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21.发明申请Dry Diazeniumdiolation Methods for Producing Nitric Oxide Releasing Medical Devices 失效用于生产一氧化氮释放医疗器械的干燥二氮烯鎓脱氮方法公开(公告)号：US20100159119A1
公开(公告)日：2010-06-24
申请号：US12340089
申请日：2008-12-19
申请人： Mingfei Chen , Peiwen Cheng , Kishore Udipi
发明人： Mingfei Chen , Peiwen Cheng , Kishore Udipi
IPC分类号： B05D3/00
CPC分类号： A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/416 , A61L2300/608 , A61L2300/61 , A61L2420/02
摘要： The methods of the present disclosure in a broad aspect provide for dry diazeniumdiolation procedures for producing nitric oxide releasing medical devices. These medical devices may alternatively have cap coats applied prior to dry diazeniumdiolation to produce nitric oxide releasing medical devices with cap coats.
摘要翻译： 在宽泛的方面，本公开的方法提供了用于产生释放一氧化氮的医疗装置的干燥二氮烯鎓脱硫方法。 可替代地，这些医疗装置可以在干燥二氮烯鎓脱硫之前施加盖涂层以产生一氧化氮释放具有盖涂层的医疗装置。
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公开(公告)号：US20090043378A1
公开(公告)日：2009-02-12
申请号：US11861822
申请日：2007-09-26
申请人： Peiwen Cheng , Mingfei Chen , Kishore Udipi
发明人： Peiwen Cheng , Mingfei Chen , Kishore Udipi
IPC分类号： A61F2/82 , A61K31/4353 , A61P9/00
CPC分类号： A61L27/16 , A61K31/4353 , A61L27/50 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/606
摘要： A self-orienting biocompatible polymer system incorporating a hydrophilic surface and a hydrophobic core are disclosed. The hydrophilic surface aids in biocompatibility while the hydrophobic core allows the polymer system to accommodate a hydrophobic drug. Medical devices coated with the polymer system are also disclosed.
摘要翻译： 公开了一种结合亲水表面和疏水核心的自取向生物相容性聚合物体系。 亲水表面有助于生物相容性，而疏水核心允许聚合物体系容纳疏水性药物。 还公开了涂覆有聚合物体系的医疗装置。
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23.发明申请公开(公告)号：US20090028966A1
公开(公告)日：2009-01-29
申请号：US11782146
申请日：2007-07-24
申请人： Mingfei Chen , Peiwen Cheng , Kishore Udipi
发明人： Mingfei Chen , Peiwen Cheng , Kishore Udipi
IPC分类号： A61K47/30 , A61K31/436 , C07C209/00 , C08F283/10 , C08C19/22 , A61K33/00
CPC分类号： C07C213/04 , A61L31/04 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/416 , C08F8/30 , C08F8/32 , C08G63/6852 , C08G63/912 , C08F220/18 , C07C219/08
摘要： Biocompatible polymers having polymer backbones with at least one secondary amine suitable for diazeniumdiolation are disclosed. Specifically, methods for providing secondary amines-containing polymers using epoxide-opening reactions are provided. More specifically, nitric oxide-releasing medical devices made using these polymers are disclosed.
摘要翻译： 公开了具有聚合物主链与至少一种适用于二氮烯鎓脱硫的仲胺的生物相容性聚合物。 具体地说，提供了使用环氧化物开放反应提供含仲胺聚合物的方法。 更具体地，公开了使用这些聚合物制备的释放一氧化氮的医疗装置。
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24.发明申请Controlled Radical Polymerization-Derived Block Copolymer Compositions for Medical Device Coatings 审中-公开用于医疗器械涂层的受控自由基聚合衍生的嵌段共聚物组合物公开(公告)号：US20080305143A1
公开(公告)日：2008-12-11
申请号：US12064110
申请日：2006-08-09
申请人： Mingfei Chen , Peiwen Cheng , Kishore Udipi
发明人： Mingfei Chen , Peiwen Cheng , Kishore Udipi
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , C08F293/005 , C08F2438/01 , C09D153/00
摘要： Controlled radical polymerization-derived biocompatible block copolymer coatings for medical devices are disclosed. Specifically, block copolymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed. The present application also discloses providing vascular stents with drug-eluting controlled release block copolymer coatings and related methods for making these medical devices and coatings.
摘要翻译： 公开了用于医疗装置的受控自由基聚合衍生的生物相容性嵌段共聚物涂层。 具体地，公开了设计用于控制体内从医疗器械释放生物活性剂的嵌段共聚物涂层。 本申请还公开了提供血管支架药物洗脱控制释放嵌段共聚物涂层和制备这些医疗装置和涂层的相关方法。
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25.发明授权Biocompatible polymers for coating or fabricating implantable medical devices 有权用于涂覆或制造可植入医疗器械的生物相容性聚合物公开(公告)号：US09056153B2
公开(公告)日：2015-06-16
申请号：US12414858
申请日：2009-03-31
申请人： Mingfei Chen , Peiwen Cheng , Kishore Udipi
发明人： Mingfei Chen , Peiwen Cheng , Kishore Udipi
IPC分类号： C08F220/26 , A61F2/04 , A61K31/436 , A61F2/06 , A61L31/04 , A61L27/16 , A61L27/34 , A61L31/10
CPC分类号： A61L31/048 , A61L27/16 , A61L27/34 , A61L31/10 , C08L33/06
摘要： The present disclosure generally relates to biocompatible polymers for coating or fabricating implantable medical devices and to implantable medical devices having the present biocompatible polymers. The disclosed biocompatible polymers exhibit superior biocompatibility and therefore minimize unwanted immune reaction from a patient into whom a medical device is implanted.
摘要翻译： 本公开内容通常涉及用于涂覆或制造可植入医疗装置的生物相容性聚合物和具有本生物相容性聚合物的可植入医疗装置。 所公开的生物相容性聚合物表现出优异的生物相容性，并且因此将植入医疗装置的患者的不希望的免疫反应最小化。
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26.发明授权Medical devices comprising polymeric drug delivery systems with drug solubility gradients 有权包括具有药物溶解度梯度的聚合物药物递送系统的医疗装置公开(公告)号：US08852620B2
公开(公告)日：2014-10-07
申请号：US11780713
申请日：2007-07-20
申请人： Mingfei Chen , Peiwen Cheng , Kishore Udipi
发明人： Mingfei Chen , Peiwen Cheng , Kishore Udipi
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/048 , A61L31/16 , A61L2300/416 , A61L2300/60 , A61L2420/02 , C08F220/12 , C08F226/10
摘要： Disclosed are drug delivery systems comprising drugs admixed with polymers having drug solubility gradients and methods of making the polymers. Also disclosed are medical devices having coatings thereon comprising the drug solubility gradient-containing polymers and at least one drug.
摘要翻译： 公开了包含与具有药物溶解度梯度的聚合物混合的药物的药物递送系统和制备聚合物的方法。 还公开了具有其上包含药物溶解度梯度的聚合物和至少一种药物的涂层的医疗装置。
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27.发明授权Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation 失效将反应性仲胺引入可用于二氮烯鎓脱硫的聚合物主链的方法公开(公告)号：US08273828B2
公开(公告)日：2012-09-25
申请号：US11782146
申请日：2007-07-24
申请人： Mingfei Chen , Peiwen Cheng , Kishore Udipi
发明人： Mingfei Chen , Peiwen Cheng , Kishore Udipi
CPC分类号： C07C213/04 , A61L31/04 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/416 , C08F8/30 , C08F8/32 , C08G63/6852 , C08G63/912 , C08F220/18 , C07C219/08
摘要： Biocompatible polymers having polymer backbones with at least one secondary amine suitable for diazeniumdiolation are disclosed. Specifically, methods for providing secondary amines-containing polymers using epoxide-opening reactions are provided. More specifically, nitric oxide-releasing medical devices made using these polymers are disclosed.
摘要翻译： 公开了具有聚合物主链与至少一种适用于二氮烯鎓脱硫的仲胺的生物相容性聚合物。 具体地说，提供了使用环氧化物开放反应提供含仲胺聚合物的方法。 更具体地，公开了使用这些聚合物制备的释放一氧化氮的医疗装置。
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28.发明授权公开(公告)号：US08241619B2
公开(公告)日：2012-08-14
申请号：US11383257
申请日：2006-05-15
申请人： Peiwen Cheng , Mingfei Chen , Kishore Udipi
发明人： Peiwen Cheng , Mingfei Chen , Kishore Udipi
IPC分类号： A61K31/74
CPC分类号： A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/416 , C08L33/10 , C08L33/14
摘要： Disclosed are hindered amine nitric oxide (NO) donating polymers for coating implantable medical devices. The polymers include sterically hindered secondary amines that do not react with monomer carbonyls or electrophilic alkenes, facilitating the synthesis of the NO donating polymers. The polymers are coated on implantable medical devices, providing anti-restenosis therapy by the release of NO at the implantation site.
摘要翻译： 公开了用于涂覆可植入医疗装置的受阻胺一氧化氮（NO）供体聚合物。 聚合物包括不与单体羰基或亲电烯烃反应的空间位阻仲胺，促进NO供体聚合物的合成。 聚合物涂覆在可植入的医疗装置上，通过植入部位的NO释放提供抗再狭窄治疗。
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29.发明授权4-aza-caprolactone-based polymeric compositions useful for the manufacture of biodegradable medical devices and as medical device coatings 有权用于制造可生物降解的医疗器械和医疗器械涂层的4-氮杂 - 己内酯基聚合物组合物公开(公告)号：US08137687B2
公开(公告)日：2012-03-20
申请号：US12064108
申请日：2006-08-09
申请人： Mingfei Chen , Peiwen Cheng , Kishore Udipi
发明人： Mingfei Chen , Peiwen Cheng , Kishore Udipi
IPC分类号： A61F2/04 , A61F2/06 , C07D267/10 , C08L67/00 , C08G63/685 , A61K39/395
摘要： N-substituted 4-aza-caprolactone biodegradable polymers, including derivatives thereof, useful for making implantable medical devices and coatings therefore are provided. The medical devices and coatings of the present invention can also be used for in situ controlled release drug delivery and are useful for treating or preventing medical conditions such as restenosis, aneurisms and vulnerable plaque.
摘要翻译： 因此，提供了可用于制造可植入医疗装置和涂层的N-取代的4-氮杂 - 己内酯可生物降解聚合物，包括其衍生物。 本发明的医疗装置和涂层也可以用于原位控释药物递送，并且可用于治疗或预防医疗状况如再狭窄，动脉瘤和易损斑块。
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公开(公告)号：US20100262238A1
公开(公告)日：2010-10-14
申请号：US12422425
申请日：2009-04-13
申请人： Mingfei Chen , David Shumaker , Peiwen Cheng , Kishore Udipi
发明人： Mingfei Chen , David Shumaker , Peiwen Cheng , Kishore Udipi
IPC分类号： A61F2/02 , C08F130/02 , A61K31/436 , A61F2/04
CPC分类号： A61K31/80 , A61K47/58 , A61K47/6957
摘要： The present disclosure in a broad aspect provides for diazeniumdiolated phosphorylcholine polymers and associated methods for achieving nitric oxide release. The present polymers have superior biocompatibility and are useful for coating or fabricating medical devices such as a vascular stent.
摘要翻译： 本发明在广泛的方面提供二氮烯二烯基磷酸胆碱聚合物和用于实现一氧化氮释放的相关方法。 本发明的聚合物具有优异的生物相容性，并且可用于涂覆或制造诸如血管支架的医疗装置。
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