摘要:
The invention provides two process for synthesizing substituted aminothiazolone compounds as inhibitors of 11-β-hydroxy steroid dehydrogenase type 1. The processes allow the stereoselective synthesis of the desired compounds without the use of stoichiometric amounts of chiral catalysts.
摘要:
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要:
A vacuum electronics isolation system utilizes an isolation circuit for providing a low voltage for operating a controller and to provide low voltage control signals for operating the vacuum motor to isolate the high voltage power source from the user.
摘要:
The present invention reliably computes cardiac output with a noninvasive procedure. The system measures the electrical impedance of a patient's body, during a time interval of interest. The system then obtains frequency transforms of various time segments of the first derivative of the impedance signal. Each such transform is integrated over a frequency range of interest, and the values of the integrals are plotted as a function of time. The graph so derived has characteristic extrema which can be used to identify critical points in the impedance derivative signal. These critical points can be used to determine parameters which are used in a calculation of stroke volume and cardiac output.
摘要:
The present invention relates to indoline alkaloid compounds. In particular, indoline alkaloid compounds of the invention have antibacterial activity and/or are capable of resensitizing the susceptibility of methicillin-resistant S. aureus to a β-lactam antibiotic. The present invention also relates to a method for producing and using the same.
摘要:
The present invention relates to indoline alkaloid compounds. In particular, indoline alkaloid compounds of the invention have antibacterial activity and/or are capable of resensitizing the susceptibility of methicillin-resistant S. aureus to a β-lactam antibiotic. The present invention also relates to a method for producing and using the same.
摘要:
Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
摘要:
A vacuum electronics isolation system utilizes an isolation circuit for providing a low voltage for operating a controller and to provide low voltage control signals for operating the vacuum motor to isolate the high voltage power source from the user.
摘要:
Enhanced removal and/or control of adhesives or sticky materials, “stickies”, from recovered paper stock or virgin pulp fibers is achieved using a combination of enzyme treatment with adsorbents and/or absorbents. Pulp stock to be treated is typically obtained from old magazines, newspapers, household waste, but may include corrugated boxes and office waste. Virgin pulps may include mechanical, chemical, or semi-chemical pulps. Enzymes typically include hydrolases such as cellulases, hemicellulases, pectinases, amylases, and lipases such as esterases, lyases such as pectate lyases, and oxidoreductases. Adsorbents include activated bentonite, microparticles, talc, clay and modified silica. Absorbents typically include water soluble polymers, dispersants, coagulatants and agglomerants.