公开(公告)号：US20180134654A1

公开(公告)日：2018-05-17

申请号：US15565846

申请日：2016-04-14

申请人： Tadashi Honda ,  Wei Li ,  Suqing Zheng ,  Albena Dinkova-Kostova

发明人： Tadashi Honda ,  Wei Li ,  Suqing Zheng ,  Albena Dinkova-Kostova

IPC分类号： C07C255/46 ,  C07C255/47 ,  A61K31/277 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00

CPC分类号： C07C255/46 ,  A61K31/277 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  C07C255/47 ,  C07C2601/16 ,  C07C2602/10 ,  C07C2602/24 ,  C07C2603/18 ,  C07C2603/26

摘要： The present invention provides a compound having the structure: wherein X is C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, cyano, aryl, heteroaryl, alkylaryl, alkylheteroaryl, alkenylaryl, alkenylheteroaryl, alkynylaryl, alkynylheteroaryl, alkoxy, alkenyloxy, alkynyloxy, aryloxy, heteroaryloxy, acyl, alkylhydroxy, alkylamino, alkenylamino, alkynylamino, amido, carboxyl, or carboxyl ester, or forms an unsubstituted or substituted cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, indane or tetralin with Y, Y is H or forms an unsubstituted or substituted cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, indane or tetralin with X, or forms an unsubstituted or substituted monocycle with Z; and Z is H or forms an unsubstituted or substituted monocycle with Y; wherein when X and Y are both H, then X is C2alkenyl or C2 alkynyl, and when Y is H forms a substituted cyclohexyl, cycloheptyl with X, the cyclohexyl is other than a trisubstituted cyclohexyl bearing CH3, i-Pr and (CH2)2CO2CH3 groups or CH3, i-Pr and (CH2)3NH2, or a salt or ester thereof.

公开(公告)号：US09732687B2

公开(公告)日：2017-08-15

申请号：US12975449

申请日：2010-12-22

申请人： Wei Li ,  David B. Brown ,  Chang H Kim ,  Gongshin Qi ,  Steven J. Schmieg

发明人： Wei Li ,  David B. Brown ,  Chang H Kim ,  Gongshin Qi ,  Steven J. Schmieg

IPC分类号： F01N3/10 ,  F02D41/02 ,  B01D53/94 ,  F02D41/14 ,  F01N13/00 ,  F01N3/08 ,  F01N3/20

CPC分类号： F02D41/0275 ,  B01D53/9422 ,  B01D2255/402 ,  B01D2255/407 ,  B01D2255/9032 ,  B01D2255/9035 ,  B01D2255/91 ,  F01N3/0814 ,  F01N3/0842 ,  F01N3/106 ,  F01N3/2073 ,  F01N13/009 ,  F01N2510/0682 ,  F02D41/1475

摘要： A method for removing NOX from an oxygen-rich exhaust flow produced by a combustion source that is combusting a lean mixture of air and fuel may include passing the oxygen-rich exhaust flow through an exhaust aftertreatment system that includes a NOX oxidation catalyst that includes perovskite oxide particles, a NOX storage catalyst, and a NOX reduction catalyst.

公开(公告)号：US09718818B2

公开(公告)日：2017-08-01

申请号：US14912761

申请日：2014-08-18

申请人： MERCK SHARP & DOHME CORP. ,  Duane DeMong ,  Thomas J. Greshock ,  Ronald K. Chang ,  Xing Dai ,  Hong Liu ,  John A. McCauley ,  Wei Li ,  Kallol Basu ,  Jack D. Scott ,  Michael Miller

发明人： Duane DeMong ,  Thomas J. Greshock ,  Ronald K. Chang ,  Xing Dai ,  Hong Liu ,  John A. McCauley ,  Wei Li ,  Kallol Basu ,  Jack D. Scott ,  Michael Miller

IPC分类号： A61K31/44 ,  C07D471/04 ,  C07D498/04 ,  C07D519/00 ,  C07D487/04

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D519/00

摘要： The present invention is directed to azaindazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

公开(公告)号：US20170170035A1

公开(公告)日：2017-06-15

申请号：US15083290

申请日：2016-03-29

申请人： Yu Teng ,  Wei Li

发明人： Yu Teng ,  Wei Li

IPC分类号： H01L21/67 ,  B05B7/04 ,  B05B3/08 ,  B05B15/02 ,  B05B13/02 ,  B05B17/06 ,  B05B15/04

CPC分类号： H01L21/67051 ,  B05B3/085 ,  B05B7/045 ,  B05B12/22 ,  B05B13/0278 ,  B05B15/55 ,  B05B17/0607

摘要： A cleaning device for atomizing and spraying liquid in two-phase flow comprising a nozzle provided with multiple liquid bypass pipelines each having liquid guiding outlets inclined at a predetermined angle and an exhaust mesh plate having vertical gas guiding outlets, which makes the high speed liquid flow and high speed gas flow sprayed out therefrom collide against each other sufficiently to form ultra-micro atomized particles with uniform and adjustable size. The ultra-micro atomized particles are sprayed out downwardly to the wafer surface under the acceleration and vertical orientation effects of an atomized particle guiding outlet to perform a reciprocating cleaning for the wafer. Other components such as an ultrasonic or megasonic generation unit, a gas shielding unit, a self-cleaning unit or a rotating unit can also be provided to perform the multifunction of the nozzle.

公开(公告)号：US09614768B2

公开(公告)日：2017-04-04

申请号：US13979449

申请日：2012-04-06

申请人： Wei Li

发明人： Wei Li

IPC分类号： H04L12/803 ,  H04L12/709 ,  H04L12/713 ,  H04L12/801 ,  H04L12/891

CPC分类号： H04L47/125 ,  H04L45/245 ,  H04L45/586 ,  H04L47/29 ,  H04L47/41 ,  Y02D50/30

摘要： According to an example, a stacking device in a distribution layer may monitor traffic in an aggregation link between the stacking device and a core layer. When a traffic unbalance is detected in the aggregation link, the stacking device may find a data flow that causes the traffic unbalance from data flows transferred over the aggregation link and an incoming interface through which the found data flow enters the stacking device. The stacking device may also reallocate a new MAC address to the incoming interface and may send the new MAC address allocated to the incoming interface to a terminal server, so as to enable the traffic unbalance to transit to traffic balance by way of the terminal server sending a data flow with the new MAC address as the destination MAC address.

公开(公告)号：US20160200722A1

公开(公告)日：2016-07-14

申请号：US14912761

申请日：2014-08-18

申请人： Duane DEMONG ,  Thomas J. GRESHOCK ,  Ronald K. CHANG ,  Xing DAI ,  Hong LIU ,  John A. MCCAULEY ,  Wei LI ,  Kallol BASU ,  Jack D. SCOTT ,  Michael MILLER ,  MERCK SHARP & DOHME CORP.

发明人： Duane DeMong ,  Thomas J. Greshock ,  Ronald K. Chang ,  Xing Dai ,  Hong Liu ,  John A. McCauley ,  Wei Li ,  Kallol Basu ,  Jack D. Scott ,  Michael Miller

IPC分类号： C07D471/04 ,  C07D498/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D519/00

摘要： The present invention is directed to azaindazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

摘要翻译： 本发明涉及作为LRRK2激酶的有效抑制剂并且可用于治疗或预防涉及LRRK2激酶的疾病（例如帕金森病）的唑烷化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及LRRK-2激酶的疾病中的用途。

公开(公告)号：US09285449B2

公开(公告)日：2016-03-15

申请号：US13517633

申请日：2012-06-14

申请人： Chunlei Liu ,  Wei Li ,  Bing Wu

发明人： Chunlei Liu ,  Wei Li ,  Bing Wu

IPC分类号： G06K9/00 ,  G01R33/561 ,  G01R33/44 ,  G01R33/48 ,  G01R33/565

CPC分类号： G01R33/5616 ,  G01R33/443 ,  G01R33/482 ,  G01R33/4822 ,  G01R33/4824 ,  G01R33/5611 ,  G01R33/56509 ,  G01R33/56536

摘要： Systems and methods for imaging and quantifying tissue magnetism with magnetic resonance imaging (MRI) are disclosed. According to an aspect, a method for MRI includes using an MRI system to acquire multiple image echoes of an object. The method also includes combining the image echoes. Further, the method includes generating an image of the object based on the combined image echoes for depicting a characteristic of the object.

摘要翻译： 公开了用磁共振成像（MRI）成像和定量组织磁性的系统和方法。 根据一个方面，MRI的方法包括使用MRI系统来获取对象的多个图像回波。 该方法还包括组合图像回波。 此外，该方法包括基于用于描绘对象的特征的组合图像回波来生成对象的图像。

公开(公告)号：US09252843B2

公开(公告)日：2016-02-02

申请号：US13881591

申请日：2010-10-27

申请人： Wei Li ,  Jun Yu ,  Gang Zhang

发明人： Wei Li ,  Jun Yu ,  Gang Zhang

IPC分类号： H04B5/00 ,  H04L29/06 ,  H04W4/00 ,  H04W80/02

CPC分类号： H04B5/0025 ,  G06K7/10237 ,  H04B5/0031 ,  H04L63/0492 ,  H04W4/80 ,  H04W80/02

摘要： A method and an apparatus for data transmission between a contactless front element and a security element are provided. The method includes: the contactless front element transparently transmits first data obtained from a contactless identification device to the security element through a single wire connection; the security element processes the first data to generate second data; the contactless front element transparently transmits the second data obtained from the security element through the single wire connection to the contactless identification device. Compared with the prior art, the method can transmit the contactless data in real time between the contactless front element and the security element. Thus the security element can directly respond instructions sent by a proximity coupling device during simulating Proximity Integrated Circuit Card, so that the contactless front element becomes a transparent transport channel, the time order compatibility problem can be avoided, and the safety problem can be surmounted.

摘要翻译： 提供了一种用于非接触式前部元件和安全元件之间的数据传输的方法和装置。 该方法包括：非接触式前部元件通过单线连接将从非接触识别装置获得的第一数据透明地发送到安全元件; 所述安全元件处理所述第一数据以产生第二数据; 非接触式前部元件通过单线连接将从安全元件获得的第二数据透明地发送到非接触式识别装置。 与现有技术相比，该方法可以在非接触式前置元件和安全元件之间实时传输非接触式数据。 因此，在模拟接近集成电路卡期间，安全元件可以直接响应由邻近耦合装置发送的指令，使得非接触式前部元件变为透明传输通道，可以避免时间顺序兼容性问题，并且可以克服安全问题。

公开(公告)号：US09250237B2

公开(公告)日：2016-02-02

申请号：US13990396

申请日：2011-11-29

申请人： Jun O. Liu ,  Jingxin Wang ,  Zufeng Guo ,  Wei Li ,  Shridhar Bhat ,  Manisha Das

发明人： Jun O. Liu ,  Jingxin Wang ,  Zufeng Guo ,  Wei Li ,  Shridhar Bhat ,  Manisha Das

IPC分类号： A61K31/4353 ,  C07D498/04 ,  C07D515/04 ,  C07D471/04 ,  G01N33/566 ,  A61K31/436 ,  C07D498/14 ,  C07D515/14 ,  C07K17/08

CPC分类号： C07K7/645 ,  A61K31/4353 ,  A61K31/436 ,  C07D471/04 ,  C07D498/04 ,  C07D498/14 ,  C07D515/04 ,  C07D515/14 ,  C07K17/08 ,  G01N33/566

摘要： Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

摘要翻译： 提供了包含天然产物的已知蛋白质结合结构域的新型杂合环状文库。 还提供了使用部分分离的文库化合物制备这种文库和使用命中反卷积方法的合成方法。 这种方法适用于与整个人类蛋白质组一起使用以筛选结合和鉴定命中的这些文库。

公开(公告)号：US20150381450A1

公开(公告)日：2015-12-31

申请号：US14500960

申请日：2014-09-29

申请人： Bin Zhao ,  Wei Li

发明人： Bin Zhao ,  Wei Li

IPC分类号： H04L12/26 ,  H04M3/22 ,  H04L12/841 ,  H04M1/253

CPC分类号： H04L43/0864 ,  H04L12/18 ,  H04L12/1827 ,  H04L12/1831 ,  H04L41/5038 ,  H04L43/045 ,  H04L43/062 ,  H04L43/0852 ,  H04L43/10 ,  H04L43/50 ,  H04L45/123 ,  H04L47/283 ,  H04L47/722 ,  H04L51/34 ,  H04L65/1066 ,  H04L65/4038 ,  H04M1/2535 ,  H04M1/72547 ,  H04M3/2236 ,  H04M3/432 ,  H04M3/563 ,  H04M3/565 ,  H04M7/0084 ,  H04M2250/62 ,  H04M2250/74 ,  H04W4/16

摘要： Systems and methods for improving quality of a call over network (CON) are provided. Call quality may be improved via pathway testing to determine data path quality. This may be utilized to inform buffering lengths, and also may be utilized to choose the data pathway utilized for transmitting the data. Pathway testing may employ collecting microphone data on one device, transmitting it across the various pathways, and then comparing the quality at the endpoint compared to the initial data.

摘要翻译： 提供了通过网络（CON）提高质量的系统和方法。 呼叫质量可以通过路径测试来改善，以确定数据路径质量。 这可以用于通知缓冲长度，并且还可以用于选择用于发送数据的数据路径。 路径测试可以采用在一个设备上收集麦克风数据，通过各种路径传输麦克风数据，然后比较端点的质量与初始数据进行比较。