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34 条记录 (耗时 0.1 秒)

    Anti-proliferative compounds, compositions, and methods of use thereof
    21.
    发明申请
    Anti-proliferative compounds, compositions, and methods of use thereof 有权

    公开(公告)号：US20050222090A1

    公开(公告)日：2005-10-06

    申请号：US11026303

    申请日：2004-12-29

    申请人： Xiaqin Cheng ,  Gary Cook ,  Manoj Desai ,  Edward Doerffler ,  Gong-Xin He ,  Choung Kim ,  William Lee ,  John Rohloff ,  Jianying Wang ,  Zheng-Yu Yang

    发明人： Xiaqin Cheng ,  Gary Cook ,  Manoj Desai ,  Edward Doerffler ,  Gong-Xin He ,  Choung Kim ,  William Lee ,  John Rohloff ,  Jianying Wang ,  Zheng-Yu Yang

    IPC分类号： A61K31/66 ,  A61K31/675 ,  C07F9/44 ,  C07F9/6561

    CPC分类号： C07F9/65616 ,  Y02P20/55

    摘要： Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y1A and Y1B are independently Y1; RX1 and RX2 are independently RX; Y1 is ═O, —O(RX), ═S, —N(RX), —N(O)(RX), —N(ORX), —N(O)(ORX), or —N(N(RX)(RX)); RX is independently R1, R2, R4, W3, or a protecting group; R1 is independently —H or alkyl of 1 to 18 carbon atoms; R2 is independently R3 or R4 wherein each R4 is independently substituted with 0 to 3 R3 groups or taken together at a carbon atom, two R2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3 R3 groups; R3 is R3a, R3b, R3c or R3d, provided that when R3 is bound to a heteroatom, then R3 is R3c or R3d; R3a is —H, —F, —Cl, —Br, —I, —CF3, —CN, N3, —NO2, or —OR4; R3b is ═O, —O(R4), ═S, —N(R4), —N(O)(R4), —N(OR4), —N(O)(OR4), or —N(N(R4)(R4)); R3c is —R4, —N(R4)(R4), —SR4, —S(O)R4, —S(O)2R4, —S(O)(OR4), —S(O)2(OR4), —OC(R3b)R4, —OC(R3b)OR4, —OC(R3b)(N(R4)(R4)), —SC(R3b)R4, —SC(R3b)OR4, —SC(R3b)(N(R4)(R4)), —N(R4)C(R3b)R4, —N(R4)C(R3b)OR4, N(R4)C(R3b)(N(R4)(R4)), W3 or —R5W3; R3d is —C(R3b)R4, —C(R3b)OR4, —C(R3b)W3, —C(R3b)OW3 or —C(R3b)(N(R4)(R4)); R4 is —H, or an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms; R5 is alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2 to 18 carbon atoms; W3 is W4 or W5; W4 is R6, —C(R3b)R6, —C(R3b)W5, —SOM2R6, or —SOM2W5, wherein R6 is R4 wherein each R4 is substituted with 0 to 3 R3 groups; W5 is carbocycle or heterocycle wherein W5 is independently substituted with 0 to 3 R2 groups; and M2 is 0, 1 or 2; and pharmaceutically acceptable salts thereof.

    SYSTEM FOR AND METHOD OF MANAGING WORKLOADS IN A DATABASE SYSTEM
    22.
    发明申请
    SYSTEM FOR AND METHOD OF MANAGING WORKLOADS IN A DATABASE SYSTEM 审中-公开
    在数据库系统中管理工作负载的系统和方法

    公开(公告)号：US20080133608A1

    公开(公告)日：2008-06-05

    申请号：US11566734

    申请日：2006-12-05

    申请人： Douglas Brown ,  Choung Kim ,  Anita Richards

    发明人： Douglas Brown ,  Choung Kim ,  Anita Richards

    IPC分类号： G06F17/30

    CPC分类号： G06F9/5083 ,  G06F2209/5022

    摘要： A system for and method of managing database workloads. The workload managing system comprises a historical data collector arranged to collect historical data indicative of historical database performance trends, and a current data collector arranged to collect substantially current data indicative of substantially current database performance. The system is arranged to compare the collected historical data with the collected substantially current data and to modify operation of the database based on the comparison.

    摘要翻译： 用于管理数据库工作负载的系统和方法。 工作负载管理系统包括历史数据收集器，其被布置成收集指示历史数据库性能趋势的历史数据，以及当前数据收集器，其被布置为收集指示基本上当前数据库性能的基本上当前的数据。 该系统被安排为将收集的历史数据与收集的基本上当前的数据进行比较，并且基于该比较来修改数据库的操作。