公开(公告)号：US5925016A

公开(公告)日：1999-07-20

申请号：US534856

申请日：1995-09-27

Applicant: Victor I. Chornenky ,  Michael R. Forman

Inventor： Victor I. Chornenky ,  Michael R. Forman

IPC: A61F2/958 ,  A61M25/00 ,  A61M29/00

CPC classification number: A61M25/09 ,  A61M25/10 ,  A61M2025/0047 ,  A61M2025/09008 ,  A61M2025/09083 ,  A61M2025/1052 ,  A61M2205/36 ,  A61M25/007 ,  A61M25/1011

Abstract: Systems and methods for treating thrombosis by driving the drugs or lytic agents through the thrombus by pressure, are disclosed. The system preferably comprises a guide catheter with an occlusion balloon for isolating the region proximal to the thrombus, a guide wire with an occlusion balloon for isolating the region distal to the thrombus and an infusion catheter for delivering drugs or other agents into the region distal to the thrombus under pressure. A lumen of the guide catheter is preferably provided to evacuate material proximal to the thrombus, decreasing the pressure in the proximal to the thrombus. The lumen can be coupled to a thrombus filter to remove thrombolytic material from the drug or lytic agent evacuated from the proximal region. The filtered drug or lytic agent can then be redelivered into the distal region. Recycling of the drug or lytic agent in this manner decreases the costs of the procedure. The systems and methods of the invention can be used to treat other blockages in lumens or vessels in the body or to deliver drugs or other agents to lumens, vessels or cavities within the body, as well.

Abstract translation: 公开了通过压力驱动药物或溶解剂通过血栓来治疗血栓形成的系统和方法。 该系统优选地包括具有用于隔离接近血栓的区域的阻塞球囊的引导导管，具有用于隔离远离血栓的区域的闭塞气囊的导丝和用于将药物或其它药剂递送到远端的区域的输注导管 血栓在压力下。 优选地，引导导管的内腔用于抽吸靠近血栓的材料，从而降低血栓近端的压力。 管腔可以联接到血栓过滤器以从药物或从近端区域排出的溶解剂中除去血栓溶解物质。 然后将过滤的药物或溶解剂再次送入远端区域。 以这种方式回收药物或溶解剂降低了程序的成本。 本发明的系统和方法可用于治疗身体内腔或血管中的其它阻塞物，或者将药物或其它药物递送至体内的流明，血管或空腔。

公开(公告)号：US5826588A

公开(公告)日：1998-10-27

申请号：US956963

申请日：1997-10-23

Applicant: Michael R. Forman

Inventor： Michael R. Forman

IPC: A61M25/00 ,  A61M29/02 ,  A61B19/00 ,  A61M29/00

CPC classification number: A61M25/1029 ,  A61M25/104 ,  A61M2025/1031

Abstract: A dilatation balloon (20,98) is fabricated according to a process that yields high hoop strength and uniformity in balloon wall thickness. A length of tubing (34) is axially elongated and radially expanded in a form (36) to provide the requisite biaxial orientation and strength. Then, an excimer laser (46,66,84) is used to remove the polymeric material by photo-chemical ablation, virtually without thermal effects. Dilatation balloon walls are thinned primarily along tapered sections (26,28) between proximal and distal balloon stems (30,32) and a medial working section (24) of the balloon. Material removal, particularly near the balloon stems, enables tighter wrapping of the balloon for a reduced delivery profile, and reduces rigidity near the stems for better maneuverability of the catheter in tortuous passageways. The balloon tapered sections are reduced to a wall thickness substantially equal to that of the medial section. Alternatively, an array of grooves (96) is formed in each tapered section.

Abstract translation: 膨胀球囊（20,98）根据产生高气球强度和球囊壁厚度均匀性的方法制造。 一段长度的管道（34）轴向地伸长并以（36）的形式径向扩张，以提供所需的双轴取向和强度。 然后，准分子激光器（46,66,84）用于通过光学化学消融去除聚合物材料，实际上没有热效应。 扩张球囊壁主要在近端和远端气囊杆（30,32）和球囊的内侧工作部分（24）之间的锥形部分（26,28）上变薄。 特别是气囊杆附近的材料去除使得球囊能够更紧密地包裹以减少输送轮廓，并且降低杆附近的刚度，从而更好地操纵导管在曲折通道中的机动性。 气囊锥形部分被还原成基本上等于中间部分的壁厚。 或者，在每个锥形部分中形成有凹槽阵列（96）。

公开(公告)号：US5713853A

公开(公告)日：1998-02-03

申请号：US488216

申请日：1995-06-07

Applicant: David W. Clark ,  Souise S. Clark ,  Michael R. Forman

Inventor： David W. Clark ,  Souise S. Clark ,  Michael R. Forman

IPC: A61B17/22 ,  A61F2/958 ,  A61M25/00 ,  A61M29/02 ,  A61M31/00

CPC classification number: A61M25/007 ,  A61M29/02 ,  A61B2017/22082 ,  A61M2025/105 ,  A61M25/10

Abstract: A catheter for delivering drugs or other agents is disclosed particularly suited for delivering drugs proximate the walls of a vessel or lumen, such as an artery or vein. The catheter comprises a shaft with a distal portion comprising at least one and preferably a plurality of delivery members. When deployed, the delivery members flare from the catheter shaft at an acute or obtuse angle. At least a portion of the delivery members are within a restraining member such as a sleeve or thread, for example, to maintain the delivery member within the diameter of the shaft prior to deployment. Delivery lumens provide drugs to ports in the delivery members for delivery out of the catheter. The delivery members preferably bear against the wall of the vessel when deployed, to deliver the drug or other agent proximate the walls of the blood vessel, where blood flow is slow. In another embodiment the delivery members comprise a first tapered portion, a second longitudinal portion and a plurality of drug delivery ports.

Abstract translation: 公开了用于递送药物或其它药剂的导管，其特别适合于在血管或内腔（例如动脉或静脉）的壁附近输送药物。 导管包括具有远端部分的轴，该远侧部分包括至少一个且优选地多个递送构件。 当展开时，输送构件以尖锐或钝角从导管轴上扩张。 输送构件的至少一部分在诸如套筒或螺纹的限制构件内，例如在展开之前将输送构件保持在轴的直径内。 输送流体向输送部件中的端口提供药物以从导管输送。 递送构件优选在展开时抵靠血管的壁，以在血液流动缓慢的血管壁附近递送药物或其它药剂。 在另一个实施例中，递送构件包括第一锥形部分，第二纵向部分和多个药物输送端口。

公开(公告)号：US5415636A

公开(公告)日：1995-05-16

申请号：US227254

申请日：1994-04-13

Applicant: Michael R. Forman

Inventor： Michael R. Forman

IPC: A61M25/00 ,  A61F2/82 ,  A61M25/10 ,  A61M29/02 ,  A61M29/00

CPC classification number: A61M25/104 ,  A61M2025/0175 ,  A61M2025/1015 ,  A61M2025/1052 ,  A61M2025/1079 ,  A61M25/1006

Abstract: A dilation-drug delivery catheter comprises a dilation portion for dilating a stenosis and a drug delivery portion for delivering antithrombolytic, antiproliferative, or any other type of medication, to the dilation site. The drug delivery portion of the catheter is located within the dilation portion, which can be retracted to reveal the drug delivery portion, after dilation. Occlusion balloons are preferably provided on the drug delivery portion to isolate the dilation site during drug delivery.

Abstract translation: 扩张药物递送导管包括用于扩张狭窄的扩张部分和用于将抗血栓溶解，抗增殖或任何其它类型的药物递送至扩张部位的药物递送部分。 导管的药物输送部分位于扩张部分内，其可以在扩张后缩回以露出药物输送部分。 阻塞气囊优选地设置在药物递送部分上以在药物递送期间分离扩张部位。

公开(公告)号：US07815561B2

公开(公告)日：2010-10-19

申请号：US10742445

申请日：2003-12-19

Applicant: Michael R. Forman ,  Darius Francescatti ,  Ni Ding

Inventor： Michael R. Forman ,  Darius Francescatti ,  Ni Ding

IPC: A61N5/00

CPC classification number: A61N5/1015 ,  A61N5/1027

Abstract: A breast brachytherapy applicator providing a stable semi permanent/permanent in dwelling platform that is configured to replicate anatomically the excised cancer bed and allows for a more precise anatomically correct delivery of limited field radiation treatment. This device may be used to reconstitute a resected tissue space to its pre-operative size and shape to 1) facilitate the accurate and precise delivery of adjunctive breast brachytherapy following breast cancer surgery and 2) prevent/decrease post-operative deformity as a result of surgical resection, whether for benign or malignant disease, and in particular after radiation treatment of malignant disease in the post lumpectomy patient.

Abstract translation: 一种乳房近距离放射治疗仪，其提供稳定的半永久/永久性住宅平台，其被配置为在解剖学上复制切除的癌床，并允许更精确的解剖学上正确的有限的放射治疗递送。 该装置可用于将切除的组织空间重建为其手术前的大小和形状，以便于1）促进乳腺癌手术后辅助乳房近距离放射治疗的准确和精确的传递，以及2）由于以下原因：预防/减少术后畸形 手术切除，无论是良性还是恶性疾病，特别是放射治疗乳房肿瘤切除术后患者的恶性疾病。

公开(公告)号：US07695512B2

公开(公告)日：2010-04-13

申请号：US10895269

申请日：2004-07-19

Applicant: Randall T. Lashinski ,  Gerard von Hoffmann ,  Richard S. Kusleika ,  Michael R. Forman ,  David Mark Taylor

Inventor： Randall T. Lashinski ,  Gerard von Hoffmann ,  Richard S. Kusleika ,  Michael R. Forman ,  David Mark Taylor

IPC: A61F2/24

CPC classification number: A61F2/2451 ,  A61B5/6882 ,  A61B2560/0219 ,  A61F2/2466 ,  A61F2250/0001

Abstract: Disclosed are implants and methods for remote remodeling of a mitral valve annulus. The implant comprises a body transformable from a flexible configuration for navigation to a treatment site, to a remodeling configuration for, in one application, applying pressure to the posterior leaflet of the mitral valve. On board electronics allow post deployment adjustment of the implant.

Abstract translation: 公开了用于二尖瓣环的远端重塑的植入物和方法。 植入物包括从用于导航到治疗部位的柔性构造可转换的身体到在一个应用中的重塑构型，其向二尖瓣的后小叶施加压力。 车载电子元件允许植入物的部署后调整。

公开(公告)号：US06120904A

公开(公告)日：2000-09-19

申请号：US317531

申请日：1999-05-24

Applicant: Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

Inventor： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

IPC: A61L29/00 ,  A61L29/08 ,  A61L31/00 ,  A61L31/10 ,  B05D1/36 ,  B05D7/00 ,  B05D7/02 ,  B05D7/16 ,  B05D7/24 ,  C08G18/10 ,  C08G18/48 ,  C08G18/75 ,  C08J7/00 ,  C08J7/04 ,  C09D175/12 ,  B32B27/40

CPC classification number: B05D7/52 ,  A61L29/085 ,  A61L31/10 ,  B05D7/02 ,  B05D7/16 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/755 ,  C08G18/758 ,  C09D175/12 ,  C08G2210/00 ,  C08G2270/00 ,  Y10T428/31551 ,  Y10T428/31554 ,  Y10T428/31562 ,  Y10T428/31565 ,  Y10T428/31587 ,  Y10T428/31605

Abstract: A medical device comprising an organic polymer substrate material having a coating thereon, the coating comprising an interpenetrating network of two different hydrogel polymers, one of which is a polyurethane/polyurea hydrogel polymer, the polyurethane/polyurea hydrogel polymer being linked to the substrate material by covalent urea linkages.

Abstract translation: 一种包括其上具有涂层的有机聚合物基底材料的医疗装置，所述涂层包含两种不同的水凝胶聚合物的互穿网络，其中一种是聚氨酯/聚脲水凝胶聚合物，所述聚氨酯/聚脲水凝胶聚合物通过 共价尿素键。

公开(公告)号：US6095966A

公开(公告)日：2000-08-01

申请号：US27010

申请日：1998-02-20

Applicant: Victor I. Chornenky ,  Michael R. Forman ,  Robert A. Ganz

Inventor： Victor I. Chornenky ,  Michael R. Forman ,  Robert A. Ganz

IPC: A61N5/10 ,  H01J35/32

CPC classification number: A61N5/1001 ,  H01J35/32 ,  A61N5/1002 ,  H01J2235/205

Abstract: Generally, the present invention provides a device for insertion into a body of a subject being treated to deliver localized x-ray radiation, and a method for use of such a device. The device includes an anode and a cathode, disposed within a vacuum housing. The device further includes a balloon coupled to and circumferentially surrounding the vacuum housing, and a fluid loop for circulating a cooling fluid proximate to the vacuum housing. A method for delivering localized x-ray radiation to an interior passage of a body is also described, including the steps of positioning an x-ray device at the passage to be treated and applying a high voltage to the x-ray producing unit to produce localized x-ray radiation.

Abstract translation: 通常，本发明提供一种用于插入被处理以递送局部x射线辐射的对象的身体的装置，以及使用这种装置的方法。 该装置包括设置在真空壳体内的阳极和阴极。 该装置还包括联接到并围绕真空壳体并围绕真空壳体的气囊，以及用于使靠近真空壳体的冷却流体循环的流体回路。 还描述了将局部X射线辐射递送到身体的内部通道的方法，包括以下步骤：将X射线装置定位在待治疗的通道处，并向x射线产生单元施加高电压以产生 局部x射线辐射。

公开(公告)号：US6080488A

公开(公告)日：2000-06-27

申请号：US126376

申请日：1998-03-24

Applicant: Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

Inventor： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

IPC: A61L29/08 ,  A61L31/10 ,  C08G18/10 ,  C08G18/28 ,  C08J7/04 ,  B05D1/36 ,  B32B27/00

CPC classification number: C08J7/047 ,  A61L29/085 ,  A61L31/10 ,  C08G18/10 ,  C08G18/283 ,  C08J7/04 ,  C08G2230/00 ,  C08J2475/00 ,  Y10T428/31554 ,  Y10T428/31562 ,  Y10T428/31565 ,  Y10T428/31569 ,  Y10T428/31587 ,  Y10T428/31678

Abstract: A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

公开(公告)号：US6036631A

公开(公告)日：2000-03-14

申请号：US036942

申请日：1998-03-09

Applicant: Jonathan R. McGrath ,  Michael R. Forman

Inventor： Jonathan R. McGrath ,  Michael R. Forman

IPC: A61M36/04 ,  A61N5/10 ,  A61N5/00

CPC classification number: A61N5/1014 ,  A61N2005/1005

Abstract: A device and method for treatment of cancerous tissue from a body conduit involves insertion into the body conduit of a probe including an energy-emitting element for delivering ionizing energy. The body conduit is dilated to decrease a distance between at least a portion of the body conduit and the cancerous tissue. Ionizing energy is delivered from the energy-emitting element to selectively injure the cancerous tissue, with dilation of the body conduit minimizing the radiation dose delivered to the body conduit for a given radiation dose delivered to the cancerous tissue.

Abstract translation: 用于治疗来自身体导管的癌组织的装置和方法包括插入到包括用于传递电离能的能量发射元件的探针的体导管中。 身体导管被扩张以减小身体导管的至少一部分与癌组织之间的距离。 电离能量从能量发射元件输送以选择性地损伤癌组织，由于体内导管的扩张使得递送至身体导管的辐射剂量对于递送至癌组织的给定辐射剂量是最小的。