公开(公告)号：US06544548B1

公开(公告)日：2003-04-08

申请号：US09638643

申请日：2000-08-14

申请人： Arlene J. Siller-Jackson ,  Mark E. Van Dyke ,  Scott F. Timmons ,  Cheryl R. Blanchard ,  Robert A. Smith

发明人： Arlene J. Siller-Jackson ,  Mark E. Van Dyke ,  Scott F. Timmons ,  Cheryl R. Blanchard ,  Robert A. Smith

IPC分类号： A61F1300

CPC分类号： A61K8/042 ,  A61F2013/530481 ,  A61F2013/530613 ,  A61K8/65 ,  A61K9/0024 ,  A61K9/06 ,  A61K9/146 ,  A61K9/2063 ,  A61K9/7007 ,  A61K38/015 ,  A61K38/17 ,  A61K47/42 ,  A61K47/6953 ,  A61L15/32 ,  A61L15/60 ,  A61L27/227 ,  A61L27/52 ,  A61Q19/00

摘要： A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a cation. The neutralized suspension can be filtered, washed, and dried, leaving keratin solid which can be shredded into fibers and further ground into powder. Addition of water to the solid produces a hydrogel. The powder or hydrogel may be useful as an absorbent material, as a therapeutic for skin, or as an excipient. The keratin materials can be incorporated into nonwoven films. The hydrogel can be used as a biocompatible viscoelastic filler for implant applications. Another use for the absorbent keratin and keratin hydrogel is as an excipient in pharmaceutical and cosmetic applications.

摘要翻译： 可以通过将毛发角蛋白二硫键部分氧化成磺酸残基并使磺酸残基与阳离子反应来制备能够吸收大量过量水分的可水合的高吸收性角蛋白固体纤维或粉末。 中和的悬浮液可以过滤，洗涤和干燥，留下角蛋白固体，将其切成纤维并进一步研磨成粉末。 向固体中加入水产生水凝胶。 粉末或水凝胶可用作吸收材料，作为皮肤的治疗剂或赋形剂。 角蛋白材料可以并入无纺膜中。 水凝胶可用作植入物应用的生物相容性粘弹性填料。 吸收性角蛋白和角蛋白水凝胶的另一用途是作为药物和化妆品应用中的赋形剂。

公开(公告)号：USH1931H

公开(公告)日：2001-01-02

申请号：US08982134

申请日：1997-12-01

申请人： Timothy P. Parr ,  Kenneth J. Wilson ,  Kenneth Yu ,  Klaus Schadow ,  Robert A. Smith

发明人： Timothy P. Parr ,  Kenneth J. Wilson ,  Kenneth Yu ,  Klaus Schadow ,  Robert A. Smith

IPC分类号： F23G500

CPC分类号： F23C15/00 ,  F23C2205/10 ,  F23G7/065

摘要： This invention involves an improved technique for the modulation of waste in an actively controlled compact waste incinerator afterburner. This improved technique utilizes acoustic driving to affect indirect modulation of waste flow velocities. The waste surrogate gases are modulated indirectly by periodic entrainment created by the roll-up of the main air vortex as well as indirect acoustic excitation of secondary air injection. One of the main advantages of this new configuration is the acoustic drivers used to phase inject the waste into the vortex for proper combustion are not in direct contact with the hot waste and therefore can be less expensive and more durable over the long term.

摘要翻译： 本发明涉及用于在主动控制的紧凑型垃圾焚烧炉后燃器中调节废物的改进技术。 这种改进的技术利用声学驱动来影响废物流速的间接调制。 通过主空气涡流的卷起以及二次空气喷射的间接声激发产生的周期夹带间接地调节废弃代用气体。 这种新配置的主要优点之一是用于将废物相位注入涡流以用于适当燃烧的声学驱动器不与热废物直接接触，因此可以在长期内更便宜并且更耐用。

公开(公告)号：US6159495A

公开(公告)日：2000-12-12

申请号：US362244

申请日：1999-07-28

申请人： Scott F. Timmons ,  Cheryl R. Blanchard ,  Robert A. Smith

发明人： Scott F. Timmons ,  Cheryl R. Blanchard ,  Robert A. Smith

IPC分类号： A61K9/70 ,  A61K35/36 ,  A61K38/17 ,  A61K38/39 ,  A61L15/32 ,  A61L26/00 ,  A61L27/22 ,  A61L27/34 ,  A61L27/60 ,  A61L31/04 ,  A61L31/10 ,  C07K14/47 ,  C08H1/06 ,  C12N5/00 ,  A61K13/00 ,  A61K38/00 ,  C08G63/48

CPC分类号： C12N5/0068 ,  A61K35/36 ,  A61K38/1709 ,  A61K38/39 ,  A61K9/70 ,  A61L15/32 ,  A61L26/0047 ,  A61L26/008 ,  A61L27/227 ,  A61L27/34 ,  A61L27/60 ,  A61L31/047 ,  A61L31/10 ,  C07K14/4741 ,  C08H1/06 ,  C12N2533/50 ,  Y10S530/842

摘要： Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages are broken and free cysteine thiol groups formed, separating out a more soluble keratin fraction in solution, forming a thin layer from the more soluble fraction, and air drying the keratin fraction in the presence of oxygen, thereby forming new disulfide bonds imparting strength to the resulting thin keratin film. One method includes reducing hair by heating the hair under nitrogen in an ammonium hydroxide and ammonium thioglycolate solution followed by centrifuging and collecting the supernatant containing the more soluble keratin fraction. The more soluble keratin in this method is precipitated using HCl, removed, and resuspended in ammonium hydroxide. The keratin solution thus formed is poured onto a flat surface and allowed to air dry into a thin keratin film. The film may be used as a wound dressing, a tissue-engineering scaffold, a diffusion membrane, a coating for implantable devices, and as a cell encapsulant. In another method, the keratin solution thus formed is concentrated, poured into a mold, and allowed to air dry into a three dimensional keratin product. The resulting bulk product can be used as a cross-linked implantable biomaterial for soft and hard tissue replacement. In another method, a keratin solution is emulsified and freeze dried, forming a porous, open cell keratin material.

摘要翻译： 用于生产薄角蛋白薄膜，片材和散装材料的方法以及使用这些方法形成的产品。 一种方法包括提供毛发，减少头发，使得二硫键断裂，形成游离的半胱氨酸硫醇基团，在溶液中分离出更可溶的角蛋白级分，从较可溶级分形成薄层，并将角蛋白级分空气干燥 氧的存在，从而形成新的二硫键，赋予所得薄的角蛋白薄膜强度。 一种方法包括通过在氮气下在氢氧化铵和巯基乙酸铵溶液中加热头发，然后离心并收集含有较可溶性角蛋白级分的上清液来减少头发。 该方法中较易溶解的角蛋白用HCl沉淀，除去，再悬浮于氢氧化铵中。 将如此形成的角蛋白溶液倒入平坦表面，并使其干燥成薄的角蛋白膜。 该膜可以用作伤口敷料，组织工程支架，扩散膜，用于可植入装置的涂层，以及作为细胞密封剂。 在另一种方法中，将如此形成的角蛋白溶液浓缩，倒入模具中，并使其风干至三维角蛋白产品。 所得到的散装产品可用作用于软组织和硬组织置换的交联可植入生物材料。 在另一种方法中，将角蛋白溶液乳化并冷冻干燥，形成多孔的开放细胞角蛋白材料。

公开(公告)号：US6110487A

公开(公告)日：2000-08-29

申请号：US198998

申请日：1998-11-24

申请人： Scott F. Timmons ,  Cheryl R. Blanchard ,  Robert A. Smith

发明人： Scott F. Timmons ,  Cheryl R. Blanchard ,  Robert A. Smith

IPC分类号： A61K9/70 ,  A61K35/36 ,  A61K38/17 ,  A61K38/39 ,  A61L15/32 ,  A61L26/00 ,  A61L27/22 ,  A61L27/34 ,  A61L27/60 ,  A61L31/04 ,  A61L31/10 ,  C07K14/47 ,  C08H1/06 ,  C12N5/00 ,  A61K9/00 ,  A61K38/00 ,  C08G63/48

CPC分类号： C12N5/0068 ,  A61K35/36 ,  A61K38/1709 ,  A61K38/39 ,  A61K9/70 ,  A61L15/32 ,  A61L26/0047 ,  A61L26/008 ,  A61L27/227 ,  A61L27/34 ,  A61L27/60 ,  A61L31/047 ,  A61L31/10 ,  C07K14/4741 ,  C08H1/06 ,  C12N2533/50 ,  Y10S530/842

摘要： Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages are broken and free cysteine thiol groups formed, separating out a more soluble keratin fraction in solution, forming a thin layer from the more soluble fraction, and air drying the keratin fraction in the presence of oxygen, thereby forming new disulfide bonds imparting strength to the resulting thin keratin film. One method includes reducing hair by heating the hair under nitrogen in an ammonium hydroxide and ammonium thioglycolate solution followed by centrifuging and collecting the supernatant containing the more soluble keratin fraction. The more soluble keratin in this method is precipitated using HCl, removed, and resuspended in ammonium hydroxide. The keratin solution thus formed is poured onto a flat surface and allowed to air dry into a thin keratin film. The film may be used as a wound dressing, a tissue-engineering scaffold, a diffusion membrane, a coating for implantable devices, and as a cell encapsulant. In another method, the keratin solution thus formed is concentrated, poured into a mold, and allowed to air dry into a three dimensional keratin product. The resulting bulk product can be used as a cross-linked implantable biomaterial for soft and hard tissue replacement. In another method, a keratin solution is emulsified and freeze dried, forming a porous, open cell keratin material.

摘要翻译： 用于生产薄角蛋白薄膜，片材和散装材料的方法以及使用这些方法形成的产品。 一种方法包括提供毛发，减少头发，使得二硫键断裂，形成游离的半胱氨酸硫醇基团，在溶液中分离出更可溶的角蛋白级分，从较可溶级分形成薄层，并将角蛋白级分空气干燥 氧的存在，从而形成新的二硫键，赋予所得薄的角蛋白薄膜强度。 一种方法包括通过在氮气下在氢氧化铵和巯基乙酸铵溶液中加热头发，然后离心并收集含有较可溶性角蛋白级分的上清液来减少头发。 该方法中较易溶解的角蛋白用HCl沉淀，除去，再悬浮于氢氧化铵中。 将如此形成的角蛋白溶液倒入平坦表面，并使其干燥成薄的角蛋白膜。 该膜可以用作伤口敷料，组织工程支架，扩散膜，用于可植入装置的涂层，以及作为细胞密封剂。 在另一种方法中，将如此形成的角蛋白溶液浓缩，倒入模具中，并使其风干至三维角蛋白产品。 所得到的散装产品可用作用于软组织和硬组织置换的交联可植入生物材料。 在另一种方法中，将角蛋白溶液乳化并冷冻干燥，形成多孔的开放细胞角蛋白材料。

公开(公告)号：US5948432A

公开(公告)日：1999-09-07

申请号：US979526

申请日：1997-11-26

申请人： Scott F. Timmons ,  Cheryl R. Blanchard ,  Robert A. Smith

发明人： Scott F. Timmons ,  Cheryl R. Blanchard ,  Robert A. Smith

IPC分类号： A61K9/70 ,  A61K35/36 ,  A61K38/39 ,  A61L15/32 ,  A61L26/00 ,  A61L27/22 ,  A61L27/34 ,  A61L27/60 ,  A61L31/04 ,  A61L31/10 ,  C08H1/06 ,  C12N5/00 ,  A61K38/00 ,  A01N25/34 ,  A61L15/00

CPC分类号： C12N5/0068 ,  A61K35/36 ,  A61K38/39 ,  A61K9/70 ,  A61L15/32 ,  A61L26/0047 ,  A61L26/008 ,  A61L27/227 ,  A61L27/34 ,  A61L27/60 ,  A61L31/047 ,  A61L31/10 ,  C08H1/06 ,  C12N2533/50 ,  Y10S530/842

摘要： A sheet wound dressing formed of cross linked keratin. An insoluble, largely Beta keratin fraction from human hair is acidified to a low pH, preferably less than about 3, which partially solubilizes the keratin by weakening hydrogen bonds. The suspension is added to base, such as ammonium hydroxide, forming a slurry. The slurry is cast directly onto a flat surface, allowing the re-formation of cross-links including hydrogen bonds and disulfide bonds. The resulting cross-linked keratin sheet can be used as a sheet wound dressing or as a scaffolding for growth of cells. The insoluble keratin can be derived from human hair which is washed, rinsed, dried, chopped and treated with peracetic acid to break some accessible disulfide linkages. The treated hair is filtered, rinsed, dried, and ground into a keratin powder. The keratin powder is suspended in a mixture of ammonium hydroxide and ammonium thioglycollate and heated sufficiently to dissolve the soluble keratin fraction, followed by cooling and centrifugation to concentrate the insoluble, largely Beta keratin fraction.

公开(公告)号：US5932552A

公开(公告)日：1999-08-03

申请号：US979456

申请日：1997-11-26

申请人： Cheryl R. Blanchard ,  Scott F. Timmons ,  Robert A. Smith

发明人： Cheryl R. Blanchard ,  Scott F. Timmons ,  Robert A. Smith

IPC分类号： A61K38/17 ,  A61K38/39 ,  A61L26/00 ,  A61L27/22 ,  A61L27/34 ,  A61L27/52 ,  A61L27/60 ,  A61L31/04 ,  A61L31/10 ,  C07K14/47 ,  C08H1/06 ,  A61K38/00 ,  A61K7/06 ,  A61K9/70 ,  A61L15/00

CPC分类号： C08H1/06 ,  A61K38/1709 ,  A61K38/39 ,  A61K8/042 ,  A61K8/65 ,  A61L26/0047 ,  A61L26/008 ,  A61L27/227 ,  A61L27/34 ,  A61L27/52 ,  A61L27/60 ,  A61L31/047 ,  A61L31/10 ,  A61Q19/00 ,  C07K14/4741 ,  Y10S514/944 ,  Y10S530/842

摘要： A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide linkages remain intact. The partially oxidized hair is treated with a reducing agent, thereby reducing most of the remaining disulfide linkages to cysteine-thioglycollate disulfide and cysteine groups. A soluble fraction of hair is collected and oxidized, such that the reduced sulfur groups are allowed to reform disulfide linkages, thereby binding the keratin together. The cysteic acid groups remain, providing hydrophilic sites within the hydrogel. A higher degree of partial oxidation results in a greater abundance of hydrophilic cysteic acid groups in the hydrogel.

公开(公告)号：US5912604A

公开(公告)日：1999-06-15

申请号：US794491

申请日：1997-02-04

申请人： Ian James Harvey ,  Aftab H. Khan ,  Robert A. Smith ,  James E. Smith

发明人： Ian James Harvey ,  Aftab H. Khan ,  Robert A. Smith ,  James E. Smith

IPC分类号： H01H9/16 ,  H01H33/666 ,  H01H75/00 ,  H01H75/04 ,  H01H33/66

CPC分类号： H01H33/6662 ,  H01F2007/1669 ,  H01H2009/0292 ,  H01H2033/6623 ,  H01H33/027 ,  H01H75/00 ,  H01H75/04 ,  H01H9/16

摘要： An electromagnetic actuator and an automatic recloser incorporating such actuator are disclosed. The actuator is shown to include a housing, a permanent magnet member, a coil, an armature, mounted to move axially within the housing between first and second positions, and a non-magnetic spacer. The armature, when in the second position, is spaced a distance from the housing by the spacer. The spacer is mounted to stop movement of the armature in the second position. In the preferred embodiment, the permanent magnet member includes a core and a number of magnet segments attached thereto. It is especially preferred for each of the permanent magnet segments to be arcuate shaped and that each segment be polarized substantially radially or in a direction parallel to the center radius of each segment. In a preferred embodiment, the housing is formed from a material having a high permeability and the spacer is formed from material having a relative permeability close to one or from a substantially non-magnetic material, such as acetal resin.The circuit recloser is shown to include the bistable magnetic actuator, a contact switch, a connecting member, connected between the actuator the contact switch and a spring, connected to bias the connecting member in relation to the contact switch. When the actuator is in its second position the end of the connecting member is spaced from the end of the contact switch, i.e., over travel is present. An indicator is provided for indicating whether the contact switch is open or closed.

摘要翻译： 公开了一种电磁致动器和包括这种致动器的自动重合器。 致动器被示出为包括壳体，永磁体构件，线圈，衔铁，安装成在第一和第二位置之间轴向移动，以及非磁性间隔件。 当处于第二位置时，电枢通过间隔件与壳体隔开一段距离。 安装间隔件以阻止衔铁在第二位置的移动。 在优选实施例中，永磁体构件包括芯部和附接到其上的多个磁体段。 特别优选的是，每个永磁体段都是弧形的，并且每个段基本上径向地或者在平行于每个段的中心半径的方向上极化。 在优选实施例中，壳体由具有高磁导率的材料形成，并且间隔件由具有接近于1的相对磁导率或基本上非磁性材料（例如缩醛树脂）的材料形成。 电路重合器被示为包括双稳态磁致动器，接触开关，连接构件，连接在致动器接触开关和弹簧之间，连接到相对于接触开关偏压连接构件。 当致动器处于其第二位置时，连接构件的端部与接触开关的端部间隔开，即存在过度行程。 提供一个指示器，用于指示接触开关是打开还是关闭。

公开(公告)号：US5814695A

公开(公告)日：1998-09-29

申请号：US784610

申请日：1997-01-21

申请人： John J. Fitzgerald ,  Bruce C. Kuhl ,  Philip J. McDermott ,  Robert A. Smith

发明人： John J. Fitzgerald ,  Bruce C. Kuhl ,  Philip J. McDermott ,  Robert A. Smith

IPC分类号： C08K3/36 ,  C08K5/13 ,  C08K5/17 ,  C08K5/36 ,  C08K5/372 ,  C08K5/54 ,  C08K9/06 ,  C08L83/04 ,  C08L83/06 ,  C08L83/14 ,  C08K5/24

CPC分类号： C08K5/5406 ,  C08K5/13 ,  C08K5/36 ,  C08K5/372 ,  C08L83/04 ,  C08G77/12 ,  C08G77/16 ,  C08G77/28

摘要： Condensation curable silicone mold making compositions containing an olefin or acetylene polymerization inhibitor have a longer useful life for making casts from curable resins comprising a polymerizable olefin relative to compositions where such a polymerization inhibitor is absent. Particularly preferred polymerization inhibitors are the esters of thiodipropionic acid and silicon polysulfides.

摘要翻译： 含有烯烃或乙炔聚合抑制剂的缩合固化性硅酮模塑制品组合物相对于不存在这种聚合抑制剂的组合物，具有从包含可聚合烯烃的可固化树脂制造铸件的使用寿命更长。 特别优选的聚合抑制剂是硫代二丙酸和硅多硫化物的酯。

公开(公告)号：US5728758A

公开(公告)日：1998-03-17

申请号：US635077

申请日：1996-04-19

申请人： Robert A. Smith

发明人： Robert A. Smith

IPC分类号： C08J7/04 ,  C09D129/04 ,  C09D183/04 ,  G02B1/10 ,  G02B5/23 ,  C08L29/04 ,  C08L43/04

CPC分类号： C08J7/047 ,  C09D129/04 ,  C09D183/04 ,  G02B1/105 ,  G02B5/23 ,  C08J2483/00 ,  Y10T428/31507 ,  Y10T428/31598 ,  Y10T428/31663 ,  Y10T428/31667

摘要： Describes a coating composition for the preparation of abrasion resistant coatings consisting essentially of: (a) 5 to 35 weight percent of a silane monomer mixture of (i) C.sub.1 -C.sub.12 alkyl tri(C.sub.1 -C.sub.6)alkoxysilane and (ii) tetra(C.sub.1 -C.sub.6)alkoxysilane, the weight ratio of (i) to (ii) being from 3:1 to 1:3; (b) 1 to 9 weight percent of polyvinyl alcohol that is at least 72 percent hydrolyzed; (c) a solvating amount of lower aliphatic alcohol; (d) a catalytic amount of water-soluble acid; (e) a leveling amount of nonionic surfactant; and (f) water in an amount sufficient to form hydrolysates of the silane monomers and to solubilize the polyvinyl alcohol and acid. Further described are transparent articles and photochromic articles comprising organic polymeric host material, organic photochromic compound(s), and a cured abrasion resistant coating prepared from the coating composition.

摘要翻译： 描述了用于制备耐磨涂层的涂料组合物，其基本上由以下组成：（a）5-35重量％的（i）C 1 -C 12烷基三（C 1 -C 6）烷氧基硅烷和（ii）四（C 1 -C 6）烷氧基硅烷的硅烷单体混合物 -C 6）烷氧基硅烷，（i）至（ii）的重量比为3：1至1：3; （b）1至9重量％的至少72％水解的聚乙烯醇; （c）溶剂化的低级脂族醇; （d）催化量的水溶性酸; （e）非离子表面活性剂的调配量; 和（f）水的量足以形成硅烷单体的水解产物并溶解聚乙烯醇和酸。 还描述了包含有机聚合物主体材料，有机光致变色化合物和由涂料组合物制备的固化的耐磨涂层的透明制品和光致变色制品。

公开(公告)号：US5632272A

公开(公告)日：1997-05-27

申请号：US320154

申请日：1994-10-07

申请人： Mohamed K. Diab ,  Esmaiel Kiani-Azarbayjany ,  Ibrahim M. Elfadel ,  Rex J. McCarthy ,  Walter M. Weber ,  Robert A. Smith

发明人： Mohamed K. Diab ,  Esmaiel Kiani-Azarbayjany ,  Ibrahim M. Elfadel ,  Rex J. McCarthy ,  Walter M. Weber ,  Robert A. Smith

IPC分类号： A61B5/0245 ,  A61B5/00 ,  A61B5/02 ,  A61B5/0215 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1464 ,  A61B6/00 ,  A61B8/00 ,  G06F17/00 ,  G06F19/00 ,  H04B1/12 ,  H04B3/46 ,  H04B17/00

CPC分类号： H04B1/123 ,  A61B5/14546 ,  A61B5/14551 ,  A61B5/4821 ,  A61B5/7214 ,  A61B5/7253 ,  A61B8/5276 ,  G06K9/0051 ,  A61B5/021 ,  A61B5/02154 ,  A61B5/024 ,  A61B5/029 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0816 ,  A61B5/14532 ,  A61B5/7257 ,  A61B6/00 ,  A61B8/00

摘要： The present invention involves method and apparatus for analyzing two measured signals that are modeled as containing primary and secondary portions. Coefficients relate the two signals according to a model defined in accordance with the present invention. In one embodiment, the present invention involves utilizing a transformation which evaluates a plurality of possible signal coefficients in order to find appropriate coefficients. Alternatively, the present invention involves using statistical functions or Fourier transform and windowing techniques to determine the coefficients relating to two measured signals. Use of this invention is described in particular detail with respect to blood oximetry measurements.

摘要翻译： 本发明涉及用于分析被建模为包含主要和次要部分的两个测量信号的方法和装置。 系数根据根据本发明定义的模型关联两个信号。 在一个实施例中，本发明涉及利用评估多个可能的信号系数以便找到适当系数的变换。 或者，本发明涉及使用统计功能或傅里叶变换和加窗技术来确定与两个测量信号有关的系数。 关于血液测碘法测量，特别详细地描述了本发明的用途。