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21.发明授权公开(公告)号：US08404845B2
公开(公告)日：2013-03-26
申请号：US12675270
申请日：2008-08-27
申请人： Gopinadhan N. Anilkumar , Stuart B. Rosenblum , Srikanth Venkatraman , F. George Njoroge , Joseph A. Kozlowski
发明人： Gopinadhan N. Anilkumar , Stuart B. Rosenblum , Srikanth Venkatraman , F. George Njoroge , Joseph A. Kozlowski
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention relates to 2,3-Substituted Azaindole Derivatives, compositions comprising at least one 2,3-Substituted Azaindole Derivatives, and methods of using the 2,3-Substituted Azaindole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及2,3-取代的Azaindole衍生物，包含至少一种2,3-取代的Azaindole衍生物的组合物，以及使用2,3-取代的Azaindole衍生物治疗或预防病毒感染或病毒相关的方法 病人无序。
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22.发明申请FUSED TRICYCLIC COMPOUNDS AND DERIVATIVES THEREOF USEFUL FOR THE TREATMENT OF VIRAL DISEASES 审中-公开用于治疗病毒性疾病的融合三聚体化合物及其衍生物公开(公告)号：US20120276047A1
公开(公告)日：2012-11-01
申请号：US13512073
申请日：2010-11-23
IPC分类号： A61K31/437 , C07D471/14 , C07D491/048 , C07D495/04 , A61K31/4188 , C07D513/04 , A61K31/429 , C07D498/04 , A61K31/424 , A61K31/4184 , A61P31/12 , A61P37/02 , A61K31/7088 , A61K39/00 , A61K39/395 , A61K38/21 , C07D471/04
CPC分类号： C07D471/04 , C07D471/14 , C07D493/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to novel fused tricyclic compounds, compositions comprising at least one fused tricyclic compound, and methods of using fused tricyclic compounds for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及新的稠合三环化合物，包含至少一种稠合三环化合物的组合物，以及使用稠合三环化合物治疗或预防患者病毒感染或病毒相关病症的方法。
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23.发明申请FUSED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEAS 审中-公开融合三聚体化合物及其用于治疗病毒性疾病的方法公开(公告)号：US20130156731A1
公开(公告)日：2013-06-20
申请号：US13518336
申请日：2010-12-20
IPC分类号： A61K45/06 , A61K31/454 , C07D403/14 , C07D409/14 , A61K31/4184
CPC分类号： C07D403/14 , A61K31/4184 , A61K31/454 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/08 , C07D409/14
摘要： The present invention relates to novel Fused Tricyclic Compounds, compositions comprising at least one Fused Tricyclic Compound, and methods of using Fused Tricyclic Compounds for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及新型融合三环化合物，包含至少一种熔融三环化合物的组合物，以及使用熔融三环化合物治疗或预防患者病毒感染或病毒相关病症的方法。
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24.发明申请公开(公告)号：US20100260711A1
公开(公告)日：2010-10-14
申请号：US12743023
申请日：2008-11-13
IPC分类号： A61K31/549 , C07D417/14 , A61K31/4439 , C07D401/06 , A61P31/12 , A61P31/14 , A61K38/21 , A61K39/395
CPC分类号： C07D417/14
摘要： The present invention relates to 3-Aminosulfonyl Substituted Indole Derivatives, compositions comprising at least one 3-Aminosulfonyl Substituted Indole Derivative, and methods of using the 3-Aminosulfonyl Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及3-氨基磺酰基取代的吲哚衍生物，包含至少一种3-氨基磺酰基取代的吲哚衍生物的组合物，以及使用3-氨基磺酰基取代的吲哚衍生物用于治疗或预防病毒感染或病毒相关病症的方法 患者。
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25.发明授权公开(公告)号：US09139569B2
公开(公告)日：2015-09-22
申请号：US13320427
申请日：2010-05-12
申请人： Stuart B. Rosenblum , Kevin X. Chen , Joseph A. Kozlowski , F. George Njoroge , Craig A. Coburn
发明人： Stuart B. Rosenblum , Kevin X. Chen , Joseph A. Kozlowski , F. George Njoroge , Craig A. Coburn
IPC分类号： C07D493/04 , C07D491/044 , C07D487/04 , C07D471/04 , C07D403/14 , C07C403/04
CPC分类号： C07D403/14 , C07C403/04 , C07D403/04 , C07D471/04 , C07D487/04 , C07D491/044 , C07D493/04
摘要： The present invention relates to novel Fused Tricyclic Aryl Compounds, compositions comprising at least one Fused Tricyclic Aryl Compound, and methods of using the Fused Tricyclic Aryl Compounds for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及新的熔融三环芳基化合物，包含至少一种稠合三环芳基化合物的组合物，以及使用稠合三环芳基化合物治疗或预防患者HCV感染的方法。
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26.发明申请公开(公告)号：US20120251491A1
公开(公告)日：2012-10-04
申请号：US13320427
申请日：2010-05-12
申请人： Stuart B. Rosenblum , Kevin X. Chen , Joseph A. Kozlowski , F. George Njoroge , Craig A. Coburn
发明人： Stuart B. Rosenblum , Kevin X. Chen , Joseph A. Kozlowski , F. George Njoroge , Craig A. Coburn
IPC分类号： A61K31/4178 , C07D487/04 , C07D493/04 , A61K31/4184 , A61K31/4188 , C07D471/04 , A61K31/4745 , C07D491/044 , A61K31/55 , C07D401/14 , A61K31/473 , A61K31/498 , A61K38/21 , A61K31/7088 , A61K39/12 , A61K39/395 , A61K31/7056 , A61P31/14 , A61P37/04 , A61P31/12 , C07D403/14
CPC分类号： C07D403/14 , C07C403/04 , C07D403/04 , C07D471/04 , C07D487/04 , C07D491/044 , C07D493/04
摘要： The present invention relates to novel Fused Tricyclic Aryl Compounds, compositions comprising at least one Fused Tricyclic Aryl Compound, and methods of using the Fused Tricyclic Aryl Compounds for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及新的熔融三环芳基化合物，包含至少一种稠合三环芳基化合物的组合物，以及使用稠合三环芳基化合物治疗或预防患者HCV感染的方法。
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27.发明授权公开(公告)号：US08377928B2
公开(公告)日：2013-02-19
申请号：US12743023
申请日：2008-11-13
IPC分类号： A61K31/404 , A61K31/549
CPC分类号： C07D417/14
摘要： The present invention relates to 3-Aminosulfonyl Substituted Indole Derivatives of Formula (I): The invention also relates to compositions comprising at least one 3-Aminosulfonyl Substituted Indole Derivative, and methods of using the 3-Aminosulfonyl Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及式（I）的3-氨基磺酰基取代的吲哚衍生物：本发明还涉及包含至少一种3-氨基磺酰基取代的吲哚衍生物的组合物，以及使用3-氨基磺酰基取代的吲哚衍生物用于治疗或预防 病毒感染或病毒相关疾病。
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公开(公告)号：US07244721B2
公开(公告)日：2007-07-17
申请号：US10052386
申请日：2002-01-18
申请人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. Mc Cormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse K. Wong , Latha G. Nair
发明人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. Mc Cormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse K. Wong , Latha G. Nair
IPC分类号： A61K31/497 , A61K31/407 , A61K31/454 , A61K31/4025
CPC分类号： C07K5/0804 , A61K38/00 , C07K5/0202 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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公开(公告)号：USRE43298E1
公开(公告)日：2012-04-03
申请号：US13068159
申请日：2011-04-22
申请人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. McCormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry M. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
发明人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. McCormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry M. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
IPC分类号： A61K38/00 , A01N37/18 , A61P1/16 , A61P31/12 , A61K39/12 , G01N33/53 , A61K38/07 , A61K38/06 , C07K5/08 , C07K5/10
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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30.发明申请NOVEL PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS 审中-公开新型肽作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂公开(公告)号：US20110117057A1
公开(公告)日：2011-05-19
申请号：US12973020
申请日：2010-12-20
申请人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. McCormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
发明人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. McCormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
IPC分类号： A61K38/06 , C07D207/16 , C07D403/10 , C07K5/083 , C07D209/42 , C07K5/107 , C07D215/48 , A61K38/05 , A61K38/07 , A61K38/21 , A61P31/14
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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