摘要:
Compounds of the formula (I) wherein Z is SO2(N6) or N(R7)SO2 or N(R7)SO2N(R6) useful as metalloproteinase inhibitors, especially as inhibitors of MMP12.
摘要:
The invention provides compounds of formula (I): wherein R1, R2, R3, R4, R5, X, Y, L, G1 and m have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceuticals compositions; and their use in therapy. The compounds are useful as metalloproteinase (MMP) inhibitors.
摘要:
There is provided a method for determining the activity of a protease in a sample. The method comprises (i) admixing said sample with a substrate, wherein the substrate has the formula (1a) wherein: R1 is a hydrocarbyl group; R2 is a first peptide moiety; R3 is a second peptide moiety and X is selected from the group consisting of O, S and NH; Y1 is a suitable substituent; Y2 is a suitable substituent; and (ii) determining the activity of said protease by detecting the presence of a reporter having the formula H—X—R1, wherein: X is selected from the group consisting of O, S and NH; R1 is a hydrocarbyl group. The substrate and reporter are useful for determining the efficacy of protease-modulators and candidate protease-modulators and in the diagnosis of a disease or disorder in a subject.
摘要:
A client and a method in a client in a communication network comprising a core network, for providing a communication service, is provided. The method comprises receiving a session setup request from an originating party, requesting a session with a destination party. The setup request comprises a capability indication associated with the originating party and a session type indication. The method further comprises determining capabilities of devices in a first communication context associated with the destination party and comparing the capabilities of the devices in the first communication context to the capability indication and to the session type indication in the received request Still further, the method comprises determining a level of correspondence between the capability indication and the session type indication, and the capabilities of devices in the first communication context, and indicating a device in the first communication context having a suitable level of correspondence to the capability indication associated with the originating party and the session type indication.
摘要:
A joint for assembling two furniture parts to each other. A first furniture part has a male part for co-operation with a female part of a second furniture part. Each of the male and female parts has a number of grooves. At assembly the male part is moved along the female part via co-operation between the grooves of the male and female part, respectively. The co-operating male and female parts have an insertion position and an end position, in which end position the furniture parts are assembled to each other. The grooves of one of the female and male parts are compressed during movement from the insertion position to the end position. The grooves of the pair of co-operating female part and male part are such that the furniture parts are pressed toward each other when the male part is moved along the female part.
摘要:
A cruise control arrangement for a vehicle includes a cruise control speed function, a cruise control brake function and at least one selectable economy level, having a set maximum speed value corresponding to a maximum allowed vehicle speed, a set brake speed value corresponding to a brake cruise speed and a set cruise speed value corresponding to a cruise speed, where a temporary brake speed value replaces the set brake speed value as the actually used brake speed value, and where the temporary brake speed value is dependent on the selected economy level. The behavior of the cruise control of a vehicle can be adapted to take account of economy, which makes it possible to optimize the fuel consumption of the vehicle.
摘要:
The present invention relates to a method and arrangements for updating the mapping of traffic in the form of a set of service level aggregate flows (SLS1, SLSM) to a set of partial resources (B1, BN) for forwarding the traffic in a communications network (21). Each service level aggregate flow corresponds to a service level associated with a set of service requirements. Information regarding traffic characteristics of each service level aggregate flow and performance of the set of network resources are obtained. Based on this information, the mapping of the set of service level aggregate flows to the set of network resources is updated to achieve a more efficient utilization of the set of network resources, while fulfilling the set of service requirements.
摘要:
A fuel processor for generating hydrogen rich gas or cleaned hydrogen rich gas from hydrocarbon fuel includes an inner housing and an outer housing defining a mantel space between them, wherein at least one fuel reformer unit for reforming hydrocarbon fuel to a hydrogen rich gas and optionally a gas-cleaning unit for cleaning the hydrogen rich gas from unwanted by-products are arranged in the inner housing. The fuel processor further includes a processor inlet for introducing hydrocarbon fuel into the inner housing and a processor outlet for releasing cleaned hydrogen rich gas from the inner housing. The outer housing further includes a fluid inlet for introducing a heat transporting fluid into the mantel space. The inner housing includes at least one opening for providing a fluid-connection between the inner housing and the mantel space. A method for operating such a fuel processor is also provided.
摘要:
A power-saving synchronization of refresh requesting messages transmitted from a client terminal (31) to different server terminals (33a, 33b) in multiple soft-state dialogues, e.g. in SIP. The synchronization involves a continuous detection of a large time offset (34) occurring between the refresh requesting messages in the different dialogues, and an adjustment of the negotiated length of the refresh interval indicated in the refresh requesting messages, such that the client terminal will transmit the refresh requesting messages approximately simultaneously to the different server terminals.