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    INHIBITION OF RETINAL CELL DEGENERATION OR NEOVASCULARIZATION BY CERIUM OXIDE NANOPARTICLES
    21.
    发明申请
    INHIBITION OF RETINAL CELL DEGENERATION OR NEOVASCULARIZATION BY CERIUM OXIDE NANOPARTICLES 审中-公开
    通过氧化氮纳米颗粒抑制细胞衰老或新生血管细胞

    公开(公告)号：US20110111007A1

    公开(公告)日：2011-05-12

    申请号：US12772523

    申请日：2010-05-03

    申请人： James F. McGinnis ,  Xiaohong Zhou ,  Lily L. Wong ,  Sudipta Seal

    发明人： James F. McGinnis ,  Xiaohong Zhou ,  Lily L. Wong ,  Sudipta Seal

    IPC分类号： A61F2/14 ,  A61K33/24 ,  A61P27/02 ,  A61P27/06 ,  A61P29/00 ,  A61P19/02 ,  A61P1/00 ,  A61P17/00 ,  A61K9/14 ,  B82Y5/00

    CPC分类号： A61K33/00

    摘要： The presently claimed and disclosed inventive concept(s) provides methods for reducing, reversing or inhibiting retinal cell degeneration, or neovascularization in tissues of a mammalian subject having a pathological condition involving neovascularization, by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the presently claimed and disclosed inventive concept(s) is useful, for example, for reducing, treating, reversing or inhibiting degeneration of retinal cells such as photoreceptor cells or neovascularization in ocular tissue such as the retina, macula or cornea; or other tissues such as, but not limited to, skin, synovial tissue, intestinal tissue, or bone. In addition, the method of the presently claimed and disclosed inventive concept(s) is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the presently claimed and disclosed inventive concept(s) is directed to using compositions containing nanoceria particles to reduce, treat, reverse or inhibit angiogenesis in a mammalian subject.

    摘要翻译： 目前要求权利要求和公开的发明构思通过在体内施用纳米颗粒（二氧化铈纳米颗粒）至哺乳动物受试者具有新生血管形成病理状态的组织中的视网膜细胞变性或新生血管形成， 主题。 目前权利要求和公开的发明构思的方法可用于例如减少，治疗，逆转或抑制视网膜细胞如感光细胞的变性或眼组织如视网膜，黄斑或角膜中的新生血管形成; 或其它组织，例如但不限于皮肤，滑膜组织，肠组织或骨。 此外，本发明权利要求和公开的发明构思的方法可用于减少或抑制肿瘤（肿瘤）中的新生血管形成，所述肿瘤可能是良性或恶性的，并且恶性肿瘤可以是转移性肿瘤。 因此，目前要求保护和公开的发明构思涉及使用含有纳米颗粒的组合物来减少，治疗，逆转或抑制哺乳动物受试者的血管发生。

    Functionalized Nanoceria Composition For Ophthalmic Treatment
    22.
    发明申请
    Functionalized Nanoceria Composition For Ophthalmic Treatment 有权
    功能性纳米组合物用于眼科治疗

    公开(公告)号：US20100221344A1

    公开(公告)日：2010-09-02

    申请号：US12147759

    申请日：2008-06-27

    申请人： Sudipta Seal ,  Swanand D. Patil ,  Manas K. Haldar ,  Sanku Mallik

    发明人： Sudipta Seal ,  Swanand D. Patil ,  Manas K. Haldar ,  Sanku Mallik

    IPC分类号： A61K9/14 ,  A61P27/02

    CPC分类号： C07F5/003 ,  A61K31/18 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention provides a composition comprising a plurality of nanoceria particles, a sufficient amount of at least one inhibitor of human carbonic anhydrase II associated with said plurality of nanoceria particles, and a pharmaceutically acceptable carrier containing said plurality of nanoceria particles with associated inhibitor. One preferred inhibitor of human carbonic anhydrase II comprises 4-carboxybenzene sulfonamide. The disclosed composition is useful in treatment of glaucoma.

    摘要翻译： 本发明提供一种组合物，其包含多个纳米颗粒，足量的至少一种与所述多个纳米颗粒相关联的人碳酸酐酶II抑制剂，以及含有所述多个具有相关抑制剂的纳米颗粒的药学上可接受的载体。 人碳酸酐酶II的一种优选抑制剂包括4-羧基苯磺酰胺。 所公开的组合物可用于治疗青光眼。

    CERIUM OXIDE NANOPARTICLE REGENERATIVE FREE RADICAL SENSOR
    23.
    发明申请
    CERIUM OXIDE NANOPARTICLE REGENERATIVE FREE RADICAL SENSOR 有权
    氧化亚氮纳米颗粒再生自由度传感器

    公开(公告)号：US20090071848A1

    公开(公告)日：2009-03-19

    申请号：US11915697

    申请日：2006-05-26

    申请人： Sudipta Seal ,  Hyoung Cho ,  Swanand Patil ,  Anjum Mehta

    发明人： Sudipta Seal ,  Hyoung Cho ,  Swanand Patil ,  Anjum Mehta

    IPC分类号： G01N27/26

    CPC分类号： G01N27/403 ,  C12Q1/004 ,  C12Q1/005 ,  G01N33/54346 ,  G01N33/54373

    摘要： An electrochemical sensor system for sensing free radicals or materials which generate free radicals in solution includes a working electrode coated with a plurality of cerium oxide nanoparticles and a counter electrode. A solution to be analyzed provides electrolytes to electrically couple the working electrode to the counter electrode. Electronics are connected to at least one of the working and counter electrodes for measuring and amplifying an electrical current signal generated by reduction or oxidation occurring at the working electrode, wherein in a presence of free radicals an electrical current signal flows between the working electrode and the counter electrode. The system can be used to sense the presence of hydrogen peroxide.

    摘要翻译： 用于感测在溶液中产生自由基的自由基或材料的电化学传感器系统包括涂覆有多个氧化铈纳米颗粒的工作电极和对电极。 待分析的解决方案提供电解质以将工作电极电耦合到对电极。 电子器件连接到工作电极和对电极中的至少一个，用于测量和放大在工作电极处发生的还原或氧化产生的电流信号，其中在存在自由基的情况下，电流信号在工作电极和 对电极。 该系统可用于感测过氧化氢的存在。

    Repair of zirconia-based thermal barrier coatings
    25.
    发明申请
    Repair of zirconia-based thermal barrier coatings 审中-公开
    修复氧化锆基热障涂层

    公开(公告)号：US20050129868A1

    公开(公告)日：2005-06-16

    申请号：US10733740

    申请日：2003-12-11

    申请人： Vinod Philip ,  Sudipta Seal ,  Weifeng Fei ,  Satyajit Shukla

    发明人： Vinod Philip ,  Sudipta Seal ,  Weifeng Fei ,  Satyajit Shukla

    IPC分类号： C23C4/00 ,  C23C4/10 ,  H05H1/42 ,  H05H1/26 ,  B32B35/00

    CPC分类号： H05H1/42 ,  C23C4/01 ,  C23C4/11

    摘要： A method of depositing a zirconia-based ceramic coating (24) using a low velocity oxy-fuel (LVOF) process. Particles of zirconia (14) are mixed with second constituent particles (16) of a material having a melting temperature sufficiently low to be successfully deposited by an LVOF process. The second constituent particles may have a coefficient of thermal expansion within 30% of that of the zirconia particles, and/or they may have a thermal conductivity less than or no more than 20% higher that that of the zirconia particles. The second constituent particles may include calcium titanate, strontium titanate or sodium-zirconium-phosphate-silicate (NZPS). The capability to deposit the zirconia-containing particle mix with an LVOF process facilitates the in-situ repair of a component having a damaged zirconia-based thermal barrier coating.

    摘要翻译： 使用低速氧 - 燃料（LVOF）工艺沉积氧化锆基陶瓷涂层（24）的方法。 氧化锆（14）的颗粒与熔融温度足够低的材料的第二组分颗粒（16）混合，以通过LVOF工艺成功沉积。 第二组分颗粒可以具有在氧化锆颗粒的30％以内的热膨胀系数，和/或它们的热导率可以低于或高于氧化锆颗粒的20％以上。 第二构成颗粒可以包括钛酸钙，钛酸锶或磷酸锆 - 磷酸盐 - 硅酸盐（NZPS）。 使用LVOF工艺沉积含氧化锆的颗粒混合物的能力有助于原位修复具有损坏的基于氧化锆的热障涂层的组分。

    Coated Nanoparticle Therapy for Skin Cancer
    29.
    发明申请
    Coated Nanoparticle Therapy for Skin Cancer 审中-公开
    涂层纳米粒子治疗皮肤癌

    公开(公告)号：US20130337070A1

    公开(公告)日：2013-12-19

    申请号：US13903931

    申请日：2013-05-28

    申请人： Peter Brenneisen ,  Sudipta Seal

    发明人： Peter Brenneisen ,  Sudipta Seal

    IPC分类号： A61K9/14 ,  A61K31/721 ,  A61K33/24

    CPC分类号： A61K9/146 ,  A61K31/721 ,  A61K33/24 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/915 ,  A61K2300/00

    摘要： Disclosed herein are compositions useful as therapy and prevention of skin neoplasms, namely melanoma. Also disclosed herein are methods of using polymer-coated cerium nanoparticles as therapy against skin cancer. Further, disclosed are combination therapies involving polymer-coated cerium nanoparticles with other anti-neoplastic agents.

    摘要翻译： 本文公开了可用作治疗和预防皮肤肿瘤（即黑色素瘤）的组合物。 本文还公开了使用聚合物包被的铈纳米颗粒作为治疗皮肤癌的方法。 此外，公开了包括聚合物包被的铈纳米颗粒与其他抗肿瘤剂的组合疗法。

    Functionalized fly ash and oil scavenging using the same
    30.
    发明授权
    Functionalized fly ash and oil scavenging using the same 有权
    功能化飞灰和采用同样的清除油

    公开(公告)号：US08318625B2

    公开(公告)日：2012-11-27

    申请号：US13180161

    申请日：2011-07-11

    申请人： Sudipta Seal ,  David L. Reid ,  Larry L. Hench

    发明人： Sudipta Seal ,  David L. Reid ,  Larry L. Hench

    IPC分类号： B01J29/06 ,  B01J20/18 ,  B01J20/22

    CPC分类号： C02F1/283 ,  B01J20/3204 ,  B01J20/3217 ,  B01J20/3238 ,  B01J20/3244 ,  B01J20/3248 ,  B01J20/3289 ,  B01J2220/4887 ,  C02F1/288 ,  C02F1/681 ,  C02F2101/32

    摘要： A method of scavenging oil from an oil-water mixture includes providing a plurality of functionalized fly ash particles having functionalized surfaces including reactive groups or reactive materials having hydrophobic groups covalently bound to the reactive groups or reactive materials. The oil-water mixture is contacted with the plurality of functionalized fly ash particles. The plurality of functionalized fly ash particles absorb oil from the oil-water mixture to form oil-laden fly ash particles. The oil-laden fly ash particles can be fed into a combustion process to generate heat from oil absorbed thereon, or absorbed oil from the oil-laden fly ash particles can be separated using a desorption process, and the oil recovered after separating.

    摘要翻译： 从油 - 水混合物中清除油的方法包括提供多个具有功能化表面的官能化飞灰颗粒，其包括反应性基团或具有与反应性基团共价结合的疏水基团的反应性物质或反应性物质。 油水混合物与多个功能化的飞灰颗粒接触。 多个功能化飞灰颗粒从油 - 水混合物中吸收油以形成含油飞灰颗粒。 可以将含油粉煤灰颗粒进料到燃烧过程中以从其上吸收的油产生热量，或者可以使用解吸过程从含油载粉煤灰颗粒中吸收的油分离，并在分离后回收油。