公开(公告)号：US20250060361A1

公开(公告)日：2025-02-20

申请号：US18938922

申请日：2024-11-06

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Anahit AGHVANYAN ,  Eli N. GLEZER ,  John KENTEN ,  George SIGAL ,  Martin STENGELIN

IPC: G01N33/53 ,  C12Q1/6804 ,  G01N21/66 ,  G01N21/76 ,  G01N21/77 ,  G01N33/533 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58

Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.

公开(公告)号：US20250060335A1

公开(公告)日：2025-02-20

申请号：US18818455

申请日：2024-08-28

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Mark BILLADEAU ,  Nicholas CARBONE ,  Charles CLINTON ,  Scott DOWDELL ,  Manish KOCHAR ,  Nicholas FOX-LYON ,  Bandele JEFFREY-COKER ,  Alexander TUCKER-SCHWARTZ ,  George SIGAL ,  Gisbert SPIELES ,  Jules VANDERSARL ,  Jacob WOHLSTADTER

IPC: G01N27/49 ,  G01N27/327

Abstract: An electrochemical cell includes a plurality of working electrode zones disposed, and defining a pattern, on a surface of the cell and at least one auxiliary electrode disposed on the surface. The auxiliary electrode having a defined interfacial potential.

公开(公告)号：US20240347167A1

公开(公告)日：2024-10-17

申请号：US18595584

申请日：2024-03-05

Applicant: MESO SCALE TECHNOLOGIES, LLC. ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

Inventor： William F. BLAKELY ,  Eli N. GLEZER ,  John H. KENTEN ,  Sudeep KUMAR ,  Anu MATHEW ,  Natalia I. OSSETROVA ,  George SIGAL

IPC: G16H20/40 ,  G01N27/327 ,  G01N33/68 ,  G01N35/00 ,  G01T1/00 ,  G01T1/02

CPC classification number: G16H20/40 ,  G01N27/3273 ,  G01N33/6893 ,  G01N35/00 ,  G01T1/00 ,  G01T1/02 ,  G01N2333/70535 ,  G01N2333/70578 ,  G01N2800/40 ,  G01N2800/60

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US20230020070A1

公开(公告)日：2023-01-19

申请号：US17849917

申请日：2022-06-27

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： John KENTEN ,  George SIGAL ,  Alexander K. TUCKER-SCHWARTZ

IPC: G01N21/64 ,  C07F15/00 ,  C12Q1/6816 ,  G01N21/66 ,  G01N33/533 ,  G01N33/58

Abstract: The invention relates to methods, compositions, kits, and assay systems for assay signal amplification. Also provided herein is a signal amplification reagent, wherein the signal amplification reagent is an antibody or antigen-binding fragment thereof.

公开(公告)号：US20220404360A1

公开(公告)日：2022-12-22

申请号：US17749716

申请日：2022-05-20

Applicant: Meso Scale Technologies, LLC.

Inventor： George SIGAL ,  Seth B. HARKINS ,  Timothy J. BREAK

IPC: G01N33/569 ,  C12Q1/6818 ,  G16B25/10 ,  G16B30/00

Abstract: The invention relates to methods and kits for determining a SARS-CoV-2 strain in a sample. The invention also provides methods and kits for detecting a single nucleotide polymorphism (SNP) in a target nucleic acid, wherein the target nucleic acid is a SARS-CoV-2 nucleic acid. The invention further provides methods and kits for detecting one or more antibody biomarkers in a sample.

公开(公告)号：US20220341843A1

公开(公告)日：2022-10-27

申请号：US17733036

申请日：2022-04-29

Applicant: Meso Scale Technologies, LLC.

Inventor： Nicholas ANDERSON ,  Jeffery DEBAD ,  Eli N. GLEZER ,  Sudeep KUMAR ,  Noel LAWRENCE ,  Kenneth PAGE ,  George SIGAL ,  Sharon WEST

IPC: G01N21/05 ,  G01N21/69 ,  G01N21/76 ,  B01L3/00 ,  G01N21/03 ,  G01F23/02 ,  G01F23/292 ,  G01N1/10

Abstract: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, thy reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.

公开(公告)号：US20220018785A1

公开(公告)日：2022-01-20

申请号：US17363758

申请日：2021-06-30

Applicant: Meso Scale Technologies, LLC.

Inventor： Alexander K. TUCKER-SCHWARTZ ,  George SIGAL

IPC: G01N21/76 ,  G01N33/58 ,  G01N33/543

Abstract: The invention relates to novel compositions comprising an electrochemiluminescence (ECL) co-reactant. In embodiments, the composition further comprises an ionic component, a surfactant, or combination thereof. In embodiments, the ECL co-reactant is triethanolamine (TEA), tert-butyldiethanolamine (tBDEA), methyldibutylethanolamine (MDEA), 3-[Bis-(2-hydroxy-ethyl)-amino]-propane-1-sulfonic acid (DEA-PS), or a combination thereof. Methods of using the compositions and kits comprising the compositions are also provided herein.

公开(公告)号：US20220003766A1

公开(公告)日：2022-01-06

申请号：US17246360

申请日：2021-04-30

Applicant: Meso Scale Technologies, LLC.

Inventor： Jacob N. WOHLSTADTER ,  George SIGAL ,  Anu MATHEW ,  Anastasia AKSYUK ,  David ROUTENBERG ,  Martin STENGELIN ,  John KENTEN ,  Timothy J. BREAK ,  Seth B. HARKINS ,  Michael TSIONSKY

IPC: G01N33/569 ,  C12Q1/70

Abstract: The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.

公开(公告)号：US20210349104A1

公开(公告)日：2021-11-11

申请号：US17246364

申请日：2021-04-30

Applicant: Meso Scale Technologies, LLC. ,  The United States of America,as represented by the Secretary,Department of Health and Human Services

Inventor： Jacob N. WOHLSTADTER ,  George SIGAL ,  Anu MATHEW ,  James WILBUR ,  Jeffery DEBAD ,  Christopher CAMPBELL ,  Hans BIEBUYCK ,  Priscilla KRAI ,  Alan KISHBAUGH ,  Leonid DZANTIEV ,  Christopher SHELBURNE ,  Pu LIU ,  Paul GOODWIN ,  Adrian MCDERMOTT ,  Sarah O'CONNELL ,  Sandeep NARPALA

IPC: G01N33/68

Abstract: The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.

公开(公告)号：US20240375109A1

公开(公告)日：2024-11-14

申请号：US18597358

申请日：2024-03-06

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Eli N. GLEZER ,  Sudeep KUMAR ,  Pankaj OBEROI ,  George SIGAL ,  Michael TSIONSKY

IPC: B01L3/00 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N33/543 ,  G01N33/68

Abstract: The invention relates to methods for conducting solid-phase binding assays. Onc example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.