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公开(公告)号：US20080057031A1
公开(公告)日：2008-03-06
申请号：US11825606
申请日：2007-07-06
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung Kim , Hyungjung Pyun , Xiaoning Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung Kim , Hyungjung Pyun , Xiaoning Sheng , Jianying Wang
IPC分类号： A61K31/675 , A61K31/7042 , A61K38/12 , A61K38/21 , A61P31/12 , C07F9/572 , C07F9/576 , C07F9/60 , C07F9/6512
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20110081314A1
公开(公告)日：2011-04-07
申请号：US12913692
申请日：2010-10-27
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： A61K38/21 , C07D245/04 , A61K31/675 , A61K31/70 , A61K31/7056 , A61K31/7068 , A61P31/14
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US08586744B2
公开(公告)日：2013-11-19
申请号：US12913704
申请日：2010-10-27
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： C07D221/18 , C07F9/02 , A61K38/12
CPC分类号： C07F9/65583
摘要： The invention is related to a method of treating disorders associated with hepatitis C by administering to an individual a pharmaceutical composition which comprises a therapeutically effective amount of an anti-viral phosphinate compound.
摘要翻译： 本发明涉及通过向个体施用包含治疗有效量的抗病毒次膦酸盐化合物的药物组合物来治疗与丙型肝炎相关的疾病的方法。
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公开(公告)号：US20110082112A1
公开(公告)日：2011-04-07
申请号：US12913704
申请日：2010-10-27
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： A61K31/675 , A61P31/14
CPC分类号： C07F9/65583
摘要： The invention is related to a method of treating disorders associated with hepatitis C by administering to an individual a pharmaceutical composition which comprises a therapeutically effective amount of an anti-viral phosphinate compound.
摘要翻译： 本发明涉及通过向个体施用包含治疗有效量的抗病毒次膦酸盐化合物的药物组合物来治疗与丙型肝炎相关的疾病的方法。
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公开(公告)号：US07893264B2
公开(公告)日：2011-02-22
申请号：US11825606
申请日：2007-07-06
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： C07D221/18 , C07F9/02 , A61K38/12
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US08674088B2
公开(公告)日：2014-03-18
申请号：US12913692
申请日：2010-10-27
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： C07D487/00
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20090227491A1
公开(公告)日：2009-09-10
申请号：US12303219
申请日：2007-07-06
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyung-Jung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyung-Jung Pyun , Xiaoning C. Sheng , Jianying Wang
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20050215513A1
公开(公告)日：2005-09-29
申请号：US10832815
申请日：2004-04-26
申请人： Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Haolun Jin , Ralph Hirschmann , Alan Huang , Choung Kim , Thorsten Kirschberg , Christopher Lee , William Lee , Richard MacKman , David Markevitch , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang
发明人： Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Haolun Jin , Ralph Hirschmann , Alan Huang , Choung Kim , Thorsten Kirschberg , Christopher Lee , William Lee , Richard MacKman , David Markevitch , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang
IPC分类号： A61K31/662 , A61K31/675 , A61K31/7072 , A61K31/7076 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/40 , C07F9/572 , C07F9/58 , C07F9/60 , C07F9/6503 , C07F9/6509 , C07F9/653 , C07F9/6539 , C07F9/655 , C07F9/6553 , C07F9/6561
CPC分类号： C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465
摘要： The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及具有抗病毒活性的磷取代的化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20060264404A1
公开(公告)日：2006-11-23
申请号：US11258621
申请日：2005-10-25
申请人： Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Manoj Desai , Maria Fardis , Craig Gibbs , Ralph Hirschmann , Alan Huang , Haolun Jin , Choung Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher Lee , William Lee , Kuei-Ying Lin , Richard Mackman , David Markevitch , Peter Nelson , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang , Lijun Zhang
发明人： Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Manoj Desai , Maria Fardis , Craig Gibbs , Ralph Hirschmann , Alan Huang , Haolun Jin , Choung Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher Lee , William Lee , Kuei-Ying Lin , Richard Mackman , David Markevitch , Peter Nelson , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang , Lijun Zhang
IPC分类号： A61K31/675 , C07F9/6512
CPC分类号： C07F9/65616 , C07F9/4006 , C07F9/4465 , C07F9/5304 , C07F9/650952 , C07F9/653 , C07F9/65507 , C07F9/65515 , C07F9/65517 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.
摘要翻译： 本发明涉及磷取代的治疗剂，含有这种磷取代剂的组合物，以及包括施用这种磷取代剂的治疗方法，以及可用于制备这种药剂的方法和中间体。
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公开(公告)号：US20060079478A1
公开(公告)日：2006-04-13
申请号：US10833293
申请日：2004-04-26
申请人： Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Alan Huang , Choung Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher Lee , Kuei-Ying Lin , Richard Mackman , David Markevitch , Peter Nelson , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang , Lijun Zhang
发明人： Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Alan Huang , Choung Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher Lee , Kuei-Ying Lin , Richard Mackman , David Markevitch , Peter Nelson , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang , Lijun Zhang
IPC分类号： A61K31/7076 , A61K31/7072 , C07H19/04 , A61K31/675
CPC分类号： A61K31/7076 , A61K31/675 , A61K31/7072 , A61K47/548 , C07H19/04
摘要： The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及磷取代的抗癌化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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