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135 条记录 (耗时 0.031 秒)

    Silver halide photographic materials comprising blocked photographic reagants releasing plug groups
    22.
    发明授权
    Silver halide photographic materials comprising blocked photographic reagants releasing plug groups 失效
    卤化银照相材料包括封闭的摄影试剂释放插塞组

    公开(公告)号：US4888268A

    公开(公告)日：1989-12-19

    申请号：US234008

    申请日：1988-08-16

    申请人： Isamu Itoh ,  Mitsunori Ono ,  Yoshio Inagaki

    发明人： Isamu Itoh ,  Mitsunori Ono ,  Yoshio Inagaki

    IPC分类号： G03C7/305

    CPC分类号： G03C7/30511 ,  Y10S430/156 ,  Y10S430/158 ,  Y10S430/159 ,  Y10S430/161

    摘要： A silver halide photographic material, which contains at least one blocked photographic reagent having in the molecule thereof at least one group selected from ##STR1## group and capable of releasing a photographically useful reagent by cleavage of the --N--C--bond by a nucleophilic attack of a nucleophilic reagent on the carbonyl group and a subsequent intramolecular electron transfer reaction or intramolecular nucleophilic reaction and which has at least one photosensitive silver halide emulsion layer, is photographically processed in the presence of an amine. A photographic material which includes, in combination, a photographic reagent precursor capable of releasing a photographically useful reagent timely on photographic processing and a photosensitive silver halide emulsion layer is provided along with a method of processing the photographic material.

    摘要翻译： 一种卤化银照相材料，其含有至少一种在其分子中具有至少一个选自“IMAGE”组的基团的封闭的照相试剂，并且能够通过亲核攻击来切割-NC键而释放照相用试剂 羰基上的亲核试剂和随后的分子内电子转移反应或分子内亲核反应并且具有至少一个光敏卤化银乳剂层，在胺的存在下进行照相处理。 提供了一种照相材料，其组合包括能够及时在照相处理和感光卤化银乳剂层上释放照相用试剂的照相试剂前体以及处理照相材料的方法。

    Xanthohumol-enriched hop extract
    23.
    发明授权
    Xanthohumol-enriched hop extract 有权
    富含黄曲霉毒素的啤酒花提取物

    公开(公告)号：US07833552B2

    公开(公告)日：2010-11-16

    申请号：US12190965

    申请日：2008-08-13

    申请人： Mitsunori Ono ,  Naoto Yamaguchi

    发明人： Mitsunori Ono ,  Naoto Yamaguchi

    IPC分类号： A01N65/00

    CPC分类号： A61K36/185

    摘要： A method for preparing a xanthohumol-rich hop composition. The method includes providing a solution that contains xanthohumol-containing hop substances and effecting precipitation of non-xanthohumol hop substances by adjusting both the salt concentration and pH value of the solution. The xanthohumol-rich hop composition prepared by this method can be used for treating various diseases, e.g., skin disorders, and bacterial infection.

    摘要翻译： 一种制备富含黄腐酚的啤酒花组合物的方法。 该方法包括提供含有含黄腐酚的啤酒花物质的溶液，并通过调节溶液的盐浓度和pH值来实现非黄褐酮啤酒花物质的沉淀。 通过该方法制备的富含黄腐酚酸的啤酒花组合物可用于治疗各种疾病，例如皮肤病和细菌感染。

    Pyrimidine compounds
    25.
    发明授权
    Pyrimidine compounds 失效
    嘧啶化合物

    公开(公告)号：US07470685B2

    公开(公告)日：2008-12-30

    申请号：US11041537

    申请日：2005-01-21

    申请人： Lijun Sun ,  Mitsunori Ono ,  Elena Kostik ,  Yumiko Wada

    发明人： Lijun Sun ,  Mitsunori Ono ,  Elena Kostik ,  Yumiko Wada

    IPC分类号： A61K31/506 ,  A61P3/10 ,  A61P17/06 ,  A61P19/02 ,  A61P25/28 ,  C07D239/24 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04

    CPC分类号： C07D239/48 ,  A61K31/506 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

    摘要： This invention features pyrimidine compounds of formula (I): R1 is in which one of Ra and Rb is H or alkyl, and the other is aryl or heteroaryl optionally substituted with Rd and Rem; each of R2 and R4 is H; R3 is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is NRc; Y is covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which Rc is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; Rd is halogen, CN, alkyl, alkyloxy, alkylcarbonyl, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, hydroxyalkyl, alkylamino, or alkylaminocarbonyl; Re is halogen, CN, hydroxyl, alkyl, aryl, heteroaryl, alkoxyl, aryloxyl, or heteroaryloxyl; and m is 0, 1, 2, 3, or 4. The pyrimidine compounds can be used to treat an IL-12 overproduction-related disorder (e.g., rheumatoid arthritis, sepsis, Crohn's disease, multiple sclerosis, psoriasis, or insulin-dependent diabetes mellitus).

    摘要翻译： 本发明的特征在于式（I）的嘧啶化合物：其中R 1和R b中的一个是H或烷基，另一个是任选被Rd和Rem取代的芳基或杂芳基; R2和R4各自为H; R3是H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基; R5是H或烷基; n是0，1，2，3，4，5或6; X是NRc; Y是共价键，CH2，C（O），C-N-Rc，C-N-ORc，C-N-SRc，O，S，S（O），S（O 2）或NRc; Z是N或CH; U和V之一是N，另一个是CRc; 并且W是O，S，S（O），S（O 2），NR c或NC（O）R c; 其中R c是H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基; Rd是卤素，CN，烷基，烷氧基，烷基羰基，烷氧基羰基，芳氧基羰基，杂芳氧基羰基，羟基烷基，烷基氨基或烷基氨基羰基; Re是卤素，CN，羟基，烷基，芳基，杂芳基，烷氧基，芳氧基或杂芳氧基; 嘧啶化合物可用于治疗IL-12过度生产相关疾病（例如类风湿性关节炎，败血症，克罗恩病，多发性硬化，牛皮癣或胰岛素依赖型 糖尿病）。

    Synthesis of taxol enhancers
    26.
    发明授权
    Synthesis of taxol enhancers 失效
    紫杉醇增强剂的合成

    公开(公告)号：US07435843B2

    公开(公告)日：2008-10-14

    申请号：US11440429

    申请日：2006-05-24

    申请人： Shoujun Chen ,  Lijun Sun ,  Zhi-Qiang Xia ,  Keizo Koya ,  Mitsunori Ono

    发明人： Shoujun Chen ,  Lijun Sun ,  Zhi-Qiang Xia ,  Keizo Koya ,  Mitsunori Ono

    IPC分类号： C07C327/56

    CPC分类号： C07D213/77 ,  C07C327/56 ,  C07C2601/14 ,  C07D209/42 ,  C07D209/44 ,  C07D213/83 ,  C07D261/18 ,  C07D307/54 ,  C07D333/38 ,  Y02P20/55

    摘要： Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): The thiohydrazide product compound is represented by Structural Formula (II): In Structural Formulas (I)-(II), R1 and R2 are independently an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1 and R2 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. When R2 is an aryl group or a substituted aryl group, then R5 is a hydrazine protecting group; and when R2 is an aliphatic or substituted aliphatic group, then R5 is —H or a hydrazine protecting group. R10 is —H or a substituted or unsubstituted alkyl group. The method comprising the step of reacting the starting compound with a thionylating reagent.

    摘要翻译： 公开了从酰肼起始化合物制备硫代酰肼产物化合物的方法。 酰肼起始化合物由结构式（I）表示：硫代酰肼产物化合物由结构式（II）表示：在结构式（I） - （II）中，R 1和R 2 > 2 独立地是脂族基团，取代的脂族基团，芳基或取代的芳基，或R 1和R 2与 与它们键合的碳原子和氮原子形成任选地与芳环稠合的非芳族杂环。 当R 2是芳基或取代的芳基时，R 5是肼保护基; 当R 2是脂族或取代的脂族基团时，R 5是-H或肼保护基。 R 10是-H或取代或未取代的烷基。 该方法包括使起始化合物与亚硫酰化试剂反应的步骤。

    Synthesis of taxol enhancers
    28.
    发明申请
    Synthesis of taxol enhancers 失效
    紫杉醇增强剂的合成

    公开(公告)号：US20060281811A1

    公开(公告)日：2006-12-14

    申请号：US11440429

    申请日：2006-05-24

    申请人： Shoujun Chen ,  Lijun Sun ,  Zhi-Qiang Xia ,  Keizo Koya ,  Mitsunori Ono

    发明人： Shoujun Chen ,  Lijun Sun ,  Zhi-Qiang Xia ,  Keizo Koya ,  Mitsunori Ono

    IPC分类号： A61K31/235 ,  A61K31/195

    CPC分类号： C07D213/77 ,  C07C327/56 ,  C07C2601/14 ,  C07D209/42 ,  C07D209/44 ,  C07D213/83 ,  C07D261/18 ,  C07D307/54 ,  C07D333/38 ,  Y02P20/55

    摘要： Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): The thiohydrazide product compound is represented by Structural Formula (II): In Structural Formulas (I)-(II), R1 and R2 are independently an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1 and R2 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. When R2 is an aryl group or a substituted aryl group, then R5 is a hydrazine protecting group; and when R2 is an aliphatic or substituted aliphatic group, then R5 is —H or a hydrazine protecting group. R10 is —H or a substituted or unsubstituted alkyl group. The method comprising the step of reacting the starting compound with a thionylating reagent.

    摘要翻译： 公开了从酰肼起始化合物制备硫代酰肼产物化合物的方法。 酰肼起始化合物由结构式（I）表示：硫代酰肼产物化合物由结构式（II）表示：在结构式（I） - （II）中，R 1和R 2 > 2 独立地是脂族基团，取代的脂族基团，芳基或取代的芳基，或R 1和R 2与 与它们键合的碳原子和氮原子形成任选地与芳环稠合的非芳族杂环。 当R 2是芳基或取代的芳基时，R 5是肼保护基; 当R 2是脂族或取代的脂族基团时，R 5是-H或肼保护基。 R 10是-H或取代或未取代的烷基。 该方法包括使起始化合物与亚硫酰化试剂反应的步骤。

    Compositions for treating diabetes or obesity
    29.
    发明申请
    Compositions for treating diabetes or obesity 审中-公开
    用于治疗糖尿病或肥胖的组合物

    公开(公告)号：US20060188590A1

    公开(公告)日：2006-08-24

    申请号：US11326102

    申请日：2006-01-04

    申请人： Mitsunori Ono

    发明人： Mitsunori Ono

    IPC分类号： A61K36/906 ,  A61K36/185 ,  A61K31/7048 ,  A61K31/353 ,  A61K31/522 ,  A61K36/63

    CPC分类号： A61K36/45 ,  A61K31/353 ,  A61K31/522 ,  A61K31/7048 ,  A61K36/48 ,  A61K36/87 ,  A61K45/06 ,  A61K2300/00

    摘要： This invention relates to a composition that includes two compounds selected from a group of nine members, i.e., an α-glucosidase inhibitor, an intestinal glucose transporter inhibitor, a glycation inhibitor, a nitric oxide production inhibitor, an aldose reductase inhibitor, a PPAR agonist, an adipocytokine activator, a glucose uptake enhancer, and a thermogenesis enhancer, in which the two compounds are two different members; and each compound is naturally occurring in a plant and is provided in the form of a plant extract. This invention also relates to a method of treating diabetes or obesity with the above-mentioned composition.

    摘要翻译： 本发明涉及一种组合物，其包含两种选自九个成员的化合物，即α-葡糖苷酶抑制剂，肠葡萄糖转运蛋白抑制剂，糖化抑制剂，一氧化氮产生抑制剂，醛糖还原酶抑制剂，PPAR激动剂 ，脂肪细胞因子激活剂，葡萄糖摄取增强剂和生热促进剂，其中两种化合物是两种不同的成员; 并且每种化合物天然存在于植物中并且以植物提取物的形式提供。 本发明还涉及用上述组合物治疗糖尿病或肥胖症的方法。