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    Oligonucleotide therapies for modulating the effects of herpesviruses
    25.
    发明授权
    Oligonucleotide therapies for modulating the effects of herpesviruses 失效
    用于调节疱疹病毒的作用的寡核苷酸疗法

    公开(公告)号：US5658891A

    公开(公告)日：1997-08-19

    申请号：US329212

    申请日：1994-10-26

    申请人： Kenneth G. Draper ,  David J. Ecker ,  Christopher K. Mirabelli ,  Stanley T. Crooke

    发明人： Kenneth G. Draper ,  David J. Ecker ,  Christopher K. Mirabelli ,  Stanley T. Crooke

    IPC分类号： A61K31/70 ,  A61K38/00 ,  A61K48/00 ,  A61P31/12 ,  A61P31/22 ,  C07H21/00 ,  C07K14/03 ,  C12N7/04 ,  C12N15/09 ,  C12N15/113 ,  C12Q1/68 ,  C12N5/10

    CPC分类号： C12N15/1133 ,  C07K14/005 ,  A61K38/00 ,  C12N2310/3125 ,  C12N2310/315 ,  C12N2710/16622

    摘要： Compositions and methods are provided for the treatment and diagnosis of herpesvirus infections. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with RNA or DNA deriving from a gene corresponding to one of the open reading frames UL5, UL8, UL9, UL13, UL29, UL30, UL39, UL40, UL42 AND UL52 of herpes simplex virus type 1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a translation initiation site; it is also preferred that they comprise the sequence CAT. Methods of treating animals suspected of being infected with herpesvirus comprising contacting the animal with an oligonucleotide specifically hybridizable with RNA or DNA deriving from one of the foregoing genes of the herpesvirus; are disclosed. Methods for treatment of infections caused by herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, human herpes virus 6, Epstein Barr virus or varicella zoster virus are disclosed.

    摘要翻译： 提供组合物和方法用于治疗和诊断疱疹病毒感染。 根据优选实施方案，提供寡核苷酸，其与衍生自相应于疱疹的开放阅读框UL5，UL8，UL9，UL13，UL29，UL30，UL39，UL29，UL30，UL39，UL40，UL42和UL52中的一个的基因的RNA或DNA特异性杂交 单克隆病毒类型1.寡核苷酸包含足以实现所述特异性杂交的同一性和数目的核苷酸单元。 在其它优选实施方案中，寡核苷酸与翻译起始位点特异性杂交; 还优选它们包含序列CAT。 治疗疑似感染疱疹病毒的动物的方法，包括使动物与可衍生自疱疹病毒的前述基因之一的RNA或DNA特异性杂交的寡核苷酸接触; 被披露。 公开了用于治疗由单纯疱疹病毒1型，2型单纯疱疹病毒，巨细胞病毒，人疱疹病毒6，爱泼斯坦巴尔病毒或水痘带状疱疹病毒引起的感染的方法。