公开(公告)号：US20080058378A1

公开(公告)日：2008-03-06

申请号：US11852455

申请日：2007-09-10

Applicant: Brian Budzik ,  David Cooper ,  Ian Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Graham Walker

Inventor： Brian Budzik ,  David Cooper ,  Ian Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Graham Walker

IPC: A61K31/445 ,  A61P43/00

CPC classification number: C07D405/12 ,  C07D235/26

Abstract: Compounds of formula (I) and salts and solvates are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract translation: 提供式（I）化合物和盐和溶剂化物：其中R 4是氟，R 5选自氢，卤素，氰基，C 1〜 C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 1-6烷氧基和C 1-6 - 被一个或多个氟原子取代的烷氧基; 和R 6选自卤素，氰基，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基， C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基，C 1-6烷氧基和C 1-6烷基， 1-6个被一个或多个氟原子取代的烷氧基，Q是氢或C 1-6烷基。 预期化合物可用于治疗，例如治疗精神病和认知障碍。

公开(公告)号：US20070143283A1

公开(公告)日：2007-06-21

申请号：US11608473

申请日：2006-12-08

Applicant: Stephan Spencer ,  David Cooper ,  Brian Klais

Inventor： Stephan Spencer ,  David Cooper ,  Brian Klais

IPC: G06F17/30

CPC classification number: G06F16/951 ,  G06F16/958

Abstract: A system and method for optimizing the rankings of web pages of a commercial website within search engine keyword search results. A proxy website is created based on the content on the commercial website. When a search engine spider reaches the commercial website, the commercial website directs the search engine spider to the proxy website. The proxy website includes a series of proxy web pages that correspond to web pages on the commercial website along with modifications that enhance the rankings of the pages by the search engines. However, hyperlinks containing complex, dynamic URLs are replaced with spider-friendly versions. When a human visitor selects a proxy web page listing on the search engine results page, that visitor is directed to the proxy web page. The proxy server delivers the same content to the human visitor as to the search engine spider, only with simplified URLs for the latter.

Abstract translation: 一种用于优化搜索引擎关键词搜索结果中商业网站的网页排名的系统和方法。 代理网站是根据商业网站上的内容创建的。 当搜索引擎蜘蛛到达商业网站时，商业网站将搜索引擎蜘蛛引导到代理网站。 代理网站包括与商业网站上的网页对应的一系列代理网页，以及增强搜索引擎对页面排名的修改。 但是，包含复杂动态URL的超链接将替换为蜘蛛友好版本。 当人类访问者在搜索引擎结果页面上选择代理网页列表时，该访问者被引导到代理网页。 代理服务器向搜索引擎蜘蛛的人员提供相同的内容，只有后者的简化网址。

公开(公告)号：US20050284779A1

公开(公告)日：2005-12-29

申请号：US11163020

申请日：2005-10-03

Applicant: David Cooper

Inventor： David Cooper

IPC: B42D15/00 ,  B65D85/30 ,  G09F3/00 ,  G11B33/04

CPC classification number: B42D15/00 ,  G11B33/045

Abstract: A CD and DVD index sheet includes a tabbed single- or multi-page sheet placed on or between CD or DVD discs stored on a spool. The index sheet tab extends beyond the circumference of the discs and may be written or printed on to provide easy identification of an individual disc on the spool. The remainder of the index sheet may be printed or written on to provide additional information.

Abstract translation: CD和DVD索引表包括放置在卷轴上存储的CD或DVD光盘之间或之间的标签单页或多页。 索引片标签延伸超过圆盘的圆周，并且可以被写入或打印，以便容易地识别卷轴上的单个盘。 索引表的其余部分可能被打印或写入以提供附加信息。

公开(公告)号：US20050063901A1

公开(公告)日：2005-03-24

申请号：US10671313

申请日：2003-09-24

Applicant: Stephen Miller ,  David Cooper ,  Gerald Woltermann ,  William Cormier

Inventor： Stephen Miller ,  David Cooper ,  Gerald Woltermann ,  William Cormier

IPC: B01J21/00 ,  B01J29/00 ,  C01B33/36 ,  C01B37/02 ,  C01B39/00 ,  C01B39/40 ,  C01B39/48 ,  C01F7/00

CPC classification number: C01B39/40 ,  C01B37/02 ,  C01B39/48 ,  Y10S423/22 ,  Y10S423/27

Abstract: Molecular sieves are prepared by forming a reaction mixture slurry, spray drying the reaction mixture slurry to form particles, and heating the spray dried reaction mixture at a temperature and pressure sufficient to cause crystallization of the molecular sieve. The reaction mixture contains an organic templating agent capable of forming the molecular sieve. The template may be added to the reaction mixture either by adding all of the template prior to spray drying, or by adding a portion of the template prior to spray drying with the remainder being added after spray drying.

Abstract translation: 通过形成反应混合物浆料，喷雾干燥反应混合物浆料以形成颗粒并在足以引起分子筛结晶的温度和压力下加热喷雾干燥的反应混合物来制备分子筛。 反应混合物含有能形成分子筛的有机模板剂。 模板可以通过在喷雾干燥之前加入所有模板，或通过在喷雾干燥之前加入一部分模板，其余部分在喷雾干燥之后加入到反应混合物中。

公开(公告)号：US20050023504A1

公开(公告)日：2005-02-03

申请号：US10626645

申请日：2003-07-25

Applicant: Douglas Placek ,  Bernhard Kinker ,  David Cooper ,  Robert Simko

Inventor： Douglas Placek ,  Bernhard Kinker ,  David Cooper ,  Robert Simko

IPC: C10M169/04 ,  C09K5/00

CPC classification number: C10M169/041 ,  C10M2207/2825 ,  C10M2207/2835 ,  C10M2209/084 ,  C10M2209/086 ,  C10M2209/1033 ,  C10M2209/1055 ,  C10M2209/1065 ,  C10M2209/1085 ,  C10M2223/023 ,  C10M2223/0405 ,  C10M2223/0415 ,  C10N2230/02 ,  C10N2230/08 ,  C10N2230/10 ,  C10N2230/64 ,  C10N2230/68 ,  C10N2240/08 ,  C10N2240/201

Abstract: The present invention concerns a functional fluid comprising A) 1 to 99% by weight based on the total weight of the functional fluid of alkyl(meth)acrylate polymers obtainable by polymerizing a mixture of olefinically unsaturated monomers, which consists of a) 1-100 wt % based on the total weight of the ethylenically unsaturated monomers of one or more ethylenically unsaturated ester compounds of formula (I) where R is hydrogen or methyl, R1 means a linear or branched alkyl residue with 1-6 carbon atoms, R2 and R3 independently represent hydrogen or a group of the formula —COOR′, where R′ means hydrogen or a alkyl group with 1-6 carbon atoms, b) 0-99 wt % based on the total weight of the ethylenically unsaturated monomers of one or more ethylenically unsaturated ester compounds of formula (II) where R is hydrogen or methyl, R4 means a linear or branched alkyl residue with 7-40 carbon atoms, R5 and R6 independently are hydrogen or a group of the formula —COOR″, where R″ means hydrogen or an alkyl group with 7-40 carbon atoms, c) 0-50 wt % based on the total weight of the ethylenically unsaturated monomers comonomers, and B) 1 to 99% by weight based on the total weight of the functional fluid of an oxygen containing compound selected from to group of organophosphorus compounds, carboxylic acid esters and/or polyether polyols.

Abstract translation: 本发明涉及一种功能性流体，其包含A）1至99重量％，基于通过聚合烯属不饱和单体的混合物获得的（甲基）丙烯酸烷基酯聚合物的官能流体的总重量，其由a）1-100 基于一种或多种式（I）的烯键式不饱和酯化合物（其中R是氢或甲基）的烯属不饱和单体的总重量，R 1表示具有1-6个碳原子的直链或支链烷基， R 2和R 3独立地表示氢或式-COOR'的基团，其中R'表示氢或具有1-6个碳原子的烷基，b）0-99重量％，基于总重量 的一种或多种式（II）的烯键式不饱和酯化合物的烯属不饱和单体，其中R是氢或甲基，R 4表示具有7-40个碳原子的直链或支链烷基，R 5和R“ 6>独立地是氢或式-COOR“的基团，其中R”' 和氢或具有7-40个碳原子的烷基，c）基于烯键式不饱和单体共聚单体的总重量为0-50重量％，和B）基于功能流体的总重量为1至99重量％ 的选自有机磷化合物，羧酸酯和/或聚醚多元醇的含氧化合物。

公开(公告)号：USD432153S

公开(公告)日：2000-10-17

申请号：US100982

申请日：1999-02-22

Applicant: David Cooper ,  Russell J. Kalil ,  David G. Perkins ,  Lauri A. Ventresca ,  Robb D. Bonilla ,  Elizabeth P. Staples ,  William R. Wrisley

Designer： David Cooper ,  Russell J. Kalil ,  David G. Perkins ,  Lauri A. Ventresca ,  Robb D. Bonilla ,  Elizabeth P. Staples ,  William R. Wrisley

公开(公告)号：US6010895A

公开(公告)日：2000-01-04

申请号：US388353

申请日：1995-02-14

Applicant: Nicholas John Deacon ,  Jennifer Catherine Learmont ,  Dale Alan McPhee ,  Suzanne Crowe ,  David Cooper

Inventor： Nicholas John Deacon ,  Jennifer Catherine Learmont ,  Dale Alan McPhee ,  Suzanne Crowe ,  David Cooper

IPC: G01N33/569 ,  A61K31/70 ,  A61K39/21 ,  A61P31/12 ,  C07H21/04 ,  C07K14/16 ,  C12N7/00 ,  C12N15/00 ,  C12Q1/68 ,  C12Q1/70 ,  C12N7/04

CPC classification number: C07K14/005 ,  C12N7/00 ,  C12Q1/703 ,  A61K2039/5254 ,  A61K2039/53 ,  C12N2740/16021 ,  C12N2740/16122 ,  C12N2740/16322

Abstract: This invention is directed toward non-pathogenic human immunodeficiency virus type 1 (HIV-1) strains containing deletions in the nef gene and U3 region of the long terminal repeat (LTR). A blood donor infected with HIV-1 and a cohort of six blood or blood product recipients infected from this donor were identified. These individuals, who remained free of HIV-1-related disease with stable and normal CD4.sup.+ lymphocyte counts 10 to 14 years after infection, were termed long-term nonprogressors (LTNPs). The molecular characterization of HIV-1 sequences obtained from either virus isolates or patient peripheral blood mononuclear cells (PBMCs) of LTNPs identified similar deletions in the nef gene and in the region of overlap of nef and the U3 region of the LTR. Full-length sequencing of one isolate genome and amplification of selected HIV-1 genome regions from other cohort members revealed no other abnormalities of obvious functional significance. These deletions corresponded to amino acids 166-206, or nucleotides 9281 to 9437, of the HIV-1.sub.NL43 nef/LTR region. These data illustrate the importance of nef or the U3 region of the LTR in determining the pathogenicity of HIV-1. These non-pathogenic strains should prove useful, inter alia, in the development of HIV-1-specific diagnostic reagents.

Abstract translation: 本发明涉及在长末端重复（LTR）的nef基因和U3区域中含有缺失的非致病性人类免疫缺陷病毒1型（HIV-1）菌株。 鉴定了感染HIV-1的献血者和由该供体感染的六个血液或血液制品受体的队列。 这些个体在感染后10至14年内仍然没有HIV-1相关疾病，具有稳定和正常的CD4 +淋巴细胞计数，被称为长期非进展者（LTNP）。 从LTNPs的病毒分离株或患者外周血单核细胞（PBMC）获得的HIV-1序列的分子表征鉴定了nef基因和nef与LTR的U3区域的重叠区域的相似缺失。 一个分离基因组的全长测序和来自其他队列成员的所选HIV-1基因组区域的扩增显示没有其他明显功能意义的异常。 这些缺失对应于HIV-1NL43 nef / LTR区的氨基酸166-206或核苷酸9281至9437。 这些数据说明了nef或LTR的U3区域在确定HIV-1的致病性方面的重要性。 这些非致病菌株尤其应用于开发HIV-1特异性诊断试剂。

公开(公告)号：USD348247S

公开(公告)日：1994-06-28

申请号：US9360

申请日：1993-06-09

Applicant: David Cooper

Designer： David Cooper

公开(公告)号：US4250469A

公开(公告)日：1981-02-10

申请号：US17053

申请日：1979-03-02

Applicant: David Cooper ,  Philip J. Davidson

Inventor： David Cooper ,  Philip J. Davidson

IPC: H03C1/16 ,  H03C1/06

CPC classification number: H03C1/16

Abstract: In a high efficiency amplitude modulation circuit. A pulse width modulation switch is arranged with a low pass filter to attentuate switching frequencies of the switch. A diode is connected in parallel with the input terminals of the low pass filter which diode provides a current discharge path for the filter while the switch is non-conductive. A further filter is also connected in parallel with the input terminals of the low pass filter, this further filter being arranged to provide cancellation of the input susceptance of the low pass filter over at least part of its pass band. The two filters in combination are such as to present a constant input conductance over at least part of the pass band of the low pass filter.

Abstract translation: 在高效振幅调制电路中。 脉冲宽度调制开关配有低通滤波器以注意开关的开关频率。 二极管与低通滤波器的输入端并联连接，二极管在开关不导通时为滤波器提供电流放电路径。 另外的滤波器也与低通滤波器的输入端并联连接，该另外的滤波器被布置成在其通带的至少一部分上提供低通滤波器的输入电纳的消除。 组合的两个滤波器可以在低通滤波器的至少一部分通带中呈现恒定的输入电导。

公开(公告)号：US08012919B2

公开(公告)日：2011-09-06

申请号：US12493589

申请日：2009-06-29

Applicant: Bernard Kinker ,  Matthias Fischer ,  Martin Bollinger ,  Robert Cybert ,  Ernst Bielmeier ,  David Cooper ,  Angelika Fischer ,  Melanie Croessmann

Inventor： Bernard Kinker ,  Matthias Fischer ,  Martin Bollinger ,  Robert Cybert ,  Ernst Bielmeier ,  David Cooper ,  Angelika Fischer ,  Melanie Croessmann

IPC: C10M145/14

CPC classification number: C10M149/02 ,  C10M161/00 ,  C10M2205/04 ,  C10M2209/084 ,  C10M2209/086 ,  C10M2217/023 ,  C10M2217/024 ,  C10M2217/028 ,  C10N2220/021 ,  C10N2230/041 ,  C10N2240/102

Abstract: The present invention is directed to a lubricating oil composition, a diesel engine comprising a lubricating oil composition, and a method of lubricating a diesel engine provided with an exhaust gas recirculation system, comprising lubricating said engine with a lubricating oil composition comprising an oil of lubricating viscosity, and a polymeric N-dispersant booster comprising monomer units of: a) 0 to 40 wt. % of one or more ethylenically unsaturated ester compounds of formula (I) wherein R is equal to H or CH3, R1 represents a linear or branched alkyl group with 1 to 5 carbon atoms, R2 and R3 independently represent H or a group of the formula —COOR′, wherein R′ is H or an alkyl group with 1 to 5 carbon atoms, b) 10 to 98 wt. % of one or more ethylenically unsaturated ester compounds of formula (II) wherein R is equal to H or CH3, R4 represents a linear or branched alkyl group with 6 to 15 carbon atoms, R5 and R6 independently represent H or a group of the formula —COOR″, wherein R″ is H or an alkyl group with 6 to 15 carbon atoms, c) 0 to 30 wt. % of one or more ethylenically unsaturated ester compounds of formula (III) wherein R is equal to H or CH3, R7 represents a linear or branched alkyl group with 16 to 30 carbon atoms, R8 and R9 independently represent H or a group of the formula —COOR′″, wherein R′″ is H or an alkyl group with 16 to 30 carbon atoms, d) 0 to 30 wt. % vinyl monomers, e) 7 to 25 wt. % of at least one N— dispersant monomer, wherein a)-e) add up to 100 wt. %.

Abstract translation: 本发明涉及润滑油组合物，包含润滑油组合物的柴油发动机，以及润滑具有废气再循环系统的柴油发动机的方法，包括用润滑油组合物润滑所述发动机，所述润滑油组合物包含润滑油 粘度和聚合N-分散剂增强剂，其包含以下单体单元：a）0至40wt。 ％的一种或多种式（I）的烯属不饱和酯化合物，其中R等于H或CH 3，R 1表示具有1至5个碳原子的直链或支链烷基，R2和R3独立地表示H或式 -COOR'，其中R'是H或具有1至5个碳原子的烷基，b）10至98wt。 ％的一种或多种式（II）的烯键式不饱和酯化合物，其中R等于H或CH 3，R 4表示具有6至15个碳原子的直链或支链烷基，R 5和R 6独立地表示H或式 -COOR“，其中R”为H或具有6至15个碳原子的烷基，c）0至30重量％ ％的一种或多种式（III）的烯键式不饱和酯化合物，其中R等于H或CH 3，R 7表示具有16至30个碳原子的直链或支链烷基，R8和R9独立地表示H或式 -COOR'“，其中R'”为H或具有16至30个碳原子的烷基，d）0至30重量％ ％乙烯基单体，e）7〜25wt。 ％的至少一种N-分散剂单体，其中a）-e）加到100wt。 ％。