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21.发明授权Skin repair compositions comprising circadian gene activators and a synergistic combination of Sirt1 gene activators 有权皮肤修复组合物包含昼夜节律基因激活剂和Sirt1基因激活剂的协同组合公开(公告)号：US08703161B2
公开(公告)日：2014-04-22
申请号：US12489619
申请日：2009-06-23
申请人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben
发明人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben
CPC分类号： A61K8/347 , A61K8/37 , A61K8/55 , A61K8/64 , A61K8/66 , A61K31/70 , A61K35/74 , A61K36/31 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/43 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.
摘要翻译： 增强皮肤细胞损伤的DNA修复的组合物和方法。 包含至少一种上调皮肤细胞中的昼夜节律基因表达的试剂和至少一种延缓皮肤细胞中的有丝分裂的非昼夜节律作用的局部组合物。 优选地，这样的组合物包含一种或多种角质形成细胞时钟和per1基因激活剂，连同SIRT1或一种或多种sirt1激活剂。 更优选地，sirt1激活剂是特定肽sirt1激活剂和白藜芦醇的协同组合。 优选地，这样的组合物易于使用，有效，化妆品可接受，化学，热力学和光稳定性，对于局部使用安全，几乎没有或没有副作用，并且在个人护理市场中是商业上可行的。
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公开(公告)号：US08193155B2
公开(公告)日：2012-06-05
申请号：US12367705
申请日：2009-02-09
申请人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A skin care composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; a method for inhibiting damage to human keratinocytes due to environmental aggressors by applying a composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; and a method for repairing DNA damage in human keratinocytes.
摘要翻译： 一种皮肤护理组合物，其包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶; 通过施用包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来抑制由于环境侵袭者对人角质形成细胞的损伤的方法; 以及修复人角质形成细胞DNA损伤的方法。
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公开(公告)号：US20100080845A1
公开(公告)日：2010-04-01
申请号：US12631585
申请日：2009-12-04
申请人： Daniel H. Maes , Thomas Mammone , Kerri Goldgraben
发明人： Daniel H. Maes , Thomas Mammone , Kerri Goldgraben
CPC分类号： A61K31/70 , A61K8/347 , A61K8/37 , A61K8/55 , A61K8/66 , A61K38/465 , A61K38/47 , A61Q19/00 , A61Q19/08
摘要： The present invention relates to methods and compositions for repairing adverse effects of the environment, daily stress, sun exposure, or pre-mature aging on human skin, comprising applying to the skin, prior to a period of bodily rest, a topical composition that contains resveratrol or a derivative thereof and at least one DNA repair enzyme.
摘要翻译： 本发明涉及用于修复环境，日常压力，日晒暴露或对人皮肤的熟化前衰老的不利影响的方法和组合物，其包括在身体休息期之前将皮肤施用于含有 白藜芦醇或其衍生物和至少一种DNA修复酶。
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24.发明申请Skin Repair Compositions Comprising Circadian Gene Activators And A Synergistic Combination Of Sirt1 Gene Activators 有权皮肤修复组合包含昼夜节律基因激活剂和Sirt1基因激活子的协同组合公开(公告)号：US20100028317A1
公开(公告)日：2010-02-04
申请号：US12489619
申请日：2009-06-23
申请人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben , James Timothy McCarthy
CPC分类号： A61K8/347 , A61K8/37 , A61K8/55 , A61K8/64 , A61K8/66 , A61K31/70 , A61K35/74 , A61K36/31 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/43 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.
摘要翻译： 增强皮肤细胞损伤的DNA修复的组合物和方法。 包含至少一种上调皮肤细胞中的昼夜节律基因表达的试剂和至少一种延缓皮肤细胞中的有丝分裂的非昼夜节律作用的局部组合物。 优选地，这样的组合物包含一种或多种角质形成细胞时钟和per1基因激活剂，连同SIRT1或一种或多种sirt1激活剂。 更优选地，sirt1激活剂是特定肽sirt1激活剂和白藜芦醇的协同组合。 优选地，这样的组合物易于使用，有效，化妆品可接受，化学，热力学和光稳定性，对于局部使用安全，几乎没有或没有副作用，并且在个人护理市场中是商业上可行的。
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公开(公告)号：US6017549A
公开(公告)日：2000-01-25
申请号：US940783
申请日：1997-09-30
IPC分类号： A61K9/107 , A61K8/00 , A61K8/06 , A61K8/11 , A61K8/30 , A61K8/33 , A61K8/36 , A61K8/365 , A61K8/38 , A61K8/40 , A61K8/42 , A61K8/55 , A61K8/60 , A61K8/64 , A61K8/67 , A61K8/91 , A61K9/00 , A61K31/07 , A61K47/24 , A61K47/26 , A61K47/42 , A61Q17/00 , A61Q19/00 , A61K6/00 , A01N25/32 , A01N37/18 , A61K7/00
CPC分类号： A61Q19/00 , A61K8/06 , A61K8/11 , A61K8/553 , A61K8/602 , A61K8/604 , A61K8/64 , A61K8/671 , A61Q17/00 , A61K2800/412 , A61K2800/75 , A61Q19/08
摘要： The present invention relates to a cosmetic or pharmaceutical emulsion for topical application to the skin comprising an irritating agent and at least one non-disruptive emulsifier. In a preferred embodiment the irritating agent is a retinoid. The invention also provides a method for decreasing the irritation on the skin caused by an irritating active agent in a topical cosmetic or pharmaceutical emulsion which comprises employing as an emulsifier at least one of an alkyl polyoside, a grafted water soluble protein on a hydrophobic backbone, and lecithin.
摘要翻译： 本发明涉及用于局部施用于皮肤的化妆品或药物乳液，其包含刺激剂和至少一种非破坏性乳化剂。 在优选的实施方案中，刺激剂是类视黄醇。 本发明还提供一种降低由局部化妆品或药物乳剂中的刺激性活性剂引起的对皮肤的刺激的方法，其包括在疏水骨架上使用烷基聚苷，接枝水溶性蛋白质中的至少一种作为乳化剂， 和卵磷脂。
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公开(公告)号：US5948418A
公开(公告)日：1999-09-07
申请号：US903525
申请日：1997-07-30
申请人： Daniel H. Maes , Jules Zecchino , Althea Knight
发明人： Daniel H. Maes , Jules Zecchino , Althea Knight
IPC分类号： A61K8/365 , A61K8/37 , A61K8/46 , A61K8/49 , A61K8/60 , A61K8/73 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/23 , A61Q19/00 , A61Q19/02 , A61Q19/08 , C07C323/41 , A61K7/48
CPC分类号： C07C323/41 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/23 , A61K8/365 , A61K8/37 , A61K8/375 , A61K8/46 , A61K8/4973 , A61K8/60 , A61K8/73 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/08 , A61Q5/006 , Y10S514/852 , Y10S514/859 , Y10S514/863 , Y10S514/944
摘要： Novel sulfhydryl group-containing amides and disulfide group-containing bis-amides useful for treating or preventing an abnormal biological condition or a disease, and/or improving the texture or appearance of the skin, as well as compositions containing amides and bis-amides and methods for their use are described. Such types of abnormal biological conditions or diseases include skin atrophy, i.e., the thinning and/or general degradation of the dermis often characterized by a decrease in collagen and/or elastin as well as decreased number, size and doubling potential of fibroblast cells, and other maladies including, but are not limited to dry skin, severe dry skin, dandruff, acne, keratoses, psoriasis, eczema, skin flakiness, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, hyperkeratotic skin, inflammatory dermatoses, age-related skin changes and skin in need of cleansers.
摘要翻译： 可用于治疗或预防异常生物学病症或疾病，和/或改善皮肤的质地或外观的新型含巯基的酰胺和含二硫基的双酰胺以及含有酰胺和双酰胺的组合物和 描述使用它们的方法。 这种类型的异常生物学条件或疾病包括皮肤萎缩，即真皮的变薄和/或一般降解，其特征在于胶原和/或弹性蛋白的减少以及成纤维细胞的数量，大小和倍数增加的潜力，以及 其他疾病包括但不限于干性皮肤，严重干性皮肤，头皮屑，痤疮，角化病，牛皮癣，湿疹，皮肤瘙痒，瘙痒，老年斑，斑点，黑斑病，皱纹，疣，瑕疵皮肤，色素沉着过度皮肤，角化过度皮肤 ，炎性皮肤病，年龄相关的皮肤变化和需要清洁剂的皮肤。
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公开(公告)号：US09782448B2
公开(公告)日：2017-10-10
申请号：US13957647
申请日：2013-08-02
IPC分类号： A61K36/752 , A61K8/34 , A61K8/49 , A61K8/63 , A61K8/97 , A61Q19/00 , A61K31/05 , A61K31/19 , A61K35/614 , A61K36/02 , A61K36/28 , A61K36/38 , A61K36/575 , A61K8/9706
CPC分类号： A61K36/752 , A61K8/347 , A61K8/498 , A61K8/63 , A61K8/97 , A61K8/9706 , A61K31/05 , A61K31/19 , A61K35/614 , A61K36/02 , A61K36/28 , A61K36/38 , A61K36/575 , A61K2800/75 , A61Q19/008
摘要： A method for treating intact irritated or inflamed skin with a composition comprising at least one Histamine Receptor pathway inhibitor; at least one Lipoxygenase pathway inhibitor; at least one Cyclooxygenase pathway inhibitor and at least one Chemotaxis pathway inhibitor.
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公开(公告)号：US20130095046A1
公开(公告)日：2013-04-18
申请号：US13441164
申请日：2012-04-06
IPC分类号： A61K36/324
CPC分类号： A61K36/324 , A61K8/361 , A61K8/4973 , A61K8/63 , A61K8/68 , A61K8/97 , A61K2800/75 , A61K2800/782 , A61Q17/00 , A61Q19/00 , A61Q19/007 , A61Q19/08
摘要： The invention relates to a method for improving skin lipid barrier function by applying to the skin a composition comprising effective amounts of a protease inhibitor and a cell differentiation enhancer. The composition is useful in promoting skin lipid barrier repair and maintaining the integrity of the lipid barrier. In this regard, the compositions can be used in the treatment and prevention of dry skin, and associated chrono/proto-aging conditions, in the treatment and prevention of irritation on the skin, in the treatment and prevention of UV-related damage to the skin, and in the enhancement of the retention of self-tanning.
摘要翻译： 本发明涉及通过向皮肤施用包含有效量的蛋白酶抑制剂和细胞分化增强剂的组合物来改善皮肤脂质屏障功能的方法。 该组合物可用于促进皮肤脂质屏障修复并保持脂质屏障的完整性。 在这方面，组合物可以用于治疗和预防干性皮肤，以及相关的计时/原始老化条件，用于治疗和预防对皮肤的刺激，治疗和预防与紫外线相关的损伤 皮肤，并增强保持自鞣性。
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公开(公告)号：US20120219537A1
公开(公告)日：2012-08-30
申请号：US13452415
申请日：2012-04-20
申请人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A method for repairing DNA damage in human keratinocytes by applying to the keratinocytes a composition comprising at least one CLOCK or PER1 gene activator and at least one DNA repair enzyme.
摘要翻译： 一种通过向角化细胞施用包含至少一种CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来修复人角质形成细胞中的DNA损伤的方法。
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公开(公告)号：US20110268688A1
公开(公告)日：2011-11-03
申请号：US12993549
申请日：2009-06-17
CPC分类号： A61K9/0014 , A61K8/347 , A61K8/361 , A61K8/375 , A61K8/498 , A61K8/55 , A61K8/894 , A61K47/14 , A61K47/24 , A61Q19/06
摘要： A topical composition comprising at least one adipogenesis inhibitor and at least one adipocyte lipolytic agent and, optionally, at least one skin tightening agent; a method for improving the appearance of facial or body skin, treating the appearance of cellulite, or treating the face or body to improve the appearance of skin and uneven skin surfaces.
摘要翻译： 一种局部组合物，其包含至少一种脂肪形成抑制剂和至少一种脂肪细胞脂肪分解剂和任选的至少一种皮肤紧固剂; 改善面部或身体皮肤外观，治疗脂肪团的外观，或治疗面部或身体以改善皮肤外观和不均匀皮肤表面的方法。
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