公开(公告)号：US08221822B2

公开(公告)日：2012-07-17

申请号：US12182703

申请日：2008-07-30

Applicant: Aiden Flanagan ,  Tim O'Connor

Inventor： Aiden Flanagan ,  Tim O'Connor

IPC: A61L33/00 ,  B05D3/00 ,  B05D1/36 ,  B05D1/02 ,  B29D22/00 ,  B22D3/00

CPC classification number: A61L31/146 ,  A61L27/16 ,  A61L27/54 ,  A61L27/56 ,  A61L31/16 ,  A61L2300/608 ,  B05D1/12 ,  B05D3/0466 ,  B05D3/06 ,  B05D7/52 ,  B05D2202/00 ,  B23K26/32 ,  B23K26/324 ,  B23K26/34 ,  B23K35/0244 ,  B23K35/365 ,  B23K2101/34 ,  B23K2103/30 ,  B23K2103/50 ,  B23K2103/52 ,  B33Y80/00 ,  Y10T428/12 ,  Y10T428/1352 ,  Y10T428/1355

Abstract: Methods for making medical devices having porous coatings. Methods may comprise providing a tubing section having inner and outer surfaces and positioning a nozzle proximate to a target surface of the parent tubing section. A powder form of the porous coating may be delivered toward the tubing section, and a laser may be directed at the powder to melt the powder to form a melt pool. The melt pool can solidify to form the porous coating on the target surface. Portions of the parent tubing section may then be cut away to form the support structure of the medical device, such as a stent.

Abstract translation: 制造具有多孔涂层的医疗装置的方法。 方法可以包括提供具有内表面和外表面并且将喷嘴定位在母管部分的目标表面附近的管段。 多孔涂层的粉末形式可以朝向管道部分递送，并且激光可以被引导到粉末以熔化粉末以形成熔池。 熔池可以固化以在目标表面上形成多孔涂层。 然后可以将母管部分的部分切除以形成医疗装置（例如支架）的支撑结构。

公开(公告)号：US07901726B2

公开(公告)日：2011-03-08

申请号：US11897808

申请日：2007-08-31

Applicant: David McMorrow ,  Anthony Malone ,  Tim O'Connor ,  Barry J. O'Brien

Inventor： David McMorrow ,  Anthony Malone ,  Tim O'Connor ,  Barry J. O'Brien

IPC: B05D3/00

CPC classification number: A61L31/14 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416

Abstract: According to an aspect of the present invention a method is provided which a porous medical article is contacted with a solution that contains a therapeutic agent and a solvent in order to load the pores of the medical article, after which the solvent is sublimated.

Abstract translation: 根据本发明的一个方面，提供了一种方法，使多孔医疗制品与含有治疗剂和溶剂的溶液接触，以便加载医疗用品的孔，之后溶剂升华。

公开(公告)号：US07875069B2

公开(公告)日：2011-01-25

申请号：US11526278

申请日：2006-09-21

Applicant: Barry Heaney ,  Dave McMorrow ,  Anthony Malone ,  Aiden Flanagan ,  Tim O'Connor

Inventor： Barry Heaney ,  Dave McMorrow ,  Anthony Malone ,  Aiden Flanagan ,  Tim O'Connor

IPC: A61F2/06

CPC classification number: A61F2/91 ,  A61F2/852 ,  A61F2/86 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2250/0063 ,  A61F2250/0068

Abstract: An implantable stent comprising a first strut having an abluminal surface, and subluminal surface, and at least one side surface; a first depression formed in the abluminal surface; and a first support element at least partially disposed in the first depression; wherein at least a portion of the first support element extends beyond the abluminal surface of the first strut.

Abstract translation: 一种可植入支架，其包括具有近端表面的第一支柱和亚锥形表面以及至少一个侧表面; 形成在外侧表面的第一凹陷; 以及至少部分地设置在所述第一凹部中的第一支撑元件; 其中所述第一支撑元件的至少一部分延伸超过所述第一支柱的所述外侧表面。

公开(公告)号：US20090081272A1

公开(公告)日：2009-03-26

申请号：US11860233

申请日：2007-09-24

Applicant: John Clarke ,  David McMorrow ,  Aiden Flanagan ,  Tim O'Connor ,  Jan Weber ,  Barry J. O'Brien

Inventor： John Clarke ,  David McMorrow ,  Aiden Flanagan ,  Tim O'Connor ,  Jan Weber ,  Barry J. O'Brien

IPC: A61F2/00

CPC classification number: A61L31/022 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/00

Abstract: An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent, and (b) a particulate composition disposed in the depression such that it regulates transport of chemical species between the depression and the exterior of the device upon implantation or insertion of the device into a subject.

Abstract translation: 提供了一种植入式或可插入的医疗装置，其包括作为部件：（a）底物组分，其包含至少部分地填充有包含第一治疗剂的含治疗剂的材料的凹陷，和（b）处理的颗粒组合物 在凹陷中，使得在将装置植入或插入到受试者中时，其调节化学物质在装置的凹陷和外部之间的运输。

公开(公告)号：US20080243231A1

公开(公告)日：2008-10-02

申请号：US12072666

申请日：2008-02-27

Applicant: Aiden Flanagan ,  David McMorrow ,  Anthony Malone ,  Tim O'Connor

Inventor： Aiden Flanagan ,  David McMorrow ,  Anthony Malone ,  Tim O'Connor

IPC: B05D3/12 ,  A61F2/06

CPC classification number: A61F2/06 ,  A61L31/082 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416

Abstract: The present invention is generally directed to implantable medical devices for delivering therapeutic agents to the body tissue of a patient and methods for making such medical devices. In particular, the present invention is directed to implantable medical devices, such as intravascular stents, having a surface that includes a plurality of cavities and a plurality of pores and a composition disposed in the pores and/or cavities, as well as, implantable medical devices, such as intravascular stents, having a surface that has a coating composition disposed on the surface, wherein the coating composition includes a plurality of cavities and a plurality of pores and another coating composition disposed in the pores and/or cavities.

Abstract translation: 本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置和用于制造这种医疗装置的方法。 特别地，本发明涉及可植入医疗装置，例如血管内支架，其具有包括多个空腔的表面和多个孔以及设置在孔和/或空腔中的组合物，以及植入式医疗 装置，例如血管内支架，其具有设置在表面上的涂层组合物的表面，其中所述涂层组合物包括多个空腔和多个孔以及设置在孔和/或空腔中的另一涂层组合物。

公开(公告)号：US20080241351A1

公开(公告)日：2008-10-02

申请号：US12057135

申请日：2008-03-27

Applicant: Liliana Atanasoka ,  Aiden Flanagan ,  Tim O'Connor ,  Dave McMorrow ,  Robert Nolan ,  Anthony Malone ,  Jan Weber

Inventor： Liliana Atanasoka ,  Aiden Flanagan ,  Tim O'Connor ,  Dave McMorrow ,  Robert Nolan ,  Anthony Malone ,  Jan Weber

IPC: A61L31/16 ,  B01J19/08 ,  B05D1/12

CPC classification number: B05B5/00 ,  A61F2/91 ,  A61F2210/009 ,  A61L31/14 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/60 ,  A61L2300/62 ,  B05C3/09 ,  B05D1/18 ,  B05D1/32 ,  B05D3/207 ,  B05D2401/32

Abstract: The present invention is directed to methods, processes, and systems for delivering therapeutic agent to a medical device. Under some methods, processes, and systems of the invention, particles including a magnetic material and a therapeutic agent may be directed towards a medical device via magnetic attraction. In another embodiment particles including a magnetic material may force a therapeutic agent/solvent solution into porous matrix by using a magnetic attraction. In still another embodiment, a medical device having at least a portion thereof including a magnetic material is used to attract and adhere particles comprising magnetic material and therapeutic agent to a target surface of the medical device, wherein the particles are fused to the target surface.

Abstract translation: 本发明涉及将治疗剂递送到医疗装置的方法，过程和系统。 在一些方法下，本发明的方法和系统，包括磁性材料和治疗剂的颗粒可以通过磁吸引而引向医疗装置。 在另一个实施方案中，包括磁性材料的颗粒可以通过使用磁吸引剂将治疗剂/溶剂溶液强制成多孔基质。 在另一个实施例中，使用包括磁性材料的至少其一部分的医疗装置将包含磁性材料和治疗剂的颗粒吸附并附着到医疗装置的靶表面上，其中所述颗粒与目标表面融合。

公开(公告)号：US20080095921A1

公开(公告)日：2008-04-24

申请号：US11858347

申请日：2007-09-20

Applicant: Tim O'Connor ,  Dave McMorrow ,  Gabriel Sobrino ,  Liam Ward ,  Noel Hynes

Inventor： Tim O'Connor ,  Dave McMorrow ,  Gabriel Sobrino ,  Liam Ward ,  Noel Hynes

IPC: B05D1/22

CPC classification number: B05C1/022 ,  A61L2420/02

Abstract: The present invention relates to a coating assembly and methods that employ the coating assembly to control the thickness of therapeutic or other coatings delivered to a medical device during a coating process. In one embodiment the coating assembly may include a coating plate having a coating transfer surface and a shoulder having a first height, a mandrel moveable over the coating transfer surface, and a coating dispenser positioned in fluid communication with the coating transfer surface. The invention also includes a method of coating a medical device. This method may include placing a medical device on a mandrel, dispensing coating onto a coating transfer surface of a coating plate, moving the mandrel and the medical device over the coating transfer surface of the coating plate so that coating resident on the coating transfer surface transfers to an exposed surface of the medical device, and removing the medical device from the mandrel.

Abstract translation: 本发明涉及涂覆组件和方法，其使用涂层组件来控制在涂覆过程期间递送到医疗装置的治疗剂或其它涂层的厚度。 在一个实施方案中，涂层组件可以包括具有涂层转移表面和具有第一高度的肩部，可在涂层转移表面上移动的芯棒的涂布板和与涂层转移表面流体连通的涂布分配器。 本发明还包括涂覆医疗装置的方法。 该方法可以包括将医疗装置放置在心轴上，将涂层分配到涂布板的涂层转移表面上，将心轴和医疗装置移动到涂布板的涂层转移表面上，使得驻留在涂层转移表面上的涂层转移 到医疗装置的暴露表面，并且从心轴移除医疗装置。

公开(公告)号：US20080077218A1

公开(公告)日：2008-03-27

申请号：US11856994

申请日：2007-09-18

Applicant: Dave McMorrow ,  Tim O'Connor ,  Aiden Flanagan ,  Anthony Malone

Inventor： Dave McMorrow ,  Tim O'Connor ,  Aiden Flanagan ,  Anthony Malone

IPC: A61N1/00 ,  A61F2/06

CPC classification number: A61L31/146 ,  A61F2/91 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00

Abstract: The present invention is directed to methods, processes, and systems for selectively driving therapeutic into at least a portion of a porous matrix of a medical implant. Under methods and processes of the invention, a medical implant may be provided having at least a portion thereof comprising a porous matrix. An injector in fluid communication with a fluid source deliver therapeutic within the porous matrix. The porous matrix may be configured to control the elution rate.

Abstract translation: 本发明涉及用于选择性地将治疗剂驱动到医用植入物的多孔基质的至少一部分中的方法，方法和系统。 在本发明的方法和方法下，可以提供医疗植入物，其至少一部分包括多孔基质。 与流体源流体连通的注射器在多孔基质内递送治疗剂。 多孔基质可以被配置为控制洗脱速率。

公开(公告)号：US12145396B2

公开(公告)日：2024-11-19

申请号：US16693502

申请日：2019-11-25

Applicant: Tim O'Connor

Inventor： Tim O'Connor

IPC: B43L1/00 ,  B42F13/16 ,  B43L1/10 ,  G09B19/00 ,  G09F1/02 ,  G09F1/06 ,  G09F7/00 ,  G09F7/06

Abstract: A series of devices that allow for embedding of an image as a background while also affording the user the ability to write and print on the surface, with erasable capabilities, thus providing a multifunctional product for use in numerous industries. The devices are manufactured from predominately corrugated plastic. In one embodiment a one piece, removably attachable, cabinet system and graphic display system. In an additional embodiment, a writable board, or peg board comprising a front panel and a rear panel wherein the panels are interconnected by parallel rows, or corrugations, these panels include a writable and erasable surface. The present invention relates to assemblies of corrugated systems to better serve personal, business, and educational needs.

公开(公告)号：US20130066257A1

公开(公告)日：2013-03-14

申请号：US13608237

申请日：2012-09-10

Applicant: Martyn Folan ,  John Clarke ,  Aiden Flanagan ,  Anthony Malone ,  Tim O'Connor

Inventor： Martyn Folan ,  John Clarke ,  Aiden Flanagan ,  Anthony Malone ,  Tim O'Connor

IPC: A61B17/22 ,  A61M37/00

CPC classification number: A61M25/104 ,  A61B17/320725 ,  A61B2017/22061 ,  A61M25/1002 ,  A61M2025/1004 ,  A61M2025/105 ,  A61M2025/1059 ,  A61M2025/1086

Abstract: A medical balloon assembly including an inflatable balloon and at least one cutting element extending from the balloon is disclosed. The inflatable balloon includes an outer wall facing outward and an inner wall facing outward. The cutting element comprises a plurality of openings therein including a first opening and a second opening. The first opening is closed off by a portion of the outer wall. The cutting element further includes a passageway extending from the first opening to the second opening. The passageway is defined by the cutting element and the portion of the outer wall which closes off the passageway. The passageway may contain a therapeutic agent.

Abstract translation: 公开了一种医用气囊组件，其包括可充气球囊和从球囊延伸的至少一个切割元件。 充气气囊包括面向外的外壁和面向外的内壁。 切割元件包括多个开口，其中包括第一开口和第二开口。 第一开口被外壁的一部分封闭。 切割元件还包括从第一开口延伸到第二开口的通道。 通道由切割元件和封闭通道的外壁部分限定。 通道可以含有治疗剂。