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公开(公告)号：US09783795B2
公开(公告)日：2017-10-10
申请号：US12913174
申请日：2010-10-27
CPC分类号： C12N9/6445 , A61K38/00 , C12N9/6424
摘要： Peptides of from about 7 to about 50 amino acid residues in length that have epitopes that bind to more than one HLA class II protein and stimulate CD4+ T cells for treatment of cancer from one of three serine proteases overexpressed in ovarian cancer and other cancers—stratum corneum chymotryptic enzyme, matriptase, and hepsin—are described. Since the peptides bind to more than one HLA class II protein variant, they can be used to treat cancer in most patients of a population having a variety of HLA class II alleles. The peptides can be loaded onto autologous dendritic cells of a cancer patient and infused into the patient to activate a CD4+ and CD8+ T cell response that recognizes tumor cells expressing the peptide antigen.
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22.发明申请Inhibition of dendritic cell-driven regulatory T cell activation and potentiation of tumor antigen-specific T cell responses by interleukin-15 and MAP kinase inhibitor 有权通过白细胞介素-15和MAP激酶抑制剂抑制树突状细胞驱动的调节性T细胞活化和增强肿瘤抗原特异性T细胞应答公开(公告)号：US20090136447A1
公开(公告)日：2009-05-28
申请号：US12286122
申请日：2008-09-27
CPC分类号： C12N5/0636 , A61K38/2086 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , C12N5/0639 , C12N2501/02 , C12N2501/22 , C12N2501/23 , C12N2501/25 , A61K2300/00
摘要： The invention involves the discovery that if dendritic cells loaded with a tumor antigen are cultured in interleukin-15 (IL-15), or if T cells activated by the dendritic cells are cultured in IL-15, Treg activity that is specific for the tumor antigen is reduced. This reduction in Treg activity results in an increase in anti-tumor immune response. Another embodiment of the invention involves the discovery that incubating dendritic cells with a MAP kinase inhibitor in combination with IL-15 gives synergistic benefits when the dendritic cells are used to activate T cells. Dendritic cell and T cell compositions incubated with IL-15 or a MAP kinase inhibitor are provided.
摘要翻译： 本发明涉及如下发现：如果在白细胞介素-15（IL-15）中培养载有肿瘤抗原的树突状细胞，或者如果在IL-15中培养由树突细胞活化的T细胞，则特异于肿瘤的Treg活性 抗原减少。 Treg活性的这种降低导致抗肿瘤免疫反应的增加。 本发明的另一个实施方案涉及发现当树突状细胞用于激活T细胞时，将具有MAP激酶抑制剂与IL-15组合的树突细胞产生协同效益。 提供与IL-15或MAP激酶抑制剂一起孵育的树突状细胞和T细胞组合物。
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公开(公告)号：US08546137B2
公开(公告)日：2013-10-01
申请号：US12286122
申请日：2008-09-27
CPC分类号： C12N5/0636 , A61K38/2086 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , C12N5/0639 , C12N2501/02 , C12N2501/22 , C12N2501/23 , C12N2501/25 , A61K2300/00
摘要： The invention involves the discovery that if dendritic cells loaded with a tumor antigen are cultured in interleukin-15 (IL-15), or if T cells activated by the dendritic cells are cultured in IL-15, Treg activity that is specific for the tumor antigen is reduced. This reduction in Treg activity results in an increase in anti-tumor immune response. Another embodiment of the invention involves the discovery that incubating dendritic cells with a MAP kinase inhibitor in combination with IL-15 gives synergistic benefits when the dendritic cells are used to activate T cells. Dendritic cell and T cell compositions incubated with IL-15 or a MAP kinase inhibitor are provided.
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公开(公告)号：US20080152663A1
公开(公告)日：2008-06-26
申请号：US11986352
申请日：2007-11-21
CPC分类号： C12N9/6445 , A61K38/00 , C12N9/6424
摘要： The invention involves peptides of from about 7 to about 50 amino acid residues in length that have epitopes that bind to more than one HLA class II protein and stimulate CD4+ T cells for treatment of cancer from one of three serine proteases overexpressed in ovarian cancer and other cancers—stratum corneum chymotryptic enzyme, matriptase, and hepsin. Since the peptides bind to more than one HLA class II protein variant, they can be used to treat cancer in most patients of a population having a variety of HLA class II alleles. The peptides can be loaded onto autologous dendritic cells of a cancer patient and infused into the patient to activate a CD4+ and CD8+ T cell response that recognizes tumor cells expressing the peptide antigen.
摘要翻译： 本发明涉及长度为约7至约50个氨基酸残基的肽，其具有结合多于一个HLA II类蛋白的表位并刺激CD4 + T细胞用于治疗来自卵巢癌和其它过表达的三种丝氨酸蛋白酶之一的癌症 癌症角质层糜蛋白酶，脱氧核糖核酸酶和hepsin。 由于肽结合多于一个HLA II类蛋白质变体，所以它们可用于治疗具有多种HLA II类等位基因的群体的大多数患者中的癌症。 肽可以加载到癌症患者的自体树突状细胞上，并输注到患者中以激活识别表达肽抗原的肿瘤细胞的CD4 +和CD8 + T细胞应答。
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25.发明授权公开(公告)号：US08430936B2
公开(公告)日：2013-04-30
申请号：US12270071
申请日：2008-11-13
IPC分类号： C10L1/18
CPC分类号： C10L1/2225 , C10L1/222 , C10L1/223 , C10L10/00 , Y02E50/13
摘要： Biodiesel fuels, renewable diesel fuels and feedstocks to these fuels (derived from plant seed oils or animal fats) are viewed as more environmentally friendly, renewable alternative fuels or supplemental fuels with petroleum-based diesel. Alkyl phenol amine aldehyde condensates improve the stability of biofuels by inhibiting the degradation processes. Alkyl phenylene diamines employed together with alkyl phenol amine aldehyde condensates in the biofuels give synergistically improved stability of the fuels.
摘要翻译： 这些燃料（来自植物种子油或动物脂肪）的生物柴油燃料，可再生柴油燃料和原料被视为更环保的可再生替代燃料或具有石油基柴油的补充燃料。 烷基酚胺醛缩合物通过抑制降解过程改善了生物燃料的稳定性。 与生物燃料中的烷基酚胺醛缩合物一起使用的烷基亚苯基二胺可协同地提高燃料的稳定性。
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公开(公告)号：US07785841B2
公开(公告)日：2010-08-31
申请号：US11012787
申请日：2004-12-15
申请人： Timothy J. O'Brien
发明人： Timothy J. O'Brien
IPC分类号： C12P19/34 , C12Q1/00 , C12Q1/68 , C12P19/26 , C12P19/28 , C12P19/36 , C12P19/38 , C12P19/40 , G01N1/00 , G01N21/00
CPC分类号： C12N9/6424 , A61K39/00 , A61K48/00 , A61K2039/53 , C12N9/6472 , C12N9/6489 , C12Q1/37 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/573 , G01N33/574 , G01N33/57449 , G01N2333/96486 , Y10T436/25
摘要： The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of PUMP-1 protease (matrix metalloprotease 7). The detected proteases are themselves specifically over-expressed in certain cancers, and their presence may serve for early detection of associated ovarian and other malignancies, and for the design of interactive therapies for cancer treatment.
摘要翻译： 所公开的与组织cDNA的定量扩增（PCR）组合使用的核酸引物组可以指示组织样品中特异性蛋白酶的存在。 具体地说，本发明涉及PUMP-1蛋白酶（基质金属蛋白酶7）的表达。 检测到的蛋白酶本身在某些癌症中特异性过度表达，并且它们的存在可用于早期检测相关的卵巢癌和其他恶性肿瘤，并且用于设计用于癌症治疗的交互式治疗。
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27.发明授权Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof 有权卵巢癌中过表达的跨膜丝氨酸蛋白酶及其用途公开(公告)号：US07638277B2
公开(公告)日：2009-12-29
申请号：US11400825
申请日：2006-04-07
IPC分类号： C12Q1/68
CPC分类号： C12N9/6424 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4748 , C07K14/705 , C07K16/3069 , C07K2317/34 , C12N9/6472 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/574
摘要： The present invention provides a TADG-12 protein and a DNA fragment encoding such protein. Also provided is a vector/host cell capable of expressing the DNA. The present invention further provides various methods of early detection of associated ovarian and other malignancies, and of interactive therapies for cancer treatment by utilizing the DNA and/or protein disclosed herein.
摘要翻译： 本发明提供了TADG-12蛋白质和编码这种蛋白质的DNA片段。 还提供能够表达DNA的载体/宿主细胞。 本发明进一步提供各种早期检测相关卵巢癌和其他恶性肿瘤的方法，以及利用本文公开的DNA和/或蛋白质进行癌症治疗的相互作用治疗。
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28.发明申请公开(公告)号：US20090293344A1
公开(公告)日：2009-12-03
申请号：US12144245
申请日：2008-06-23
IPC分类号： C10L1/16
CPC分类号： C10L1/221 , C10L1/026 , C10L1/1817 , C10L1/1985 , C10L1/2383 , Y02E50/13
摘要： Water may be removed from a biofuel or biofuel intermediate by using a demulsifier. The demulsifier includes the product of oxyalkylating a resin prepared from a formulation including a phenol and a compound selected from the group consisting of an aldehyde, a diamine a polyamine and mixtures thereof. The demulsifier may also be used with admixtures of biofuels, biofuel intermediates, or biofuel feedstocks with conventional hydrocarbons.
摘要翻译： 水可以通过使用破乳剂从生物燃料或生物燃料中间体中除去。 破乳剂包括由包含苯酚和选自醛，二胺，多胺及其混合物的化合物的制剂制备的树脂进行烷氧基化的产物。 破乳剂也可与生物燃料，生物燃料中间体或具有常规烃的生物燃料原料的混合物一起使用。
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29.发明申请公开(公告)号：US20090274618A1
公开(公告)日：2009-11-05
申请号：US11978259
申请日：2007-10-29
IPC分类号： A61K51/00 , C12N15/00 , C12N1/21 , C12N5/06 , C12N5/04 , C12N15/87 , C12N15/82 , C12N15/11 , A61K31/7088 , A61K39/395 , A61K39/00 , C12Q1/37
CPC分类号： C12N9/6424 , A61K39/00 , C12Q1/6851 , C12Q1/6886 , C12Q2600/136 , Y10T436/25
摘要： The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity, methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis, treatment and prevention of cancer, particularly breast and ovarian cancer.
摘要翻译： 本发明提供编码TADG-15蛋白质和TADG-15蛋白质的DNA。 还提供了能够表达适于在重组细胞中表达的本发明的DNA的载体和在细胞中表达DNA所需的调节元件。 本发明还提供了抑制TADG-15表达和/或蛋白酶活性的方法，检测TADG-15mRNA和/或蛋白质的方法以及筛选TADG-15抑制剂的方法。 另外，本发明提供了通过TADG-15进行的细胞特异性靶向和针对TADG-15接种个体的方法。 所描述的方法可用于诊断，治疗和预防癌症，特别是乳腺癌和卵巢癌。
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公开(公告)号：US07026057B2
公开(公告)日：2006-04-11
申请号：US10055301
申请日：2002-01-23
IPC分类号： B32B15/04
CPC分类号： C23C14/0015 , C23C14/0084 , C23C14/06 , C23C14/165 , C23C28/021 , C23C28/023 , C23C30/00 , Y10S428/938 , Y10T428/12458 , Y10T428/12535 , Y10T428/12576 , Y10T428/12806 , Y10T428/12847 , Y10T428/12868 , Y10T428/12875 , Y10T428/12882 , Y10T428/12896 , Y10T428/12979 , Y10T442/2344
摘要： A new article of manufacture, for example a faucet or other article of hardware, has a specified decorative color, and is resistant to corrosion, abrasion and attack by chemicals. The article includes a substrate, one or more corrosion resistant layers applied to the substrate, a thin transition layer having a composition that varies systematically from a first composition to a second composition and in which the first composition has, at least in part, the function of corrosion protection, and in which the second composition determines the visible color or that portion of the substrate to which the transition layer is applied.
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