Abstract:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
Abstract:
This invention relates to pharmaceutical compositions comprising fixed-dose combinations of a dipeptidyl peptidase-4 inhibitor and pioglitazone, methods of preparing such pharmaceutical compositions, and methods of treating Type 2 diabetes with such pharmaceutical compositions.
Abstract:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
Abstract:
The invention provides compounds of formula (I) and methods for inhibition of kinases, more specifically p70S6 kinases, and more preferably p70S6, Akt-1 and Akt-2 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
Abstract:
http://www.wipo/int/pctdb/images/PCT-IMAGES/31122008/CN2008001226_31122008_gz_en.×4-b.jpgA surgical stapling head assembly with a rotary cutter comprises a casing (101), an annular cutter (103), a staple driver (102) and a staple holder. Said staple driver (102) is connected with the annular cutter (103) by a bearing structure (109) with guiding projections (115a, 115b, 115c) disposed thereon, on the outer wall of the anti-expansion tube (104) or the inner wall of the casing (101) is molded with a metal cylinder member (105), on which is provided with a forward helix track (106) and a backward track (107) independent and communicated with each other, the guiding projections (115a, 115b, 115c) engaging with the two guiding tracks (106, 107) to guide the annular cutter (103) to forward in way of helix.
Abstract:
The present invention relates to a supported catalyst composition for polymerization of olefins comprising at least two catalytic components; and a polymerization process using that catalyst composition; and a method for its preparation.
Abstract:
Systems and methods are disclosed to detect unsafe system states by capturing and analyzing data from a plurality of sensors detecting parameters of the system; and applying temporal difference (TD) learning to learn a function to approximate an expected future reward given current and historical sensor readings.
Abstract:
The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chlorides and ADAM-10 modulators therefrom.
Abstract:
Experimental data is presented which shows that laser scoring of glass sheets (112) with existing techniques produces unacceptable levels of residual stress in the separated sheets as the scoring speed is increased. Methods for solving this problem are disclosed which employ elongated and, preferably, asymmetrically-truncated laser beams (13). The methods allow glass sheets (112) to be scored at speeds of 1000 mm/s and above with low levels of residual stress, e.g., levels of residual stress which are less than or equal to 500 psi. Such low levels of residual stress translate into low levels of distortion during the manufacture of display panels (e.g., LCD panels) as well as in improved properties of the separated edges. The methods can be used with glasses of various types including glasses having low coefficients of thermal expansion.