公开(公告)号：US5447156A

公开(公告)日：1995-09-05

申请号：US222053

申请日：1994-04-04

申请人： Charles L. Dumoulin ,  Paul A. Bottomley ,  Steven P. Souza

发明人： Charles L. Dumoulin ,  Paul A. Bottomley ,  Steven P. Souza

IPC分类号： G01R33/48 ,  A61B5/055 ,  G01R33/34 ,  G01R33/563

CPC分类号： G01R33/563 ,  G01R33/34084

摘要： A magnetic resonance (MR) active invasive device system employs a radio-frequency (RF) coil embedded in an invasive device for the purpose of generating MR angiograms of a selected blood vessels. A subject is first placed in a polarizing magnetic field. The invasive device is then placed into a selected blood vessel of the subject such that the RF coil of the invasive device is located at or near the root of a vessel tree desired to be imaged. The RF coil is then used to alter the nuclear spin magnetization of blood flowing within the vessel. This is done by employing an RF excitation signal to the coil at the Larmor frequency of the blood. The nutation of spin magnetization can change the amount of longitudinal spin magnetization or the Amount of magnetization in the transverse plane. Because the size of the radio-frequency coil in the invasive device is small, the change in spin magnetization is limited to blood flowing by the invasive device. An MR imaging pulse sequence is then applied to the subject to obtain image information from the region containing the desired vessel tree. The MR imaging pulse sequence is designed to selectively detect the blood whose spin magnetization has been changed by the MR-active invasive device. Since only blood which the magnetization has modified is detected with the imaging sequence, the vessel tree is imaged.

摘要翻译： 磁共振（MR）有源侵入性装置系统采用嵌入在侵入性装置中的射频（RF）线圈，用于产生选定血管的MR血管造影。 首先将被摄体置于极化磁场中。 然后将侵入性装置放置在受试者的所选择的血管中，使得侵入性装置的RF线圈位于期望成像的血管树的根部处或附近。 RF线圈然后用于改变在血管内流动的血液的核自旋磁化。 这通过在血液的拉莫尔频率处对线圈采用RF激励信号来完成。 自旋磁化的章动可以改变纵向自旋磁化的量或横向平面中的磁化量。 由于侵入性装置中的射频线圈的尺寸小，所以自旋磁化强度的变化受限于由侵入性装置流动的血液。 然后将MR成像脉冲序列应用于受试者以从包含所需血管树的区域获得图像信息。 MR成像脉冲序列被设计成选择性地检测其自旋磁化已被MR活性侵入性装置改变的血液。 由于仅利用成像序列检测到磁化已经改变的血液，所以对血管树进行成像。

公开(公告)号：US4885539A

公开(公告)日：1989-12-05

申请号：US202624

申请日：1988-06-06

申请人： Peter B. Roemer ,  Paul A. Bottomley ,  William A. Edelstein

发明人： Peter B. Roemer ,  Paul A. Bottomley ,  William A. Edelstein

IPC分类号： A61B5/055 ,  G01R33/34 ,  H01F7/20

CPC分类号： G01R33/34046

摘要： A RF volume coil with optimized signal-to-noise ratio, for NMR use, has a reduced length L.sub.c, which is between about 0.3r.sub.s and about 1.5r.sub.s, where r.sub.s is the radius of a sample-to-be-investigated, contained within the cylindrical volume coil, with the volume coil radius r.sub.c being between about 1.0r.sub.s and about 1.6r.sub.s. the "short" volume coil has an improved SNR for a voxel located substantially on the central plane of the coil, relative to the SNR of a "normal"-lenth volume coil with L.sub.c .gtoreq.4r.sub.s.

公开(公告)号：US4484138A

公开(公告)日：1984-11-20

申请号：US394355

申请日：1982-07-01

申请人： Paul A. Bottomley ,  William A. Edelstein

发明人： Paul A. Bottomley ,  William A. Edelstein

IPC分类号： A61B10/00 ,  A61B5/055 ,  G01R33/46 ,  G01R33/48 ,  G01R33/565 ,  G01R33/08

CPC分类号： G01R33/565

摘要： A method for eliminating the effects of a spurious free induction decay (FID) NMR signal due to imperfect 180.degree. RF pulses comprises applying a large magnitude, short duration magnetic field gradient pulse, termed the "crusher" pulse immediately following the 180.degree. pulse. When the method is employed with NMR pulse sequences in which the 180.degree. pulse is part of a spin echo type refocusing RF pulse sequence, the 180.degree. pulse is preceded by a magnetic field gradient pulse termed the "primer", having an equal integral with respect to time as the crusher pulse. The method is effective in removing NMR image artifacts produced by spurious FID in both planar and three-dimensional NMR imaging methods.

摘要翻译： 消除由于不完美的180°RF脉冲引起的无杂散感应衰减（FID）NMR信号的影响的方法包括施加大幅度的短持续时间的磁场梯度脉冲，紧跟在180度脉冲之后称为“破碎机”脉冲。 当采用NMR脉冲序列（其中180°脉冲是自旋回波型重聚焦RF脉冲序列的一部分）时，180°脉冲之前是称为“引物”的磁场梯度脉冲，其具有与 尊重时间作为破碎机脉冲。 该方法在平面和三维核磁共振成像方法中有效地去除由寄生FID产生的NMR图像伪影。

公开(公告)号：US4431968A

公开(公告)日：1984-02-14

申请号：US365229

申请日：1982-04-05

申请人： William A. Edelstein ,  Paul A. Bottomley

发明人： William A. Edelstein ,  Paul A. Bottomley

IPC分类号： A61B10/00 ,  A61B5/055 ,  G01R33/48 ,  G01R33/54 ,  G06T1/00 ,  G01R33/08

CPC分类号： G01R33/4822

摘要： Selective excitation is used to define a thick planar slab of excited nuclear spins in a nuclear magnetic resonance (NMR) imaging sample. The thick slab is selected such that the excited spins are contained well within the optimum sensitive region defined by the radio frequency (RF) transmitter and receiver coils. Three-dimensional spatial information of an NMR imaging parameter, such as nuclear spin density or nuclear spin relaxation time, is collected simultaneously from the excited slab and can be used to construct a series of several tomographic section images of the slab. The spatial information is encoded in the NMR signal by application of pulsed gradient magnetic fields subsequent to excitation. Image picture information is obtained from the NMR signals via three-dimensional Fourier transformation.

摘要翻译： 选择性激发用于在核磁共振（NMR）成像样品中定义激发的核自旋的厚平板。 选择厚板，使得激发的自旋完全包含在由射频（RF）发射器和接收器线圈限定的最佳敏感区域内。 核磁共振成像参数（如核自旋密度或核自旋弛豫时间）的三维空间信息可以从激发的板块同时采集，并可用于构建板坯的一系列断层图像。 通过在激发后施加脉冲梯度磁场，在NMR信号中编码空间信息。 通过三维傅里叶变换从NMR信号获得图像图像信息。

公开(公告)号：US09492651B2

公开(公告)日：2016-11-15

申请号：US12047602

申请日：2008-03-13

申请人： Paul A. Bottomley ,  Parag V. Karmarkar ,  Justin M. Allen ,  William A. Edelstein

发明人： Paul A. Bottomley ,  Parag V. Karmarkar ,  Justin M. Allen ,  William A. Edelstein

IPC分类号： A61N1/05 ,  A61N1/37 ,  A61N1/08

CPC分类号： A61N1/08 ,  A61N1/05 ,  A61N1/086 ,  A61N1/3718 ,  Y10T29/49117

摘要： RF/MRI compatible leads include at least one conductor that turns back on itself at least twice in a lengthwise direction, and can turn back on itself at least twice at multiple locations along its length. The at least one electrical lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2W/kg. Related devices and methods of fabricating leads are also described.

摘要翻译： RF / MRI兼容的引线包括至少一个导体，其沿​​长度方向至少翻转两次，并且可以在其长度的多个位置处至少翻转两次。 至少一个电引线可以被配置成使得引线将局部组织加热到小于约10摄氏度（通常约5摄氏度或更低），或者当患者暴露于峰值输入处的目标RF频率时不加热局部组织 SAR至少约4W / kg和/或全身平均SAR至少约2W / kg。 还描述了制造引线的相关器件和方法。

公开(公告)号：US09482728B2

公开(公告)日：2016-11-01

申请号：US12521570

申请日：2007-12-31

申请人： Paul A. Bottomley ,  Shashank Sathyanarayana

发明人： Paul A. Bottomley ,  Shashank Sathyanarayana

IPC分类号： A61B5/055 ,  G01R33/28 ,  G01R33/34 ,  G01R33/36 ,  G01R33/421 ,  G01R33/422 ,  G01R33/483 ,  G01R33/44

CPC分类号： G01R33/285 ,  G01R33/34053 ,  G01R33/34084 ,  G01R33/3685 ,  G01R33/421 ,  G01R33/422 ,  G01R33/445 ,  G01R33/4833 ,  Y10T29/49016

摘要： Featured are a device with localized sensitivity to magnetic resonance signals, an imaging system using such a device and MRI methods for performing internal MRI or MRI Endoscopy. Such an MRI method includes introducing an MRI antenna or probe into the specimen to be imaged, the antenna being configured in accordance with the devices described herein, so that the spatial coordinate frame of imaging is inherently locked or defined with respect to the introduced antenna thereby providing imaging of the specimen from the point of view of the antenna. Further such imaging is conducted so that the MRI signal is confined substantially to a volume with respect to a particular region of the antenna or probe.

摘要翻译： 特色是对磁共振信号具有局部敏感性的装置，使用这种装置的成像系统和用于执行内部MRI或MRI内窥镜检查的MRI方法。 这样的MRI方法包括将MRI天线或探针引入待成像的样本中，天线根据本文所述的装置来配置，使得成像的空间坐标系相对于引入的天线固有地被锁定或定义， 从天线的角度提供样本的成像。 进一步进行这样的成像，使得MRI信号基本上被限制在相对于天线或探针的特定区域的体积。

公开(公告)号：US09248270B2

公开(公告)日：2016-02-02

申请号：US12047832

申请日：2008-03-13

申请人： Parag V. Karmarkar ,  Paul A. Bottomley ,  Justin M. Allen ,  William A. Edelstein ,  Peter Piferi ,  Brian Gore

发明人： Parag V. Karmarkar ,  Paul A. Bottomley ,  Justin M. Allen ,  William A. Edelstein ,  Peter Piferi ,  Brian Gore

IPC分类号： A61N1/05 ,  A61N1/04 ,  B29C33/12 ,  G01N3/32 ,  A61N1/08 ,  B29L31/00

CPC分类号： A61N1/08 ,  A61N1/0488 ,  A61N1/05 ,  A61N1/086 ,  B29C33/126 ,  B29L2031/753 ,  G01N3/32 ,  Y10T29/49071

摘要： MRI/RF compatible leads include at least one conductor, a respective conductor having at least one segment with a multi-layer stacked coil configuration. The lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related leads and methods of fabricating leads are also described.

摘要翻译： MRI / RF兼容引线包括至少一个导体，具有至少一个具有多层堆叠线圈配置的段的相应导体。 引线可以被配置为使得铅在局部组织中加热小于约10摄氏度（通常约5摄氏度或更低），或者当患者暴露于至少峰值输入SAR的目标RF频率时不加热局部组织 约4W / kg和/或全身平均SAR至少约2W / kg。 还描述了制造引线的相关引线和方法。

公开(公告)号：US06549800B1

公开(公告)日：2003-04-15

申请号：US09549921

申请日：2000-04-14

申请人： Ergin Atalar ,  Paul A. Bottomley ,  Elias Zerhouin ,  Henry Halperin ,  Elliot McVeigh ,  Albert C. Lardo

发明人： Ergin Atalar ,  Paul A. Bottomley ,  Elias Zerhouin ,  Henry Halperin ,  Elliot McVeigh ,  Albert C. Lardo

IPC分类号： A61B505

CPC分类号： A61B5/415 ,  A61B1/273 ,  A61B1/303 ,  A61B1/307 ,  A61B1/31 ,  A61B5/055 ,  A61B5/418 ,  A61B5/42 ,  A61B5/4381 ,  A61B10/0275 ,  A61B2090/374 ,  G01R33/285 ,  G01R33/34084 ,  G01R33/3628 ,  H01Q1/36 ,  H01Q1/362 ,  H01Q1/40 ,  H01Q1/44 ,  H01Q11/08

摘要： The systems and methods of the present invention provide for MRI probes adapted for insertion into a plurality of body orifices, in order to evaluate the anatomy of proximate anatomic structures, to diagnose abnormalities thereof and to treat the diagnosed abnormalities. MRI probes are described that are suitable for use in the mediastinum, in the pancreaticohepaticobiliary system, in the tracheobronchopulmonary system, in the head and neck, in the genitourinary system, the gastrointestinal system, the vascular system, and in the evaluation, diagnosis and treatment of internal fluid collections.

摘要翻译： 本发明的系统和方法提供适于插入多个体孔的MRI探针，以评估近端解剖结构的解剖结构，诊断其异常并治疗诊断异常。 描述了适用于纵隔，胰胆管系统，气管支气管系统，头颈部，泌尿生殖系统，胃肠系统，血管系统以及评估，诊断和治疗中的MRI探针 的内部流体收集。

公开(公告)号：US06263229B1

公开(公告)日：2001-07-17

申请号：US09191563

申请日：1998-11-13

申请人： Ergin Atalar ,  Jeffrey C. Lestio ,  Harry K. Charles, Jr. ,  Bliss G. Carkhuff ,  Paul A. Bottomley

发明人： Ergin Atalar ,  Jeffrey C. Lestio ,  Harry K. Charles, Jr. ,  Bliss G. Carkhuff ,  Paul A. Bottomley

IPC分类号： A61B5055

CPC分类号： G01R33/34084 ,  G01R33/34007 ,  G01R33/341 ,  G01R33/3657 ,  G01R33/3678

摘要： The present invention provides several embodiments of methods of making magnetic resonance catheter coils which include employing a flexible electrically insulative base member, depositing an electrically conductive material on the base member in a predetermined pattern to create at least one pair of generally parallel electrically conductive coil elements which are electrically connected to each other. A catheter is provided over the coil assembly. In one embodiment, a second pair of generally parallel electrically conductive coil elements are provided in order to create a quadrature coil. In this latter embodiment, the electrically insulative base member may have the first pair of coil elements created on one surface thereof and a second pair on the other with the base member subsequently being deformed to create a tubular coil having one pair of coil elements on the outside and the other pair on the inside. In some embodiments, tuning and matching circuits and decoupling circuits may be provided. The (a) coils, (b) coil assemblies, as well as (c) catheter coils containing coil assemblies produced by these methods are also disclosed. The coils may be miniaturized so as to facilitate ready insertion within a suitable sheath, such as a probe or catheter, into a patient, including into body openings, or into blood vessels or into interior regions of the body.

摘要翻译： 本发明提供了制造磁共振导管线圈的方法的几个实施例，其包括采用柔性电绝缘基底部件，以预定图案在基底部件上沉积导电材料，以产生至少一对大致平行的导电线圈元件 它们彼此电连接。 在线圈组件上提供导管。 在一个实施例中，提供第二对大致平行的导电线圈元件以便产生正交线圈。 在后一个实施例中，电绝缘基体可以具有在其一个表面上形成的第一对线圈元件，而另一对线圈元件可以具有另一对线圈元件，而第二对线圈元件随后变形，从而形成管状线圈，该管状线圈在其上具有一对线圈元件 外面和另一对在里面。 在一些实施例中，可以提供调谐和匹配电路和去耦电路。 还公开了（a）线圈，（b）线圈组件，以及（c）包含由这些方法制造的线圈组件的导管线圈。 线圈可以被小型化，以便于在适当的护套（例如探针或导管）内容易地插入患者体内，包括进入体内开口，或进入血管或进入体内的内部区域。

公开(公告)号：US5699801A

公开(公告)日：1997-12-23

申请号：US457833

申请日：1995-06-01

申请人： Ergin Atalar ,  Paul A. Bottomley ,  Elias A. Zerhouni

发明人： Ergin Atalar ,  Paul A. Bottomley ,  Elias A. Zerhouni

IPC分类号： A61B10/00 ,  A61B5/055 ,  A61B10/02 ,  A61B19/00 ,  G01R33/34

CPC分类号： G01R33/34084 ,  A61B5/055 ,  G01R33/341 ,  G01R33/3657 ,  G01R33/3678 ,  G01R33/34007

摘要： The invention provides a method for magnetic resonance imaging and spectroscopic analysis of the interior of a specimen which includes positioning the specimen within a main magnetic field, introducing an invasive probe having an elongated receiver coil into or adjacent to the specimen with the coil having at least one pair of elongated electrical conductors, preferably, generally parallel to each other disposed within a dielectric material and having a pair of ends electrically connected to each other. RF pulses are provided to the region of interest to excite magnetic resonance signals, gradient magnetic pulses are applied to the region of interest with the receiver coil receiving magnetic resonance signals and emitting responsive output signals which may be processed by a computer to provide image information for display in a desired manner. The method in a preferred form involves employing a flexible receiver coil which has uniform sensitivity along the coil and may be operated even when the magnetic resonance signal is in an oblique position. Tuning capacitance may be distributed along the length of the coil and/or a Faraday screen provided to minimize dielectric losses between the coil and the surrounding material of the specimen. The method may be used on a wide variety of specimens and in a preferred use is introduced into small blood vessels of a patient to facilitate determination of atherosclerotic plaque. Medical intervention procedures, such as plaque removal, may be employed generally simultaneously with the imaging of the present invention. Corresponding apparatus is provided.

摘要翻译： 本发明提供了一种用于磁共振成像和样品内部光谱分析的方法，其包括将样品定位在主磁场内，将具有细长的接收器线圈的侵入性探针引入到试样中或与样品相邻，线圈至少具有 一对细长的电导体，优选地大致彼此平行地设置在电介质材料内并且具有彼此电连接的一对端部。 将RF脉冲提供给感兴趣的区域以激励磁共振信号，梯度磁脉冲被施加到感兴趣的区域，接收器线圈接收磁共振信号并且发出可由计算机处理的响应输出信号，以提供图像信息 以期望的方式显示。 优选形式的方法涉及使用具有沿线圈的均匀灵敏度的柔性接收器线圈，并且即使当磁共振信号处于倾斜位置时也可以进行操作。 调谐电容可以沿着线圈的长度和/或法拉第屏幕分布，以最小化线圈和样品的周围材料之间的介电损耗。 该方法可以用于各种各样的样品，并且优选的用途被引入到患者的小血管中以便于确定动脉粥样硬化斑块。 医疗干预程序，例如除斑，可以与本发明的成像通常同时使用。 提供相应的设备。