚簇。 在一个例子中，双组分不包括将知道和证明的结果提供给双组分方法或系统。 可以使用分级方法，将验证的群集作为输入返回到双重聚类方法或系统。 不会聚集的数据可能被丢弃。 因此，可以采用非常大的未知数据集来了解数据。 该系统也适用于并行化。

公开(公告)号：US08063050B2

公开(公告)日：2011-11-22

申请号：US11773949

申请日：2007-07-05

Applicant: Ian S. Mitchell ,  James F. Blake ,  Rui Xu ,  Nicholas C. Kallan ,  Dengming Xiao ,  Keith Lee Spencer ,  Josef R. Bencsik ,  Eli M. Wallace ,  Stephen T. Schlachter ,  Anna L. Banka ,  Jun Liang ,  Brian Safina ,  Birong Zhang ,  Christine Chabot ,  Steven Do

Inventor： Ian S. Mitchell ,  James F. Blake ,  Rui Xu ,  Nicholas C. Kallan ,  Dengming Xiao ,  Keith Lee Spencer ,  Josef R. Bencsik ,  Eli M. Wallace ,  Stephen T. Schlachter ,  Anna L. Banka ,  Jun Liang ,  Brian Safina ,  Birong Zhang ,  Christine Chabot ,  Steven Do

IPC: C07D239/70 ,  A61K31/496 ,  A61P35/00

CPC classification number: A61K31/517 ,  C07D239/70 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12

Abstract: The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

Abstract translation: 本发明提供了包含分解的对映异构体，分解的非对映异构体，溶剂合物和其药学上可接受的盐的化合物，其包含式I：还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和用于治疗过度增殖性疾病 癌症。

公开(公告)号：US20110065716A1

公开(公告)日：2011-03-17

申请号：US12811957

申请日：2009-01-09

Applicant: Josef R. Bencsik ,  James F. Blake ,  Nicholas C. Kallan ,  Ian S. Mitchell ,  Keith Lee Spencer ,  Dengming Xiao ,  Rui Xu ,  Christine Chabot ,  Steven Do ,  Jun Liang ,  Brian Safina ,  Birong Zhang

Inventor： Josef R. Bencsik ,  James F. Blake ,  Nicholas C. Kallan ,  Ian S. Mitchell ,  Keith Lee Spencer ,  Dengming Xiao ,  Rui Xu ,  Christine Chabot ,  Steven Do ,  Jun Liang ,  Brian Safina ,  Birong Zhang

IPC: A61K31/517 ,  C07D403/04 ,  A61P35/00 ,  A61P25/28 ,  A61P9/00 ,  A61P29/00 ,  A61P15/00 ,  A61P17/00

CPC classification number: C07D239/70

Abstract: The present invention provides compounds, including pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases, such as cancer.

Abstract translation: 本发明提供包含式（I）的化合物，包括其药学上可接受的盐：还提供使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。

公开(公告)号：US20110053959A1

公开(公告)日：2011-03-03

申请号：US12812384

申请日：2009-01-09

Applicant: Anna Banka ,  Josef R. Bencsik ,  James F. Blake ,  Kin Chiu Fong ,  Martin F. Hentemann ,  Ian S. Mitchell ,  Douglas McCord Sammond ,  Tony P. Tang ,  Eli M. Wallace ,  Rui Xu

Inventor： Anna Banka ,  Josef R. Bencsik ,  James F. Blake ,  Kin Chiu Fong ,  Martin F. Hentemann ,  Ian S. Mitchell ,  Douglas McCord Sammond ,  Tony P. Tang ,  Eli M. Wallace ,  Rui Xu

IPC: A61K31/517 ,  C07D471/20 ,  A61P7/00 ,  A61P37/06 ,  A61P3/10 ,  A61P9/10 ,  A61P31/12 ,  A61P1/16 ,  A61P25/28 ,  A61P17/06 ,  A61P29/00 ,  A61P35/04 ,  A61P35/00 ,  A61P25/16

CPC classification number: C07D471/10 ,  C07D487/10

Abstract: The present invention provides compounds of Formula (I) including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitors and for the treatment of Akt-mediated diseases, for example, hyperproliferative diseases such as cancer.

Abstract translation: 本发明提供式（I）化合物，其包括互变异构体，拆分的对映异构体，拆分的非对映体，溶剂合物，代谢物，盐和药学上可接受的前药。 还提供了使用本发明化合物作为Akt蛋白激酶抑制剂和治疗Akt介导的疾病例如过度增殖性疾病如癌症的方法。

公开(公告)号：US20100168123A1

公开(公告)日：2010-07-01

申请号：US12567258

申请日：2009-09-25

Applicant: Ian S. Mitchell ,  Keith L. Spencer ,  Peter Stengel ,  Yongxin Han ,  Nicholas C. Kallan ,  Mark Munson ,  Guy P.A. Vigers ,  James Blake ,  Anthony Piscopio ,  John Josey ,  Scott Miller ,  Dengming Xiao ,  Rui Xu ,  Chang Rao ,  Bing Wang ,  April L. Bernacki

Inventor： Ian S. Mitchell ,  Keith L. Spencer ,  Peter Stengel ,  Yongxin Han ,  Nicholas C. Kallan ,  Mark Munson ,  Guy P.A. Vigers ,  James Blake ,  Anthony Piscopio ,  John Josey ,  Scott Miller ,  Dengming Xiao ,  Rui Xu ,  Chang Rao ,  Bing Wang ,  April L. Bernacki

IPC: A61K31/497 ,  C07D401/04 ,  C07D471/04 ,  C07D403/04 ,  C07D487/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D239/94 ,  B41M3/008 ,  B44F1/10 ,  C07D231/56 ,  C07D237/28 ,  C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D409/04 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  G09F13/16 ,  Y10T428/24802 ,  Y10T428/24851 ,  Y10T428/25 ,  Y10T428/31507 ,  Y10T428/31551 ,  Y10T428/31786 ,  Y10T428/31855

Abstract: The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

Abstract translation: 本发明提供包括分解对映异构体，非对映异构体，溶剂化物和药学上可接受的盐的化合物，其包含式为：A-L-CR，其中CR为环状核心基团，L为连接基团，A如本文所定义。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。

公开(公告)号：US20100035143A1

公开(公告)日：2010-02-11

申请号：US12222247

申请日：2008-08-06

Applicant: Rui Xu ,  Yong Qiang Deng ,  Cheng Hua Fu

Inventor： Rui Xu ,  Yong Qiang Deng ,  Cheng Hua Fu

IPC: H01M2/02

CPC classification number: H01M2/0272 ,  H01M2/0262 ,  H01M2/027 ,  H01M2/0275 ,  H01M2/028 ,  H01M2/0413 ,  H01M10/052

Abstract: The present invention is to provide a lithium battery can be exempted from short circuit problems caused by metallic particles agitated through the manufacturing process and later usage. Said lithium battery includes a battery cover, anode films, separators, cathode films, an organic electrolyte, a cylindrical housing with a neck portion formed on an upper portion of the cylindrical housing. Said neck portion is spread with a layer of polymeric based composite materials onto an inner wall inside the neck portion, damages happened to the neck portion will not cause short circuit also.

Abstract translation: 本发明是提供一种锂电池，可以免除由于制造过程中的金属颗粒而引起的短路问题和以后的使用。 所述锂电池包括电池盖，阳极膜，隔板，阴极膜，有机电解质，具有形成在所述圆筒形壳体的上部上的颈部的圆柱形壳体。 所述颈部部分用聚合物基复合材料层涂覆在颈部内部的内壁上，颈部损伤也不会引起短路。