公开(公告)号：US09186209B2

公开(公告)日：2015-11-17

申请号：US13554459

申请日：2012-07-20

Applicant: Jan Weber ,  Aiden Flanagan ,  Tim O'Connor

Inventor： Jan Weber ,  Aiden Flanagan ,  Tim O'Connor

IPC: A61B18/14 ,  A61N1/05 ,  A61B18/00

CPC classification number: A61N1/0551 ,  A61B2018/00511 ,  A61B2018/00577 ,  F04C2270/0421

Abstract: Systems for nerve modulation and methods for making and using the same are disclosed. An example system for nerve modulation may include a first elongate element having a distal end and a proximal end and having a helical guide having a proximal end and a distal end. The system may also include a second elongate element having a distal end and a proximal end and having a nerve modulation element proximate the distal end. A sheath may be disposed about both the first and second elongate elements. Pulling proximally on the proximal end of the first elongate element may cause simultaneous radial and longitudinal displacement of the nerve modulation element.

Abstract translation: 公开了神经调制系统及其制造和使用方法。 用于神经调节的示例性系统可以包括具有远端和近端的具有近端和远端的螺旋引导件的第一细长元件。 该系统还可以包括具有远端和近端并且具有靠近远端的神经调制元件的第二细长元件。 鞘可围绕第一和第二细长元件设置。 在第一细长元件的近端上向近侧拉动可引起神经调制元件的同时径向和纵向位移。

公开(公告)号：US08586072B2

公开(公告)日：2013-11-19

申请号：US11983796

申请日：2007-11-09

Applicant: Jan Weber ,  Aiden Flanagan ,  Tim O'Connor ,  Barry J. O'Brien ,  John Clarke ,  David McMorrow

Inventor： Jan Weber ,  Aiden Flanagan ,  Tim O'Connor ,  Barry J. O'Brien ,  John Clarke ,  David McMorrow

IPC: A61F2/00 ,  A61L27/30 ,  A61L31/16 ,  A61N1/05

CPC classification number: A61F2/06 ,  A61F2250/0068 ,  A61L27/30 ,  A61L27/54 ,  A61L31/082 ,  A61L31/16 ,  A61L2300/00 ,  A61L2400/12 ,  A61N1/05

Abstract: According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device.

公开(公告)号：US20110130829A1

公开(公告)日：2011-06-02

申请号：US13000594

申请日：2009-06-19

Applicant: John Clarke ,  Tim O'Connor ,  Barry J. O'Brien ,  David McMorrow ,  Jan Weber ,  Aiden Flanagan

Inventor： John Clarke ,  Tim O'Connor ,  Barry J. O'Brien ,  David McMorrow ,  Jan Weber ,  Aiden Flanagan

IPC: A61F2/82 ,  A61L29/08 ,  A61L29/16 ,  A61L27/28 ,  A61L27/54

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61F2250/0014 ,  A61F2250/0025 ,  A61F2250/0026 ,  A61F2250/0037 ,  A61F2250/0067 ,  A61L27/30 ,  A61L27/54 ,  A61L29/10 ,  A61L29/16 ,  A61L31/082 ,  A61L31/146 ,  A61L2300/416 ,  A61L2300/63

Abstract: The present invention pertains to implantable or insertable medical devices which comprise a substrate and one or more therapeutic-agent-containing regions contain one or more therapeutic agents. In various aspects of the invention, one or more characteristics of such therapeutic-agent-containing regions are controlled. Further aspects of the invention relate to methods of forming such devices and to methods of using such devices.

Abstract translation: 本发明涉及可植入或可插入的医疗装置，其包括基质和含有一种或多种治疗剂的一种或多种含治疗剂的区域。 在本发明的各个方面，控制这种含治疗剂的区域的一个或多个特征。 本发明的其它方面涉及形成这种装置的方法以及使用这种装置的方法。

公开(公告)号：US07913642B2

公开(公告)日：2011-03-29

申请号：US11858347

申请日：2007-09-20

Applicant: Tim O'Connor ,  Dave McMorrow ,  Gabriel Sobrino ,  Liam Ward ,  Noel Hynes

Inventor： Tim O'Connor ,  Dave McMorrow ,  Gabriel Sobrino ,  Liam Ward ,  Noel Hynes

IPC: B05C1/00

CPC classification number: B05C1/022 ,  A61L2420/02

Abstract: The present invention relates to a coating assembly and methods that employ the coating assembly to control the thickness of therapeutic or other coatings delivered to a medical device during a coating process. In one embodiment the coating assembly may include a coating plate having a coating transfer surface and a shoulder having a first height, a mandrel moveable over the coating transfer surface, and a coating dispenser positioned in fluid communication with the coating transfer surface. The invention also includes a method of coating a medical device. This method may include placing a medical device on a mandrel, dispensing coating onto a coating transfer surface of a coating plate, moving the mandrel and the medical device over the coating transfer surface of the coating plate so that coating resident on the coating transfer surface transfers to an exposed surface of the medical device, and removing the medical device from the mandrel.

Abstract translation: 本发明涉及涂覆组件和方法，其使用涂层组件来控制在涂覆过程期间递送到医疗装置的治疗剂或其它涂层的厚度。 在一个实施方案中，涂层组件可以包括具有涂层转移表面和具有第一高度的肩部，可在涂层转移表面上移动的芯棒的涂布板和与涂层转移表面流体连通的涂布分配器。 本发明还包括涂覆医疗装置的方法。 该方法可以包括将医疗装置放置在心轴上，将涂层分配到涂布板的涂层转移表面上，将心轴和医疗装置移动到涂布板的涂层转移表面上，使得驻留在涂层转移表面上的涂层转移 到医疗装置的暴露表面，并且从心轴移除医疗装置。

公开(公告)号：US20100008970A1

公开(公告)日：2010-01-14

申请号：US12334113

申请日：2008-12-12

Applicant: Barry O'Brien ,  Ben Arcand ,  James Lee Shippy, III ,  Liliana Atanasoska ,  Aiden Flanagan ,  John T. Clarke ,  Tim O'Connor ,  Yixin Xu ,  Dave McMorrow ,  Jan Weber ,  John Kremer ,  Michael Kuehling ,  Dominique Seidel

Inventor： Barry O'Brien ,  Ben Arcand ,  James Lee Shippy, III ,  Liliana Atanasoska ,  Aiden Flanagan ,  John T. Clarke ,  Tim O'Connor ,  Yixin Xu ,  Dave McMorrow ,  Jan Weber ,  John Kremer ,  Michael Kuehling ,  Dominique Seidel

IPC: A61K31/337 ,  A61F2/00 ,  B05D1/02

CPC classification number: A61L31/088 ,  A61L31/16 ,  A61L2300/45 ,  A61L2300/61

Abstract: A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent.

Abstract translation: 包括生物腐蚀性金属部分和治疗剂的药物洗脱内用假体。 在一些方面，内假体包括多个离散沉积物和多个覆盖层，每个覆盖层覆盖多个离散沉积物之一。 每个离散沉积物包括一种或多种治疗剂，并且每个上覆层包括一种或多种生物可腐蚀金属。 在其他方面，生物腐蚀性金属部分包括具有不同电负性的至少两个生物可腐蚀金属区域。 所述至少两个生物浸渍金属区域彼此电接触。 生物腐蚀性金属在生理环境中侵蚀以释放治疗剂。

公开(公告)号：US20090327229A1

公开(公告)日：2009-12-31

申请号：US12147573

申请日：2008-06-27

Applicant: Tim O'Connor ,  Tomasz Kasperkiewicz

Inventor： Tim O'Connor ,  Tomasz Kasperkiewicz

IPC: G06F7/06 ,  G06F17/30

CPC classification number: G06F16/58

Abstract: Various techniques for a method for generating location information for a digital media file. In one implementation, the method may include receiving a first digital media file with location information and a second digital media file without location information, receiving a location hierarchy of the first digital media file, wherein the location hierarchy is determined using a reverse-geocoding algorithm and using the location hierarchy of the first digital media file to determine a location hierarchy of the second digital media file.

Abstract translation: 用于产生数字媒体文件的位置信息的方法的各种技术。 在一个实现中，该方法可以包括接收具有位置信息的第一数字媒体文件和没有位置信息的第二数字媒体文件，接收第一数字媒体文件的位置层次结构，其中使用反向地理编码算法 以及使用所述第一数字媒体文件的位置层级来确定所述第二数字媒体文件的位置层级。

公开(公告)号：US20090061071A1

公开(公告)日：2009-03-05

申请号：US11897808

申请日：2007-08-31

Applicant: David McMorrow ,  Anthony Malone ,  Tim O'Connor ,  Barry J. O'Brien

Inventor： David McMorrow ,  Anthony Malone ,  Tim O'Connor ,  Barry J. O'Brien

IPC: A61K9/22

CPC classification number: A61L31/14 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416

Abstract: According to an aspect of the present invention a method is provided which a porous medical article is contacted with a solution that contains a therapeutic agent and a solvent in order to load the pores of the medical article, after which the solvent is sublimated.

Abstract translation: 根据本发明的一个方面，提供了一种方法，使多孔医疗制品与含有治疗剂和溶剂的溶液接触，以便加载医疗用品的孔，之后溶剂升华。

公开(公告)号：US20090048666A1

公开(公告)日：2009-02-19

申请号：US11893417

申请日：2007-08-14

Applicant: Tim O'Connor

Inventor： Tim O'Connor

IPC: A61F2/06

CPC classification number: A61L31/084 ,  A61L27/303 ,  A61L27/54 ,  A61L27/56 ,  A61L29/085 ,  A61L29/103 ,  A61L29/146 ,  A61L29/16 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416

Abstract: According to an aspect of the present invention, medical devices are provided which comprise a substrate, a porous carbon layer disposed on at least a portion of the substrate surface, and a polymeric layer disposed on at least a portion of the porous carbon layer.

Abstract translation: 根据本发明的一个方面，提供了包括基底，设置在基底表面的至少一部分上的多孔碳层和设置在多孔碳层的至少一部分上的聚合物层的医疗装置。

公开(公告)号：US20080097569A1

公开(公告)日：2008-04-24

申请号：US11857849

申请日：2007-09-19

Applicant: Tim O'Connor ,  Aiden Flanagan ,  Dave McMorrow ,  Anthony Malone

Inventor： Tim O'Connor ,  Aiden Flanagan ,  Dave McMorrow ,  Anthony Malone

IPC: A61F2/06

CPC classification number: A61L31/16 ,  A61F2250/0067 ,  A61L31/08 ,  A61L2300/602

Abstract: The present invention generally relates to the conditioning of coated medical devices such as stents. More specifically, the present invention relates to methods for positioning a medical device within an elution media for a predetermined time period to eliminate a burst release from the coating. Under methods and processes of the invention, a medical device target surface may be identified and coated with therapeutic. The coated surface of the medical device may then be positioned within an elution media for a predetermined period of time to release a predetermined amount of coating.

Abstract translation: 本发明一般涉及诸如支架之类的涂覆的医疗装置的调理。 更具体地，本发明涉及用于将洗涤介质中的医疗装置定位在预定时间段内以消除从涂层中爆发释放的方法。 在本发明的方法和方法下，可以鉴定医疗器械靶表面并用治疗剂涂覆。 然后可以将医疗装置的涂覆表面定位在洗脱介质中预定的时间段以释放预定量的涂层。

公开(公告)号：US20050229468A1

公开(公告)日：2005-10-20

申请号：US10933856

申请日：2004-09-03

Applicant: Serge Zaderey ,  Steven Timm ,  Gary Williams ,  Victoria Peters ,  Laura Peter ,  Tim Lesser ,  Tim O'Connor

Inventor： Serge Zaderey ,  Steven Timm ,  Gary Williams ,  Victoria Peters ,  Laura Peter ,  Tim Lesser ,  Tim O'Connor

IPC: F41G1/38

CPC classification number: F41G1/38

Abstract: A reticle of a projectile weapon aiming system such as a riflescope includes a primary aiming mark adapted to be sighted-in at a first selected range and further includes a plurality of secondary aiming marks spaced apart below the primary aiming mark. The secondary aiming marks are positioned to compensate for ballistic drop at preselected incremental ranges beyond the first selected range, for a selected group of ammunition having similar ballistic characteristics. Angles subtended by adjacent aiming marks of the reticle can be adjusted by changing the optical power of the riflescope, to thereby compensate for ballistic characteristics of different ammunition. In some embodiments, the reticle includes a set of windage aiming marks spaced apart along at least one secondary horizontal axis intersecting a selected one of the secondary aiming marks, to facilitate compensation for the effect of crosswinds on the trajectory of the projectile.

Abstract translation: 射击武器瞄准系统如路镜的掩模版包括适于在第一选定范围内被瞄准的主瞄准标记，并且还包括在主瞄准标记下方间隔开的多个次瞄准标记。 第二瞄准标记被定位成补偿具有类似弹道特性的选定组的弹药的超出第一选定范围的预选增量范围的弹道降落。 可以通过改变步枪镜的光功率来调整由掩模版的相邻瞄准标记所对向的角度，从而补偿不同弹药的弹道特性。 在一些实施例中，掩模版包括沿着与所选择的第二瞄准标记相交的至少一个副水平轴线间隔开的一组风向瞄准标记，以便于补偿侧风对射弹轨迹的影响。