Peptide epitopes of apolipoprotein B
    21.
    再颁专利
    Peptide epitopes of apolipoprotein B 失效
    载脂蛋白B的肽表位

    公开(公告)号:USRE43581E1

    公开(公告)日:2012-08-14

    申请号:US13177897

    申请日:2011-07-07

    摘要: The present invention relates to antibodies raised against fragments of apolipoprotein B, in particular defined peptides thereof, for immunization or therapeutic treatment of mammals, including humans, against ischemic cardiovascular diseases, using one or more of said antibodies.

    摘要翻译: 本发明涉及使用一种或多种所述抗体针对缺血性心血管疾病免疫或治疗哺乳动物(包括人)的载脂蛋白B的片段,特别是其定义的肽,针对该抗体产生抗体。

    Method and device for demodulation of signals
    22.
    发明授权
    Method and device for demodulation of signals 有权
    用于信号解调的方法和装置

    公开(公告)号:US08063648B2

    公开(公告)日:2011-11-22

    申请号:US12308080

    申请日:2007-05-10

    CPC分类号: G01D1/16 G01D21/00 G01L1/125

    摘要: A method and device are provided for demodulation of an output signal from a transducer (1) driven by an alternating excitation signal having an excitation frequency. The transducer produces an amplitude-modulated output signal (y(t)) containing the quantity to be measured. The device has sampling units (5,6,7) to sample the output signal from the transducer and the output signal from the excitation unit, and a computation unit (8) to compute a first complex valued quantity ( Y) including information on the amplitude and phase of the output signal at the excitation frequency based on sampled values of the output signal from the transducer, compute a second complex valued quantity (Ū, Ī) including information on the amplitude and phase of the excitation signal at the excitation frequency based on sampled values of the excitation signal, forming a complex valued output quotient between the first and second complex valued quantities, and compute the demodulated output signal (Od) based on the output quotient.

    摘要翻译: 提供一种方法和装置,用于解调来自由具有激励频率的交替激励信号驱动的换能器(1)的输出信号。 换能器产生包含待测量的幅度调制输出信号(y(t))。 该设备具有采样单元(5,6,7)以对来自换能器的输出信号和来自激励单元的输出信号进行采样,以及计算单元(8),用于计算第一复数值(Y),其包括关于 基于来自换能器的输出信号的采样值,激励频率处的输出信号的振幅和相位计算包括基于激励频率的激励信号的幅度和相位的信息的第二复数值(Ū,Ī) 在激励信号的采样值上,在第一和第二复数量之间形成复值输出商,并基于输出商计算解调输出信号(Od)。

    Method and Device for Demodulation of Signals
    24.
    发明申请
    Method and Device for Demodulation of Signals 有权
    用于解调信号的方法和装置

    公开(公告)号:US20100109766A1

    公开(公告)日:2010-05-06

    申请号:US12308080

    申请日:2007-05-10

    IPC分类号: H03D3/00

    CPC分类号: G01D1/16 G01D21/00 G01L1/125

    摘要: A method and device are provided for demodulation of an output signal from a transducer (1) driven by an alternating excitation signal having an excitation frequency. The transducer produces an amplitude-modulated output signal (y(t)) containing the quantity to be measured. The device has sampling units (5,6,7) to sample the output signal from the transducer and the output signal from the excitation unit, and a computation unit (8) to compute a first complex valued quantity ( Y) including information on the amplitude and phase of the output signal at the excitation frequency based on sampled values of the output signal from the transducer, compute a second complex valued quantity (Ū, Ī) including information on the amplitude and phase of the excitation signal at the excitation frequency based on sampled values of the excitation signal, forming a complex valued output quotient between the first and second complex valued quantities, and compute the demodulated output signal (Od) based on the output quotient.

    摘要翻译: 提供一种方法和装置,用于解调来自由具有激励频率的交替激励信号驱动的换能器(1)的输出信号。 换能器产生包含待测量的幅度调制输出信号(y(t))。 该设备具有采样单元(5,6,7)以对来自换能器的输出信号和来自激励单元的输出信号进行采样,以及计算单元(8),用于计算第一复数值(Y),其包括关于 基于来自换能器的输出信号的采样值,激励频率处的输出信号的振幅和相位计算包括基于激励频率的激励信号的幅度和相位的信息的第二复数值(Ū,Ī) 在激励信号的采样值上,在第一和第二复数量之间形成复值输出商,并基于输出商计算解调输出信号(Od)。

    Antibodies against a peptide epitope of apolipoprotein B
    26.
    发明授权
    Antibodies against a peptide epitope of apolipoprotein B 有权
    针对载脂蛋白B的肽表位的抗体

    公开(公告)号:US07537758B2

    公开(公告)日:2009-05-26

    申请号:US11485549

    申请日:2006-07-12

    IPC分类号: A61K39/395 C07K16/18 C07K4/12

    摘要: The present invention relates to antibodies raised against fragments of apolipoprotein B, in particular defined peptides thereof, for immunization or therapeutic treatment of mammals, including humans, against ischemic cardiovascular diseases, using one or more of said antibodies.

    摘要翻译: 本发明涉及使用一种或多种所述抗体针对缺血性心血管疾病免疫或治疗哺乳动物(包括人)的载脂蛋白B的片段,特别是其定义的肽,针对该抗体产生抗体。

    ANTIBODY IMMUNIZATION THERAPY FOR TREATMENT OF ATHEROSCLEROSIS
    28.
    发明申请
    ANTIBODY IMMUNIZATION THERAPY FOR TREATMENT OF ATHEROSCLEROSIS 失效
    用于治疗甲状腺功能亢进症的抗体免疫治疗

    公开(公告)号:US20080075716A1

    公开(公告)日:2008-03-27

    申请号:US11928221

    申请日:2007-10-30

    IPC分类号: A61K39/395 A61P9/10 C07K16/18

    摘要: The present invention relates to passive immunization for treating or preventing atherosclerosis using an isolated human antibody directed towards at least one oxidized fragment of apolipoprotein B in the manufacture of a pharmaceutical composition for therapeutical or prophylactical treatment of atherosclerosis by means of passive immunization, as well as method for preparing such antibodies, and a method for treating a mammal, preferably a human using such an antibody to provide for passive immunization.

    摘要翻译: 本发明涉及用于治疗或预防动脉粥样硬化的被动免疫,其使用针对至少一种载脂蛋白B的氧化片段的分离的人抗体制造用于通过被动免疫治疗或预防性治疗动脉粥样硬化的药物组合物,以及 制备这种抗体的方法,以及使用这种抗体治疗哺乳动物,优选人的方法以提供被动免疫。

    Method for isostatic or pseudo-isostatic pressing employing a
surrounding casing of glass
    30.
    发明授权
    Method for isostatic or pseudo-isostatic pressing employing a surrounding casing of glass 失效
    采用玻璃外围的等静压或假等静压的方法

    公开(公告)号:US5284616A

    公开(公告)日:1994-02-08

    申请号:US828952

    申请日:1992-02-10

    摘要: A method for the manufacture of objects from powdered material by isostatic or pseudo-isostatic pressing. A porous body (10), with open pores in contact with the external surface(s), is preformed from a powdered material, whereupon at least one layer (11, 12) of a powdered material is applied onto the external surface of the preformed porous body by dipping. The preformed porous body is covered with a casing (13) of glass, or a material which forms glass upon heating, arranged outside the intermediate layer (12). The casing is made impenetrable to the pressure medium by heating, whereupon the preformed body is compacted to an essentially dense body. The pore system of the preformed porous body is evacuated by applying a sub-atmospheric pressure by means of at least one suction cup (21) which is applied on the external surface to be coated in connection with and during the dipping of the body in a slurry (20) of powdered materials included in the layer (11, 12).

    摘要翻译: PCT No.PCT / SE91 / 00854 Sec。 371日期:1992年2月10日 102(e)日期1992年2月10日PCT 1991年12月12日PCT PCT。 出版物WO92 / 11107 日期:1992年7月9日。一种通过等静压或假等压压制从粉末材料制造物体的方法。 具有与外表面接触的开放孔的多孔体(10)由粉末材料预成型,于是将至少一层粉末材料层(11,12)施加到预成型件的外表面上 多孔体浸渍。 预成型的多孔体被覆盖有玻璃的壳体(13)或者在加热时形成玻璃的材料,其布置在中间层(12)的外部。 通过加热使壳体不透气于压力介质,由此将预成型体压实成基本致密的体。 通过施加至少一个吸盘(21)施加低于大气压的预制多孔体的孔隙系统,该吸盘与被涂覆的外表面相连并在其内部浸入 包含在层(11,12)中的粉末材料的浆料(20)。