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69 条记录 (耗时 0.024 秒)

    Process for preparing optically active 3-hydroxypyrrolidine derivatives
    21.
    发明授权
    Process for preparing optically active 3-hydroxypyrrolidine derivatives 失效
    制备光学活性3-羟基吡咯烷衍生物的方法

    公开(公告)号：US5144042A

    公开(公告)日：1992-09-01

    申请号：US682273

    申请日：1991-04-09

    申请人： Nobuo Seido ,  Yoshiki Okeda ,  Hidenori Kumobayashi

    发明人： Nobuo Seido ,  Yoshiki Okeda ,  Hidenori Kumobayashi

    IPC分类号： C07B53/00 ,  C07C31/34 ,  C07C211/27 ,  C07C309/65 ,  C07C309/73 ,  C07D207/12

    CPC分类号： C07D207/12

    摘要： A process for preparing optically active 3-hydroxypyrrolidine derivatives useful as intermediates represented by formula (III): ##STR1## wherein Q represents a substituted or unsubstituted phenyl group; and * indicates an asymmetric carbon atom, comprising reacting an optically active 4-halo-3-hydroxybutane derivative represented by formula (I): ##STR2## wherein * is as defined above; R.sup.1 represents a lower alkyl group or a substituted or unsubstituted phenyl group; and X represents a halogen atom, with a benzylamine derivative represented by formula (II):H.sub.2 NCH.sub.2 Q (II)wherein Q is as defined above, is disclosed. The starting compound (I) is easily available through chemical synthesis. Any complicated procedure or use of an expensive reagent is not required.

    Process for preparing optically active 6-t-butyoxy-3,5-dihydroxyhexanoic esters
    23.
    发明授权
    Process for preparing optically active 6-t-butyoxy-3,5-dihydroxyhexanoic esters 失效
    光学活性6-叔丁氧基-3,5-二羟基己酸酯的制备方法

    公开(公告)号：US4994602A

    公开(公告)日：1991-02-19

    申请号：US485692

    申请日：1990-02-27

    申请人： Nobuo Seido ,  Noboru Sayo ,  Hidenori Kumobayashi

    发明人： Nobuo Seido ,  Noboru Sayo ,  Hidenori Kumobayashi

    IPC分类号： C07C67/31 ,  C07C69/708

    CPC分类号： C07C67/31 ,  C07C69/708

    摘要： A process for preparing an optically active 6-t-butoxy-3,5-dihydroxyhexanoic ester represented by formula: ##STR1## wherein t-Bu represents a t-butyl group; and R.sup.4 represents a lower alkyl group, which is useful as a precursor of a lactone moiety of campactin, mevinolin or analogues thereof is disclosed, comprising asymmetrically hydrogenating a 4-t-butoxyacetoacetic ester in the presence of a ruthenium-optically active phosphine complex to obtain an optically active 4-t-butyoxy-3-hydroxybutanoic ester, reacting the ester with a lithium enolate of an acetic ester to obtain an optically active 6-t-butyoxy-5-hydroxy-3-oxohexanoic ester, and asymmetrically hydrogenating the resulting ester in the presence of a ruthenium-optically active phosphine complex as a catalyst. The desired product can be obtained in good yield at high stereoselectivity.

    Rhodium-phosphine complex
    25.
    发明授权
    Rhodium-phosphine complex 失效
    铑膦络合物

    公开(公告)号：US4605750A

    公开(公告)日：1986-08-12

    申请号：US651123

    申请日：1984-09-17

    申请人： Hidenori Kumobayashi ,  Susumu Akutagawa

    发明人： Hidenori Kumobayashi ,  Susumu Akutagawa

    IPC分类号： C07B53/00 ,  B01J31/00 ,  B01J31/24 ,  C07B31/00 ,  C07B61/00 ,  C07C67/00 ,  C07C209/68 ,  C07F15/00

    CPC分类号： B01J31/2452 ,  C07C209/68 ,  C07F15/008 ,  B01J2231/645 ,  B01J2531/0266 ,  B01J2531/52 ,  B01J2531/822

    摘要： A novel rhodium-phosphine complex represented by the formula (I):[Rh(BINAP).sub.2 ].sup.+ Y.sup.-wherein BINAP represents 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl, and Y represents ClO.sub.4, PF.sub.6, BF.sub.4, PCl.sub.6 or B(C.sub.6 H.sub.4) is described. This complex can be used as a catalyst for various organic syntheses and also for asymmetric syntheses such as an asymmetric isomerization reaction and an asymmetric hydrogenation reaction. Due to its high activity, the complex is very useful as a catalyst.

    摘要翻译： 由式（I）表示的新型铑 - 膦配合物：[Rh（BINAP）2] + Y-，其中BINAP表示2,2'-双（二苯基膦基）-1,1'-联萘，Y表示ClO4，PF6 ，BF4，PC16或B（C6H4）。 该络合物可用作各种有机合成的催化剂，也可用作不对称异构化反应和不对称氢化反应的不对称合成。 由于其活性高，络合物作为催化剂是非常有用的。

    Process for producing cyclohexylbutyric acid derivative
    30.
    发明授权
    Process for producing cyclohexylbutyric acid derivative 失效
    环己基丁酸衍生物的制备方法

    公开(公告)号：US5442105A

    公开(公告)日：1995-08-15

    申请号：US175505

    申请日：1993-12-30

    申请人： Noboru Sayo ,  Noboru Sano ,  Hidenori Kumobayashi

    发明人： Noboru Sayo ,  Noboru Sano ,  Hidenori Kumobayashi

    IPC分类号： C07C69/675 ,  C07C227/32 ,  C07C229/28 ,  C07C247/12 ,  C07D303/48 ,  C07C61/08

    CPC分类号： C07C227/32 ,  C07C229/28 ,  C07C247/12 ,  C07C69/675 ,  C07D303/48 ,  C07C2101/14

    摘要： A process for for producing a (2R,3S)-cyclohexylnorstatine or a salt thereof is disclosed, which comprises the steps of: enantioselectively hydrogenating a 4-cyclohexyl-2-halogeno-3-oxobutyric acid ester in the presence of a ruthenium-phosphine complex to produce a 4-cyclohexyl-2-halogeno-(3R)-hydroxybutyric acid ester (2); epoxidizing the compound (2) in the presence of a base to produce a 4-cyclohexyl-(2S,3R)-epoxybutyric acid ester (3); reacting the compound (3) with a lower trialkylsilyl azide in the presence of a Lewis acid to produce a (3S)-azide-4-cyclohexyl-(2S)-substituted butyric acid ester (4); subjecting the compound (4) to hydrogenolysis to produce a (2S,3S)-cyclohexylnorstatine derivative (5); and inverting the configuration at the 2-position of the compound (5).

    摘要翻译： 公开了一种制备（2R，3S） - 环己基异腈或其盐的方法，其包括以下步骤：在钌 - 磷化氢存在下对4-选择性氢化4-环己基-2-卤代-3-氧代丁酸酯 复合以制备4-环己基-2-卤代 - （3R） - 羟基丁酸酯（2）; 在碱的存在下使化合物（2）环氧化，得到4-环己基 - （2S，3R） - 环氧丁酸酯（3）; 在路易斯酸存在下使化合物（3）与低级三烷基甲硅烷基叠氮化物反应，得到（3S） - 叠氮-4-环己基 - （2S） - 取代的丁酸酯（4）; 使化合物（4）进行氢解以制备（2S，3S） - 环己基稳定剂衍生物（5）; 并使化合物（5）的2位的构型反转。